Kenneth B Margulies

Kenneth B Margulies

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Kenneth B Margulies

Kenneth B Margulies

Publications by authors named "Kenneth B Margulies"

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100Publications

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Multi-ethnic genome-wide association study for atrial fibrillation.

Authors:
Carolina Roselli Mark D Chaffin Lu-Chen Weng Stefanie Aeschbacher Gustav Ahlberg Christine M Albert Peter Almgren Alvaro Alonso Christopher D Anderson Krishna G Aragam Dan E Arking John Barnard Traci M Bartz Emelia J Benjamin Nathan A Bihlmeyer Joshua C Bis Heather L Bloom Eric Boerwinkle Erwin B Bottinger Jennifer A Brody Hugh Calkins Archie Campbell Thomas P Cappola John Carlquist Daniel I Chasman Lin Y Chen Yii-Der Ida Chen Eue-Keun Choi Seung Hoan Choi Ingrid E Christophersen Mina K Chung John W Cole David Conen James Cook Harry J Crijns Michael J Cutler Scott M Damrauer Brian R Daniels Dawood Darbar Graciela Delgado Joshua C Denny Martin Dichgans Marcus Dörr Elton A Dudink Samuel C Dudley Nada Esa Tonu Esko Markku Eskola Diane Fatkin Stephan B Felix Ian Ford Oscar H Franco Bastiaan Geelhoed Raji P Grewal Vilmundur Gudnason Xiuqing Guo Namrata Gupta Stefan Gustafsson Rebecca Gutmann Anders Hamsten Tamara B Harris Caroline Hayward Susan R Heckbert Jussi Hernesniemi Lynne J Hocking Albert Hofman Andrea R V R Horimoto Jie Huang Paul L Huang Jennifer Huffman Erik Ingelsson Esra Gucuk Ipek Kaoru Ito Jordi Jimenez-Conde Renee Johnson J Wouter Jukema Stefan Kääb Mika Kähönen Yoichiro Kamatani John P Kane Adnan Kastrati Sekar Kathiresan Petra Katschnig-Winter Maryam Kavousi Thorsten Kessler Bas L Kietselaer Paulus Kirchhof Marcus E Kleber Stacey Knight Jose E Krieger Michiaki Kubo Lenore J Launer Jari Laurikka Terho Lehtimäki Kirsten Leineweber Rozenn N Lemaitre Man Li Hong Euy Lim Henry J Lin Honghuang Lin Lars Lind Cecilia M Lindgren Marja-Liisa Lokki Barry London Ruth J F Loos Siew-Kee Low Yingchang Lu Leo-Pekka Lyytikäinen Peter W Macfarlane Patrik K Magnusson Anubha Mahajan Rainer Malik Alfredo J Mansur Gregory M Marcus Lauren Margolin Kenneth B Margulies Winfried März David D McManus Olle Melander Sanghamitra Mohanty Jay A Montgomery Michael P Morley Andrew P Morris Martina Müller-Nurasyid Andrea Natale Saman Nazarian Benjamin Neumann Christopher Newton-Cheh Maartje N Niemeijer Kjell Nikus Peter Nilsson Raymond Noordam Heidi Oellers Morten S Olesen Marju Orho-Melander Sandosh Padmanabhan Hui-Nam Pak Guillaume Paré Nancy L Pedersen Joanna Pera Alexandre Pereira David Porteous Bruce M Psaty Sara L Pulit Clive R Pullinger Daniel J Rader Lena Refsgaard Marta Ribasés Paul M Ridker Michiel Rienstra Lorenz Risch Dan M Roden Jonathan Rosand Michael A Rosenberg Natalia Rost Jerome I Rotter Samir Saba Roopinder K Sandhu Renate B Schnabel Katharina Schramm Heribert Schunkert Claudia Schurman Stuart A Scott Ilkka Seppälä Christian Shaffer Svati Shah Alaa A Shalaby Jaemin Shim M Benjamin Shoemaker Joylene E Siland Juha Sinisalo Moritz F Sinner Agnieszka Slowik Albert V Smith Blair H Smith J Gustav Smith Jonathan D Smith Nicholas L Smith Elsayed Z Soliman Nona Sotoodehnia Bruno H Stricker Albert Sun Han Sun Jesper H Svendsen Toshihiro Tanaka Kahraman Tanriverdi Kent D Taylor Maris Teder-Laving Alexander Teumer Sébastien Thériault Stella Trompet Nathan R Tucker Arnljot Tveit Andre G Uitterlinden Pim Van Der Harst Isabelle C Van Gelder David R Van Wagoner Niek Verweij Efthymia Vlachopoulou Uwe Völker Biqi Wang Peter E Weeke Bob Weijs Raul Weiss Stefan Weiss Quinn S Wells Kerri L Wiggins Jorge A Wong Daniel Woo Bradford B Worrall Pil-Sung Yang Jie Yao Zachary T Yoneda Tanja Zeller Lingyao Zeng Steven A Lubitz Kathryn L Lunetta Patrick T Ellinor

