Professor Kenji Hashimoto, PhD - Chiba University Center for Forensic Mental Health - Professor

Professor Kenji Hashimoto

PhD

Chiba University Center for Forensic Mental Health

Professor

Chiba, Chiba | Japan

Main Specialties: Psychiatry

Additional Specialties: Neuropsychopharmacology

ORCID logohttps://orcid.org/0000-0002-8892-0439

Professor Kenji Hashimoto, PhD - Chiba University Center for Forensic Mental Health - Professor

Professor Kenji Hashimoto

PhD

Introduction

Primary Affiliation: Chiba University Center for Forensic Mental Health - Chiba, Chiba , Japan

Specialties:

Additional Specialties:

Research Interests:

Publications

144Publications

3456Reads

368Profile Views

508PubMed Central Citations

Impact of consuming green and yellow vegetables on the depressive symptoms of junior and senior high school students in Japan.

PLoS One 2019 7;14(2):e0211323. Epub 2019 Feb 7.

Center for Forensic Mental Health, Chiba University, Chiba, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211323PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366731PMC
November 2019
5 Reads
3.234 Impact Factor

Rapid-acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective.

Authors:
Kenji Hashimoto

Psychiatry Clin Neurosci 2019 Oct 11;73(10):613-627. Epub 2019 Jul 11.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.1111/pcn.12902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851782PMC
October 2019
15 Reads
1.620 Impact Factor

Is (S)-norketamine an alternative antidepressant for esketamine?

Eur Arch Psychiatry Clin Neurosci 2019 Oct 14;269(7):867-868. Epub 2018 Jul 14.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

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http://dx.doi.org/10.1007/s00406-018-0922-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739277PMC
October 2019
6 Reads
3.525 Impact Factor

Dietary intake of glucoraphanin prevents the reduction of dopamine transporter in the mouse striatum after repeated administration of MPTP.

Neuropsychopharmacol Rep 2019 Sep 27;39(3):247-251. Epub 2019 May 27.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.1002/npr2.12060DOI Listing
September 2019
7 Reads

Beneficial effects of (R)-ketamine, but not its metabolite (2R,6R)-hydroxynorketamine, in the depression-like phenotype, inflammatory bone markers, and bone mineral density in a chronic social defeat stress model.

Behav Brain Res 2019 08 11;368:111904. Epub 2019 Apr 11.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2019.111904DOI Listing
August 2019
22 Reads
3.028 Impact Factor

Cognitive Impairment That Is Induced by (R)-Ketamine Is Abolished in NMDA GluN2D Receptor Subunit Knockout Mice.

Int J Neuropsychopharmacol 2019 07;22(7):449-452

Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan.

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http://dx.doi.org/10.1093/ijnp/pyz025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600477PMC
July 2019
14 Reads
4.009 Impact Factor

Abnormal composition of gut microbiota contributes to delirium-like behaviors after abdominal surgery in mice.

CNS Neurosci Ther 2019 Jun 24;25(6):685-696. Epub 2019 Jan 24.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.1111/cns.13103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515708PMC
June 2019
43 Reads
3.931 Impact Factor

Gamma-band auditory steady-state response is associated with plasma levels of d-serine in schizophrenia: An exploratory study.

Schizophr Res 2019 06 25;208:467-469. Epub 2019 Feb 25.

Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; The International Research Center for Neurointelligence (WPI-IRCN) at The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2019.02.012DOI Listing
June 2019
2 Reads
3.923 Impact Factor

Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation.

Proc Natl Acad Sci U S A 2019 04 19;116(14):7083-7088. Epub 2019 Mar 19.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 260-8670 Chiba, Japan;

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http://dx.doi.org/10.1073/pnas.1819234116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452650PMC
April 2019
7 Reads
9.809 Impact Factor

Metabolomics of Major Depressive Disorder and Bipolar Disorder: Overview and Future Perspective.

Authors:
Kenji Hashimoto

Adv Clin Chem 2018;84:81-99. Epub 2018 Feb 1.

Chiba University Center for Forensic Mental Health, Chiba, Japan. Electronic address:

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http://dx.doi.org/10.1016/bs.acc.2017.12.005DOI Listing
April 2019
2 Reads
1 Citation
2.650 Impact Factor

Lack of dopamine D receptors in the antidepressant actions of (R)-ketamine in a chronic social defeat stress model.

Eur Arch Psychiatry Clin Neurosci 2019 Mar 29. Epub 2019 Mar 29.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.

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http://dx.doi.org/10.1007/s00406-019-01012-1DOI Listing
March 2019
5 Reads
3.525 Impact Factor

Lack of Opioid System in the Antidepressant Actions of Ketamine.

Biol Psychiatry 2019 03 10;85(6):e25-e27. Epub 2018 Dec 10.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.11.006DOI Listing
March 2019
12 Reads
10.255 Impact Factor

Impact of FAAH gene, hyperactivation in emotion processing brain regions and Lavender oil preparation Silexan in anxiety.

