Kenneth D Aldape

Kenneth D Aldape

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Kenneth D Aldape

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Tissue 2-Hydroxyglutarate as a Biomarker for Mutations in Gliomas.

Clin Cancer Res 2019 Jun 18;25(11):3366-3373. Epub 2019 Feb 18.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3205DOI Listing
June 2019

Dendritic cell vaccines for high-grade gliomas.

Ther Clin Risk Manag 2018 26;14:1299-1313. Epub 2018 Jul 26.

MacFeeters-Hamilton Neuro-Oncology Program, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.2147/TCRM.S135865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067774PMC
July 2018

Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma.

J Clin Oncol 2018 05 12;36(14):1419-1427. Epub 2018 Feb 12.

Frederick F. Lang, Charles Conrad, Candelaria Gomez-Manzano, W.K. Alfred Yung, Raymond Sawaya, Jeffrey S. Weinberg, Sujit S. Prabhu, Ganesh Rao, Gregory N. Fuller, Kenneth D. Aldape, Joy Gumin, Luis M. Vence, Ignacio Wistuba, Jaime Rodriguez-Canales, Pamela A. Villalobos, and Juan Fueyo, The University of Texas MD Anderson Cancer Center; Brett Ewald, Joanna J. Peterkin, and Frank Tufaro, DNAtrix, Houston, TX; Clemens M.F. Dirven, Erasmus University Medical Center, Rotterdam, the Netherlands; and Sonia Tejada, Ricardo D. Valle, and Marta M. Alonso, Clínica Universidad de Navarra, Pamplona, Spain.

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http://ascopubs.org/doi/10.1200/JCO.2017.75.8219
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http://dx.doi.org/10.1200/JCO.2017.75.8219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075856PMC
May 2018

A gene expression signature predicts recurrence-free survival in meningioma.

Oncotarget 2018 Mar 15;9(22):16087-16098. Epub 2018 Feb 15.

The University of Texas MD Anderson Cancer Center, Department of Translational Molecular Pathology, Houston, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.24498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882319PMC
March 2018

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Nature 2018 01 20;553(7686):101-105. Epub 2017 Dec 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nature25169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422PMC
January 2018

Glut3 Addiction: A Druggable Vulnerability in Glioblastoma.

Cancer Cell 2017 12;32(6):726-727

Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.11.017DOI Listing
December 2017

Gli1-induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1.

EMBO Rep 2017 08 16;18(8):1318-1330. Epub 2017 Jun 16.

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

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http://dx.doi.org/10.15252/embr.201643124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538423PMC
August 2017

Insights From Molecular Profiling of Adult Glioma.

J Clin Oncol 2017 Jul 22;35(21):2386-2393. Epub 2017 Jun 22.

Phedias Diamandis and Kenneth D. Aldape, Princess Margaret Cancer Centre; and Kenneth D. Aldape, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2017.73.9516DOI Listing
July 2017

Global epigenetic profiling identifies methylation subgroups associated with recurrence-free survival in meningioma.

Acta Neuropathol 2017 03 27;133(3):431-444. Epub 2017 Jan 27.

Princess Margaret Cancer Centre, MacFeeters-Hamilton Brain Tumour Centre, College Street 101, Toronto, M5G 1L7, ON, Canada.

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http://dx.doi.org/10.1007/s00401-017-1678-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600514PMC
March 2017

Atypical meningioma-is it time to standardize surgical sampling techniques?

Neuro Oncol 2017 03;19(3):453-454

Department of Pathology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1093/neuonc/now245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464334PMC
March 2017

Treatment of Adult Lower-Grade Glioma in the Era of Genomic Medicine.

Am Soc Clin Oncol Educ Book 2016 ;35:75-81

From the University of California, San Francisco, San Francisco, CA; Harvard Medical School, Boston, MA; Toronto General Hospital/Research Institute, Toronto, Canada; University of Maryland, Baltimore, MD.

