Kennan Marsh

Kennan Marsh

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Kennan Marsh

Kennan Marsh

Publications by authors named "Kennan Marsh"

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Assessing Supersaturation and Its Impact on In Vivo Bioavailability of a Low-Solubility Compound ABT-072 With a Dual pH, Two-Phase Dissolution Method.

J Pharm Sci 2016 09 16;105(9):2886-2895. Epub 2016 Jun 16.

NCE-Formulation Sciences, Drug Product Development, Abbvie Inc., North Chicago, Illinois 60064. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2016.04.036DOI Listing
September 2016

Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans.

Drug Metab Dispos 2016 08 13;44(8):1139-47. Epub 2016 May 13.

Drug Metabolism and Pharmacokinetics, Research & Development (J.S., M.S., A.J.L., X.Z., V.F.), Process Chemistry (A.R.), Clinical Pharmacology and Pharmacometrics-Clinical Pharmacokinetics/Pharmacodynamics (R.M.), Exploratory Science (K.M.), and Drug Analysis (X.W., O.K.), AbbVie, North Chicago, Illinois.

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http://dx.doi.org/10.1124/dmd.115.067512DOI Listing
August 2016

Metabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in Humans.

Drug Metab Dispos 2016 08 13;44(8):1164-73. Epub 2016 May 13.

Drug Metabolism and Pharmacokinetics, Research & Development (J.S., M.S., A.J.L., X.Z., V.F.), Process Chemistry (A.R.), Drug Analysis (O.K.), Exploratory Science (K.M.), CPPM-Clinical PK/PD (A.K., R.M.), AbbVie, North Chicago, Illinois 60064.

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http://dx.doi.org/10.1124/dmd.115.067488DOI Listing
August 2016

Species-dependent metabolism of a novel selective α7 neuronal acetylcholine receptor agonist ABT-107.

Xenobiotica 2013 Sep 18;43(9):803-16. Epub 2013 Jan 18.

Department of Drug Metabolism and Pharmacokinetics, AbbVie, Inc., North Chicago, IL 60064, USA.

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http://dx.doi.org/10.3109/00498254.2012.760763DOI Listing
September 2013

High potency improvements to weak aryl uracil HCV polymerase inhibitor leads.

Bioorg Med Chem Lett 2013 Aug 4;23(15):4367-9. Epub 2013 Jun 4.

AbbVie, Department R4AJ, Building AP52N, 1 North Waukegan Road, North Chicago, IL 60064, United States.

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http://dx.doi.org/10.1016/j.bmcl.2013.05.078DOI Listing
August 2013

Discovery of diphenyl lactam derivatives as N-type calcium channel blockers.

Bioorg Med Chem Lett 2012 Feb 8;22(4):1716-8. Epub 2012 Jan 8.

Abbott Laboratories, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.12.100DOI Listing
February 2012

Role of α7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-α (TNF-α) as revealed by subtype selective agonists.

J Neuroimmunol 2011 Oct 10;239(1-2):37-43. Epub 2011 Sep 10.

Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S016557281100224
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http://dx.doi.org/10.1016/j.jneuroim.2011.08.007DOI Listing
October 2011

Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists.

Bioorg Med Chem Lett 2011 Mar 21;21(5):1338-41. Epub 2011 Jan 21.

Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.01.056DOI Listing
March 2011

Discovery of TRPV1 antagonist ABT-116.

Bioorg Med Chem Lett 2010 Jun 14;20(11):3291-4. Epub 2010 Apr 14.

Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Dept R4PM, AP10-207, 100 Abbott Park Road, Abbott Park, IL 60064-6100, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.04.047DOI Listing
June 2010

Tumour-selective antivascular effects of the novel anti-mitotic compound A-318315: An in vivo rat regional haemodynamic study.

Clin Exp Pharmacol Physiol 2010 May 4;37(5-6):636-40. Epub 2010 Feb 4.

Abbott Laboratories, Global Pharmaceutical Research and Development, Abbott Park, IL, USA.

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http://dx.doi.org/10.1111/j.1440-1681.2010.05365.xDOI Listing
May 2010

Identification of proteasome gene regulation in a rat model for HIV protease inhibitor-induced hyperlipidemia.

Arch Toxicol 2010 Apr 6;84(4):263-70. Epub 2010 Mar 6.

Abbott Laboratories Global Pharmaceuticals Research and Development, 100 Abbott Park Rd, Abbott Park, IL 60064-6123, USA.

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http://dx.doi.org/10.1007/s00204-010-0527-7DOI Listing
April 2010

Bioavailability of generic ritonavir and lopinavir/ritonavir tablet products in a dog model.

J Pharm Sci 2010 Feb;99(2):626-31

Abbott Laboratories, Abbott Park, Illinois 60064, USA.

