Kenneth Aldape

Kenneth Aldape

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Kenneth Aldape

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cIMPACT-NOW: a practical summary of diagnostic points from Round 1 updates.

Brain Pathol 2019 07 22;29(4):469-472. Epub 2019 May 22.

Department of Pathology, Amsterdam University Medical Centers/VUmc, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/bpa.12732DOI Listing
July 2019

Tissue 2-Hydroxyglutarate as a Biomarker for Mutations in Gliomas.

Clin Cancer Res 2019 Jun 18;25(11):3366-3373. Epub 2019 Feb 18.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3205DOI Listing
June 2019

Proteomic analysis of meningiomas reveals clinically-distinct molecular patterns.

Neuro Oncol 2019 May 11. Epub 2019 May 11.

Princess Margaret Cancer Centre, MacFeeters Hamilton Centre for Neuro-Oncology Research, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/neuonc/noz084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682208PMC
May 2019

Needle in a Haystack: Identifying Drivers of Malignant Transformation in Neurofibromas.

Neuro Oncol 2019 May 16. Epub 2019 May 16.

MacFeeters-Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/neuonc/noz086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682205PMC
May 2019

Challenges and opportunities in meningiomas: recommendations from the International Consortium on Meningiomas.

Neuro Oncol 2019 Jan;21(Supplement_1):i2-i3

Division of Neurosurgery, University Health Network, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/neuonc/noy181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347075PMC
January 2019

Imaging and diagnostic advances for intracranial meningiomas.

Neuro Oncol 2019 Jan;21(Supplement_1):i44-i61

Center for Skull Base and Pituitary Surgery, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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https://academic.oup.com/neuro-oncology/article/21/Supplemen
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http://dx.doi.org/10.1093/neuonc/noy143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347083PMC
January 2019

World Health Organization 2016 Classification of Central Nervous System Tumors.

Neurol Clin 2018 08;36(3):439-447

MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, 101 College Street, 14-601, Toronto, Ontario M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ncl.2018.04.003DOI Listing
August 2018

Dendritic cell vaccines for high-grade gliomas.

Ther Clin Risk Manag 2018 26;14:1299-1313. Epub 2018 Jul 26.

MacFeeters-Hamilton Neuro-Oncology Program, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.2147/TCRM.S135865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067774PMC
July 2018

Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma.

J Clin Oncol 2018 05 12;36(14):1419-1427. Epub 2018 Feb 12.

Frederick F. Lang, Charles Conrad, Candelaria Gomez-Manzano, W.K. Alfred Yung, Raymond Sawaya, Jeffrey S. Weinberg, Sujit S. Prabhu, Ganesh Rao, Gregory N. Fuller, Kenneth D. Aldape, Joy Gumin, Luis M. Vence, Ignacio Wistuba, Jaime Rodriguez-Canales, Pamela A. Villalobos, and Juan Fueyo, The University of Texas MD Anderson Cancer Center; Brett Ewald, Joanna J. Peterkin, and Frank Tufaro, DNAtrix, Houston, TX; Clemens M.F. Dirven, Erasmus University Medical Center, Rotterdam, the Netherlands; and Sonia Tejada, Ricardo D. Valle, and Marta M. Alonso, Clínica Universidad de Navarra, Pamplona, Spain.

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http://ascopubs.org/doi/10.1200/JCO.2017.75.8219
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http://dx.doi.org/10.1200/JCO.2017.75.8219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075856PMC
May 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

The multiforme of glioblastoma.

Neuro Oncol 2018 03;20(4):437-438

Division of Neurosurgery, Department of Surgery, University of Toronto, Division of Pathology, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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https://academic.oup.com/neuro-oncology/article/20/4/437/495
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http://dx.doi.org/10.1093/neuonc/noy025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909657PMC
March 2018

A gene expression signature predicts recurrence-free survival in meningioma.

Oncotarget 2018 Mar 15;9(22):16087-16098. Epub 2018 Feb 15.

The University of Texas MD Anderson Cancer Center, Department of Translational Molecular Pathology, Houston, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.24498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882319PMC
March 2018

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.