Authors:
Kenji Hashimoto

Eur Arch Psychiatry Clin Neurosci 2019 Mar;269(2):145-146

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba, 260-8670, Japan.

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http://dx.doi.org/10.1007/s00406-019-00987-1DOI Listing
March 2019
1 Read
3.525 Impact Factor

Increased BDNF-TrkB signaling in the nucleus accumbens plays a role in the risk for psychosis after cannabis exposure during adolescence.

Pharmacol Biochem Behav 2019 02 8;177:61-68. Epub 2019 Jan 8.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00913057183064
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http://dx.doi.org/10.1016/j.pbb.2019.01.002DOI Listing
February 2019
15 Reads
2.781 Impact Factor

Increased expression of inwardly rectifying Kir4.1 channel in the parietal cortex from patients with major depressive disorder.

J Affect Disord 2019 02 5;245:265-269. Epub 2018 Nov 5.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2018.11.016DOI Listing
February 2019
27 Reads
3.383 Impact Factor

Plasma estradiol levels and antidepressant effects of omega-3 fatty acids in pregnant women.

Brain Behav Immun 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynecology, Tokyo Medical University, Tokyo, Japan; Division of Health Care Research, Center for Public Health Sciences, National Cancer Center Japan, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.bbi.2019.02.014DOI Listing
February 2019
3 Reads
5.889 Impact Factor

Role of Soluble Epoxide Hydrolase in Metabolism of PUFAs in Psychiatric and Neurological Disorders.

Authors:
Kenji Hashimoto

Front Pharmacol 2019 30;10:36. Epub 2019 Jan 30.

Division of Clinical Neuroscience, Center for Forensic Mental Health, Chiba University, Chiba, Japan.

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http://dx.doi.org/10.3389/fphar.2019.00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363819PMC
January 2019
1 Read

Role of Actinobacteria and Coriobacteriia in the antidepressant effects of ketamine in an inflammation model of depression.

Pharmacol Biochem Behav 2019 01 5;176:93-100. Epub 2018 Dec 5.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2018.12.001DOI Listing
January 2019
6 Reads
2.781 Impact Factor

Lack of rapid antidepressant effects of Kir4.1 channel inhibitors in a chronic social defeat stress model: Comparison with (R)-ketamine.

Pharmacol Biochem Behav 2019 01 28;176:57-62. Epub 2018 Nov 28.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2018.11.010DOI Listing
January 2019
3 Reads
2.781 Impact Factor

An update on ketamine and its two enantiomers as rapid-acting antidepressants.

Expert Rev Neurother 2019 Jan 4;19(1):83-92. Epub 2018 Dec 4.

a Division of Clinical Neuroscience , Chiba University Center for Forensic Mental Health , Chiba , Japan.

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http://dx.doi.org/10.1080/14737175.2019.1554434DOI Listing
January 2019
6 Reads
2.834 Impact Factor

Key role of gut microbiota in anhedonia-like phenotype in rodents with neuropathic pain.

Transl Psychiatry 2019 01 31;9(1):57. Epub 2019 Jan 31.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.1038/s41398-019-0379-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355832PMC
January 2019
4 Reads
4.360 Impact Factor

Schizophrenia-Like Dopamine Release Abnormalities in a Mouse Model of NMDA Receptor Hypofunction.

Schizophr Bull 2019 01;45(1):138-147

Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL.

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http://dx.doi.org/10.1093/schbul/sby003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293233PMC
January 2019
4 Reads
1 Citation
8.450 Impact Factor

Keap1-Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress.

Eur Arch Psychiatry Clin Neurosci 2018 Dec 8;268(8):865-870. Epub 2017 Nov 8.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.

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http://dx.doi.org/10.1007/s00406-017-0848-0DOI Listing
December 2018
22 Reads
3 Citations
3.525 Impact Factor

Role of Inflammatory Bone Markers in the Antidepressant Actions of (R)-Ketamine in a Chronic Social Defeat Stress Model.

Int J Neuropsychopharmacol 2018 11;21(11):1025-1030

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.1093/ijnp/pyy065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209851PMC
November 2018
2 Reads
4.010 Impact Factor

Lack of Antidepressant Effects of Low-Voltage-Sensitive T-Type Calcium Channel Blocker Ethosuximide in a Chronic Social Defeat Stress Model: Comparison with (R)-Ketamine.

Int J Neuropsychopharmacol 2018 11;21(11):1031-1036

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.1093/ijnp/pyy072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209850PMC
November 2018
2 Reads
4.010 Impact Factor

AMPA Receptor Activation-Independent Antidepressant Actions of Ketamine Metabolite (S)-Norketamine.