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http://dx.doi.org/10.1200/EDBK_158869DOI Listing
January 2017

PCR Techniques in Characterizing DNA Methylation.

Methods Mol Biol 2016 ;1392:177-86

Princess Margaret Cancer Center and Ontario Cancer Institute, 610 University Avenue, Toronto, ON, Canada, M5G 2M9.

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http://dx.doi.org/10.1007/978-1-4939-3360-0_16DOI Listing
November 2016

Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22.

Nat Cell Biol 2016 09 8;18(9):954-966. Epub 2016 Aug 8.

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1038/ncb3396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026327PMC
September 2016

Sox2: regulation of expression and contribution to brain tumors.

CNS Oncol 2016 Jul 27;5(3):159-73. Epub 2016 May 27.

McFeeters-Hamilton Center for Neuro-Oncology Research, 101 College St., Toronto, ON, M5G 1L7, Canada.

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http://dx.doi.org/10.2217/cns-2016-0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042636PMC
July 2016

TERT Promoter Mutations and Risk of Recurrence in Meningioma.

J Natl Cancer Inst 2016 May 13;108(5). Epub 2015 Dec 13.

Affiliations of authors:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg , Heidelberg , Germany (FS, DS, CK, DR, JB, AK, DC, SS, AvD); Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg , Germany (FS, DS, CK, DR, AK, DC, AvD); Department of Pathology (AO), Department of Genomic Medicine (QW), Department of Radiation Oncology (QW, EPS), and Department of Bioinformatics and Computational Biology (QW), The University of Texas MD Anderson Cancer Center , Houston, TX ; Department of Radiation Oncology (SA, JD) and Department of Neurosurgery (MSc, TU, CHM), University Hospital Heidelberg , Heidelberg , Germany ; Department of Neuropathology, Charité Medical University , Berlin , Germany (AK); Department of Pathology, University Hospital Nürnberg , Nürnberg , Germany (AFO): Department of Neurosurgery, Medical Faculty of the Ruprecht-Karls-University of Heidelberg , Mannheim , Germany (SB); Department of Neuropathology, Institute of Pathology and Neuropathology, University Tübingen , Tübingen , Germany (JS); Department of Neuropathology, University of Bonn , Bonn , Germany (AB); Department of Neurosurgery (BB) and Institute of Neuropathology (WP), University Hospital Münster , Münster , Germany (BB); Department of Neurosurgery, University Hospital Bonn , Bonn , Germany (KG, MSi); Department of Neurosurgery, University Hospital Würzburg , Würzburg , Germany (AFK); Department of Neurosurgery, University Hospital Hamburg , Hamburg , Germany (KL); Department of Neuropathology, Otto von Guericke University Magdeburg , Magdeburg , Germany (CM); Institute of Pathology, Saarland University , Homburg, Saarland , Germany (YJK); Department of Neurosurgery, Saarland University , Homburg , Germany (RK); MacFeeters-Hamilton Brain Tumour Centre, Princess Margaret Cancer Center , Toronto, Ontario , Canada (KDA); Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg , Germany (TH).

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http://dx.doi.org/10.1093/jnci/djv377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849806PMC
May 2016

PIK3CA mutations in meningioma.

Neuro Oncol 2016 05;18(5):603-4

Department of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada (G.Z.); Princess Margaret Cancer Centre and MacFeeters-Hamilton Centre for Neuro-Oncology Research, Toronto, Ontario, Canada (S.K., K.D.A.).

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http://dx.doi.org/10.1093/neuonc/now029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827051PMC
May 2016

Adult brainstem gliomas: Correlation of clinical and molecular features.

J Neurol Sci 2015 18;353(1-2):92-7. Epub 2015 Apr 18.

Division of Neuro-oncology, The Ohio State University Comprehensive Cancer Center, 320 W 10th Avenue, Starling Loving Hall Suite M410, Columbus, OH 43210, United States.