Cell 2018 02;172(5):1050-1062.e14

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.01.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346737PMC
February 2018

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Nature 2018 01 20;553(7686):101-105. Epub 2017 Dec 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nature25169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422PMC
January 2018

A change at the helm of Neuro-Oncology.

Authors:
Kenneth Aldape

Neuro Oncol 2018 01;20(1)

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD.

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http://dx.doi.org/10.1093/neuonc/nox229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761578PMC
January 2018

Glut3 Addiction: A Druggable Vulnerability in Glioblastoma.

Cancer Cell 2017 12;32(6):726-727

Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.11.017DOI Listing
December 2017

Molecular Signatures for Tumor Classification: An Analysis of The Cancer Genome Atlas Data.

J Mol Diagn 2017 11 1;19(6):881-891. Epub 2017 Sep 1.

Princess Margaret Cancer Centre and MacFeeters-Hamilton Centre for Neuro-Oncology Research, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2017.07.008DOI Listing
November 2017

IDH mutation testing in gliomas-where do we draw the line?

Neuro Oncol 2017 11;19(12):1568-1569

Division of Neurosurgery, Department of Surgery and Division of Pathology, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/neuonc/nox164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716201PMC
November 2017

Prognostic significance of preoperative neutrophilia on recurrence-free survival in meningioma.

Neuro Oncol 2017 Oct;19(11):1503-1510

MacFeeters-Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio.

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http://dx.doi.org/10.1093/neuonc/nox089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737603PMC
October 2017

Gli1-induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1.

EMBO Rep 2017 08 16;18(8):1318-1330. Epub 2017 Jun 16.

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

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http://dx.doi.org/10.15252/embr.201643124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538423PMC
August 2017

Insights From Molecular Profiling of Adult Glioma.

J Clin Oncol 2017 Jul 22;35(21):2386-2393. Epub 2017 Jun 22.

Phedias Diamandis and Kenneth D. Aldape, Princess Margaret Cancer Centre; and Kenneth D. Aldape, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2017.73.9516DOI Listing
July 2017

Precision histology: how deep learning is poised to revitalize histomorphology for personalized cancer care.

NPJ Precis Oncol 2017 19;1(1):22. Epub 2017 Jun 19.

Princess Margaret Cancer Centre, MacFeeters-Hamilton Centre for Neuro-Oncology Research, College Street 101, Toronto, ON M5G 1L7 Canada.

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http://dx.doi.org/10.1038/s41698-017-0022-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871847PMC
June 2017

Integrating molecular markers into the World Health Organization classification of CNS tumors: a survey of the neuro-oncology community.

Neuro Oncol 2017 03;19(3):336-344

MacFeeters-Hamilton Brain Tumour Centre, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/neuonc/now181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464323PMC
March 2017

Global epigenetic profiling identifies methylation subgroups associated with recurrence-free survival in meningioma.

Acta Neuropathol 2017 03 27;133(3):431-444. Epub 2017 Jan 27.

Princess Margaret Cancer Centre, MacFeeters-Hamilton Brain Tumour Centre, College Street 101, Toronto, M5G 1L7, ON, Canada.

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http://dx.doi.org/10.1007/s00401-017-1678-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600514PMC
March 2017

Atypical meningioma-is it time to standardize surgical sampling techniques?

Neuro Oncol 2017 03;19(3):453-454

Department of Pathology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1093/neuonc/now245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464334PMC
March 2017

Treatment of Adult Lower-Grade Glioma in the Era of Genomic Medicine.

Am Soc Clin Oncol Educ Book 2016 ;35:75-81

From the University of California, San Francisco, San Francisco, CA; Harvard Medical School, Boston, MA; Toronto General Hospital/Research Institute, Toronto, Canada; University of Maryland, Baltimore, MD.

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http://dx.doi.org/10.1200/EDBK_158869DOI Listing
January 2017

Next-generation molecular diagnostics.

Handb Clin Neurol 2016 ;134:121-30

Division of Pediatric Neurooncology, German Cancer Research Center, Heidelberg University Hospital, Heidelberg, Germany; Department of Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1016/B978-0-12-802997-8.00007-4DOI Listing
December 2016

PCR Techniques in Characterizing DNA Methylation.

Methods Mol Biol 2016 ;1392:177-86

Princess Margaret Cancer Center and Ontario Cancer Institute, 610 University Avenue, Toronto, ON, Canada, M5G 2M9.