Biol Psychiatry 2018 10 14;84(8):591-600. Epub 2018 May 14.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063223183152
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http://dx.doi.org/10.1016/j.biopsych.2018.05.007DOI Listing
October 2018
19 Reads
10.260 Impact Factor

Essential Role of Keap1-Nrf2 Signaling in Mood Disorders: Overview and Future Perspective.

Authors:
Kenji Hashimoto

Front Pharmacol 2018 16;9:1182. Epub 2018 Oct 16.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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https://www.frontiersin.org/article/10.3389/fphar.2018.01182
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http://dx.doi.org/10.3389/fphar.2018.01182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198170PMC
October 2018
34 Reads

No Sex-Specific Differences in the Acute Antidepressant Actions of (R)-Ketamine in an Inflammation Model.

Int J Neuropsychopharmacol 2018 10;21(10):932-937

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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https://academic.oup.com/ijnp/article/21/10/932/5035197
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http://dx.doi.org/10.1093/ijnp/pyy053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165956PMC
October 2018
1 Read
4.010 Impact Factor

Expression of heat shock protein HSP-70 in the retrosplenial cortex of rat brain after administration of (R,S)-ketamine and (S)-ketamine, but not (R)-ketamine.

Pharmacol Biochem Behav 2018 09 17;172:17-21. Epub 2018 Jul 17.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2018.07.003DOI Listing
September 2018
5 Reads
2.781 Impact Factor

Role of Keap1-Nrf2 Signaling in Anhedonia Symptoms in a Rat Model of Chronic Neuropathic Pain: Improvement With Sulforaphane.

Front Pharmacol 2018 8;9:887. Epub 2018 Aug 8.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.3389/fphar.2018.00887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092692PMC
August 2018
7 Reads
1 Citation

Impact of aerobic exercise on cognitive impairment and oxidative stress markers in methamphetamine-dependent patients.

Psychiatry Res 2018 08 17;266:328-333. Epub 2018 Mar 17.

Collaborative Innovation Center for Brain Science, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.psychres.2018.03.032DOI Listing
August 2018
38 Reads
1 Citation
2.470 Impact Factor

Biomarkers for Alzheimer's disease: from pathogenesis to drug development.

Authors:
Kenji Hashimoto

Eur Arch Psychiatry Clin Neurosci 2018 Aug;268(5):441-442

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba, 260-8670, Japan.

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http://dx.doi.org/10.1007/s00406-018-0912-4DOI Listing
August 2018
4 Reads
3.525 Impact Factor

(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice.

Neuropsychopharmacology 2018 08 3;43(9):1900-1907. Epub 2018 May 3.

Research Headquarters, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama, 331-9530, Japan.

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http://dx.doi.org/10.1038/s41386-018-0084-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046044PMC
August 2018
32 Reads
1 Citation
7.050 Impact Factor

Lack of correlation between phonetic magnetic mismatch field and plasma d-serine levels in humans.

Clin Neurophysiol 2018 07 24;129(7):1444-1448. Epub 2018 Apr 24.

Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Japan; The International Research Center for Neurointelligence (WPI-IRCN) at The University of Tokyo Institutes for Advanced Study (UTIAS), Japan. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2018.04.603DOI Listing
July 2018
4 Reads
3.100 Impact Factor

Impaired visual, working, and verbal memory in first-episode, drug-naive patients with major depressive disorder in a Chinese population.

PLoS One 2018 23;13(4):e0196023. Epub 2018 Apr 23.

Department of Psychiatry, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196023PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912727PMC
July 2018
17 Reads
3.234 Impact Factor

What Are the Causes for Discrepancies of Antidepressant Actions of (2R,6R)-Hydroxynorketamine?

Biol Psychiatry 2018 07 27;84(1):e7-e8. Epub 2017 Dec 27.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Inohana, Chiba, Japan; Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.

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http://dx.doi.org/10.1016/j.biopsych.2017.12.007DOI Listing
July 2018
3 Reads
2 Citations
10.260 Impact Factor

Author Correction: Lack of metabolism in (R)-ketamine's antidepressant actions in a chronic social defeat stress model.

Sci Rep 2018 Jul 12;8(1):10833. Epub 2018 Jul 12.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.1038/s41598-018-28860-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041312PMC
July 2018
16 Reads
5.080 Impact Factor

Lack of dopamine supersensitivity in rats after chronic administration of blonanserin: Comparison with haloperidol.

Eur J Pharmacol 2018 Jul 22;830:26-32. Epub 2018 Apr 22.

Drug Research Division, Sumitomo Dainippon Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan.

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http://dx.doi.org/10.1016/j.ejphar.2018.04.014DOI Listing
July 2018
26 Reads
2.532 Impact Factor

Deletion of serine racemase confers D-serine -dependent resilience to chronic social defeat stress.

