Kenner C Rice

Kenner C Rice

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Interactions between reinforcement history and drug-primed reinstatement: Studies with MDPV and mixtures of MDPV and caffeine.

Addict Biol 2020 Apr 1:e12904. Epub 2020 Apr 1.

Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.

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http://dx.doi.org/10.1111/adb.12904DOI Listing
April 2020

Toll-Like Receptor-4 Antagonist (+)-Naltrexone Protects Against Carbamyl-Platelet Activating Factor (Cpaf)-Induced Preterm Labor in Mice.

Am J Pathol 2020 Feb 18. Epub 2020 Feb 18.

Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2020.01.008DOI Listing
February 2020

The synthetic cathinone 3,4-methylenedioxypyrovalerone increases impulsive action in rats.

Behav Pharmacol 2020 Feb 24. Epub 2020 Feb 24.

Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

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http://dx.doi.org/10.1097/FBP.0000000000000548DOI Listing
February 2020

Effects of the synthetic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) on ethanol consumption and place conditioning in male mice.

Psychopharmacology (Berl) 2019 Dec 15;236(12):3567-3578. Epub 2019 Jul 15.

Department of Pharmaceutical Sciences, Mercer University College of Pharmacy, Mercer University Health Sciences Center, 3001 Mercer University Dr., Atlanta, GA, 30341, USA.

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http://dx.doi.org/10.1007/s00213-019-05328-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895420PMC
December 2019

Self-administration of the synthetic cathinones 3,4-methylenedioxypyrovalerone (MDPV) and α-pyrrolidinopentiophenone (α-PVP) in rhesus monkeys.

Psychopharmacology (Berl) 2019 Dec 26;236(12):3677-3685. Epub 2019 Jul 26.

Department of Pharmacology, University of Texas Health Science Center, 7703 Floyd Curl Drive, Mail Code 7764, San Antonio, TX, 78229, USA.

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http://dx.doi.org/10.1007/s00213-019-05339-4DOI Listing
December 2019

Sex differences in oral oxycodone self-administration and stress-primed reinstatement in rats.

Addict Biol 2019 Dec 12:e12822. Epub 2019 Dec 12.

Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.

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http://dx.doi.org/10.1111/adb.12822DOI Listing
December 2019

Toll-Like Receptor-4 Antagonist (+)-Naloxone Confers Sexually Dimorphic Protection From Inflammation-Induced Fetal Programming in Mice.

Endocrinology 2019 11;160(11):2646-2662

Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1210/en.2019-00493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936318PMC
November 2019

Stereoselective neurochemical, behavioral, and cardiovascular effects of α-pyrrolidinovalerophenone enantiomers in male rats.

Addict Biol 2019 Nov 13:e12842. Epub 2019 Nov 13.

Designer Drug Research Unit, Intramural Research Program of the National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1111/adb.12842DOI Listing
November 2019

Repeated administration of synthetic cathinone 3,4-methylenedioxypyrovalerone persistently increases impulsive choice in rats.

Behav Pharmacol 2019 10;30(7):555-565

Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

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http://dx.doi.org/10.1097/FBP.0000000000000492DOI Listing
October 2019

Sex differences in α-pyrrolidinopentiophenone (α-PVP)-induced taste avoidance, place preference, hyperthermia and locomotor activity in rats.

Pharmacol Biochem Behav 2019 10 21;185:172762. Epub 2019 Aug 21.

Psychopharmacology Laboratory, Center for Behavioral Neuroscience, American University, 4400 Massachusetts Ave, NW, Washington, DC 20016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2019.172762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748333PMC
October 2019

M100907 and BD 1047 attenuate the acute toxic effects of methamphetamine.

Neurotoxicology 2019 09 1;74:91-99. Epub 2019 Jun 1.

Department of Pharmaceutical Sciences, Mercer University College of Pharmacy, Mercer University Health Sciences Center, Atlanta, GA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuro.2019.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750996PMC
September 2019

Metabolites of the ring-substituted stimulants MDMA, methylone and MDPV differentially affect human monoaminergic systems.