Nat Genet 2018 Sep 11;50(9):1225-1233. Epub 2018 Jun 11.

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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September 2018

Microtubules Provide a Viscoelastic Resistance to Myocyte Motion.

Biophys J 2018 Sep 28. Epub 2018 Sep 28.

Department of Physiology, Pennsylvania Muscle Institute, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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September 2018

Advanced Morphologic Analysis for Diagnosing Allograft Rejection: The Case of Cardiac Transplant Rejection.

Transplantation 2018 Aug;102(8):1230-1239

Cardiovascular Research Institute, University of Pennsylvania, Philadelphia, PA.

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August 2018

Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure.

Nat Med 2018 Aug 11;24(8):1225-1233. Epub 2018 Jun 11.

Department of Physiology, Pennsylvania Muscle Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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August 2018

Targeting Calpain for Heart Failure Therapy: Implications From Multiple Murine Models.

JACC Basic Transl Sci 2018 Aug 28;3(4):503-517. Epub 2018 Aug 28.

Division of Cardiovascular Medicine, Department of Internal Medicine & François M. Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine; Iowa City, Iowa.

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August 2018

A deep-learning classifier identifies patients with clinical heart failure using whole-slide images of H&E tissue.

PLoS One 2018 3;13(4):e0192726. Epub 2018 Apr 3.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States of America.

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July 2018

GLP-1 Receptor Expression Within the Human Heart.

Endocrinology 2018 Apr;159(4):1570-1584

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada.

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April 2018

Increased Afterload Augments Sunitinib-Induced Cardiotoxicity in an Engineered Cardiac Microtissue Model.

JACC Basic Transl Sci 2018 Apr 30;3(2):265-276. Epub 2018 May 30.

Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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April 2018

Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects.

Circ Genom Precis Med 2018 Mar;11(3):e001901

From the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.H., M.P.M., J.B., K.B.M., T.P.C.); Cardiovascular Research Center (N.R.T., V.A.P., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, Boston; Department of Statistics, University of Illinois at Urbana-Champaign (S.D.Z.); Heidelberg University Hospital, Germany (B.M., H.A.K.); Department of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Germany (F.R., M.S.); INSERM UMRS1166-IACN, Hôpital Pitié-Salpêtrière, Paris, France (E.V., F.C.); Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, MA (H.L.); Department of Epidemiology, University of Washington, Seattle (N.L.S.); Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands (J.F.F.); Boston University School of Medicine, MA (R.S.V.); Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (P.v.d.H.); Medical and Population Genetics Program, Broad Institute, Cambridge, MA (C.N.-C.); Center for Applied Genomics, Children's Hospital of Philadelphia, PA (J.L., C.E.K., H.H.); Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.); Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, CA (E.A.A.); Department of Cardiovascular Medicine, Cleveland Clinic, OH (C.S.M., W.H.W.T.); and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center, OH (M.M., J.D.M.).

