Kenneth Cornetta

Kenneth Cornetta

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Kenneth Cornetta

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Gene Transfer to HSCs: Finding the Leukemia in Murine Leukemia Viruses.

Authors:
Kenneth Cornetta

Mol Ther 2019 Jun 17;27(6):1072-1073. Epub 2019 May 17.

Medical and Molecular Genetics, Indiana University School of Medicine, Walther Hall 980 W. Walnut Street, R3 C649, Indianapolis, IN 46202-5121, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554636PMC
June 2019

Equitable Access to Gene Therapy: A Call to Action for the American Society of Gene and Cell Therapy.

Mol Ther 2018 12 16;26(12):2715-2716. Epub 2018 Nov 16.

Moi Teaching and Referral Hospital, Eldoret, Kenya; Moi University School of Medicine, Eldoret, Kenya.

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https://linkinghub.elsevier.com/retrieve/pii/S15250016183053
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http://dx.doi.org/10.1016/j.ymthe.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277505PMC
December 2018

Equitable Access to Gene Therapy: A Call to Action for the American Society of Gene and Cell Therapy.

Mol Ther 2018 12 16;26(12):2715-2716. Epub 2018 Nov 16.

Moi Teaching and Referral Hospital, Eldoret, Kenya; Moi University School of Medicine, Eldoret, Kenya.

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https://linkinghub.elsevier.com/retrieve/pii/S15250016183053
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http://dx.doi.org/10.1016/j.ymthe.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277505PMC
December 2018

Absence of Replication-Competent Lentivirus in the Clinic: Analysis of Infused T Cell Products.

Mol Ther 2018 01 12;26(1):280-288. Epub 2017 Sep 12.

Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-5156, USA.

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http://dx.doi.org/10.1016/j.ymthe.2017.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762981PMC
January 2018

Lentivirus Mediated Correction of Artemis-Deficient Severe Combined Immunodeficiency.

Hum Gene Ther 2017 01 7;28(1):112-124. Epub 2016 Sep 7.

1 Department of Pediatrics, University of California School of Medicine and University of California San Francisco Benioff Children's Hospital , San Francisco, San Francisco, California.

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http://dx.doi.org/10.1089/hum.2016.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278830PMC
January 2017

Integration of Palliative Care Into Comprehensive Cancer Treatment at Moi Teaching and Referral Hospital in Western Kenya.

J Glob Oncol 2015 Oct 23;1(1):23-29. Epub 2015 Sep 23.

, and , School of Medicine, Indiana University; , Palliative Care Program, St. Vincent Indianapolis Hospital, Indianapolis, IN; , and , Moi Teaching and Referral Hospital; and and , Moi University, Eldoret, Kenya.

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http://dx.doi.org/10.1200/JGO.2015.000125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551647PMC
October 2015

Integration of Palliative Care Into Comprehensive Cancer Treatment at Moi Teaching and Referral Hospital in Western Kenya.

J Glob Oncol 2015 Oct 23;1(1):23-29. Epub 2015 Sep 23.

, and , School of Medicine, Indiana University; , Palliative Care Program, St. Vincent Indianapolis Hospital, Indianapolis, IN; , and , Moi Teaching and Referral Hospital; and and , Moi University, Eldoret, Kenya.

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http://dx.doi.org/10.1200/JGO.2015.000125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551647PMC
October 2015

Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A.

Nat Commun 2013 ;4:2773

1] Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA [2] Children's Research Institute, Children's Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA [3] MACC Fund Research Center, Milwaukee, Wisconsin 53226, USA.

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http://dx.doi.org/10.1038/ncomms3773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868233PMC
June 2014

Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma.

Clin Cancer Res 2014 May 14;20(9):2457-65. Epub 2014 Mar 14.