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http://dx.doi.org/10.1007/978-1-4939-3360-0_16DOI Listing
November 2016

Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients.

Neuro Oncol 2016 09 14;18(9):1209-18. Epub 2016 May 14.

Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland (A.K.L, C.M.); American Kennel Club Canine Health Foundation, Raleigh, North Carolina (D.E.B); Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama (J.W.K); Department of Biomedical Sciences, Section of Anatomic Pathology, Cornell University College of Veterinary Medicine, Ithaca, New York (A.D.M); Departments of Pathology and Laboratory Medicine and Neurology, Lineberger Comprehensive Cancer Center and Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina (C.R.M); Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana (R.T.B); Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado , (R.A.P); Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina (M.B.); Department of Small Animal Clinical Sciences, Texas A&M University, College Station, Texas (J.M.L, C.E.B); Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland (R.M.S, C.H.); Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio , (W.K.); Veterinary and Comparative Neuro-Oncology Laboratory, Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia (J.H.R); Department of Surgery and Radiology, School of Veterinary Medicine, University of California, Davis, California (P.J.D); Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois (T.M.F); National Institute of Neurological Disorders and Stroke and National Cancer Institute, Bethesda, Maryland (K.C., M.R.G); De

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http://dx.doi.org/10.1093/neuonc/now051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999002PMC
September 2016

Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22.

Nat Cell Biol 2016 09 8;18(9):954-966. Epub 2016 Aug 8.

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1038/ncb3396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026327PMC
September 2016

Sox2: regulation of expression and contribution to brain tumors.

CNS Oncol 2016 Jul 27;5(3):159-73. Epub 2016 May 27.

McFeeters-Hamilton Center for Neuro-Oncology Research, 101 College St., Toronto, ON, M5G 1L7, Canada.

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http://dx.doi.org/10.2217/cns-2016-0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042636PMC
July 2016

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.

Authors:
Vijay Ramaswamy Thomas Hielscher Stephen C Mack Alvaro Lassaletta Tong Lin Kristian W Pajtler David T W Jones Betty Luu Florence M G Cavalli Kenneth Aldape Marc Remke Martin Mynarek Stefan Rutkowski Sridharan Gururangan Roger E McLendon Eric S Lipp Christopher Dunham Juliette Hukin David D Eisenstat Dorcas Fulton Frank K H van Landeghem Mariarita Santi Marie-Lise C van Veelen Erwin G Van Meir Satoru Osuka Xing Fan Karin M Muraszko Daniela P C Tirapelli Sueli M Oba-Shinjo Suely K N Marie Carlos G Carlotti Ji Yeoun Lee Amulya A Nageswara Rao Caterina Giannini Claudia C Faria Sofia Nunes Jaume Mora Ronald L Hamilton Peter Hauser Nada Jabado Kevin Petrecca Shin Jung Luca Massimi Massimo Zollo Giuseppe Cinalli László Bognár Almos Klekner Tibor Hortobágyi Sarah Leary Ralph P Ermoian James M Olson Jeffrey R Leonard Corrine Gardner Wieslawa A Grajkowska Lola B Chambless Jason Cain Charles G Eberhart Sama Ahsan Maura Massimino Felice Giangaspero Francesca R Buttarelli Roger J Packer Lyndsey Emery William H Yong Horacio Soto Linda M Liau Richard Everson Andrew Grossbach Tarek Shalaby Michael Grotzer Matthias A Karajannis David Zagzag Helen Wheeler Katja von Hoff Marta M Alonso Teresa Tuñon Ulrich Schüller Karel Zitterbart Jaroslav Sterba Jennifer A Chan Miguel Guzman Samer K Elbabaa Howard Colman Girish Dhall Paul G Fisher Maryam Fouladi Amar Gajjar Stewart Goldman Eugene Hwang Marcel Kool Harshad Ladha Elizabeth Vera-Bolanos Khalida Wani Frank Lieberman Tom Mikkelsen Antonio M Omuro Ian F Pollack Michael Prados H Ian Robins Riccardo Soffietti Jing Wu Phillipe Metellus Uri Tabori Ute Bartels Eric Bouffet Cynthia E Hawkins James T Rutka Peter Dirks Stefan M Pfister Thomas E Merchant Mark R Gilbert Terri S Armstrong Andrey Korshunov David W Ellison Michael D Taylor

J Clin Oncol 2016 07 6;34(21):2468-77. Epub 2016 Jun 6.