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March 2018

Prognostic Implications of Changes in Albumin Following Left Ventricular Assist Device Implantation in Patients With Severe Heart Failure.

Am J Cardiol 2017 Dec 30;120(11):2003-2007. Epub 2017 Aug 30.

Department of Medicine, Cardiovascular Division, University of Pennsylvania, Philadelphia, Pennsylvania; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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December 2017

Mechanically dynamic PDMS substrates to investigate changing cell environments.

Biomaterials 2017 Nov 17;145:23-32. Epub 2017 Aug 17.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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November 2017

Cardiomyocyte-Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans.

J Am Heart Assoc 2017 Sep 7;6(9). Epub 2017 Sep 7.

Department of Orthopaedic Surgery, University of Connecticut, Storrs, CT

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September 2017

Low ejection fraction in donor hearts is not directly associated with increased recipient mortality.

J Heart Lung Transplant 2017 Jun 4;36(6):611-615. Epub 2017 Feb 4.

Division of Cardiovascular Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

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June 2017

Detailed Echocardiographic Phenotyping in Breast Cancer Patients: Associations With Ejection Fraction Decline, Recovery, and Heart Failure Symptoms Over 3 Years of Follow-Up.

Circulation 2017 Apr 19;135(15):1397-1412. Epub 2017 Jan 19.

From Department of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia, PA (H.K.N.); Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (B. Finkelman, B. French, B.K.); and Department of Medicine, Division of Cardiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (B. Finkelman, T.P., D.H., A.M.S., K.B.M., B.K.).

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April 2017

Development of dilated cardiomyopathy and impaired calcium homeostasis with cardiac-specific deletion of ESRRβ.

Am J Physiol Heart Circ Physiol 2017 Apr 27;312(4):H662-H671. Epub 2017 Jan 27.

Cardiovascular Institute, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts.

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April 2017

Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction.

Circ Res 2017 Mar 7;120(7):1151-1161. Epub 2016 Dec 7.

From the Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia (P.Z., V.T., H.S.-C., M.B., J.A.B., S.V., K.B.M., T.P.C., J.A.C.); Rowan University School of Osteopathic Medicine, Stratford, NJ (L.T.); Children's Hospital of Philadelphia Research Institute, PA (P.-T.D., H.I.); Division of Nephrology/Hypertension, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.R.T.); Office of Nursing Research, School of Nursing, University of Pennsylvania, Philadelphia (J.C.); Departments of Kinesiology, Anatomy, and Physiology, Kansas State University, Manhattan (D.C.P.).

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March 2017

Right ventricular response to pulsatile load is associated with early right heart failure and mortality after left ventricular assist device.

J Heart Lung Transplant 2017 01 24;36(1):97-105. Epub 2016 Jun 24.

Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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January 2017

Intravenous Allogeneic Mesenchymal Stem Cells for Nonischemic Cardiomyopathy: Safety and Efficacy Results of a Phase II-A Randomized Trial.

Circ Res 2017 Jan 16;120(2):332-340. Epub 2016 Nov 16.

From the Division of Cardiology, Department of Medicine, Stony Brook University, NY (J.B., H.A.S.); MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC (S.E.E., M.J.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC (S.J.G., R.J.K.); Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA (A.A.Q., R.T.C.); CardioCell LLC, San Diego, CA (S.S.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (A.S.A., J.E.W.); Stemedica Cell Technologies Inc, San Diego, CA (N.I.T.); Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA (Y.-A.K.); Division of Cardiology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (K.B.M.); and Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL (M.G.).

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January 2017

Sparse simultaneous signal detection for identifying genetically controlled disease genes.

J Am Stat Assoc 2017 5;112(519):1032-1046. Epub 2017 Jan 5.

Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania.