J Psychopharmacol 2019 Jul 30;33(7):831-841. Epub 2019 Apr 30.

1 Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1177/0269881119844185DOI Listing
July 2019

The Supplement Adulterant -Methylphenethylamine Increases Blood Pressure by Acting at Peripheral Norepinephrine Transporters.

J Pharmacol Exp Ther 2019 06 21;369(3):328-336. Epub 2019 Mar 21.

Designer Drug Research Unit (C.W.S., J.S.P., M.H.B.) and Preclinical Pharmacology Section (E.B.T.), National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland; and Drug Design and Synthesis Section, National Institute on Drug Abuse and National Institute of Alcohol Abuse and Alcoholism Intramural Research Programs, Rockville, Maryland (K.C.R.).

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http://dx.doi.org/10.1124/jpet.118.255976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533570PMC
June 2019

Sensitization to the prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA).

Neuropharmacology 2019 06 25;151:13-20. Epub 2019 Mar 25.

Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Psychiatry and Behavioral Science, Emory University School of Medicine, Atlanta, GA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2019.03.017DOI Listing
June 2019

The adrenergic receptor antagonist carvedilol interacts with serotonin 2A receptors both in vitro and in vivo.

Pharmacol Biochem Behav 2019 06 15;181:37-45. Epub 2019 Apr 15.

Section on Drug Design and Synthesis, National Institute on Drug Abuse and Chemical Biology Research Branch, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.pbb.2019.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570414PMC
June 2019

Behavioral economic analysis of the reinforcing effects of "bath salts" mixtures: studies with MDPV, methylone, and caffeine in male Sprague-Dawley rats.

Psychopharmacology (Berl) 2019 Mar 29;236(3):1031-1041. Epub 2018 Sep 29.

Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr - MC# 7764, San Antonio, TX, 78229, USA.

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http://link.springer.com/10.1007/s00213-018-5046-x
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http://dx.doi.org/10.1007/s00213-018-5046-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440875PMC
March 2019

Stereoselective effects of the second-generation synthetic cathinone α-pyrrolidinopentiophenone (α-PVP): assessments of conditioned taste avoidance in rats.

Psychopharmacology (Berl) 2019 Mar 17;236(3):1067-1077. Epub 2018 Oct 17.

Psychopharmacology Laboratory, Center for Behavioral Neuroscience, American University, 4400 Massachusetts Ave, NW, Washington, DC, 20016, USA.

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http://dx.doi.org/10.1007/s00213-018-5070-xDOI Listing
March 2019

Role of mu-opioid agonist efficacy on antinociceptive interactions between mu agonists and the nociceptin opioid peptide agonist Ro 64-6198 in rhesus monkeys.

Eur J Pharmacol 2019 Feb 12;844:175-182. Epub 2018 Dec 12.

Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2018.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445635PMC
February 2019

The 5-HT Receptor (5-HTR) Regulates Impulsive Action and Cocaine Cue Reactivity in Male Sprague-Dawley Rats.

J Pharmacol Exp Ther 2019 01 29;368(1):41-49. Epub 2018 Oct 29.

Center for Addiction Research and Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas (D.J.S., S.J.S., R.G.F., N.C.A., K.A.C.); Department of Statistical Sciences and Operations Research, Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, Virginia (E.L.B., Q.W.); Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Bethesda, Maryland (K.C.R.); and Department of Psychiatry, Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, Virginia (F.G.M.)

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.118.25
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http://dx.doi.org/10.1124/jpet.118.251199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290084PMC
January 2019

Effects of acute treatments with the serotonin 2A antagonist M100907 alone or in combination with the serotonin 2C agonist WAY163909 on methamphetamine self-administration in rhesus monkeys.

Drug Alcohol Depend 2019 01 13;194:252-256. Epub 2018 Nov 13.

