Kenneth D Setchell

Kenneth D R Setchell

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Kenneth D Setchell

Kenneth D R Setchell

Publications by authors named "Kenneth D R Setchell"

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1PubMed Central Citations

Analysis of chlorhexidine gluconate in skin using tape stripping and ultrahigh-performance liquid chromatography-tandem mass spectrometry.

J Pharm Biomed Anal 2020 May 6;183:113111. Epub 2020 Feb 6.

Division of Pathology & Laboratory Medicine; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2020.113111DOI Listing
May 2020

Open-label Phase 3 Continuation Study of Cholic Acid in Patients With Inborn Errors of Bile Acid Synthesis.

J Pediatr Gastroenterol Nutr 2020 Apr;70(4):423-429

Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH.

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http://dx.doi.org/10.1097/MPG.0000000000002618DOI Listing
April 2020

Utilizing centralized biorepository samples for biomarkers of cystic fibrosis lung disease severity.

J Cyst Fibros 2019 Dec 20. Epub 2019 Dec 20.

Division of Pulmonology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1016/j.jcf.2019.12.007DOI Listing
December 2019

Bile Acid Synthesis Disorder Masquerading as Intractable Vitamin D-Deficiency Rickets.

J Endocr Soc 2019 Feb 31;3(2):397-402. Epub 2018 Dec 31.

Division of Pediatric Endocrinology and Metabolism, Children's of Alabama, University of Alabama at Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.1210/js.2018-00314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364623PMC
February 2019

Progranulin associates with hexosaminidase A and ameliorates GM2 ganglioside accumulation and lysosomal storage in Tay-Sachs disease.

J Mol Med (Berl) 2018 12 20;96(12):1359-1373. Epub 2018 Oct 20.

Department of Orthopaedic Surgery, New York University Medical Center, 301 East 17th Street, New York, NY, 10003, USA.

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http://dx.doi.org/10.1007/s00109-018-1703-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240367PMC
December 2018

Inborn Errors of Bile Acid Metabolism.

Clin Liver Dis 2018 11 22;22(4):671-687. Epub 2018 Aug 22.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 240 Sabin Way, Cincinnati, OH 45229, USA; Division of Pathology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 240 Sabin Way, Cincinnati, OH 45229, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10893261183005
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http://dx.doi.org/10.1016/j.cld.2018.06.006DOI Listing
November 2018

Long-Term Cholic Acid Therapy in Zellweger Spectrum Disorders.

Case Rep Gastroenterol 2018 May-Aug;12(2):360-372. Epub 2018 Jun 28.

Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1159/000490095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062720PMC
June 2018

Oral Cholic Acid Is Efficacious and Well Tolerated in Patients With Bile Acid Synthesis and Zellweger Spectrum Disorders.

J Pediatr Gastroenterol Nutr 2018 02;66(2):e57-e59

Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1097/MPG.0000000000001764DOI Listing
February 2018

Tissue Localization of Glycosphingolipid Accumulation in a Gaucher Disease Mouse Brain by LC-ESI-MS/MS and High-Resolution MALDI Imaging Mass Spectrometry.

SLAS Discov 2017 12 17;22(10):1218-1228. Epub 2017 Jul 17.

3 Division of Human Genetics, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

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http://dx.doi.org/10.1177/2472555217719372DOI Listing
December 2017

Bile Acid Synthesis Disorders in Arabs: A 10-year Screening Study.

J Pediatr Gastroenterol Nutr 2017 12;65(6):613-620

Pediatric Hepatology and Pediatric Liver Transplantation Unit and National Reference Centre for Rare Pediatric Liver Diseases, Hepatinov, Bicêtre Universitary Hospital, University of Paris-Sud, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre.

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http://dx.doi.org/10.1097/MPG.0000000000001734DOI Listing
December 2017

The history and basic science development of soy isoflavones.

Menopause 2017 Dec;24(12):1338-1350

Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

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http://dx.doi.org/10.1097/GME.0000000000001018DOI Listing
December 2017

Severe Neonatal Cholestasis in Cerebrotendinous Xanthomatosis: Genetics, Immunostaining, Mass Spectrometry.

J Pediatr Gastroenterol Nutr 2017 11;65(5):561-568

*The Department of Pediatrics, Jinshan Hospital, Fudan University, Shanghai, China †Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH ‡Center for Pediatric Liver Diseases, Children's Hospital of Fudan University §Department of Pediatrics, Shanghai Medical College of Fudan University, Shanghai, China ||Institut für Pathologie, Medizinische Universität Graz, Graz, Austria.

