Kenneth H Kraemer

Kenneth H Kraemer

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Kenneth H Kraemer

Kenneth H Kraemer

Publications by authors named "Kenneth H Kraemer"

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71Publications

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Neurodegeneration as the presenting symptom in 2 adults with xeroderma pigmentosum complementation group F.

Neurol Genet 2018 Jun 8;4(3):e240. Epub 2018 Jun 8.

Department of Neurology (N.M.S., M.D.G.), University of California San Francisco, CA; Laboratory of Cancer Biology and Genetics (J.J.D., K.H.K.), Center for Cancer Research, National Cancer Institute, National Institutes of Health; NIH Undiagnosed Diseases Program (C.G., R.G., M.C.V.M., W.A.G., C.T.), National Human Genome Research Institute, National Institutes of Health, Bethesda, MD; and Department of Molecular Medicine (M.J.Y., E.A.W., L.J.N.), Center on Aging, The Scripps Research Institute, Jupiter, FL.

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June 2018

Four-dimensional, dynamic mosaicism is a hallmark of normal human skin that permits mapping of the organization and patterning of human epidermis during terminal differentiation.

PLoS One 2018 13;13(6):e0198011. Epub 2018 Jun 13.

Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States of America.

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June 2018

Recurrent scarring papulovesicular lesions on sun-exposed skin in a 22-year-old man.

J Am Acad Dermatol 2018 Mar 28;78(3):637-642. Epub 2017 Sep 28.

Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:

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March 2018

Forty years of research on xeroderma pigmentosum at the US National Institutes of Health.

Photochem Photobiol 2015 Mar-Apr;91(2):452-9. Epub 2015 Jan 8.

Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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September 2015

Mutations in the TTDN1 gene are associated with a distinct trichothiodystrophy phenotype.

J Invest Dermatol 2015 Mar 7;135(3):734-741. Epub 2014 Oct 7.

Dermatology Branch, Center for Cancer Research, National Cancer Institute National Institutes of Health, Bethesda, MD USA.

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March 2015

Living with xeroderma pigmentosum: comprehensive photoprotection for highly photosensitive patients.

Photodermatol Photoimmunol Photomed 2014 Apr-Jun;30(2-3):146-52. Epub 2014 Feb 19.

Dermatology Branch, Center for Cancer Research, National Institutes of Health, National Cancer Institute, Bethesda, MD, USA.

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October 2014

Growth and nutrition in children with trichothiodystrophy.

J Pediatr Gastroenterol Nutr 2014 Oct;59(4):458-64

*Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases †DNA Repair Section, Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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October 2014

Global contributions to the understanding of DNA repair and skin cancer.

J Invest Dermatol 2014 Oct 10;134(e1):E8-17. Epub 2014 Oct 10.

Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

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October 2014

High frequency of PTEN mutations in nevi and melanomas from xeroderma pigmentosum patients.

Pigment Cell Melanoma Res 2014 May 21;27(3):454-64. Epub 2014 Feb 21.

Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA; Division of Dermatology, Graduate School of Medicine, Kobe University, Kobe, Japan.

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May 2014

Repair of UV photolesions in xeroderma pigmentosum group C cells induced by translational readthrough of premature termination codons.

Proc Natl Acad Sci U S A 2013 Nov 11;110(48):19483-8. Epub 2013 Nov 11.

Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.

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November 2013

Histopathology of the inner ear in patients with xeroderma pigmentosum and neurologic degeneration.

Otol Neurotol 2013 Sep;34(7):1230-6

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA.

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September 2013

Abnormal XPD-induced nuclear receptor transactivation in DNA repair disorders: trichothiodystrophy and xeroderma pigmentosum.

Eur J Hum Genet 2013 Aug 12;21(8):831-7. Epub 2012 Dec 12.

DNA Repair Section, Dermatology Branch, Center for Cancer Research, National Cancer Institute/NIH, Bethesda, MD 20892, USA.

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August 2013

Do not underestimate nucleotide excision repair: it predicts not only melanoma risk but also survival outcome.

J Invest Dermatol 2013 Jul;133(7):1713-7

Department of Dermatology, Venerology, and Allergology, University Medical Center Göttingen, Göttingen, Germany.

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July 2013

Montagna Symposium 2011: 60th Anniversary--Advances in Science and Medicine Catalyzed by Pioneering Skin Research.

J Invest Dermatol 2012 May;132(5):1317-20

Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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May 2012

Shining a light on xeroderma pigmentosum.

J Invest Dermatol 2012 Mar 5;132(3 Pt 2):785-96. Epub 2012 Jan 5.

DNA Repair Section, Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4258, USA.

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March 2012

Xeroderma pigmentosum and other diseases of human premature aging and DNA repair: molecules to patients.

Mech Ageing Dev 2011 Jun-Jul;132(6-7):340-7. Epub 2011 Jun 25.

University of Pittsburgh, Pittsburgh, PA, United States.

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December 2011

Ocular manifestations of trichothiodystrophy.

Ophthalmology 2011 Dec 28;118(12):2335-42. Epub 2011 Sep 28.

National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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December 2011

Nucleotide excision repair proteins rapidly accumulate but fail to persist in human XP-E (DDB2 mutant) cells.

Photochem Photobiol 2011 May-Jun;87(3):729-33. Epub 2011 Mar 9.