Authors' Affiliations: Departments of Medicine, Surgery, Pathology and Laboratory Medicine, Microbiology, Immunology and Molecular Genetics, and Molecular and Medical Pharmacology; Jonsson Comprehensive Cancer Center; Department of Ophthalmology, Jules Stein Eye Institute; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research; Howard Hughes Medical Institute, University of California, Los Angeles (UCLA); The Angeles Clinic Research Institute, Los Angeles; Department of Medicine, University of California San Diego (UCSD) Moores Cancer Center, La Jolla; Divisions of Chemistry and Biology, California Institute of Technology, Pasadena, California; Department of Medical and Molecular Genetics, Indiana University, and the Indiana University Viral Production Facility (IU VPF), Indianapolis, Indiana; Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada; Mayo Clinic Scottsdale, Scottsdale, Arizona; Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut; and Center for Immunology, Roswell Park Cancer Institute, Buffalo, New York.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-3017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070853PMC
May 2014

Development and Evaluation of Quality Metrics for Bioinformatics Analysis of Viral Insertion Site Data Generated Using High Throughput Sequencing.

Biomedicines 2014 May 6;2(2):195-210. Epub 2014 May 6.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, IB 130, 975 West Walnut Street, Indianapolis, IN 46202, USA.

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http://www.mdpi.com/2227-9059/2/2/195
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http://dx.doi.org/10.3390/biomedicines2020195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423470PMC
May 2014

Design and Potential of Non-Integrating Lentiviral Vectors.

Biomedicines 2014 Jan 27;2(1):14-35. Epub 2014 Jan 27.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.3390/biomedicines2010014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423482PMC
January 2014

Transgenic sheep generated by lentiviral vectors: safety and integration analysis of surrogates and their offspring.

Transgenic Res 2013 Aug 23;22(4):737-45. Epub 2012 Nov 23.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, IB 130, 975 W. Walnut St., Indianapolis, IN, 4620, USA.

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http://dx.doi.org/10.1007/s11248-012-9674-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606283PMC
August 2013

Partnership between CTSI and business schools can promote best practices for core facilities and resources.

Clin Transl Sci 2013 Aug 19;6(4):297-302. Epub 2013 Apr 19.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1111/cts.12059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740459PMC
August 2013

Balancing personalized medicine and personalized care.

Acad Med 2013 Mar;88(3):309-13

Medical and molecular genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1097/ACM.0b013e3182806345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584182PMC
March 2013

-Moving Biologic Agents into Approved Treatment Options.

Authors:
Kenneth Cornetta

Biomedicines 2013 Mar 11;1(1):1-2. Epub 2013 Mar 11.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 W, Walnut Street Room 130, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.3390/biomedicines1010001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423464PMC
March 2013

Advancing translational research through the NHLBI Gene Therapy Resource Program (GTRP).

Hum Gene Ther Clin Dev 2013 Mar 3;24(1):5-10. Epub 2013 Apr 3.

Division of Cardiovascular Sciences; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1089/humc.2013.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003470PMC
March 2013

Developing novel lentiviral vectors into clinical products.

Methods Enzymol 2012 ;507:89-108

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1016/B978-0-12-386509-0.00005-3DOI Listing
June 2012

Efficient large volume lentiviral vector production using flow electroporation.

Hum Gene Ther 2012 Feb 24;23(2):243-9. Epub 2011 Oct 24.

Department of Medical and Molecular Genetics, Indiana University School of Medicine , Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1089/hum.2011.088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311912PMC
February 2012

Using Pulmozyme DNase treatment in lentiviral vector production.

Hum Gene Ther Methods 2012 Feb;23(1):65-71

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1089/hgtb.2011.204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015072PMC
February 2012

Platelet gene therapy improves hemostatic function for integrin alphaIIbbeta3-deficient dogs.

Proc Natl Acad Sci U S A 2011 Jun 23;108(23):9583-8. Epub 2011 May 23.

Department of Pediatrics and Biomedical Resource Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.1073/pnas.1016394108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111318PMC
June 2011

Replication-competent lentivirus analysis of clinical grade vector products.

Mol Ther 2011 Mar 21;19(3):557-66. Epub 2010 Dec 21.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1038/mt.2010.278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048188PMC
March 2011

Identifying viral integration sites using SeqMap 2.0.