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http://dx.doi.org/10.1002/jps.21712DOI Listing
February 2010

Cardiovascular effects of torcetrapib in conscious and pentobarbital-anesthetized dogs.

J Cardiovasc Pharmacol 2009 Dec;54(6):543-51

Department of Integrative Pharmacology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064-6119, USA.

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http://dx.doi.org/10.1097/FJC.0b013e3181bfb158DOI Listing
December 2009

Synthesis and evaluation of inhibitors of cytochrome P450 3A (CYP3A) for pharmacokinetic enhancement of drugs.

Bioorg Med Chem Lett 2009 Sep 30;19(18):5444-8. Epub 2009 Jul 30.

Abbott Laboratories, Departments of Antiviral Research (D-R4CQ), Building AP-52, 200 Abbott Park Road, Abbott Park, IL 60064-3537, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.07.118DOI Listing
September 2009

Design of a new histamine H3 receptor antagonist chemotype: (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, synthesis, and structure-activity relationships.

J Med Chem 2009 Aug;52(15):4640-9

Department of Neuroscience Research, Global Pharmaceutical Research Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6123, USA.

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http://dx.doi.org/10.1021/jm900480xDOI Listing
August 2009

Water-soluble prodrugs of the human immunodeficiency virus protease inhibitors lopinavir and ritonavir.

J Med Chem 2009 May;52(9):2964-70

Antiviral Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA.

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http://dx.doi.org/10.1021/jm900080gDOI Listing
May 2009

HIV protease inhibitors inhibit the development of preerythrocytic-stage plasmodium parasites.

J Infect Dis 2009 Jan;199(1):134-41

NYU School of Medicine, Dept. of Pediatrics, Div. of Infectious Disease, 550 First Ave., 8W New Bellevue, NY, NY 10010, USA.

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http://dx.doi.org/10.1086/594369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988424PMC
January 2009

Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins.

J Med Chem 2008 Nov 8;51(21):6902-15. Epub 2008 Oct 8.

Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA.

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http://dx.doi.org/10.1021/jm800669sDOI Listing
November 2008

The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.

J Med Chem 2008 Sep 7;51(17):5423-30. Epub 2008 Aug 7.

Department of Neuroscience Research, Global Pharmaceutical Research Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6123, USA.

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http://dx.doi.org/10.1021/jm8003625DOI Listing
September 2008

Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists.

Bioorg Med Chem 2008 Sep 7;16(18):8516-25. Epub 2008 Aug 7.

Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Dept R4PM, AP10-207, 100 Abbott Park Road, Abbott Park, IL 60064-6100, USA.

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http://dx.doi.org/10.1016/j.bmc.2008.08.005DOI Listing
September 2008

Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O2 consumption in dogs.

Am J Physiol Heart Circ Physiol 2008 Jan 2;294(1):H238-48. Epub 2007 Nov 2.

Department of Integrative Pharmacology R46R, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Rd., Abbott Park, IL 60064-6119, USA.

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http://dx.doi.org/10.1152/ajpheart.01181.2007DOI Listing
January 2008

Evaluation of the effects of serial phlebotomy on the transcriptome of major tissues and on the response to toxicants in rats.

Toxicol Lett 2008 Jan 9;176(2):138-48. Epub 2007 Oct 9.

Department of Cellular, Molecular and Exploratory Toxicology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S037842740700971
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http://dx.doi.org/10.1016/j.toxlet.2007.09.014DOI Listing
January 2008

Synthesis, potency, and in vivo profiles of quinoline containing histamine H3 receptor inverse agonists.

J Med Chem 2007 Nov 6;50(22):5439-48. Epub 2007 Oct 6.

Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6123, USA.

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http://dx.doi.org/10.1021/jm0705051DOI Listing
November 2007

Plasma and cerebrospinal fluid pharmacokinetics of intravenously administered ABT-751 in non-human primates.

Cancer Chemother Pharmacol 2007 Sep 23;60(4):563-7. Epub 2006 Dec 23.

Pediatric Oncology Branch, National Cancer Institute (NCI), Bethesda, MD 20892, USA.

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http://link.springer.com/10.1007/s00280-006-0402-7
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http://dx.doi.org/10.1007/s00280-006-0402-7DOI Listing
September 2007

Discovery of imidazolidine-2,4-dione-linked HIV protease inhibitors with activity against lopinavir-resistant mutant HIV.

Bioorg Med Chem 2006 Oct 7;14(19):6695-712. Epub 2006 Jul 7.

Global Pharmaceutical Research and Development, 200 Abbott Park Road 047D AP52 Abbott Park, IL 60064, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096808960600449
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http://dx.doi.org/10.1016/j.bmc.2006.05.063DOI Listing
October 2006