DNA Repair Section, Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

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September 2011

Ophthalmic manifestations and histopathology of xeroderma pigmentosum: two clinicopathological cases and a review of the literature.

Surv Ophthalmol 2011 Jul-Aug;56(4):348-61

Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.

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August 2011

UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells.

DNA Repair (Amst) 2011 Jan 13;10(1):5-15. Epub 2010 Oct 13.

DNA Repair Section, Dermatology Branch, CCR, National Cancer Institute, Bethesda, MD 20892, USA.

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January 2011

Brittle hair, developmental delay, neurologic abnormalities, and photosensitivity in a 4-year-old girl.

J Am Acad Dermatol 2010 Aug;63(2):323-8

DNA Repair Section, Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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August 2010

Founder mutations in xeroderma pigmentosum.

J Invest Dermatol 2010 Jun;130(6):1491-3

Dermatology Branch, National Cancer Institute, Bethesda, MD 20892, USA.

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June 2010

Both XPD alleles contribute to the phenotype of compound heterozygote xeroderma pigmentosum patients.

J Exp Med 2009 Dec 23;206(13):3031-46. Epub 2009 Nov 23.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, BP 10142, 67404 Illkirch Cedex, C.U. Strasbourg, France.

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December 2009

The nucleosome-binding protein HMGN2 modulates global genome repair.

FEBS J 2009 Nov 16;276(22):6646-57. Epub 2009 Oct 16.

Department of Biology, Texas Woman's University, Denton, TX 76204-5799, USA.

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November 2009

Unexpected occurrence of xeroderma pigmentosum in an uncle and nephew.

Arch Dermatol 2009 Nov;145(11):1285-91

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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November 2009

Evidence of ultraviolet type mutations in xeroderma pigmentosum melanomas.

Proc Natl Acad Sci U S A 2009 Apr 27;106(15):6279-84. Epub 2009 Mar 27.

Basic Research Laboratory, Laboratory of Pathology, Dermatology Branch, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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April 2009

Activation of ATM depends on chromatin interactions occurring before induction of DNA damage.

Nat Cell Biol 2009 Jan 14;11(1):92-6. Epub 2008 Dec 14.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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January 2009

Skin cancers, blindness, and anterior tongue mass in African brothers.

J Am Acad Dermatol 2008 Nov;59(5):881-6

Basic Research Laboratory, DNA Repair Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4258, USA.

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November 2008

Influence of XPB helicase on recruitment and redistribution of nucleotide excision repair proteins at sites of UV-induced DNA damage.

DNA Repair (Amst) 2007 Sep 16;6(9):1359-70. Epub 2007 May 16.

Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4258, USA.

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September 2007

New areas of focus at workshop on human diseases involving DNA repair deficiency and premature aging.

Mech Ageing Dev 2007 Feb;128(2):229-35

Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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February 2007

Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome.

Hum Mutat 2006 Nov;27(11):1092-103

DNA Repair Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4258, USA.

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November 2006

Structural and molecular hair abnormalities in trichothiodystrophy.

J Invest Dermatol 2006 Oct 25;126(10):2210-6. Epub 2006 May 25.

DNA Repair Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4258, USA.

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October 2006

Rare diseases provide rare insights into DNA repair pathways, TFIIH, aging and cancer center.

DNA Repair (Amst) 2005 Feb;4(2):293-302

Laboratory of Molecular Gerontology, NIH, National Institute on Aging, Baltimore, MD 21224, USA.

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February 2005

Characterization of tiger-tail banding and hair shaft abnormalities in trichothiodystrophy.

J Am Acad Dermatol 2005 Feb;52(2):224-32

DNA Repair Section, National Cancer Institute, Bethesda, Maryland, USA.

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February 2005

Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin.

Proc Natl Acad Sci U S A 2004 Oct 11;101(42):15076-81. Epub 2004 Oct 11.

Departments of Therapeutic Radiology, Genetics, and Dermatology, and Yale Comprehensive Cancer Center, Yale School of Medicine, New Haven, CT 06520-8040, USA.

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October 2004

From proteomics to disease.

Nat Genet 2004 Jul;36(7):677-8

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July 2004

Two essential splice lariat branchpoint sequences in one intron in a xeroderma pigmentosum DNA repair gene: mutations result in reduced XPC mRNA levels that correlate with cancer risk.

Hum Mol Genet 2004 Feb 8;13(3):343-52. Epub 2003 Dec 8.

Basic Research Laboratory, Center for Cancer Research, National Cancer Institute/NIH, Building 37 Room 4002 MSC 4258, Bethesda, MD 20892-4258, USA.

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February 2004

Chromosomal protein HMGN1 enhances the rate of DNA repair in chromatin.

EMBO J 2003 Apr;22(7):1665-75

Protein Section, LM, Basic Research Laboratory, CCR, NCI, NIH, Bethesda, MD 20892, USA.

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April 2003

The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant.

J Immunol 2002 Oct;169(7):3825-30

Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.

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October 2002

Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells.

Cancer Res 2002 Sep;62(17):4899-902

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA.

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September 2002

Topical enzyme therapy for skin diseases?

J Am Acad Dermatol 2002 Mar;46(3):463-6

Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bldg. 37, Room 3E24, Bethesda, MD 20892, USA.

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March 2002