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January 2017

Effect of Heart Failure With Preserved Ejection Fraction on Nitric Oxide Metabolites.

Am J Cardiol 2016 Dec 15;118(12):1855-1860. Epub 2016 Sep 15.

Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

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December 2016

Lack of Benefit for Liraglutide in Heart Failure-Reply.

JAMA 2016 12;316(22):2429-2430

Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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December 2016

Comparing Raman and fluorescence lifetime spectroscopy from human atherosclerotic lesions using a bimodal probe.

J Biophotonics 2016 09 22;9(9):958-66. Epub 2016 Mar 22.

Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller University Jena, Helmholtzweg 4, 07743, Jena, Germany.

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September 2016

Hyperamylinemia Increases IL-1β Synthesis in the Heart via Peroxidative Sarcolemmal Injury.

Diabetes 2016 09 22;65(9):2772-83. Epub 2016 Jun 22.

Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY

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September 2016

Evolving Challenges for Targeting Metabolic Abnormalities in Heart Failure.

JACC Heart Fail 2016 07 11;4(7):567-569. Epub 2016 May 11.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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July 2016

Transcription Factor 7-like 2 Mediates Canonical Wnt/β-Catenin Signaling and c-Myc Upregulation in Heart Failure.

Circ Heart Fail 2016 06 14;9(6). Epub 2016 Jun 14.

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY.

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June 2016

Comparison of Causes of Death After Heart Transplantation in Patients With Left Ventricular Ejection Fractions ≤35% Versus >35.

Am J Cardiol 2016 Apr 28;117(8):1322-6. Epub 2016 Jan 28.

Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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April 2016

Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes.

Science 2016 Apr;352(6284):aaf0659

Department of Physiology, Pennsylvania Muscle Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

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April 2016

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.

Circulation 2016 Feb 27;133(8):706-16. Epub 2016 Jan 27.

From Cardiovascular Institute University of Pennsylvania Perelman School of Medicine, Smilow Translational Research Center, Philadelphia, PA (K.C.B., J.B., A.J., K.B.M., J.E.R.); A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA (N.W.S.); and Center of Cancer Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (M.A., C.M., A.J.W., L.L.W., I.A.B.).

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February 2016

Mitochondrial protein hyperacetylation in the failing heart.

JCI Insight 2016 Feb 25;2(1). Epub 2016 Feb 25.

Cardiovascular Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida, USA.

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February 2016

Bayesian integration of genetics and epigenetics detects causal regulatory SNPs underlying expression variability.

Nat Commun 2015 Oct 12;6:8555. Epub 2015 Oct 12.

Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland 20742, USA.

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October 2015

Intracellular Na+ Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+-Glucose Cotransport.

J Am Heart Assoc 2015 Aug 27;4(9):e002183. Epub 2015 Aug 27.

Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY (R.L., S.S., X.P., F.D., S.D.).

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August 2015

MetaDiff: differential isoform expression analysis using random-effects meta-regression.

BMC Bioinformatics 2015 Jul 2;16:208. Epub 2015 Jul 2.

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, 44106, USA.

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July 2015

Enhanced bioactive myocardial transforming growth factor-β in advanced human heart failure.

Circ J 2014 9;78(11):2711-8. Epub 2014 Oct 9.

Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children.

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June 2015

Fluorescence Lifetime Imaging Combined with Conventional Intravascular Ultrasound for Enhanced Assessment of Atherosclerotic Plaques: an Ex Vivo Study in Human Coronary Arteries.

J Cardiovasc Transl Res 2015 Jun 1;8(4):253-63. Epub 2015 May 1.

Department of Biomedical Engineering, University of California Davis, 451 E. Health Sciences Drive, Davis, CA, 95616, USA.

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June 2015

Effects of sildenafil on ventricular and vascular function in heart failure with preserved ejection fraction.

Circ Heart Fail 2015 May 17;8(3):533-41. Epub 2015 Mar 17.