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http://dx.doi.org/10.1016/j.jns.2015.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782610PMC
February 2016

Phase 2 trial of dasatinib in target-selected patients with recurrent glioblastoma (RTOG 0627).

Neuro Oncol 2015 Jul 10;17(7):992-8. Epub 2015 Mar 10.

Department of Neurology and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York (A.B.L. current); Memorial Sloan Kettering Cancer Center, New York, New York (A.B.L. during accrual, L.M.D.); NRG Oncology Statistics and Data Management Center, Philadelphia, Pennsylvania (S.L.P., S.G., M.W); The University of Texas MD Anderson Cancer Center, Houston, Texas (M.R.G., K.D.A. during accrual; R.K.); Neuro-Oncology Branch, National Cancer Institute/National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland (M.R.G. current); University of Toronto and Princess Margaret Cancer Centre, Toronto, Canada (K.D.A. current); Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania (J.H.B., S.M.C.); Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy Pittsburgh, Pennsylvania (J.H.B.); NCI Community Oncology Research Program - Kansas City, Prairie Village, Kansas (R.G.); Arizona Oncology Services Foundation, Tucson, Arizona (E.Y.); Penn State University and The Milton S. Hershey Medical Center, Hershey, Pennsylvania (H.W.); University of Maryland Medical Systems, Baltimore, Maryland (M.P.M.).

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http://dx.doi.org/10.1093/neuonc/nov011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762006PMC
July 2015

Histologic variability in solitary fibrous tumors reflects angiogenic and growth factor signaling pathway alterations.

Hum Pathol 2015 Jul 15;46(7):1015-26. Epub 2015 Apr 15.

Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston TX 70030.

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http://dx.doi.org/10.1016/j.humpath.2015.03.014DOI Listing
July 2015