Yerkes National Primate Research Center, Emory University, 954 Gatewood Road N.E., Atlanta, GA, USA; Department of Psychiatry and Behavioral Science, Emory School of Medicine, Emory University, Atlanta, GA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drugalcdep.2018.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312465PMC
January 2019

Extracellular esterase activity as an indicator of endoplasmic reticulum calcium depletion.

Biomarkers 2018 Dec 10;23(8):756-765. Epub 2018 Aug 10.

a Molecular Mechanisms of Cellular Stress and Inflammation , Intramural Research Program, National Institute on Drug Abuse , Baltimore , MD , USA.

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http://dx.doi.org/10.1080/1354750X.2018.1490968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348867PMC
December 2018

Comparative neuropharmacology of N-(2-methoxybenzyl)-2,5-dimethoxyphenethylamine (NBOMe) hallucinogens and their 2C counterparts in male rats.

Neuropharmacology 2018 11 1;142:240-250. Epub 2018 Mar 1.

Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00283908183009
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http://dx.doi.org/10.1016/j.neuropharm.2018.02.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119551PMC
November 2018

Preclinical Evaluation of the First Adenosine A Receptor Partial Agonist Radioligand for Positron Emission Tomography Imaging.

J Med Chem 2018 11 13;61(22):9966-9975. Epub 2018 Nov 13.

Laboratory of Neuroimaging , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Bethesda , Maryland 20892-1013 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01009DOI Listing
November 2018

Exercise Reverses Nociceptive Sensitization, Upregulated Neuropeptide Signaling, Inflammatory Changes, Anxiety, and Memory Impairment in a Mouse Tibia Fracture Model.

Anesthesiology 2018 09;129(3):557-575

From the Anesthesiology Service (X.S., W.L., P.S., J.D.C.) the Palo Alto Veterans Institute of Research (T.-z.G., W.S.K.) Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Department of Anesthesia, Stanford University School of Medicine, Stanford, California (X.S., W.L., P.S., J.D.C.) Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland (K.C.R., A.S.).

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http://dx.doi.org/10.1097/ALN.0000000000002332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092202PMC
September 2018

Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats.

Brain Behav Immun 2018 08 30;72:45-50. Epub 2017 Aug 30.

Department of Psychology and Neuroscience, and The Center for Neuroscience, University of Colorado, Boulder, CO, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S08891591173040
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http://dx.doi.org/10.1016/j.bbi.2017.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832500PMC
August 2018

A rapid solution-based method for determining the affinity of heroin hapten-induced antibodies to heroin, its metabolites, and other opioids.

Anal Bioanal Chem 2018 Jun 19;410(16):3885-3903. Epub 2018 Apr 19.

Laboratory of Adjuvant and Antigen Research, US Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA.

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http://link.springer.com/10.1007/s00216-018-1060-4
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http://dx.doi.org/10.1007/s00216-018-1060-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956019PMC
June 2018

Relative reinforcing effects of second-generation synthetic cathinones: Acquisition of self-administration and fixed ratio dose-response curves in rats.

Neuropharmacology 2018 05 12;134(Pt A):28-35. Epub 2017 Aug 12.

Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; South Texas Veterans Health Care System, San Antonio, TX 78229, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2017.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809320PMC
May 2018

Role of monoaminergic systems and ambient temperature in bath salts constituent 3,4-methylenedioxypyrovalerone (MDPV)-elicited hyperthermia and locomotor stimulation in mice.

Neuropharmacology 2018 05 5;134(Pt A):13-21. Epub 2017 Sep 5.

Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00283908173042
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http://dx.doi.org/10.1016/j.neuropharm.2017.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837893PMC
May 2018

Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HT receptor (5-HTR) antagonist M100907.

Bioorg Med Chem Lett 2018 05 16;28(8):1381-1385. Epub 2018 Mar 16.

Center for Addiction Research, United States; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183016
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http://dx.doi.org/10.1016/j.bmcl.2018.02.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613932PMC
May 2018

Disease modifying actions of interleukin-6 blockade in a rat model of bone cancer pain.