Neurochem Int 2018 06 14;116:43-51. Epub 2018 Mar 14.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Chiba, 260-8670, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neuint.2018.03.008DOI Listing
June 2018
35 Reads
1 Citation
3.092 Impact Factor

Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury.

Eur Arch Psychiatry Clin Neurosci 2018 Jun 7. Epub 2018 Jun 7.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China.

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http://dx.doi.org/10.1007/s00406-018-0909-zDOI Listing
June 2018
8 Reads
1 Citation
3.525 Impact Factor

Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.

Proc Natl Acad Sci U S A 2018 06 7;115(25):E5815-E5823. Epub 2018 May 7.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 260-8670 Chiba, Japan;

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http://dx.doi.org/10.1073/pnas.1802179115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016799PMC
June 2018
28 Reads
1 Citation
9.810 Impact Factor

Neuropsychiatric Phenotypes Produced by GABA Reduction in Mouse Cortex and Hippocampus.

Neuropsychopharmacology 2018 05 6;43(6):1445-1456. Epub 2017 Dec 6.

Unit on Genetics of Cognition and Behavior, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

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http://www.nature.com/doifinder/10.1038/npp.2017.296
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http://dx.doi.org/10.1038/npp.2017.296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916365PMC
May 2018
49 Reads
1 Citation
7.050 Impact Factor

Regional differences in dendritic spine density confer resilience to chronic social defeat stress.

Acta Neuropsychiatr 2018 Apr 1;30(2):117-122. Epub 2017 Jun 1.

Division of Clinical Neuroscience,Chiba University Center for Forensic Mental Health,Chiba,Japan.

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http://dx.doi.org/10.1017/neu.2017.16DOI Listing
April 2018
57 Reads

Lack of metabolism in (R)-ketamine's antidepressant actions in a chronic social defeat stress model.

Sci Rep 2018 03 5;8(1):4007. Epub 2018 Mar 5.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.1038/s41598-018-22449-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838158PMC
March 2018
5.080 Impact Factor

5-Hydroxytryptamine-Independent Antidepressant Actions of (R)-Ketamine in a Chronic Social Defeat Stress Model.

Int J Neuropsychopharmacol 2018 02;21(2):157-163

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.1093/ijnp/pyx100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793842PMC
February 2018
8 Reads
3 Citations
4.010 Impact Factor

Dietary glucoraphanin prevents the onset of psychosis in the adult offspring after maternal immune activation.

Sci Rep 2018 02 1;8(1):2158. Epub 2018 Feb 1.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.

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http://dx.doi.org/10.1038/s41598-018-20538-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794794PMC
February 2018
12 Reads
1 Citation
5.080 Impact Factor

Mechanistic Target of Rapamycin-Independent Antidepressant Effects of (R)-Ketamine in a Social Defeat Stress Model.

Biol Psychiatry 2018 Jan 31;83(1):18-28. Epub 2017 May 31.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.05.016DOI Listing
January 2018
36 Reads
12 Citations
10.260 Impact Factor

Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine.

Int J Neuropsychopharmacol 2018 01;21(1):84-88

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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https://academic.oup.com/ijnp/article/21/1/84/4633900
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http://dx.doi.org/10.1093/ijnp/pyx108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795355PMC
January 2018
13 Reads
7 Citations
4.010 Impact Factor

Possible role of the gut microbiota-brain axis in the antidepressant effects of (R)-ketamine in a social defeat stress model.

Transl Psychiatry 2017 12 18;7(12):1294. Epub 2017 Dec 18.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.1038/s41398-017-0031-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802627PMC
December 2017
45 Reads
7 Citations
4.360 Impact Factor

Comparison of (R)-ketamine and lanicemine on depression-like phenotype and abnormal composition of gut microbiota in a social defeat stress model.

Sci Rep 2017 Nov 16;7(1):15725. Epub 2017 Nov 16.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.1038/s41598-017-16060-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691133PMC
November 2017
19 Reads
2 Citations
5.080 Impact Factor

Alterations in amino acid levels in mouse brain regions after adjunctive treatment of brexpiprazole with fluoxetine: comparison with (R)-ketamine.

Psychopharmacology (Berl) 2017 Nov 26;234(21):3165-3173. Epub 2017 Jul 26.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba, 260-8670, Japan.

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http://dx.doi.org/10.1007/s00213-017-4700-zDOI Listing
November 2017
11 Reads
1 Citation
3.880 Impact Factor

[Biomarkers for Mood Disorders and a Novel Antidepressant (R)-ketamine].

Authors:
Kenji Hashimoto

Brain Nerve 2017 Oct;69(10):1143-1148

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health.

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http://dx.doi.org/10.11477/mf.1416200882DOI Listing
October 2017
18 Reads

Alterations in glutamatergic signaling in the brain of dopamine supersensitivity psychosis and non-supersensitivity psychosis model rats.