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Authors:
Daniel J Brat Roel G W Verhaak Kenneth D Aldape W K Alfred Yung Sofie R Salama Lee A D Cooper Esther Rheinbay C Ryan Miller Mark Vitucci Olena Morozova A Gordon Robertson Houtan Noushmehr Peter W Laird Andrew D Cherniack Rehan Akbani Jason T Huse Giovanni Ciriello Laila M Poisson Jill S Barnholtz-Sloan Mitchel S Berger Cameron Brennan Rivka R Colen Howard Colman Adam E Flanders Caterina Giannini Mia Grifford Antonio Iavarone Rajan Jain Isaac Joseph Jaegil Kim Katayoon Kasaian Tom Mikkelsen Bradley A Murray Brian Patrick O'Neill Lior Pachter Donald W Parsons Carrie Sougnez Erik P Sulman Scott R Vandenberg Erwin G Van Meir Andreas von Deimling Hailei Zhang Daniel Crain Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Troy Shelton Mark Sherman Peggy Yena Aaron Black Jay Bowen Katie Dicostanzo Julie Gastier-Foster Kristen M Leraas Tara M Lichtenberg Christopher R Pierson Nilsa C Ramirez Cynthia Taylor Stephanie Weaver Lisa Wise Erik Zmuda Tanja Davidsen John A Demchok Greg Eley Martin L Ferguson Carolyn M Hutter Kenna R Mills Shaw Bradley A Ozenberger Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean Claude Zenklusen Brenda Ayala Julien Baboud Sudha Chudamani Mark A Jensen Jia Liu Todd Pihl Rohini Raman Yunhu Wan Ye Wu Adrian Ally J Todd Auman Miruna Balasundaram Saianand Balu Stephen B Baylin Rameen Beroukhim Moiz S Bootwalla Reanne Bowlby Christopher A Bristow Denise Brooks Yaron Butterfield Rebecca Carlsen Scott Carter Lynda Chin Andy Chu Eric Chuah Kristian Cibulskis Amanda Clarke Simon G Coetzee Noreen Dhalla Tim Fennell Sheila Fisher Stacey Gabriel Gad Getz Richard Gibbs Ranabir Guin Angela Hadjipanayis D Neil Hayes Toshinori Hinoue Katherine Hoadley Robert A Holt Alan P Hoyle Stuart R Jefferys Steven Jones Corbin D Jones Raju Kucherlapati Phillip H Lai Eric Lander Semin Lee Lee Lichtenstein Yussanne Ma Dennis T Maglinte Harshad S Mahadeshwar Marco A Marra Michael Mayo Shaowu Meng Matthew L Meyerson Piotr A Mieczkowski Richard A Moore Lisle E Mose Andrew J Mungall Angeliki Pantazi Michael Parfenov Peter J Park Joel S Parker Charles M Perou Alexei Protopopov Xiaojia Ren Jeffrey Roach Thaís S Sabedot Jacqueline Schein Steven E Schumacher Jonathan G Seidman Sahil Seth Hui Shen Janae V Simons Payal Sipahimalani Matthew G Soloway Xingzhi Song Huandong Sun Barbara Tabak Angela Tam Donghui Tan Jiabin Tang Nina Thiessen Timothy Triche David J Van Den Berg Umadevi Veluvolu Scot Waring Daniel J Weisenberger Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Andrew W Xu Lixing Yang Travis I Zack Jianhua Zhang B Arman Aksoy Harindra Arachchi Chris Benz Brady Bernard Daniel Carlin Juok Cho Daniel DiCara Scott Frazer Gregory N Fuller JianJiong Gao Nils Gehlenborg David Haussler David I Heiman Lisa Iype Anders Jacobsen Zhenlin Ju Sol Katzman Hoon Kim Theo Knijnenburg Richard Bailey Kreisberg Michael S Lawrence William Lee Kalle Leinonen Pei Lin Shiyun Ling Wenbin Liu Yingchun Liu Yuexin Liu Yiling Lu Gordon Mills Sam Ng Michael S Noble Evan Paull Arvind Rao Sheila Reynolds Gordon Saksena Zack Sanborn Chris Sander Nikolaus Schultz Yasin Senbabaoglu Ronglai Shen Ilya Shmulevich Rileen Sinha Josh Stuart S Onur Sumer Yichao Sun Natalie Tasman Barry S Taylor Doug Voet Nils Weinhold John N Weinstein Da Yang Kosuke Yoshihara Siyuan Zheng Wei Zhang Lihua Zou Ty Abel Sara Sadeghi Mark L Cohen Jenny Eschbacher Eyas M Hattab Aditya Raghunathan Matthew J Schniederjan Dina Aziz Gene Barnett Wendi Barrett Darell D Bigner Lori Boice Cathy Brewer Chiara Calatozzolo Benito Campos Carlos Gilberto Carlotti Timothy A Chan Lucia Cuppini Erin Curley Stefania Cuzzubbo Karen Devine Francesco DiMeco Rebecca Duell J Bradley Elder Ashley Fehrenbach Gaetano Finocchiaro William Friedman Jordonna Fulop Johanna Gardner Beth Hermes Christel Herold-Mende Christine Jungk Ady Kendler Norman L Lehman Eric Lipp Ouida Liu Randy Mandt Mary McGraw Roger Mclendon Christopher McPherson Luciano Neder Phuong Nguyen Ardene Noss Raffaele Nunziata Quinn T Ostrom Cheryl Palmer Alessandro Perin Bianca Pollo Alexander Potapov Olga Potapova W Kimryn Rathmell Daniil Rotin Lisa Scarpace Cathy Schilero Kelly Senecal Kristen Shimmel Vsevolod Shurkhay Suzanne Sifri Rosy Singh Andrew E Sloan Kathy Smolenski Susan M Staugaitis Ruth Steele Leigh Thorne Daniela P C Tirapelli Andreas Unterberg Mahitha Vallurupalli Yun Wang Ronald Warnick Felicia Williams Yingli Wolinsky Sue Bell Mara Rosenberg Chip Stewart Franklin Huang Jonna L Grimsby Amie J Radenbaugh Jianan Zhang
June 2015

Mitotic Index is an Independent Predictor of Recurrence-Free Survival in Meningioma.