Pain 2018 04;159(4):684-698

Cancer Biology Graduate Interdisciplinary Program, University of Arizona Cancer Center, Tucson, AZ, USA.

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http://dx.doi.org/10.1097/j.pain.0000000000001139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911943PMC
April 2018

Application of Receptor Theory to the Design and Use of Fixed-Proportion Mu-Opioid Agonist and Antagonist Mixtures in Rhesus Monkeys.

J Pharmacol Exp Ther 2018 04 12;365(1):37-47. Epub 2018 Jan 12.

Department of Pharmacology and Toxicology, School of Medicine (J.C.C., S.S.N., M.L.B.), and Department of Medicinal Chemistry, School of Pharmacy (S.O., Y.Z.), Virginia Commonwealth University, Richmond, Virginia; and Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland (K.C.R.)

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.117.24
Publisher Site
http://dx.doi.org/10.1124/jpet.117.246439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830633PMC
April 2018

Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged rats.

Psychoneuroendocrinology 2018 04 19;90:92-101. Epub 2018 Feb 19.

Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.psyneuen.2018.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864558PMC
April 2018

Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists.

J Chem Inf Model 2018 04 11;58(4):816-825. Epub 2018 Apr 11.

Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry , Chinese Academy of Sciences , Changchun , Jilin , 130022 , China.

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http://dx.doi.org/10.1021/acs.jcim.7b00717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700752PMC
April 2018

Inhibition of Cocaine and 3,4-Methylenedioxypyrovalerone (MDPV) Self-Administration by Lorcaserin Is Mediated by 5-HT2C Receptors in Rats.

J Pharmacol Exp Ther 2018 03 7;364(2):359-366. Epub 2017 Dec 7.

Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas (B.M.G., G.T.C.); South Texas Veterans Health Care System, San Antonio, Texas (G.T.C.); and Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland (A.S., K.C.R.)

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http://dx.doi.org/10.1124/jpet.117.246082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787931PMC
March 2018

Role of signalling molecules in behaviours mediated by the δ opioid receptor agonist SNC80.

Br J Pharmacol 2018 03 9;175(6):891-901. Epub 2018 Feb 9.

Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://doi.wiley.com/10.1111/bph.14131
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http://dx.doi.org/10.1111/bph.14131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825297PMC
March 2018

Cellular and behavioral effects of lipopolysaccharide treatment are dependent upon neurokinin-1 receptor activation.

J Neuroinflammation 2018 Feb 27;15(1):60. Epub 2018 Feb 27.

Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, 501 D.W. Brooks Drive, Athens, GA, 30602, USA.

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http://dx.doi.org/10.1186/s12974-018-1098-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389133PMC
February 2018

The efficacy of (+)-Naltrexone on alcohol preference and seeking behaviour is dependent on light-cycle.

Brain Behav Immun 2018 Jan 30;67:181-193. Epub 2017 Aug 30.

Discipline of Physiology, Adelaide Medical School, University of Adelaide, South Australia, Australia; ARC Centre of Excellence for Nanoscale Biophotonics, University of Adelaide, South Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2017.08.021DOI Listing
January 2018

Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood.

Neuropharmacology 2018 Jan 22;128:460-473. Epub 2017 Sep 22.

Discipline of Physiology, Adelaide Medical School, University of Adelaide, South Australia, Australia; ARC Centre of Excellence for Nanoscale BioPhotonics, University of Adelaide, South Australia, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00283908173044
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http://dx.doi.org/10.1016/j.neuropharm.2017.09.028DOI Listing
January 2018

Maintenance on naltrexone+amphetamine decreases cocaine-vs.-food choice in male rhesus monkeys.

Drug Alcohol Depend 2017 12 13;181:85-93. Epub 2017 Oct 13.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 N. 12th St., Richmond, VA 23298, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drugalcdep.2017.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683900PMC
December 2017

Antagonism of the kappa opioid receptor attenuates THC-induced place aversions in adult male Sprague-Dawley rats.

Pharmacol Biochem Behav 2017 Dec 31;163:30-35. Epub 2017 Oct 31.