From the Department of Medicine, Division of Cardiology, Mayo Clinic, Rochester, MN (B.A.B., H.C., G.L., M.M.R.); Department of Medicine, Massachusetts General Hospital, Boston (G.D.L., M.J.S.); Department of Medicine, Duke Clinical Research Institute, Durham, NC (S.E.M.); Department of Medicine, Cardiology Unit, University of Vermont College of Medicine, Burlington (M.L.W.); Department of Medicine, Michael E. DeBakey VA Medical Center and Department of Medicine, Baylor College of Medicine, Houston, TX (A.D.); and Department of Medicine, University of Pennsylvania, Translational Research Center, Philadelphia (K.B.M.).

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May 2015

CaMKII Phosphorylation of Na(V)1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure.

J Proteome Res 2015 May 13;14(5):2298-311. Epub 2015 Apr 13.

†Department of Pharmacology, University of California Davis, Genome Building 3513, Davis, California 95616, United States.

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May 2015

Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study.

Circulation 2015 May 14;131(20):1763-71. Epub 2015 Apr 14.

From Brigham and Women's Hospital, Harvard Medical School, Boston, MA (M.M.G.); Duke University Medical Center, Durham, NC (K.J.A., G.M.F., C.M.O., S.E.M., K.L.L., A.F.H.); Mayo Clinic, Rochester, MN (M.M.R.); Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX (A.D.); Ottawa Heart Institute, Ontario, Canada (H.H.); Emory University, Atlanta, GA (J.B.); Cleveland Clinic, OH (W.H.W.T.); MetroHealth Campus of Case Western Reserve University, Cleveland, OH (M.E.D.); University of Vermont, Burlington (M.M.L.); Washington University, St. Louis, MO (D.L.M.); Hennepin County Medical Center, Minneapolis, MN (S.R.G.); Morehouse School of Medicine, Atlanta, GA (E.O.O.); Christiana Care Health System, Newark, DE (M.T.S.); University of Pennsylvania, Philadelphia (K.B.M., T.P.C.); Tufts Medical Center, Boston, MA (M.A.K.); Massachusetts General Hospital, Boston (M.J.S.); and National Heart, Lung, and Blood Institute, Bethesda, MD (M.R.S.).

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May 2015

RNA-Seq identifies novel myocardial gene expression signatures of heart failure.

Genomics 2015 Feb 17;105(2):83-9. Epub 2014 Dec 17.

Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, United States. Electronic address:

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February 2015

Effect of inorganic nitrate on exercise capacity in heart failure with preserved ejection fraction.

Circulation 2015 Jan 22;131(4):371-80; discussion 380. Epub 2014 Dec 22.

From the Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Perelman School of Medicine, Philadelphia (P.Z., P.S.-K., P.K., K.B.M., T.P.C., J.A.C.); Division of Cardiology, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA (D.R., P.S.-K., S.G., R.B., J.A.C.); Children's Hospital of Philadelphia Research Institute, Philadelphia, PA (P.-T.D., H.I.); Division of Nephrology/Hypertension. Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.R.T.); and Departments of Kinesiology, Anatomy, and Physiology, Kansas State University, Manhattan (D.C.P.).

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January 2015

Epigenetic memory and cardiac cell therapy.

J Am Coll Cardiol 2014 Aug;64(5):449-50

Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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August 2014

Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model.

J Am Heart Assoc 2014 Aug 21;3(4). Epub 2014 Aug 21.

Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY (S.D., S.S., F.D.) Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY (S.D., F.D.).

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August 2014

A bioengineered hydrogel system enables targeted and sustained intramyocardial delivery of neuregulin, activating the cardiomyocyte cell cycle and enhancing ventricular function in a murine model of ischemic cardiomyopathy.

Circ Heart Fail 2014 Jul 5;7(4):619-26. Epub 2014 Jun 5.