Brain Pathol 2015 May 29;25(3):266-75. Epub 2014 Oct 29.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1111/bpa.12174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297750PMC
May 2015

Breast cancer with brain metastases: clinicopathologic features, survival, and paired biomarker analysis.

Oncologist 2015 May 23;20(5):466-73. Epub 2015 Mar 23.

Departments of Pathology, Biostatistics, Neurosurgery, and Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1634/theoncologist.2014-0107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425375PMC
May 2015

C11orf95-RELA fusion present in a primary supratentorial ependymoma and recurrent sarcoma.

Brain Tumor Pathol 2015 Apr 12;32(2):105-11. Epub 2014 Nov 12.

Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA,

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http://dx.doi.org/10.1007/s10014-014-0205-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400240PMC
April 2015

Randomized phase II adjuvant factorial study of dose-dense temozolomide alone and in combination with isotretinoin, celecoxib, and/or thalidomide for glioblastoma.

Neuro Oncol 2015 Feb 19;17(2):266-73. Epub 2014 Sep 19.

Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (M.P.-P., M.D.G., V.A.L., J.F.D.G., C.A.C., M.E.L., W.K.A.Y., M.R.G.); Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (K.R.H.); General Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (M.J.F., L.W.L.); Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (A.M.); Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas (K.D.A); Department of Neurosurgery, Kaiser Permanente Redwood City Medical Center, Redwood City, California (V.A.L.); Department of Neurological Surgery, Ohio State University Comprehensive Cancer Center, Columbus, Ohio (V.K.P.); Department of Neurosurgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (H.C.); Atlanta Regional Community Clinical Oncology Program, Georgia Cancer Specialists, Canton, Georgia (G.V.-.R.); Department of Neurosciences, Medical University of South Carolina Brain & Spine Tumor Program, Charleston, South Carolina (P.G.); Department of Hematology and Oncology, The University of Kansas Cancer Center, Overland Park, Kansas (M.E.S.); Department of Hematology and Oncology, Saint Francis Medical Center, Cape Girardeau, Missouri (J.D.F.); Department of Neurosurgery, University of Texas Health Science Center, Houston, Texas (S.H.H.); Department of Neurology, West Virginia University, Morgantown, West Virginia (J.G.); Department of Radiation Oncology, Keck School of Medicine, University of Southern California, U.S.C Norris Cancer Hospital, Los Angeles, California (E.L.C.); Department of Radiation Oncology, University of Louisville, James Graham Brown Cancer Center, Louisville, Kentucky (S.Y.W.).

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http://dx.doi.org/10.1093/neuonc/nou155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288521PMC
February 2015

Isocitrate dehydrogenase status and molecular subclasses of glioma and glioblastoma.

Neurosurg Focus 2014 Dec;37(6):E13

Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children;

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http://dx.doi.org/10.3171/2014.9.FOCUS14505DOI Listing
December 2014

Recursive partitioning analysis of prognostic variables in newly diagnosed anaplastic oligodendroglial tumors.

Neuro Oncol 2014 Nov 4;16(11):1541-6. Epub 2014 Jul 4.