Vijay Ramaswamy, Stephen C. Mack, Alvaro Lassaletta, Betty Luu, Florence M.G. Cavalli, Uri Tabori, Ute Bartels, Eric Bouffet, Cynthia E. Hawkins, James T. Rutka, Peter Dirks, and Michael D. Taylor, The Hospital for Sick Children; Vijay Ramaswamy, Kenneth Aldape, James T. Rutka, and Michael D. Taylor, University of Toronto; Kenneth Aldape, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario; Christopher Dunham and Juliette Hukin, British Columbia Children's Hospital; Juliette Hukin, University of British Columbia, Vancouver, British Columbia; David D. Eisenstat, Dorcas Fulton, and Frank K.H. van Landeghem, University of Alberta, Edmonton; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Nada Jabado and Kevin Petrecca, McGill University, Montreal, Quebec, Canada; Thomas Hielscher, Kristian W. Pajtler, David T.W. Jones, Marcel Kool, Stefan M. Pfister, and Andrey Korshunov, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Marc Remke, University Hospital Düsseldorf, Düsseldorf; Martin Mynarek, Stefan Rutkowski, and Katja von Hoff, University Medical Center Hamburg-Eppendorf, Hamburg; Ulrich Schüller, Ludwig-Maximilians-Universität, Munich, Germany; Stephen C. Mack, Cleveland Clinic Foundation, Cleveland; Maryam Fouladi, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Tong Lin, Amar Gajjar, Thomas E. Merchant, and David W. Ellison, St Jude Children's Research Hospital, Memphis; Lola B. Chambless, Vanderbilt Medical Center, Nashville, TN; Sridharan Gururangan, Roger E. McLendon, and Eric S. Lipp, Duke University, Durham; Jing Wu, University of North Carolina at Chapel Hill, Chapel Hill, NC; Mariarita Santi, Children's Hospital of Philadelphia; Lyndsey Emery, Hospital of the University of Pennsylvania, Philadelphia; Ronald L. Hamilton and Ian F. Pollack, University of Pittsburgh School of Medicine; Frank Lieberman, University of Pittsburgh Medical Cen

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http://dx.doi.org/10.1200/JCO.2015.65.7825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962737PMC
July 2016

TERT Promoter Mutations and Risk of Recurrence in Meningioma.

J Natl Cancer Inst 2016 May 13;108(5). Epub 2015 Dec 13.

Affiliations of authors:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg , Heidelberg , Germany (FS, DS, CK, DR, JB, AK, DC, SS, AvD); Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg , Germany (FS, DS, CK, DR, AK, DC, AvD); Department of Pathology (AO), Department of Genomic Medicine (QW), Department of Radiation Oncology (QW, EPS), and Department of Bioinformatics and Computational Biology (QW), The University of Texas MD Anderson Cancer Center , Houston, TX ; Department of Radiation Oncology (SA, JD) and Department of Neurosurgery (MSc, TU, CHM), University Hospital Heidelberg , Heidelberg , Germany ; Department of Neuropathology, Charité Medical University , Berlin , Germany (AK); Department of Pathology, University Hospital Nürnberg , Nürnberg , Germany (AFO): Department of Neurosurgery, Medical Faculty of the Ruprecht-Karls-University of Heidelberg , Mannheim , Germany (SB); Department of Neuropathology, Institute of Pathology and Neuropathology, University Tübingen , Tübingen , Germany (JS); Department of Neuropathology, University of Bonn , Bonn , Germany (AB); Department of Neurosurgery (BB) and Institute of Neuropathology (WP), University Hospital Münster , Münster , Germany (BB); Department of Neurosurgery, University Hospital Bonn , Bonn , Germany (KG, MSi); Department of Neurosurgery, University Hospital Würzburg , Würzburg , Germany (AFK); Department of Neurosurgery, University Hospital Hamburg , Hamburg , Germany (KL); Department of Neuropathology, Otto von Guericke University Magdeburg , Magdeburg , Germany (CM); Institute of Pathology, Saarland University , Homburg, Saarland , Germany (YJK); Department of Neurosurgery, Saarland University , Homburg , Germany (RK); MacFeeters-Hamilton Brain Tumour Centre, Princess Margaret Cancer Center , Toronto, Ontario , Canada (KDA); Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg , Germany (TH).