From the Department of Cardiothoracic Surgery, Stanford University, CA (J.E.C., J.W.M., Y.S., J.B.P., B.B.E., Y.J.W.); and Departments of Surgery, Division of Cardiovascular Surgery (J.E.C., J.W.M., C.M.B., A.T., A.S.F., G.H., W.H., P.A.), Bioengineering (B.P.P., M.S.D., J.A.B.), and Cardiology (A.M., K.B.M.), University of Pennsylvania, Philadelphia.

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July 2014

GLP-1 agonist therapy for advanced heart failure with reduced ejection fraction: design and rationale for the functional impact of GLP-1 for heart failure treatment study.

Circ Heart Fail 2014 Jul;7(4):673-9

From the Perelman School of Medicine, University of Pennsylvania, Philadelphia (K.B.M., T.P.C.); Duke Clinical Research Institute, Durham, NC (K.J.A., A.F.H.); Mayo Clinic, Rochester, MN (M.M.R.); Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, Bethesda, MD (M.R.S.); and Harvard Medical School, Boston, MA (E.B.).

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July 2014

Gene expression and genetic variation in human atria.

Heart Rhythm 2014 Feb 28;11(2):266-71. Epub 2013 Oct 28.

Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts; Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

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February 2014

Emerging Tools for Computer-Aided Diagnosis and Prognostication.

J Clin Trials 2014 Feb;4(2):e117

Department of Medicine, Division of Cardiovascular Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania.

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February 2014

Dynamic left ventricular assist device inflow obstruction.

Circ Heart Fail 2014 Jan;7(1):225-6

Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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January 2014

BET bromodomains mediate transcriptional pause release in heart failure.

Cell 2013 Aug;154(3):569-82

Case Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center, Cleveland, OH 44106, USA.

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August 2013

Hybrid mathematical model of cardiomyocyte turnover in the adult human heart.

PLoS One 2012 19;7(12):e51683. Epub 2012 Dec 19.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.

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June 2013

Management of ventricular arrhythmias in patients with ventricular assist devices.

Curr Opin Cardiol 2013 May;28(3):360-8

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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May 2013

Divergent mitochondrial biogenesis responses in human cardiomyopathy.

Circulation 2013 May 15;127(19):1957-67. Epub 2013 Apr 15.

Department of Anesthesiology, Division of Molecular Medicine, David Geffen School of Medicine at UCLA, BH-569 CHS, BOX 957115, Los Angeles, CA 90095, USA.

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May 2013

Synergistic effects of SDF-1α chemokine and hyaluronic acid release from degradable hydrogels on directing bone marrow derived cell homing to the myocardium.

Biomaterials 2012 Nov 24;33(31):7849-57. Epub 2012 Jul 24.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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November 2012

Myocardial reverse remodeling.

Cardiovasc Ther 2012 Jun 25;30(3):172-81. Epub 2010 Nov 25.

Department of Medicine, Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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June 2012

A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues.

Tissue Eng Part A 2012 May 4;18(9-10):910-9. Epub 2012 Jan 4.

Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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May 2012

Guanylyl cyclase (GC)-A and GC-B activities in ventricles and cardiomyocytes from failed and non-failed human hearts: GC-A is inactive in the failed cardiomyocyte.

J Mol Cell Cardiol 2012 Mar 22;52(3):727-32. Epub 2011 Nov 22.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

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March 2012

Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats.

Circ Res 2012 Feb 24;110(4):598-608. Epub 2012 Jan 24.

Department of Pharmacology, University of California-Davis, 451 Health Sciences Drive, Davis, CA 95616, USA.

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February 2012

Ischemia induces P-selectin-mediated selective progenitor cell engraftment in the isolated-perfused heart.

J Mol Cell Cardiol 2012 Jan 25;52(1):105-12. Epub 2011 Oct 25.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.

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January 2012

Differential expression of PDE5 in failing and nonfailing human myocardium.

Circ Heart Fail 2012 Jan 1;5(1):79-86. Epub 2011 Dec 1.