Psychopharmacology (Berl) 2017 Oct 25;234(20):3027-3036. Epub 2017 Jul 25.

Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuou-ku, Chiba, Chiba, 260-8670, Japan.

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http://dx.doi.org/10.1007/s00213-017-4695-5DOI Listing
October 2017
81 Reads
3.880 Impact Factor

Sigma-1 Receptor Agonists and Their Clinical Implications in Neuropsychiatric Disorders.

Adv Exp Med Biol 2017 ;964:153-161

Chiba University, Chiba, Japan.

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http://dx.doi.org/10.1007/978-3-319-50174-1_11DOI Listing
September 2017
6 Reads
4 Citations

(R)-Ketamine Shows Greater Potency and Longer Lasting Antidepressant Effects Than Its Metabolite (2R,6R)-Hydroxynorketamine.

Biol Psychiatry 2017 09 23;82(5):e43-e44. Epub 2016 Dec 23.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2016.12.020DOI Listing
September 2017
22 Reads
20 Citations
10.260 Impact Factor

Intake of 7,8-dihydroxyflavone from pregnancy to weaning prevents cognitive deficits in adult offspring after maternal immune activation.

Eur Arch Psychiatry Clin Neurosci 2017 Aug 17;267(5):479-483. Epub 2017 Apr 17.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.

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http://dx.doi.org/10.1007/s00406-017-0802-1DOI Listing
August 2017
4 Reads
1 Citation
3.525 Impact Factor

Increased EphA4-ephexin1 signaling in the medial prefrontal cortex plays a role in depression-like phenotype.

Sci Rep 2017 08 2;7(1):7133. Epub 2017 Aug 2.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.

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http://dx.doi.org/10.1038/s41598-017-07325-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541046PMC
August 2017
10 Reads
1 Citation
5.080 Impact Factor

Alterations in the inflammatory cytokines and brain-derived neurotrophic factor contribute to depression-like phenotype after spared nerve injury: improvement by ketamine.

Sci Rep 2017 06 9;7(1):3124. Epub 2017 Jun 9.

Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.

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http://dx.doi.org/10.1038/s41598-017-03590-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466642PMC
June 2017
21 Reads
2 Citations
5.080 Impact Factor

Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese.

Cancer Chemother Pharmacol 2017 Jun 26;79(6):1179-1186. Epub 2017 Apr 26.

Department of Breast and Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1007/s00280-017-3314-9DOI Listing
June 2017
38 Reads
2.770 Impact Factor

Reduced Mismatch Negativity is Associated with Increased Plasma Level of Glutamate in First-episode Psychosis.

Sci Rep 2017 05 23;7(1):2258. Epub 2017 May 23.

Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

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http://dx.doi.org/10.1038/s41598-017-02267-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442101PMC
May 2017
8 Reads
2 Citations
5.080 Impact Factor

The recency ratio is associated with reduced CSF glutamate in late-life depression.

Neurobiol Learn Mem 2017 May 18;141:14-18. Epub 2017 Mar 18.

Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA; Department of Psychiatry, School of Medicine, New York University, New York City, NY, USA.

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http://dx.doi.org/10.1016/j.nlm.2017.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460071PMC
May 2017
23 Reads
1 Citation
3.652 Impact Factor

Bifidobacterium in the gut microbiota confer resilience to chronic social defeat stress in mice.

Sci Rep 2017 04 3;7:45942. Epub 2017 Apr 3.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan.

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http://dx.doi.org/10.1038/srep45942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377462PMC
April 2017
37 Reads
8 Citations
5.080 Impact Factor

Increased serum G72 protein levels in patients with schizophrenia: a potential candidate biomarker.

Acta Neuropsychiatr 2017 Apr 14;29(2):80-86. Epub 2016 Jul 14.

6Division of Clinical Neuroscience,Chiba University Center for Forensic Mental Health,Chiba,Japan.

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http://dx.doi.org/10.1017/neu.2016.34DOI Listing
April 2017
7 Reads
2 Citations

Antidepressant Potential of ()-Ketamine in Rodent Models: Comparison with ()-Ketamine.

J Pharmacol Exp Ther 2017 Apr 23;361(1):9-16. Epub 2017 Jan 23.

Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan (K.F., H.T., M.I., T.H., J.Y., S.C.); and Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan (K.H.)

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http://dx.doi.org/10.1124/jpet.116.239228DOI Listing
April 2017
7 Reads
20 Citations
3.972 Impact Factor

An Infected Aneurysm of the Vertebral Artery Treated with a Stent-graft: A Case Report.

Neurol Med Chir (Tokyo) 2015 6;55(11):852-5. Epub 2015 Oct 6.

Department of Neurosurgery, Kishiwada City Hospital.

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http://dx.doi.org/10.2176/nmc.cr.2015-0046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663024PMC
April 2017
5 Reads
0.650 Impact Factor

Effects of a single bilateral infusion of R-ketamine in the rat brain regions of a learned helplessness model of depression.