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http://dx.doi.org/10.1093/jnci/djv377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849806PMC
May 2016

PIK3CA mutations in meningioma.

Neuro Oncol 2016 05;18(5):603-4

Department of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada (G.Z.); Princess Margaret Cancer Centre and MacFeeters-Hamilton Centre for Neuro-Oncology Research, Toronto, Ontario, Canada (S.K., K.D.A.).

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http://dx.doi.org/10.1093/neuonc/now029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827051PMC
May 2016

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis.

Mol Cell 2016 Mar;61(5):705-719

Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Cancer Biology Program, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888784PMC
March 2016

Adult brainstem gliomas: Correlation of clinical and molecular features.

J Neurol Sci 2015 18;353(1-2):92-7. Epub 2015 Apr 18.

Division of Neuro-oncology, The Ohio State University Comprehensive Cancer Center, 320 W 10th Avenue, Starling Loving Hall Suite M410, Columbus, OH 43210, United States.

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http://dx.doi.org/10.1016/j.jns.2015.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782610PMC
February 2016

Bringing IDH into the Fold.

Cancer Cell 2016 Feb;29(2):139-40

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada; Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, ON M5T 2S8, Canada.

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http://dx.doi.org/10.1016/j.ccell.2016.01.010DOI Listing
February 2016

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Authors:
Dominik Sturm Brent A Orr Umut H Toprak Volker Hovestadt David T W Jones David Capper Martin Sill Ivo Buchhalter Paul A Northcott Irina Leis Marina Ryzhova Christian Koelsche Elke Pfaff Sariah J Allen Gnanaprakash Balasubramanian Barbara C Worst Kristian W Pajtler Sebastian Brabetz Pascal D Johann Felix Sahm Jüri Reimand Alan Mackay Diana M Carvalho Marc Remke Joanna J Phillips Arie Perry Cynthia Cowdrey Rachid Drissi Maryam Fouladi Felice Giangaspero Maria Łastowska Wiesława Grajkowska Wolfram Scheurlen Torsten Pietsch Christian Hagel Johannes Gojo Daniela Lötsch Walter Berger Irene Slavc Christine Haberler Anne Jouvet Stefan Holm Silvia Hofer Marco Prinz Catherine Keohane Iris Fried Christian Mawrin David Scheie Bret C Mobley Matthew J Schniederjan Mariarita Santi Anna M Buccoliero Sonika Dahiya Christof M Kramm André O von Bueren Katja von Hoff Stefan Rutkowski Christel Herold-Mende Michael C Frühwald Till Milde Martin Hasselblatt Pieter Wesseling Jochen Rößler Ulrich Schüller Martin Ebinger Jens Schittenhelm Stephan Frank Rainer Grobholz Istvan Vajtai Volkmar Hans Reinhard Schneppenheim Karel Zitterbart V Peter Collins Eleonora Aronica Pascale Varlet Stephanie Puget Christelle Dufour Jacques Grill Dominique Figarella-Branger Marietta Wolter Martin U Schuhmann Tarek Shalaby Michael Grotzer Timothy van Meter Camelia-Maria Monoranu Jörg Felsberg Guido Reifenberger Matija Snuderl Lynn Ann Forrester Jan Koster Rogier Versteeg Richard Volckmann Peter van Sluis Stephan Wolf Tom Mikkelsen Amar Gajjar Kenneth Aldape Andrew S Moore Michael D Taylor Chris Jones Nada Jabado Matthias A Karajannis Roland Eils Matthias Schlesner Peter Lichter Andreas von Deimling Stefan M Pfister David W Ellison Andrey Korshunov Marcel Kool

Cell 2016 Feb;164(5):1060-1072

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.cell.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139621PMC
February 2016

Phase 2 trial of dasatinib in target-selected patients with recurrent glioblastoma (RTOG 0627).

Neuro Oncol 2015 Jul 10;17(7):992-8. Epub 2015 Mar 10.