Bioinformatics 2011 Mar 17;27(5):720-2. Epub 2011 Jan 17.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1093/bioinformatics/btq722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042184PMC
March 2011

Flexibility in cell targeting by pseudotyping lentiviral vectors.

Methods Mol Biol 2010 ;614:53-68

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1007/978-1-60761-533-0_3DOI Listing
June 2010

Flow-through electroporation based on constant voltage for large-volume transfection of cells.

J Control Release 2010 May 29;144(1):91-100. Epub 2010 Jan 29.

Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.1016/j.jconrel.2010.01.030DOI Listing
May 2010

Alternate receptor usage of neuropilin-1 and glucose transporter protein 1 by the human T cell leukemia virus type 1.

Virology 2010 Jan 13;396(2):203-12. Epub 2009 Nov 13.

Department of Microbiology and Immunology, Indiana University School of Medicine, 635 Barnhill Drive, Rm#420, Indianapolis, IN, USA.

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http://dx.doi.org/10.1016/j.virol.2009.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789895PMC
January 2010

The National Gene Vector Biorepository's Pharm/Tox Database.

Mol Ther 2009 Apr;17(4):582-4

Indiana University Vector Production Facility, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1038/mt.2009.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835100PMC
April 2009

Detection of replication competent retrovirus and lentivirus.

Methods Mol Biol 2009 ;506:243-63

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1007/978-1-59745-409-4_17DOI Listing
February 2009

Production of retroviral vectors for clinical use.

Methods Mol Biol 2008 ;433:17-32

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1007/978-1-59745-237-3_2DOI Listing
August 2008

Efficient and stable gene expression into human osteoclasts using an HIV-1-based lentiviral vector.

DNA Cell Biol 2008 Jun;27(6):315-20

Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1089/dna.2007.0656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980781PMC
June 2008

Retroviral vector production by transient transfection.

CSH Protoc 2008 Apr 1;2008:pdb.prot4881. Epub 2008 Apr 1.

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http://dx.doi.org/10.1101/pdb.prot4881DOI Listing
April 2008

Generation of stable vector-producing cells for retroviral vectors.

CSH Protoc 2008 Apr 1;2008:pdb.prot4882. Epub 2008 Apr 1.

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http://dx.doi.org/10.1101/pdb.prot4882DOI Listing
April 2008

Transduction of cell lines by retroviral vectors.

CSH Protoc 2008 Apr 1;2008:pdb.prot4883. Epub 2008 Apr 1.

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http://dx.doi.org/10.1101/pdb.prot4883DOI Listing
April 2008

Transduction of primary hematopoietic cells by retroviral vectors.

CSH Protoc 2008 Apr 1;2008:pdb.prot4884. Epub 2008 Apr 1.

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http://dx.doi.org/10.1101/pdb.prot4884DOI Listing
April 2008

Retroviral vectors for gene transfer.

CSH Protoc 2008 Apr 1;2008:pdb.top29. Epub 2008 Apr 1.

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http://dx.doi.org/10.1101/pdb.top29DOI Listing
April 2008

Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization.

Stem Cells 2007 Dec 27;25(12):3234-43. Epub 2007 Sep 27.

Indiana Center for Vascular Biology & Medicine, Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 975 W. Walnut Street IB 441, Indianapolis, Indiana 46202, USA.

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http://doi.wiley.com/10.1634/stemcells.2007-0388
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http://dx.doi.org/10.1634/stemcells.2007-0388DOI Listing
December 2007

Encapsulation of nucleic acids and opportunities for cancer treatment.

Pharm Res 2007 Apr 15;24(4):618-27. Epub 2007 Feb 15.

Department of Biomedical Engineering and College of Pharmacy, The University of Texas at Austin, 1 University Station, Mailcode C0300, Austin, TX 78712, USA.

