Publications by authors named "Kenneth L Scott"

48Publications

IMPAD1 and KDELR2 drive invasion and metastasis by enhancing Golgi-mediated secretion.

Oncogene 2020 Sep 4;39(37):5979-5994. Epub 2020 Aug 4.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41388-020-01410-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539228PMC
September 2020

Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage.

Cell 2019 01;176(1-2):127-143.e24

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA; Systems, Synthetic and Physical Biology Program, Rice University, Houston, TX 77030, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183162
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http://dx.doi.org/10.1016/j.cell.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344048PMC
January 2019

Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies.

Nat Commun 2018 11 2;9(1):4583. Epub 2018 Nov 2.

Department of Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.

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http://www.nature.com/articles/s41467-018-06949-w
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http://dx.doi.org/10.1038/s41467-018-06949-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214970PMC
November 2018

TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.

Nat Commun 2018 07 16;9(1):2731. Epub 2018 Jul 16.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://www.nature.com/articles/s41467-018-05013-x
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http://dx.doi.org/10.1038/s41467-018-05013-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048095PMC
July 2018

Cancer driver mutation prediction through Bayesian integration of multi-omic data.

PLoS One 2018 8;13(5):e0196939. Epub 2018 May 8.

Department of Bioinformatics and Computational Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196939PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940219PMC
August 2018

Differential UBE2C and HOXA1 expression in melanocytic nevi and melanoma.

J Cutan Pathol 2017 Oct 21;44(10):843-850. Epub 2017 Jul 21.

Pathology Service and Dermatopathology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/cup.12997DOI Listing
October 2017

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.

Cancer Cell 2017 06 18;31(6):820-832.e3. Epub 2017 May 18.

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502825PMC
June 2017

Ba/F3 transformation assays.

Oncotarget 2017 May;8(22):35488-35489

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.17828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482591PMC
May 2017

Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers.

Genome Res 2017 07 14;27(7):1112-1125. Epub 2017 Apr 14.

Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1101/gr.219741.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495064PMC
July 2017

Functionally Assessing Candidate Drivers Advances Precision Cancer Medicine.

Cancer Cell 2016 08;30(2):187-189

Department of Pathology, Stony Brook University, One Nichols Drive, Stony Brook, NY 11794, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.07.011DOI Listing
August 2016

Analyzing Somatic Genome Rearrangements in Human Cancers by Using Whole-Exome Sequencing.

Am J Hum Genet 2016 05;98(5):843-856

Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA; Ludwig Center, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863662PMC
May 2016

Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations.

Cancer Res 2015 Dec 1;75(24):5341-54. Epub 2015 Dec 1.

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas. Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681596PMC
December 2015

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers.

Cancer Cell 2015 Oct 1;28(4):515-528. Epub 2015 Oct 1.

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108150030
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http://dx.doi.org/10.1016/j.ccell.2015.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605878PMC
October 2015

The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism.

Cell Metab 2015 Mar;21(3):417-27

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757431PMC
March 2015

RET fusion as a novel driver of medullary thyroid carcinoma.

J Clin Endocrinol Metab 2015 Mar 29;100(3):788-93. Epub 2014 Dec 29.

Departments of Surgical Oncology (E.G.G., J.B., J.E.L., F.M.-B., N.D.P.), Institute of Personalized Cancer Therapy (P.K.-S.N., K.R.S.), Endocrine Neoplasia and Hormonal Disorders (N.L.B., S.G.W., G.J.C.), Bioinformatics and Computational Biology (K.C.), Hematopathology (X.L.), Investigational Cancer Therapeutics (F.M.-B.), Systems Biology (G.B.M.), and Pathology (M.D.W.), University of Texas MD Anderson Cancer Center, Houston, Texas 77030; Foundation Medicine (G.P., R.Y.), Cambridge, Massachusetts 02141; and Integrative Molecular and Biomedical Sciences Graduate Program (H.L., K.L.S.), Baylor College of Medicine, Houston, Texas 77030.

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http://dx.doi.org/10.1210/jc.2014-4153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333032PMC
March 2015

Circulating tumor cells from 4D model have less integrin beta 4 expression.

J Surg Res 2015 Feb 20;193(2):745-53. Epub 2014 Aug 20.

Department of Surgery, Houston Methodist Research Institute, Houston, Texas; Department of Surgery, Weill Cornell Medical College, Houston Methodist Hospital, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2014.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268315PMC
February 2015

Signaling from the Golgi: mechanisms and models for Golgi phosphoprotein 3-mediated oncogenesis.

Clin Cancer Res 2010 Apr 30;16(8):2229-34. Epub 2010 Mar 30.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855764PMC
April 2010

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.

Proc Natl Acad Sci U S A 2008 Dec 3;105(49):19384-9. Epub 2008 Dec 3.

Department of Medical Oncology, Belfer Foundation Institute for Innovative Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0810584105
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http://dx.doi.org/10.1073/pnas.0810584105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593615PMC
December 2008

Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response.

Cancer Res 2006 Sep;66(17):8397-403

Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0061DOI Listing
September 2006

CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor.

Gene 2005 Oct;359:119-26

Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S037811190500364
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http://dx.doi.org/10.1016/j.gene.2005.06.014DOI Listing
October 2005

Loss of Sin3/Rpd3 histone deacetylase restores the DNA damage response in checkpoint-deficient strains of Saccharomyces cerevisiae.

Mol Cell Biol 2003 Jul;23(13):4522-31

Department of Molecular and Human Genetics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164854PMC
http://dx.doi.org/10.1128/mcb.23.13.4522-4531.2003DOI Listing
July 2003