Departments of Neurology (A.B.L., F.M.I., L.E.A., L.M.D.), Pathology (S.C.J., M.K.R.), Epidemiology & Biostatistics (A.S.R., K.S.P.), and the Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, New York; University of California, Los Angeles, Los Angeles, California (T.F.C.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (K.D.A., A.L.R.); Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (A.F.E., D.N.L.); NorthShore University Health System, Evanston Hospital Kellogg Cancer Center, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (N.A.P.); London Regional Cancer Program, London, Ontario, Canada (B.J.F.); Barrow Neurological Institute, Phoenix, Arizona (L.S.A.); University of Calgary, Calgary, Alberta, Canada (J.G.C., G.B.R.U.); Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts (P.Y.W.); Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Children's Hospital Boston, Brigham and Women's Hospital, Boston, Massachusetts (K.L.L.); University of Virginia Health System, Charlottesville, Virginia (D.S.); University of Wisconsin, Madison, Wisconsin (H.I.R., B.G.R.); University of Washington, Fred Hutchinson Cancer Research Center and Seattle Cancer Care Alliance, Seattle, Washington (M.C.C.); Princess Margaret Hospital, Toronto, Ontario, Canada (W.P.M.); Albany Medical Center, Albany, New York (S.A.W.); Kaiser Permanente-Los Angeles Medical Center, Los Angeles, California (R.M.G.); Clemenceau Medical Center, Beirut, Lebanon and Université Saint-Esprit de Kaslik, Byblos, Lebanon (F.G.K.).

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http://dx.doi.org/10.1093/neuonc/nou083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201067PMC
November 2014

The evolving role of molecular markers in the diagnosis and management of diffuse glioma.

Clin Cancer Res 2014 Nov;20(22):5601-11

MacFeeters-Hamilton Brain Tumour Centre, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0831DOI Listing
November 2014

GBM's multifaceted landscape: highlighting regional and microenvironmental heterogeneity.

Neuro Oncol 2014 Sep 18;16(9):1167-75. Epub 2014 Mar 18.

The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (A.V., S.K.S., S.A., S.J., K.B., G.Z.); Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (G.Z.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (K.D.A.).

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http://dx.doi.org/10.1093/neuonc/nou035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136895PMC
September 2014

Lambrolizumab induced central nervous system (CNS) toxicity.

J Neurol Sci 2014 Sep 20;344(1-2):229-31. Epub 2014 Jun 20.

The University of Texas MD Anderson Cancer Center, Department of Neuro-Oncology, 1515 Holcombe Blvd Unit 431, Houston, TX 77030-4009, United States; The University of Texas MD Anderson Cancer Center, Department of Pathology, 1515 Holcombe Blvd, Houston, TX 77030-4009, United States.

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http://dx.doi.org/10.1016/j.jns.2014.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157634PMC
September 2014

Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02.

Neuro Oncol 2014 Apr 26;16(4):567-78. Epub 2014 Jan 26.

Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (P.Y.W., A.D.N., J.D.); Department of Neurosurgery, University of California, San Francisco, San Francisco, California (S.M.C., K.R.L., M.D.P.); University of Texas Health Science Center, San Antonio, Texas (J.G.K.); Division of Neuro-Oncology, Department of Neurology, University of California, Los Angeles, Los Angeles, California (T.F.C.); University of Wisconsin, Madison Wisconsin (H.I.R., M.P.M.); Neurooncology Program, Division of Hematology/Oncology, University of Pittsburgh Medical Center Cancer Pavilion, Pittsburgh, Pennsylvania (F.S.L.); Division of Neuro-Oncology, MD Anderson Cancer Center, Houston, Texas (M.R.G., M.D.G., W.K.A.Y., K.D.A.); Center for Molecular Oncologic Pathology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (S.S., A.H.L.); Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (S.S., A.H.L., K.L.L.); Investigational Drug Branch, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland (J.D.*, J.J.W.).

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http://dx.doi.org/10.1093/neuonc/not247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956354PMC
April 2014

A randomized trial of bevacizumab for newly diagnosed glioblastoma.