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http://Insights.ovid.com/crossref?an=00005176-201711000-0001
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http://dx.doi.org/10.1097/MPG.0000000000001730DOI Listing
November 2017

Oral Cholic Acid Is Efficacious and Well Tolerated in Patients With Bile Acid Synthesis and Zellweger Spectrum Disorders.

J Pediatr Gastroenterol Nutr 2017 09;65(3):321-326

*Division of Pediatric Gastroenterology, Hepatology and Nutrition †Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

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http://dx.doi.org/10.1097/MPG.0000000000001657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559188PMC
September 2017

A convenient approach to facilitate monitoring Gaucher disease progression and therapeutic response.

Analyst 2017 Sep;142(18):3380-3387

Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1039/c7an00938kDOI Listing
September 2017

Will the real bile acid sulfotransferase please stand up? Identification of as a major hepatic bile acid sulfonating enzyme in mice.

J Lipid Res 2017 06 28;58(6):1033-1035. Epub 2017 Apr 28.

Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.

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http://www.jlr.org/lookup/doi/10.1194/jlr.C077420
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http://dx.doi.org/10.1194/jlr.C077420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454499PMC
June 2017

Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis: A Human Pilot Study.

J Clin Gastroenterol 2017 Feb;51(2):e11-e16

*Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine †Research Pharmacy, Yale-New Haven Hospital §Yale University School of Public Health, New Haven, CT ‡Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN ∥Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center ¶Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH #College of Health Solutions, Arizona State University, Tempe, AZ.

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http://dx.doi.org/10.1097/MCG.0000000000000591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218875PMC
February 2017

Stable-Isotope Dilution HPLC-Electrospray Ionization Tandem Mass Spectrometry Method for Quantifying Hydroxyurea in Dried Blood Samples.

Clin Chem 2016 Dec 30;62(12):1593-1601. Epub 2016 Sep 30.

Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

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http://dx.doi.org/10.1373/clinchem.2016.263715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598440PMC
December 2016

Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.

EBioMedicine 2016 Nov 24;13:212-224. Epub 2016 Oct 24.

Department of Orthopaedic Surgery, New York University School of Medicine, New York, NY 10003, United States; Department of Cell Biology, New York University School of Medicine, New York, NY 10016, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964163046
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http://dx.doi.org/10.1016/j.ebiom.2016.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264254PMC
November 2016

Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents.

Obesity (Silver Spring) 2016 11 12;24(11):2377-2383. Epub 2016 Sep 12.

Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, California, USA.

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http://dx.doi.org/10.1002/oby.21658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846337PMC
November 2016

Long-Term Ursodeoxycholic Acid Therapy Does Not Alter Lithocholic Acid Levels in Patients with Cystic Fibrosis with Associated Liver Disease.

J Pediatr 2016 10 11;177:59-65.e1. Epub 2016 Jun 11.

Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.

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http://dx.doi.org/10.1016/j.jpeds.2016.05.008DOI Listing
October 2016

Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice.

Sci Transl Med 2016 09;8(357):357ra122

Department of Pediatrics, Emory University School of Medicine, 1760 Haygood Drive Northeast, Atlanta, GA 30322, USA. Children's Healthcare of Atlanta, 2015 Uppergate Drive Northeast, Atlanta, GA 30322, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056562PMC
http://dx.doi.org/10.1126/scitranslmed.aaf4823DOI Listing
September 2016

Cognitive Effects of Soy Isoflavones in Patients with Alzheimer's Disease.

J Alzheimers Dis 2015 ;47(4):1009-19

Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.

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http://dx.doi.org/10.3233/JAD-142958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657545PMC
July 2016

Bile Acid Signaling: Mechanism for Bariatric Surgery, Cure for NASH?

Dig Dis 2015 27;33(3):440-6. Epub 2015 May 27.

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, and Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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https://www.karger.com/Article/FullText/371699
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http://dx.doi.org/10.1159/000371699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062006PMC
March 2016

Properties of neurons derived from induced pluripotent stem cells of Gaucher disease type 2 patient fibroblasts: potential role in neuropathology.

PLoS One 2015 30;10(3):e0118771. Epub 2015 Mar 30.

Division of Human Genetics, Cincinnati Children's Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America; Synageva BioPharma Corp., Lexington, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118771PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378893PMC
February 2016

Let the bile flow!

Hepatology 2015 Dec 17;62(6):1870. Epub 2015 Oct 17.

Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

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http://dx.doi.org/10.1002/hep.28244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681672PMC
December 2015

Neuronopathic Gaucher disease: dysregulated mRNAs and miRNAs in brain pathogenesis and effects of pharmacologic chaperone treatment in a mouse model.

Hum Mol Genet 2015 Dec 29;24(24):7031-48. Epub 2015 Sep 29.

Division of Human Genetics, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH 45229, USA, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA

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http://dx.doi.org/10.1093/hmg/ddv404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654057PMC
December 2015

Ubiquitous transgene expression of the glucosylceramide-synthesizing enzyme accelerates glucosylceramide accumulation and storage cells in a Gaucher disease mouse model.

PLoS One 2014 31;9(12):e116023. Epub 2014 Dec 31.

The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America; The Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116023PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281226PMC
October 2015

Differential Requirements for L-Citrulline and L-Arginine during Antimycobacterial Macrophage Activity.

J Immunol 2015 Oct 26;195(7):3293-300. Epub 2015 Aug 26.

Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229; and

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http://dx.doi.org/10.4049/jimmunol.1500800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432794PMC
October 2015

S-equol: a potential nonhormonal agent for menopause-related symptom relief.

J Womens Health (Larchmt) 2015 Mar 18;24(3):200-8. Epub 2015 Feb 18.

1 Scientific Director, Rapid Medical Research , Cleveland, Ohio.

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http://dx.doi.org/10.1089/jwh.2014.5006DOI Listing
March 2015

Treatment of bile acid amidation defects with glycocholic acid.

Hepatology 2015 Jan 23;61(1):268-74. Epub 2014 Dec 23.

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH; Clinical and Translational Research Center, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH.

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http://dx.doi.org/10.1002/hep.27401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280294PMC
January 2015

The role of small heterodimer partner in nonalcoholic fatty liver disease improvement after sleeve gastrectomy in mice.

Obesity (Silver Spring) 2014 Nov;22(11):2301-11

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1002/oby.20890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286402PMC
November 2014

Synthesis of atypical bile acids for use as investigative tools for the genetic defect of 3β-hydroxy-Δ(5)-C27-steroid oxidoreductase deficiency.

J Steroid Biochem Mol Biol 2014 Oct 19;144 Pt B:348-60. Epub 2014 Jun 19.

Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center and Department of Pediatrics of the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1016/j.jsbmb.2014.06.008DOI Listing
October 2014

The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism.

Nat Commun 2014 Sep 26;5:4993. Epub 2014 Sep 26.

Department of Oncology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1038/ncomms5993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431623PMC
September 2014

Multiple pathogenic proteins implicated in neuronopathic Gaucher disease mice.

Hum Mol Genet 2014 Aug 5;23(15):3943-57. Epub 2014 Mar 5.

The Division of Human Genetics and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA Synageva BioPharma, Lexington, MA 02421, USA

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http://dx.doi.org/10.1093/hmg/ddu105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082362PMC
August 2014

S-(-)equol production is developmentally regulated and related to early diet composition.

Nutr Res 2014 May 5;34(5):401-9. Epub 2014 Apr 5.

Division of Clinical Mass Spectrometry, Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH. Electronic address:

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http://dx.doi.org/10.1016/j.nutres.2014.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027651PMC
May 2014

Metabolism of secoisolariciresinol-diglycoside the dietary precursor to the intestinally derived lignan enterolactone in humans.

Food Funct 2014 Mar;5(3):491-501

Division of Pathology, Clinical Mass Spectrometry, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1039/c3fo60402kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996458PMC
March 2014

Gaucher disease: chemotactic factors and immunological cell invasion in a mouse model.

Mol Genet Metab 2014 Feb 10;111(2):163-71. Epub 2013 Sep 10.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10967192130031
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http://dx.doi.org/10.1016/j.ymgme.2013.09.002DOI Listing
February 2014

Phytosterols promote liver injury and Kupffer cell activation in parenteral nutrition-associated liver disease.

Sci Transl Med 2013 Oct;5(206):206ra137

Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1126/scitranslmed.3006898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070735PMC
October 2013

Automated in vivo platform for the discovery of functional food treatments of hypercholesterolemia.

PLoS One 2013 21;8(1):e52409. Epub 2013 Jan 21.

Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052409PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549914PMC
July 2013

A combination of mutations in AKR1D1 and SKIV2L in a family with severe infantile liver disease.

Orphanet J Rare Dis 2013 May 16;8:74. Epub 2013 May 16.