Psychopharmacology Laboratory, Center for Behavioral Neuroscience, American University, Washington, DC 20016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2017.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676491PMC
December 2017

High fat diet disrupts endoplasmic reticulum calcium homeostasis in the rat liver.

J Hepatol 2017 11 17;67(5):1009-1017. Epub 2017 Jul 17.

Molecular Mechanisms of Cellular Stress and Inflammation Unit, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278173206
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http://dx.doi.org/10.1016/j.jhep.2017.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122848PMC
November 2017

Reinforcing effects of abused 'bath salts' constituents 3,4-methylenedioxypyrovalerone and α-pyrrolidinopentiophenone and their enantiomers.

Behav Pharmacol 2017 10;28(7):578-581

aDepartment of Pharmacology, University of Texas Health Science Center at San Antonio bSouth Texas Veterans Health Care System, San Antonio, Texas cMolecular Targets and Medications Discovery Branch, NIDA and NIAAA, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1097/FBP.0000000000000315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599337PMC
October 2017

Effects of orally self-administered bath salt constituent 3,4-methylenedioxypyrovalerone (MDPV) in mice.

Drug Alcohol Depend 2017 10 4;179:408-415. Epub 2017 Aug 4.

Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States. Electronic address:

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http://dx.doi.org/10.1016/j.drugalcdep.2017.06.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708564PMC
October 2017

Monoaminergic toxicity induced by cathinone phthalimide: An in vitro study.

Neurosci Lett 2017 Aug 3;655:76-81. Epub 2017 Jul 3.

Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Rd, HFT-132, Jefferson, AR, 72079, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043940173055
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http://dx.doi.org/10.1016/j.neulet.2017.06.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176714PMC
August 2017

Neuropharmacology of 3,4-Methylenedioxypyrovalerone (MDPV), Its Metabolites, and Related Analogs.

Curr Top Behav Neurosci 2017 ;32:93-117

Chemistry and Drug Metabolism Section of the Intramural Research Program, National Institute on Drug Abuse (NIDA), National Institutes of Health, Baltimore, MD, USA.

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http://link.springer.com/10.1007/7854_2016_53
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http://dx.doi.org/10.1007/7854_2016_53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392131PMC
July 2017

Effects of a Serotonin 2C Agonist and a 2A Antagonist on Actigraphy-Based Sleep Parameters Disrupted by Methamphetamine Self-Administration in Rhesus Monkeys.

Neuropsychopharmacology 2017 Jun 16;42(7):1531-1538. Epub 2016 Dec 16.

Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.1038/npp.2016.280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436115PMC
June 2017

Conditioned taste avoidance, conditioned place preference and hyperthermia induced by the second generation 'bath salt' α-pyrrolidinopentiophenone (α-PVP).

Pharmacol Biochem Behav 2017 05 17;156:48-55. Epub 2017 Apr 17.

Psychopharmacology Laboratory, Center for Behavioral Neuroscience, American University, 4400 Massachusetts Ave, NW, Washington, D.C. 20016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2017.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155479PMC
May 2017

Individual Differences in the Relative Reinforcing Effects of 3,4-Methylenedioxypyrovalerone under Fixed and Progressive Ratio Schedules of Reinforcement in Rats.

J Pharmacol Exp Ther 2017 04 8;361(1):181-189. Epub 2017 Feb 8.

Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas (B.M.G., K.I.G., G.T.C.); South Texas Veterans Health Care System, San Antonio, Texas (G.T.C.); and Chemical Biology Research Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland (K.C.R.)

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http://dx.doi.org/10.1124/jpet.116.239376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363773PMC
April 2017

Modulation of opioid receptor affinity and efficacy via N-substitution of 9β-hydroxy-5-(3-hydroxyphenyl)morphan: Synthesis and computer simulation study.

Bioorg Med Chem 2017 04 1;25(8):2406-2422. Epub 2017 Mar 1.

Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center Drive, Bethesda, MD 20892-3373, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.02.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407189PMC
April 2017

Pharmacokinetic Profiles and Pharmacodynamic Effects for Methylone and Its Metabolites in Rats.

Neuropsychopharmacology 2017 02 23;42(3):649-660. Epub 2016 Sep 23.

Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/npp.2016.213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240186PMC
February 2017

The role of regulator of G protein signaling 4 in delta-opioid receptor-mediated behaviors.

Psychopharmacology (Berl) 2017 Jan 13;234(1):29-39. Epub 2016 Sep 13.

Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1007/s00213-016-4432-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203942PMC
January 2017

Pharmacological mechanisms underlying the cardiovascular effects of the "bath salt" constituent 3,4-methylenedioxypyrovalerone (MDPV).

Br J Pharmacol 2016 12 16;173(24):3492-3501. Epub 2016 Nov 16.

Designer Drug Research Unit, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD.

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http://dx.doi.org/10.1111/bph.13640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120154PMC
December 2016

Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury.

Brain Behav Immun 2016 Nov 9;58:348-356. Epub 2016 Aug 9.

University of Colorado Boulder, Department of Psychology and Neuroscience, Center for Neuroscience, Boulder, CO, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067205PMC
http://dx.doi.org/10.1016/j.bbi.2016.08.004DOI Listing
November 2016

Novel Toll-like receptor-4 antagonist (+)-naloxone protects mice from inflammation-induced preterm birth.

Sci Rep 2016 11 7;6:36112. Epub 2016 Nov 7.

Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.

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http://dx.doi.org/10.1038/srep36112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098167PMC
November 2016

Discriminative Stimulus Effects of Binary Drug Mixtures: Studies with Cocaine, MDPV, and Caffeine.

J Pharmacol Exp Ther 2016 10 4;359(1):1-10. Epub 2016 Aug 4.

Departments of Pharmacology (G.T.C., M.A., K.G., E.L.R., C.P.F.) and Psychiatry (C.P.F.), University of Texas Health Science Center at San Antonio, and South Texas Veterans Health Care System (G.T.C.), San Antonio, Texas; and Chemical Biology Research Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland (K.C.R.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034708PMC
http://dx.doi.org/10.1124/jpet.116.234252DOI Listing
October 2016

Effects of 3,4-methylenedioxypyrovalerone (MDPV) pre-exposure on the aversive effects of MDPV, cocaine and lithium chloride: Implications for abuse vulnerability.

Drug Alcohol Depend 2016 Oct 7;167:121-7. Epub 2016 Aug 7.

Psychopharmacology Laboratory, Center for Behavioral Neuroscience, American University, 4400 Massachusetts Ave, NW Washington, D.C. 20016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drugalcdep.2016.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548127PMC
October 2016

Characterization of the discriminative stimulus effects of lorcaserin in rats.

J Exp Anal Behav 2016 09 18;106(2):107-16. Epub 2016 Sep 18.

Departments of Pharmacology, University of Texas Health Science Center at San Antonio, TEXAS.

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http://dx.doi.org/10.1002/jeab.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042862PMC
September 2016

Comparison of (+)- and (-)-Naloxone on the Acute Psychomotor-Stimulating Effects of Heroin, 6-Acetylmorphine, and Morphine in Mice.

J Pharmacol Exp Ther 2016 08 8;358(2):209-15. Epub 2016 Jun 8.

Department of Drug Abuse Research, Division for Forensic Sciences, Norwegian Institute of Public Health, Oslo, Norway (G.S.E., J.M.A., F.B., M.S.-S.B., V.V., J.M.); Institute of Clinical Medicine, University of Oslo, Oslo, Norway (V.V., J.M.); University of Maryland School of Medicine, Baltimore, Maryland (M.A.H.); and Section on Drug Design and Synthesis, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland (K.C.R).

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http://dx.doi.org/10.1124/jpet.116.233544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959094PMC
August 2016

Blockade of Cocaine or σ Receptor Agonist Self Administration by Subtype-Selective σ Receptor Antagonists.