N Engl J Med 2014 Feb;370(8):699-708

From the University of Texas M.D. Anderson Cancer Center (M.R.G., T.S.A., J.S.W., P.D.B., I.W.T.-L., E.P.S., K.D.A.) and the University of Texas Health Science Center School of Nursing (T.S.A.), Houston; American College of Radiology (J.J.D., S.P., M.W.) and Thomas Jefferson University (M.W.-W.) - both in Philadelphia; the University of Chicago, Chicago (J.J.D.); Tel-Aviv Medical Center, Tel Aviv, Israel (D.T.B.); Cleveland Clinic, Cleveland (M.A.V.); the University of Utah, Salt Lake City (H.C.); Ohio State University, Columbus (A.C.); University of Wisconsin, Madison (R.J.); Mayo Clinic, Jacksonville, FL (K.A.J.); University of Virginia, Charlottesville (D.S.); Southeast Cancer Control Consortium, Winston-Salem, NC (V.W.S.); Barrow Neurologic Institute, Phoenix, AZ (D.G.B.); Emory University, Atlanta (W.J.C.); and the University of Maryland, Baltimore (M.P.M.).

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http://dx.doi.org/10.1056/NEJMoa1308573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201043PMC
February 2014

Using the molecular classification of glioblastoma to inform personalized treatment.

J Pathol 2014 Jan;232(2):165-77

Department of Pathology, University of Texas MD Anderson Cancer Centre, Houston, TX, USA.

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http://dx.doi.org/10.1002/path.4282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138801PMC
January 2014

IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection.

Neuro Oncol 2014 Jan 4;16(1):81-91. Epub 2013 Dec 4.

Corresponding author: Daniel P. Cahill, MD, PhD, Department of Neurosurgery, 32 Fruit Street - Yawkey 9E, Massachusetts General Hospital, Brain Tumor Center/Neuro-Oncology, Boston, MA 02114.

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http://dx.doi.org/10.1093/neuonc/not159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870823PMC
January 2014

Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial.

J Clin Oncol 2013 Nov 7;31(32):4085-91. Epub 2013 Oct 7.

Mark R. Gilbert, Kenneth D. Aldape, Terri S. Armstrong, Jeffrey S. Wefel, Anita Mahajan, and Paul D. Brown, University of Texas MD Anderson Cancer Center; Terri S. Armstrong, University of Texas Health Science Center-School of Nursing, Houston, TX; Meihua Wang and Minhee Won, Radiation Therapy Oncology Group Statistical Center, Philadelphia, PA; Roger Stupp and Monika E. Hegi, Lausanne University Hospitals, Lausanne, Switzerland; Kurt A. Jaeckle, Mayo Clinic Florida, Jacksonville, FL; Deborah T. Blumenthal, Tel Aviv Medical Center, Tel Aviv; Tzahala Tzuk-Shina, Rambam Medical Center, Haifa, Israel; Christopher J. Schultz, Medical College of Wisconsin, Milwaukee, WI; Sara Erridge, University of Edinburgh, Edinburgh, Scotland; Brigitta G. Baumert, Maastricht University Medical Center, Maastricht, the Netherlands; Kristen I. Hopkins, University Hospitals Bristol, Bristol, United Kingdom; Arnab Chakravarti, Arthur G. James Cancer Hospital/Ohio State University Comprehensive Cancer Center, Columbus, OH; Walter J. Curran Jr, Emory University Winship Cancer Center, Atlanta, GA; and Minesh P. Mehta, University of Maryland, Baltimore, MD.

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http://dx.doi.org/10.1200/JCO.2013.49.6968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816958PMC
November 2013

The molecular landscape of diffuse glioma and prospects for biomarker development.

Expert Opin Med Diagn 2013 Nov 28;7(6):573-87. Epub 2013 Oct 28.

Memorial Sloan-Kettering Cancer Center, Department of Pathology and Human Oncology and Pathogenesis Program , 1275 York Avenue, NY 10065 , USA.

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November 2013

Clinical validation of a next-generation sequencing screen for mutational hotspots in 46 cancer-related genes.

J Mol Diagn 2013 Sep 26;15(5):607-22. Epub 2013 Jun 26.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1016/j.jmoldx.2013.05.003DOI Listing
September 2013

Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class.