Eur Arch Psychiatry Clin Neurosci 2017 Mar 1;267(2):177-182. Epub 2016 Aug 1.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba, 260-8670, Japan.

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March 2017
28 Reads
9 Citations
3.525 Impact Factor

Rapid and Sustained Antidepressant Action of the mGlu2/3 Receptor Antagonist MGS0039 in the Social Defeat Stress Model: Comparison with Ketamine.

Int J Neuropsychopharmacol 2017 03;20(3):228-236

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan; Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.

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http://dx.doi.org/10.1093/ijnp/pyw089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408970PMC
March 2017
53 Reads
6 Citations
4.010 Impact Factor

Reduction of dopamine D receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys.

Eur Arch Psychiatry Clin Neurosci 2017 Mar 18;267(2):173-176. Epub 2016 Apr 18.

Central Research Laboratory, Hamamatsu Photonics KK, Hamamatsu, Shizuoka, 434-0041, Japan.

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http://dx.doi.org/10.1007/s00406-016-0692-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323469PMC
March 2017
6 Reads
11 Citations
3.525 Impact Factor

Antidepressant effects of combination of brexpiprazole and fluoxetine on depression-like behavior and dendritic changes in mice after inflammation.

Psychopharmacology (Berl) 2017 Feb 15;234(4):525-533. Epub 2016 Nov 15.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba, 260-8670, Japan.

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http://dx.doi.org/10.1007/s00213-016-4483-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263204PMC
February 2017
39 Reads
4 Citations
3.880 Impact Factor

Altered serum level of matrix metalloproteinase-9 and its association with decision-making in eating disorders.

Psychiatry Clin Neurosci 2017 Feb 14;71(2):124-134. Epub 2017 Jan 14.

Research Center for Child Mental Development, Chiba University, Chiba, Japan.

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http://dx.doi.org/10.1111/pcn.12490DOI Listing
February 2017
32 Reads
1.620 Impact Factor

Increased Levels of C1q in the Prefrontal Cortex of Adult Offspring after Maternal Immune Activation: Prevention by 7,8-Dihydroxyflavone.

Clin Psychopharmacol Neurosci 2017 Feb;15(1):64-67

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.9758/cpn.2017.15.1.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290721PMC
February 2017
21 Reads
2 Citations

Harnessing host ROS-generating machinery for the robust genome replication of a plant RNA virus.

Proc Natl Acad Sci U S A 2017 02 1;114(7):E1282-E1290. Epub 2017 Feb 1.

Laboratory of Plant Pathology, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan;

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http://dx.doi.org/10.1073/pnas.1610212114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320965PMC
February 2017
36 Reads
4 Citations
9.810 Impact Factor

Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation.

J Nutr Biochem 2017 01 11;39:134-144. Epub 2016 Oct 11.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2016.10.004DOI Listing
January 2017
58 Reads
6 Citations
3.794 Impact Factor

Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets.

Curr Neuropharmacol 2016 ;14(7):721-31

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba 260-8670, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050398PMC
http://dx.doi.org/10.2174/1570159x14666160119094646DOI Listing
January 2017
178 Reads
17 Citations
3.050 Impact Factor

Adjunctive treatment of brexpiprazole with fluoxetine shows a rapid antidepressant effect in social defeat stress model: Role of BDNF-TrkB signaling.

Sci Rep 2016 12 19;6:39209. Epub 2016 Dec 19.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.1038/srep39209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171769PMC
December 2016
31 Reads
7 Citations
5.080 Impact Factor

Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression.

Eur J Pharmacol 2016 Dec 1;793:21-27. Epub 2016 Nov 1.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2016.10.037DOI Listing
December 2016
34 Reads
4 Citations
2.532 Impact Factor

Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model.

Int J Neuropsychopharmacol 2016 12 30;19(12). Epub 2016 Dec 30.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan (Dr Yang, Dr Ren, Ms Ma, and Dr Hashimoto); Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China (Drs Yang and Chen).

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http://dx.doi.org/10.1093/ijnp/pyw080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203762PMC
December 2016
44 Reads
4 Citations
4.010 Impact Factor

Altered serum level of matrix metalloproteinase-9 and its association with decision-making in eating disorders.

Psychiatry Clin Neurosci 2017 Feb 14;71(2):124-134. Epub 2017 Jan 14.

Research Center for Child Mental Development, Chiba University, Chiba, Japan.

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http://dx.doi.org/10.1111/pcn.12490DOI Listing
February 2017
32 Reads
1.620 Impact Factor

Regional differences in the expression of brain-derived neurotrophic factor (BDNF) pro-peptide, proBDNF and preproBDNF in the brain confer stress resilience.

Eur Arch Psychiatry Clin Neurosci 2016 Dec 19;266(8):765-769. Epub 2016 Apr 19.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.