Department of Medical and Molecular Genetics and Centre for Rare Diseases and Personalised Medicine, University of Birmingham School of Medicine, Birmingham, UK.

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http://dx.doi.org/10.1186/1750-1172-8-74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659031PMC
May 2013

Primary ∆4-3-oxosteroid 5β-reductase deficiency: two cases in China.

World J Gastroenterol 2012 Dec;18(47):7113-7

Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai 201102, China.

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http://dx.doi.org/10.3748/wjg.v18.i47.7113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531703PMC
December 2012

Ex vivo and in vivo effects of isofagomine on acid β-glucosidase variants and substrate levels in Gaucher disease.

J Biol Chem 2012 Feb 13;287(6):4275-87. Epub 2011 Dec 13.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.

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http://dx.doi.org/10.1074/jbc.M111.280016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281716PMC
February 2012

Pneumocystis carinii sterol 14α-demethylase activity in Saccharomyces cerevisiae erg11 knockout mutant: sterol biochemistry.

J Eukaryot Microbiol 2011 Jul-Aug;58(4):383-92. Epub 2011 May 13.

Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA.

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http://doi.wiley.com/10.1111/j.1550-7408.2011.00556.x
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http://dx.doi.org/10.1111/j.1550-7408.2011.00556.xDOI Listing
January 2012

Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk.

Am J Clin Nutr 2011 Nov 28;94(5):1284-94. Epub 2011 Sep 28.

Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, OH 45229, USA.

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http://dx.doi.org/10.3945/ajcn.111.019638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192476PMC
November 2011

Impact of perinatal exposure to equol enantiomers on reproductive development in rodents.

Reprod Toxicol 2011 Jul 20;32(1):33-42. Epub 2011 May 20.

Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.reprotox.2011.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181124PMC
July 2011

Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse.

PLoS One 2011 Apr 20;6(4):e19037. Epub 2011 Apr 20.

The Division of Human Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019037PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080394PMC
April 2011

Global gene expression profile progression in Gaucher disease mouse models.

BMC Genomics 2011 Jan 11;12:20. Epub 2011 Jan 11.

The Division of Human Genetics, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1186/1471-2164-12-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032697PMC
January 2011

Equol: pharmacokinetics and biological actions.

J Nutr 2010 Jul 2;140(7):1363S-8S. Epub 2010 Jun 2.

Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.3945/jn.109.119784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884334PMC
July 2010

Equol: history, chemistry, and formation.

J Nutr 2010 Jul 2;140(7):1355S-62S. Epub 2010 Jun 2.

Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.3945/jn.109.119776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884333PMC
July 2010

The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancer.

Carcinogenesis 2010 May 28;31(5):886-93. Epub 2010 Jan 28.

Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, OH 45229, USA.

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http://dx.doi.org/10.1093/carcin/bgq025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864409PMC
May 2010

A new amino acid derivative of ursodeoxycholate, (N-L-Glutamyl)-UDCA (UDCA-Glu), to selectively release UDCA in the colon.

Anticancer Res 2009 Dec;29(12):4971-9

Clinica di Gastroenterologia ed Epatologia dell'Università degli Studi di Perugia, Ospedale S.Maria della Misericordia, S.Andrea delle Fratte, 06156 Perugia, Italy.

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December 2009

The pharmacokinetics of S-(-)equol administered as SE5-OH tablets to healthy postmenopausal women.

J Nutr 2009 Nov 23;139(11):2037-43. Epub 2009 Sep 23.

Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.3945/jn.109.110874DOI Listing
November 2009

Oral cholic acid for hereditary defects of primary bile acid synthesis: a safe and effective long-term therapy.

Gastroenterology 2009 Oct 19;137(4):1310-1320.e1-3. Epub 2009 Jul 19.

Pediatric Hepatology Unit, Hôpital Bicêtre, Assistance Publique - Hôpitaux de Paris, Paris, France.

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http://dx.doi.org/10.1053/j.gastro.2009.07.043DOI Listing
October 2009

Report on the 8th International Symposium on the Role of Soy in Health Promotion and Chronic Disease Prevention and Treatment.

J Nutr 2009 Apr 18;139(4):796S-802S. Epub 2009 Feb 18.

Nutrition Matters, Port Townsend, WA 98368, USA.

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https://academic.oup.com/jn/article/139/4/796S/4670433
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http://dx.doi.org/10.3945/jn.108.104182DOI Listing
April 2009

Variations in phytoestrogen content between different mill dates of the same diet produces significant differences in the time of vaginal opening in CD-1 mice and F344 rats but not in CD Sprague-Dawley rats.