Cardiovascular Research Institute, University of Pennsylvania, Philadelphia, PA, USA.

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January 2012

Differential regulation of PDE5 expression in left and right ventricles of feline hypertrophy models.

PLoS One 2011 19;6(5):e19922. Epub 2011 May 19.

Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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November 2011

Biomarkers of myocardial stress and systemic inflammation in patients who engage in heart failure self-care management.

J Cardiovasc Nurs 2011 Jul-Aug;26(4):321-8

Oregon Health & Science University School of Nursing, Mail Code SN-65, 3455 SW US Veterans Hospital Rd, Portland, OR 97239-2941, USA.

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October 2011

Reciprocal transcriptional regulation of metabolic and signaling pathways correlates with disease severity in heart failure.

Circ Cardiovasc Genet 2011 Oct 9;4(5):475-83. Epub 2011 Aug 9.

Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD 21205, USA.

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October 2011

Resistance training improves vasoreactivity in end-stage heart failure patients on inotropic support.

J Cardiovasc Nurs 2011 May-Jun;26(3):218-23

Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4217, USA.

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August 2011

Functional genomics applied to cardiovascular medicine.

Circulation 2011 Jul;124(1):87-94

Penn Cardiovascular Institute and the Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.

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July 2011

Homeodomain only protein x is down-regulated in human heart failure.

J Mol Cell Cardiol 2011 Jun 5;50(6):1056-8. Epub 2011 Mar 5.

Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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June 2011

Contribution of late sodium current (I(Na-L)) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents.

Heart Rhythm 2011 May 22;8(5):762-9. Epub 2010 Dec 22.

Lankenau Institute for Medical Research and Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA.

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May 2011

Decreased cardiac functional reserve in heart failure with preserved systolic function.

J Card Fail 2011 Apr 24;17(4):301-8. Epub 2010 Dec 24.

Department of Physiology, Universityof Wisconsin School of Medicine and Public Health, 601 Science Drive, Madison, WI 53711, USA.

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April 2011

Ventilatory inefficiency reflects right ventricular dysfunction in systolic heart failure.

Chest 2011 Mar 5;139(3):617-625. Epub 2010 Aug 5.

Cardiovascular Division, Heart Failure/Transplant and Pulmonary Hypertension Programs, University of Pennsylvania School of Medicine, Philadelphia, PA. Electronic address:

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March 2011

Current status of stem cell therapy in heart failure.

Curr Cardiol Rep 2010 May;12(3):199-208

University of Pennsylvania School of Medicine, BRB II/III, Room 608, 421 Curie Boulevard, Philadelphia, PA 19014, USA.

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May 2010

Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation.

Sci Transl Med 2010 Apr;2(26):26ra26

Case Cardiovascular Research Institute, Department of Medicine, Harrington-McLaughlin Heart and Vascular Institute, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH 44106, USA.

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April 2010

Reciprocal regulation of metabolic and signaling pathways.

BMC Genomics 2010 Mar 24;11:197. Epub 2010 Mar 24.

Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.

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March 2010

Evidence for coregulation of myocardial gene expression by MEF2 and NFAT in human heart failure.

Circ Cardiovasc Genet 2009 Jun 31;2(3):212-9. Epub 2009 Mar 31.

Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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June 2009

Direct inotropic effects of exogenous and endogenous urotensin-II: divergent actions in failing and nonfailing human myocardium.

Circ Heart Fail 2009 Jan;2(1):39-46

Department of Physiology, Temple University School of Medicine, Philadelphia, Pa, USA.

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January 2009

Sex and age dimorphism of myocardial gene expression in nonischemic human heart failure.

Circ Cardiovasc Genet 2008 Dec 9;1(2):117-25. Epub 2008 Dec 9.

Lillehei Heart Institute, Division of Cardiology, Developmental Biology Center, University of Minnesota, Minneapolis, USA.

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December 2008