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http://link.springer.com/content/pdf/10.1007%2Fs00406-016-06
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http://link.springer.com/10.1007/s00406-016-0693-6
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http://dx.doi.org/10.1007/s00406-016-0693-6DOI Listing
December 2016
47 Reads
9 Citations
3.525 Impact Factor

On the Eve of Upgrading Antidepressants: (R)-Ketamine and Its Metabolites.

Neurosci Bull 2016 Dec 14;32(6):565-568. Epub 2016 Nov 14.

Institute of Mental Health, National Clinical Research Center for Mental Disorders, Key Laboratory of Mental Health and Peking University Sixth Hospital, Peking University, Beijing, 100191, China.

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http://dx.doi.org/10.1007/s12264-016-0082-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567489PMC
December 2016
39 Reads
1 Citation

Intake of 7,8-Dihydroxyflavone During Juvenile and Adolescent Stages Prevents Onset of Psychosis in Adult Offspring After Maternal Immune Activation.

Sci Rep 2016 11 8;6:36087. Epub 2016 Nov 8.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan.

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http://dx.doi.org/10.1038/srep36087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099694PMC
November 2016
46 Reads
5 Citations
5.080 Impact Factor

Depression-like phenotype by deletion of α7 nicotinic acetylcholine receptor: Role of BDNF-TrkB in nucleus accumbens.

Sci Rep 2016 11 8;6:36705. Epub 2016 Nov 8.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan.

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http://dx.doi.org/10.1038/srep36705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099687PMC
November 2016
26 Reads
2 Citations
5.080 Impact Factor

Ketamine's antidepressant action: beyond NMDA receptor inhibition.

Authors:
Kenji Hashimoto

Expert Opin Ther Targets 2016 11 28;20(11):1389-1392. Epub 2016 Sep 28.

a Division of Clinical Neuroscience , Chiba University Center for Forensic Mental Health , Chiba , Japan.

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http://dx.doi.org/10.1080/14728222.2016.1238899DOI Listing
November 2016
32 Reads
11 Citations
5.140 Impact Factor

Detrimental Side Effects of Repeated Ketamine Infusions in the Brain.

Authors:
Kenji Hashimoto

Am J Psychiatry 2016 10;173(10):1044-1045

From the Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.1176/appi.ajp.2016.16040411DOI Listing
October 2016
7 Reads
4 Citations
12.295 Impact Factor

Familial Influences on Mismatch Negativity and Its Association with Plasma Glutamate Level: A Magnetoencephalographic Study in Twins.

Mol Neuropsychiatry 2016 Oct 20;2(3):161-172. Epub 2016 Sep 20.

Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1159/000449426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109992PMC
October 2016
49 Reads

Soluble epoxide hydrolase: a new therapeutic target for depression.

Authors:
Kenji Hashimoto

Expert Opin Ther Targets 2016 10 24;20(10):1149-51. Epub 2016 Aug 24.

a Division of Clinical Neuroscience , Chiba University Center for Forensic Mental Health , Chiba , Japan.

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http://dx.doi.org/10.1080/14728222.2016.1226284DOI Listing
October 2016
2 Reads
3 Citations
5.140 Impact Factor

Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression.

Psychopharmacology (Berl) 2016 Oct 4;233(19-20):3647-57. Epub 2016 Aug 4.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.

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http://dx.doi.org/10.1007/s00213-016-4399-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021744PMC
October 2016
55 Reads
16 Citations
3.880 Impact Factor

The cognitive impairments and psychological wellbeing of methamphetamine dependent patients compared with health controls.

Prog Neuropsychopharmacol Biol Psychiatry 2016 08 13;69:31-7. Epub 2016 Apr 13.

Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2016.04.005DOI Listing
August 2016
35 Reads
7 Citations
3.690 Impact Factor

Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice.

Sci Rep 2016 07 29;6:30659. Epub 2016 Jul 29.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan.

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http://dx.doi.org/10.1038/srep30659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965765PMC
July 2016
53 Reads
13 Citations
5.080 Impact Factor

Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker.

Authors:
Kenji Hashimoto

Curr Pharm Des 2015 ;21(26):3797-806

Division of Clinical Neuroscience, Chiba University Center for Forensic, Mental Health, 1-8-1 Inohana, Chiba 260-8670, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024727PMC
http://dx.doi.org/10.2174/1381612821666150605111345DOI Listing
June 2016
11 Reads
10 Citations
3.452 Impact Factor

Increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study.

Neuropsychiatr Dis Treat 2016 23;12:1261-8. Epub 2016 May 23.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.2147/NDT.S106993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889085PMC
June 2016
7 Reads
1 Citation
2.154 Impact Factor

Impact of plasma transaminase levels on the peripheral blood glutamate levels and memory functions in healthy subjects.