J Pharmacol Exp Ther 2016 07 21;358(1):109-24. Epub 2016 Apr 21.

Psychobiology Section, Intramural Research Program, National Institutes of Health National Institute on Drug Abuse, Baltimore, Maryland (J.L.K., T.H., T.A.K.); Drug Design and Synthesis Section, Intramural Research Program, National Institutes of Health National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Baltimore, Maryland (K.C.R.); and Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (C.M., S.N., A.H.A., C.R.M.).

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http://dx.doi.org/10.1124/jpet.116.232728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931880PMC
July 2016

Characterization of the Discriminative Stimulus Effects of a NOP Receptor Agonist Ro 64-6198 in Rhesus Monkeys.

J Pharmacol Exp Ther 2016 Apr 22;357(1):17-23. Epub 2016 Jan 22.

Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan (P.A.S., K.A.Z., A.M.L., J.H.W.); National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland (A.S., K.C.R.); and Hoffman- La Roche Ltd., Basel, Switzerland (E.P.P., J.W.).

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http://dx.doi.org/10.1124/jpet.115.231134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809320PMC
April 2016

Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4.

CNS Neurol Disord Drug Targets 2015 ;14(6):692-9

Department of Psychology & Neuroscience, and Center for Neuroscience, University of Colorado - Boulder, Boulder, CO 80309-0345, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548122PMC
http://dx.doi.org/10.2174/1871527314666150529132503DOI Listing
March 2016

Stereoselective Effects of Abused "Bath Salt" Constituent 3,4-Methylenedioxypyrovalerone in Mice: Drug Discrimination, Locomotor Activity, and Thermoregulation.

J Pharmacol Exp Ther 2016 Mar 14;356(3):615-23. Epub 2016 Jan 14.

Department of Pharmacology and Toxicology (B.M.G., W.E.F.), College of Medicine (A.W.), University of Arkansas for Medical Sciences, Little Rock, Arkansas; and Drug Design and Synthesis Section, Chemical Biology Research Branch, National Institutes of Health National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland (M.S., K.C.R.)

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http://dx.doi.org/10.1124/jpet.115.229500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767395PMC
March 2016

A simple nonradioactive method for the determination of the binding affinities of antibodies induced by hapten bioconjugates for drugs of abuse.

Anal Bioanal Chem 2016 Feb 16;408(4):1191-204. Epub 2015 Dec 16.

Laboratory of Adjuvant and Antigen Research, US Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs00216-015-92
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http://link.springer.com/10.1007/s00216-015-9223-z
Publisher Site
http://dx.doi.org/10.1007/s00216-015-9223-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718952PMC
February 2016

Sigma-1 receptor mediates acquisition of alcohol drinking and seeking behavior in alcohol-preferring rats.

Behav Brain Res 2015 4;287:315-22. Epub 2015 Apr 4.

Laboratory of Addictive Disorders, Departments of Pharmacology and Experimental Therapeutics and Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01664328150023
Publisher Site
http://dx.doi.org/10.1016/j.bbr.2015.03.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424067PMC
January 2016

A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits.

Front Neurosci 2015 24;9:487. Epub 2015 Dec 24.

Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at AustinAustin, TX, USA; Department of Neurology, University of California, San FranciscoSan Francisco, CA, USA.

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http://dx.doi.org/10.3389/fnins.2015.00487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689854PMC
January 2016

Directly Observable Behavioral Effects of Lorcaserin in Rats.

J Pharmacol Exp Ther 2015 Dec 17;355(3):381-5. Epub 2015 Sep 17.

Departments of Pharmacology (K.M.S., C.P.F.) and Psychiatry (C.P.F.), University of Texas Health Science Center at San Antonio, San Antonio, Texas and Chemical Biology Research Laboratory, Department of Health and Human Services, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland (K.C.R.)

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http://dx.doi.org/10.1124/jpet.115.228148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658489PMC
December 2015

Toll-Like Receptor 4 Is an Essential Upstream Regulator of On-Time Parturition and Perinatal Viability in Mice.