Department of Neurology and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York (A.B.L. current); Memorial Sloan Kettering Cancer Center, New York, New York (A.B.L. during accrual, L.M.D.); NRG Oncology Statistics and Data Management Center, Philadelphia, Pennsylvania (S.L.P., S.G., M.W); The University of Texas MD Anderson Cancer Center, Houston, Texas (M.R.G., K.D.A. during accrual; R.K.); Neuro-Oncology Branch, National Cancer Institute/National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland (M.R.G. current); University of Toronto and Princess Margaret Cancer Centre, Toronto, Canada (K.D.A. current); Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania (J.H.B., S.M.C.); Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy Pittsburgh, Pennsylvania (J.H.B.); NCI Community Oncology Research Program - Kansas City, Prairie Village, Kansas (R.G.); Arizona Oncology Services Foundation, Tucson, Arizona (E.Y.); Penn State University and The Milton S. Hershey Medical Center, Hershey, Pennsylvania (H.W.); University of Maryland Medical Systems, Baltimore, Maryland (M.P.M.).

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http://dx.doi.org/10.1093/neuonc/nov011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762006PMC
July 2015

Histologic variability in solitary fibrous tumors reflects angiogenic and growth factor signaling pathway alterations.

Hum Pathol 2015 Jul 15;46(7):1015-26. Epub 2015 Apr 15.

Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston TX 70030.

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http://dx.doi.org/10.1016/j.humpath.2015.03.014DOI Listing
July 2015

Glioblastoma: pathology, molecular mechanisms and markers.

Acta Neuropathol 2015 Jun 6;129(6):829-48. Epub 2015 May 6.

Princess Margaret Cancer Centre and MacFeeters-Hamilton Centre for Neuro-Oncology Research, 101 College St., Toronto, ON, M5G 1L7, Canada,

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http://dx.doi.org/10.1007/s00401-015-1432-1DOI Listing
June 2015