Environ Health Perspect 2007 Dec;115(12):1717-26

Comparative Medicine Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1289/ehp.10165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137112PMC
December 2007

Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.

Cancer Cell 2007 Nov;12(5):467-78

Division of Experimental Hematology, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.10.015DOI Listing
November 2007

Inborn errors of bile acid metabolism.

Semin Liver Dis 2007 Aug;27(3):282-94

Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA.

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http://dx.doi.org/10.1055/s-2007-985073DOI Listing
August 2007

Analysis of HSD3B7 knockout mice reveals that a 3alpha-hydroxyl stereochemistry is required for bile acid function.

Proc Natl Acad Sci U S A 2007 Jul 29;104(28):11526-33. Epub 2007 Jun 29.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.0705089104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913850PMC
July 2007

Method of defining equol-producer status and its frequency among vegetarians.

J Nutr 2006 Aug;136(8):2188-93

Sanitarium Development and Innovation, Cooranbong, NSW 2265, Australia.

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http://dx.doi.org/10.1093/jn/136.8.2188DOI Listing
August 2006

Defects in bile acid biosynthesis--diagnosis and treatment.

J Pediatr Gastroenterol Nutr 2006 Jul;43 Suppl 1:S17-22

Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, OH, USA.

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http://dx.doi.org/10.1097/01.mpg.0000226386.79483.7bDOI Listing
July 2006

Assessing risks and benefits of genistein and soy.

Environ Health Perspect 2006 Jun;114(6):A332-3

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1480497PMC
http://dx.doi.org/10.1289/ehp.114-a332DOI Listing
June 2006

Hemoglobins dioxygenate nitric oxide with high fidelity.

J Inorg Biochem 2006 Apr 24;100(4):542-50. Epub 2006 Jan 24.

Division of Critical Care Medicine, Children's Hospital Medical Center, 3333 Burnet Ave, MLC7006, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.jinorgbio.2005.12.012DOI Listing
April 2006

Influences of dietary soy isoflavones on metabolism but not nociception and stress hormone responses in ovariectomized female rats.

Reprod Biol Endocrinol 2005 Oct 26;3:58. Epub 2005 Oct 26.

Physiology and Developmental Biology Department, Neuroscience Center, Brigham Young University, Provo, Utah 84602, USA.

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http://dx.doi.org/10.1186/1477-7827-3-58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1276816PMC
October 2005

Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.

J Clin Invest 2005 Sep 25;115(9):2556-63. Epub 2005 Aug 25.

Neurobiology of Disease Laboratory, Genetics and Aging Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI23610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1190368PMC
September 2005

Selecting the appropriate rodent diet for endocrine disruptor research and testing studies.

ILAR J 2004 ;45(4):401-16

Comparative Medicine Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1093/ilar.45.4.401DOI Listing
July 2005

Behavioral effects of endocrine-disrupting substances: phytoestrogens.

ILAR J 2004 ;45(4):443-54

Department of Physiology and Developmental Biology, Neuroscience Center, Brigham Young University, Provo, UT, USA.

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http://dx.doi.org/10.1093/ilar.45.4.443DOI Listing
July 2005

S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora.

Am J Clin Nutr 2005 May;81(5):1072-9

Division of Pathology, Clinical Mass Spectrometry, Cincinnati Children's Hospital Medical Center, and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati 45229, OH, USA.

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http://dx.doi.org/10.1093/ajcn/81.5.1072DOI Listing
May 2005

Phytoestrogens: hormonal action and brain plasticity.

Brain Res Bull 2005 Apr 29;65(3):193-8. Epub 2004 Dec 29.

The Neuroscience Center, Brigham Young University, 633 WIDB, Provo, UT 84602, USA.

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http://dx.doi.org/10.1016/j.brainresbull.2004.11.022DOI Listing
April 2005

Pharmacokinetics of a slow-release formulation of soybean isoflavones in healthy postmenopausal women.

J Agric Food Chem 2005 Mar;53(6):1938-44

Division of Pathology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1021/jf0488099DOI Listing
March 2005

Phytoestrogens: implications in neurovascular research.

Curr Neurovasc Res 2004 Dec;1(5):455-64

Department of Physiology and Developmental Biology, Neuroscience Center, 633 WIDB, Brigham Young University, Provo, Utah 84602, USA.

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http://dx.doi.org/10.2174/1567202043361974DOI Listing
December 2004