Endocrinology 2015 Oct 7;156(10):3828-41. Epub 2015 Jul 7.

Robinson Research Institute and School of Medicine (H.H.W., C.D., P.Y.C., M.R.H., L.M.M., S.A.R.), University of Adelaide, Adelaide SA 5005, Australia; Chemical Biology Research Branch (K.C.R.), National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20892; and Departments of Obstetrics and Gynecology, Pediatrics and Physiology (D.M.O.), University of Alberta, Edmonton, Canada AB TG62S2.

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http://dx.doi.org/10.1210/EN.2015-1089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588813PMC
October 2015

Sex differences in 3,4-methylenedioxypyrovalerone (MDPV)-induced taste avoidance and place preferences.

Pharmacol Biochem Behav 2015 Oct 26;137:16-22. Epub 2015 Jul 26.

Psychopharmacology Laboratory, Department of Psychology, American University, Washington, DC 20016, United States.

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http://dx.doi.org/10.1016/j.pbb.2015.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548123PMC
October 2015

Effect of norbinaltorphimine on ∆⁹-tetrahydrocannabinol (THC)-induced taste avoidance in adolescent and adult Sprague-Dawley rats.

Psychopharmacology (Berl) 2015 Sep 31;232(17):3193-201. Epub 2015 May 31.

Pscyhopharmacology Laboratory, Department of Psychology, American University, 4400 Massachusetts Avenue NW, Washington, DC, 20016, USA,

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http://dx.doi.org/10.1007/s00213-015-3970-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551397PMC
September 2015

(+)-Naltrexone is neuroprotective and promotes alternative activation in the mouse hippocampus after cardiac arrest/cardiopulmonary resuscitation.

Brain Behav Immun 2015 Aug 13;48:115-22. Epub 2015 Mar 13.

Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; Department of Pharmacology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2015.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548128PMC
August 2015

Individual Differences in Impulsive Action Reflect Variation in the Cortical Serotonin 5-HT2A Receptor System.

Neuropsychopharmacology 2015 Jul 10;40(8):1957-68. Epub 2015 Feb 10.

1] Center for Addiction Research, University of Texas Medical Branch, Galveston, TX, USA [2] Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.

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http://dx.doi.org/10.1038/npp.2015.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839520PMC
July 2015

Serotonin (5-HT) 5-HT2A Receptor (5-HT2AR):5-HT2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity.

ACS Chem Neurosci 2015 Jul 7;6(7):1248-58. Epub 2015 Jul 7.

⊥Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, United States.

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http://dx.doi.org/10.1021/acschemneuro.5b00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811199PMC
July 2015

Efficacy, but not antibody titer or affinity, of a heroin hapten conjugate vaccine correlates with increasing hapten densities on tetanus toxoid, but not on CRM197 carriers.

Bioconjug Chem 2015 Jun 5;26(6):1041-53. Epub 2015 Jun 5.

†Laboratory of Adjuvant and Antigen Research, US Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.5b00085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472500PMC
June 2015

Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists.

J Med Chem 2015 Jun 5;58(12):5038-52. Epub 2015 Jun 5.

†Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center Drive, Bethesda, Maryland 20892-3373, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634939PMC
June 2015

Chiral resolution and absolute configuration of the enantiomers of the psychoactive "designer drug" 3,4-methylenedioxypyrovalerone.

Chirality 2015 Apr 26;27(4):287-93. Epub 2015 Feb 26.

Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland.

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http://dx.doi.org/10.1002/chir.22423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548130PMC
April 2015

Probes for narcotic receptor mediated phenomena 49. N-substituted rac-cis-4a-arylalkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols.

Eur J Med Chem 2015 Mar 13;92:531-9. Epub 2015 Jan 13.

Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center Drive, Bethesda, MD 20892-3373, USA; Intramural Research Program, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center Drive, Bethesda, MD 20892-3373, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.01.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348089PMC
March 2015