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http://dx.doi.org/10.1007/s11095-006-9208-xDOI Listing
April 2007

Enhanced green fluorescent protein is a nearly ideal long-term expression tracer for hematopoietic stem cells, whereas DsRed-express fluorescent protein is not.

Stem Cells 2007 Mar 30;25(3):670-8. Epub 2006 Nov 30.

Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, 950 West Walnut Street, Room 302, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1634/stemcells.2006-0553DOI Listing
March 2007

G2 cell cycle arrest and cyclophilin A in lentiviral gene transfer.

Mol Ther 2006 Oct 9;14(4):546-54. Epub 2006 Aug 9.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1016/j.ymthe.2006.05.022DOI Listing
October 2006

Desensitization to imatinib in patients with leukemia.

Ann Allergy Asthma Immunol 2006 Aug;97(2):216-22

Hematological Malignancy Program/Immunology, Division of Hematology/Oncology, Indiana University Hospital, Clarion Health Partners, USA.

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http://dx.doi.org/10.1016/S1081-1206(10)60016-6DOI Listing
August 2006

Decreased homing of retrovirally transduced human bone marrow CD34+ cells in the NOD/SCID mouse model.

Exp Hematol 2006 Apr;34(4):433-42

Department of Microbiology and Immunology, Division of Hematology/Oncology, Indian University School of Medicine, Indianapolis, 46202, USA.

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http://dx.doi.org/10.1016/j.exphem.2005.12.014DOI Listing
April 2006

Augmented high-dose regimen of cyclophosphamide, carmustine, and etoposide with autologous hematopoietic stem cell transplantation for relapsed and refractory aggressive non-Hodgkin's lymphoma.

Leuk Lymphoma 2005 Oct;46(10):1477-87

Bone Marrow and Stem Cell Transplantation Program, Indiana University Medical Center, 1044 West Walnut Street, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1080/10428190500158466DOI Listing
October 2005

Product-enhanced reverse transcriptase assay for replication-competent retrovirus and lentivirus detection.

Hum Gene Ther 2005 Oct;16(10):1227-36

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1089/hum.2005.16.1227DOI Listing
October 2005

Real-Time PCR: an Effective Tool for Measuring Transduction Efficiency in Human Hematopoietic Progenitor Cells.

Mol Ther 2005 Mar 2;11(3):483-491. Epub 2004 Dec 2.

Herman B. Wells Center for Pediatric Research, Indiana University, Indianapolis, IN 46202, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2004.10.017DOI Listing
March 2005

Umbilical cord blood transplantation in adults: results of the prospective Cord Blood Transplantation (COBLT).

Biol Blood Marrow Transplant 2005 Feb;11(2):149-60

Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 W. Walnut St., Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1016/j.bbmt.2004.11.020DOI Listing
February 2005

Regulatory issues in human gene therapy.

Authors:
Kenneth Cornetta

Blood Cells Mol Dis 2003 Jul-Aug;31(1):51-6

Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 W. Walnut Street, Indianapolis, IN 46202, USA.

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April 2004

Evaluation of plasmid DNA removal from lentiviral vectors by benzonase treatment.

Hum Gene Ther 2004 Feb;15(2):221-6

Department of Microbiology and Immunology, Wells Center for Pediatric Research, Indiana University School of Medicine, 975 West Walnut Street, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1089/104303404772680029DOI Listing
February 2004

Interleukin 12 immunotherapy after autologous stem cell transplantation for hematological malignancies.

Clin Cancer Res 2002 Nov;8(11):3383-93

Bone Marrow and Stem Cell Transplantation Program, Lymphoma Program, and the Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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November 2002

Detection of ecotropic replication-competent retroviruses: comparison of s(+)/l(-) and marker rescue assays.

Hum Gene Ther 2002 Sep;13(14):1783-90

Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1089/104303402760293619DOI Listing
September 2002

Regulatory issues for clinical gene therapy trials.

Hum Gene Ther 2002 Jul;13(10):1143-9

Departments of Medicine, Microbiology and Immunology, and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1089/104303402320138925DOI Listing
July 2002