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Authors:
Daniel J Brat Roel G W Verhaak Kenneth D Aldape W K Alfred Yung Sofie R Salama Lee A D Cooper Esther Rheinbay C Ryan Miller Mark Vitucci Olena Morozova A Gordon Robertson Houtan Noushmehr Peter W Laird Andrew D Cherniack Rehan Akbani Jason T Huse Giovanni Ciriello Laila M Poisson Jill S Barnholtz-Sloan Mitchel S Berger Cameron Brennan Rivka R Colen Howard Colman Adam E Flanders Caterina Giannini Mia Grifford Antonio Iavarone Rajan Jain Isaac Joseph Jaegil Kim Katayoon Kasaian Tom Mikkelsen Bradley A Murray Brian Patrick O'Neill Lior Pachter Donald W Parsons Carrie Sougnez Erik P Sulman Scott R Vandenberg Erwin G Van Meir Andreas von Deimling Hailei Zhang Daniel Crain Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Troy Shelton Mark Sherman Peggy Yena Aaron Black Jay Bowen Katie Dicostanzo Julie Gastier-Foster Kristen M Leraas Tara M Lichtenberg Christopher R Pierson Nilsa C Ramirez Cynthia Taylor Stephanie Weaver Lisa Wise Erik Zmuda Tanja Davidsen John A Demchok Greg Eley Martin L Ferguson Carolyn M Hutter Kenna R Mills Shaw Bradley A Ozenberger Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean Claude Zenklusen Brenda Ayala Julien Baboud Sudha Chudamani Mark A Jensen Jia Liu Todd Pihl Rohini Raman Yunhu Wan Ye Wu Adrian Ally J Todd Auman Miruna Balasundaram Saianand Balu Stephen B Baylin Rameen Beroukhim Moiz S Bootwalla Reanne Bowlby Christopher A Bristow Denise Brooks Yaron Butterfield Rebecca Carlsen Scott Carter Lynda Chin Andy Chu Eric Chuah Kristian Cibulskis Amanda Clarke Simon G Coetzee Noreen Dhalla Tim Fennell Sheila Fisher Stacey Gabriel Gad Getz Richard Gibbs Ranabir Guin Angela Hadjipanayis D Neil Hayes Toshinori Hinoue Katherine Hoadley Robert A Holt Alan P Hoyle Stuart R Jefferys Steven Jones Corbin D Jones Raju Kucherlapati Phillip H Lai Eric Lander Semin Lee Lee Lichtenstein Yussanne Ma Dennis T Maglinte Harshad S Mahadeshwar Marco A Marra Michael Mayo Shaowu Meng Matthew L Meyerson Piotr A Mieczkowski Richard A Moore Lisle E Mose Andrew J Mungall Angeliki Pantazi Michael Parfenov Peter J Park Joel S Parker Charles M Perou Alexei Protopopov Xiaojia Ren Jeffrey Roach Thaís S Sabedot Jacqueline Schein Steven E Schumacher Jonathan G Seidman Sahil Seth Hui Shen Janae V Simons Payal Sipahimalani Matthew G Soloway Xingzhi Song Huandong Sun Barbara Tabak Angela Tam Donghui Tan Jiabin Tang Nina Thiessen Timothy Triche David J Van Den Berg Umadevi Veluvolu Scot Waring Daniel J Weisenberger Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Andrew W Xu Lixing Yang Travis I Zack Jianhua Zhang B Arman Aksoy Harindra Arachchi Chris Benz Brady Bernard Daniel Carlin Juok Cho Daniel DiCara Scott Frazer Gregory N Fuller JianJiong Gao Nils Gehlenborg David Haussler David I Heiman Lisa Iype Anders Jacobsen Zhenlin Ju Sol Katzman Hoon Kim Theo Knijnenburg Richard Bailey Kreisberg Michael S Lawrence William Lee Kalle Leinonen Pei Lin Shiyun Ling Wenbin Liu Yingchun Liu Yuexin Liu Yiling Lu Gordon Mills Sam Ng Michael S Noble Evan Paull Arvind Rao Sheila Reynolds Gordon Saksena Zack Sanborn Chris Sander Nikolaus Schultz Yasin Senbabaoglu Ronglai Shen Ilya Shmulevich Rileen Sinha Josh Stuart S Onur Sumer Yichao Sun Natalie Tasman Barry S Taylor Doug Voet Nils Weinhold John N Weinstein Da Yang Kosuke Yoshihara Siyuan Zheng Wei Zhang Lihua Zou Ty Abel Sara Sadeghi Mark L Cohen Jenny Eschbacher Eyas M Hattab Aditya Raghunathan Matthew J Schniederjan Dina Aziz Gene Barnett Wendi Barrett Darell D Bigner Lori Boice Cathy Brewer Chiara Calatozzolo Benito Campos Carlos Gilberto Carlotti Timothy A Chan Lucia Cuppini Erin Curley Stefania Cuzzubbo Karen Devine Francesco DiMeco Rebecca Duell J Bradley Elder Ashley Fehrenbach Gaetano Finocchiaro William Friedman Jordonna Fulop Johanna Gardner Beth Hermes Christel Herold-Mende Christine Jungk Ady Kendler Norman L Lehman Eric Lipp Ouida Liu Randy Mandt Mary McGraw Roger Mclendon Christopher McPherson Luciano Neder Phuong Nguyen Ardene Noss Raffaele Nunziata Quinn T Ostrom Cheryl Palmer Alessandro Perin Bianca Pollo Alexander Potapov Olga Potapova W Kimryn Rathmell Daniil Rotin Lisa Scarpace Cathy Schilero Kelly Senecal Kristen Shimmel Vsevolod Shurkhay Suzanne Sifri Rosy Singh Andrew E Sloan Kathy Smolenski Susan M Staugaitis Ruth Steele Leigh Thorne Daniela P C Tirapelli Andreas Unterberg Mahitha Vallurupalli Yun Wang Ronald Warnick Felicia Williams Yingli Wolinsky Sue Bell Mara Rosenberg Chip Stewart Franklin Huang Jonna L Grimsby Amie J Radenbaugh Jianan Zhang
June 2015

Breast cancer with brain metastases: clinicopathologic features, survival, and paired biomarker analysis.

Oncologist 2015 May 23;20(5):466-73. Epub 2015 Mar 23.

Departments of Pathology, Biostatistics, Neurosurgery, and Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1634/theoncologist.2014-0107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425375PMC
May 2015