Clin Cancer Res 2013 Sep 17;19(18):4951-60. Epub 2013 Jul 17.

Authors' Affiliations: Emory University School of Medicine, Departments of Biomedical Informatics and Pathology and Laboratory Medicine,Center for Comprehensive Informatics, Winship Cancer Institute, Emory University; Department of Pathology, Children's Healthcare of Atlanta, Atlanta, Georgia; Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan; Department of Pathology, Case Western Reserve University, Cleveland, Ohio; Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Pathology, Duke University Medical Center, Durham, North Carolina; Department of Pathology, Ohio State University, Columbus, Ohio; Department of Pathology, University of North Carolina, Chapel Hill, North Carolina; and Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865611PMC
September 2013

SRC family kinases as novel therapeutic targets to treat breast cancer brain metastases.

Cancer Res 2013 Sep 1;73(18):5764-74. Epub 2013 Aug 1.

Authors' Affiliations: Departments of Molecular and Cellular Oncology, Neurosurgery, and Pathology, The University of Texas MD Anderson Cancer Center; Cancer Biology Program, Graduate School of Biomedical Sciences-Houston, Houston, Texas; Women's Cancers Section, Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland; and Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781592PMC
September 2013

Brain metastases from papillary thyroid carcinomas.

Virchows Arch 2013 Apr 27;462(4):473-80. Epub 2013 Mar 27.

Department of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine 6 Ohio Drive, Suite 202, Lake Success, NY 11042, USA.

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http://dx.doi.org/10.1007/s00428-013-1394-4DOI Listing
April 2013

Predictors of survival among pediatric and adult ependymoma cases: a study using Surveillance, Epidemiology, and End Results data from 1973 to 2007.

Neuroepidemiology 2012 28;39(2):116-24. Epub 2012 Jul 28.

Dan L. Duncan Cancer Center, Baylor College of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1159/000339320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470871PMC
February 2013

αvβ8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion.

Mol Biol Cell 2013 Feb 2;24(4):474-82. Epub 2013 Jan 2.

Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1091/mbc.E12-07-0521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571870PMC
February 2013

Forkhead box M1 is regulated by heat shock factor 1 and promotes glioma cells survival under heat shock stress.

J Biol Chem 2013 Jan 28;288(3):1634-42. Epub 2012 Nov 28.

Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

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http://dx.doi.org/10.1074/jbc.M112.379362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548473PMC
January 2013

Biomarkers classification and therapeutic decision-making for malignant gliomas.

Curr Treat Options Oncol 2012 Dec;13(4):417-36

Department of Pathology and Genomic Medicine, The Methodist Hospital, 6565 Fannin St, M227, Houston, TX 77030, USA.

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December 2012

New strategies in melanoma: molecular testing in advanced disease.

Clin Cancer Res 2012 Mar 24;18(5):1195-200. Epub 2012 Jan 24.

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109407PMC
March 2012

Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma.

Cancer Cell 2011 Dec 1;20(6):810-7. Epub 2011 Dec 1.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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December 2011

Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT.

J Biol Chem 2011 Jul 11;286(26):23178-88. Epub 2011 May 11.

Program in Genes and Development, University of Texas Graduate School of Biomedical Sciences, Houston, Texas 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123085PMC
July 2011

Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition.

Cancer Res 2011 Jul 27;71(14):4932-43. Epub 2011 May 27.

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-4249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170798PMC
July 2011

Multigene sets for clinical application in glioma.

J Natl Compr Canc Netw 2011 Apr;9(4):449-56; quiz 457

Brain Tumor Center, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.6004/jnccn.2011.0040DOI Listing
April 2011

Discovering functional modules by identifying recurrent and mutually exclusive mutational patterns in tumors.

BMC Med Genomics 2011 Apr 14;4:34. Epub 2011 Apr 14.

Graduate Program in Structural and Computational Biology and Molecular Biophysics, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1186/1755-8794-4-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102606PMC
April 2011