BBA Clin 2016 Jun 23;5:101-7. Epub 2016 Feb 23.

Department of Molecular Biochemistry & Clinical Investigation, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1016/j.bbacli.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802405PMC
June 2016
35 Reads
1 Citation

Increased serum levels of serine enantiomers in patients with depression.

Acta Neuropsychiatr 2016 Jun 29;28(3):173-8. Epub 2015 Oct 29.

2Department of Psychiatry,Chiba University Graduate School of Medicine,Chiba,Japan.

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http://dx.doi.org/10.1017/neu.2015.59DOI Listing
June 2016
8 Reads
5 Citations

Omega-3 fatty acid supplementation for expectant mothers with depressive symptoms in Japan and Taiwan: An open-label trial.

Psychiatry Clin Neurosci 2016 Jun 6;70(6):253-4. Epub 2016 May 6.

Department of Obstetrics and Gynecology, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1111/pcn.12388DOI Listing
June 2016
36 Reads
3 Citations
1.620 Impact Factor

Serum oxytocin, posttraumatic coping and C-reactive protein in motor vehicle accident survivors by gender.

Neuropsychobiology 2015 2;71(4):196-201. Epub 2015 Jun 2.

Department of Psychiatry, National Disaster Medical Center, Tachikawa, Japan.

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http://dx.doi.org/10.1159/000382021DOI Listing
May 2016
9 Reads
6 Citations
2.261 Impact Factor

Effects of escitalopram, R-citalopram, and reboxetine on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration.

Pharmacol Biochem Behav 2016 May 15;144:7-12. Epub 2016 Feb 15.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2016.02.005DOI Listing
May 2016
141 Reads
4 Citations
2.781 Impact Factor

Loss of parvalbumin-immunoreactivity in mouse brain regions after repeated intermittent administration of esketamine, but not R-ketamine.

Psychiatry Res 2016 05 24;239:281-3. Epub 2016 Mar 24.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba 260-8670, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.psychres.2016.03.034DOI Listing
May 2016
8 Reads
14 Citations
2.470 Impact Factor

Regulation of brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain by serotonin.

Authors:
Kenji Hashimoto

Eur Arch Psychiatry Clin Neurosci 2016 Apr;266(3):195-7

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba, 260-8670, Japan.

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http://dx.doi.org/10.1007/s00406-016-0682-9DOI Listing
April 2016
18 Reads
3.525 Impact Factor

Ethnic differences in the serum levels of proBDNF, a precursor of brain-derived neurotrophic factor (BDNF), in mood disorders.

Authors:
Kenji Hashimoto

Eur Arch Psychiatry Clin Neurosci 2016 Apr 4;266(3):285-7. Epub 2015 Sep 4.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba, 260-8670, Japan.

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http://dx.doi.org/10.1007/s00406-015-0641-xDOI Listing
April 2016
17 Reads
1 Citation
3.525 Impact Factor

Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress.

Proc Natl Acad Sci U S A 2016 Mar 14;113(13):E1944-52. Epub 2016 Mar 14.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan;

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http://dx.doi.org/10.1073/pnas.1601532113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822604PMC
March 2016
54 Reads
28 Citations
9.810 Impact Factor

Serine enantiomers as diagnostic biomarkers for schizophrenia and bipolar disorder.

Authors:
Kenji Hashimoto

Eur Arch Psychiatry Clin Neurosci 2016 Feb 12;266(1):83-5. Epub 2015 May 12.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba, 260-8670, Japan.

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http://dx.doi.org/10.1007/s00406-015-0602-4DOI Listing
February 2016
3 Reads
2 Citations
3.525 Impact Factor

Effects of add-on tipepidine on treatment-resistant depression: an open-label pilot trial.

Acta Neuropsychiatr 2016 Feb 20;28(1):51-4. Epub 2015 Jul 20.

2Division of Clinical Neuroscience,Chiba University Center for Forensic Mental Health,Chiba,Japan.

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http://dx.doi.org/10.1017/neu.2015.43DOI Listing
February 2016
4 Reads

Assessment of a multi-assay biological diagnostic test for mood disorders in a Japanese population.

Neurosci Lett 2016 Jan 11;612:167-171. Epub 2015 Dec 11.

Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 5650871, Japan; Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka 5650871, Japan.

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http://dx.doi.org/10.1016/j.neulet.2015.12.019DOI Listing
January 2016
29 Reads
5 Citations
2.060 Impact Factor

A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance.

Nat Commun 2015 Dec 10;6:10090. Epub 2015 Dec 10.

Division of Biological Sciences, Department of Molecular Biology, Nagoya University Graduate School of Science, Nagoya 464-8602, Japan.

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http://dx.doi.org/10.1038/ncomms10090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682051PMC
December 2015
48 Reads
3 Citations
10.742 Impact Factor

Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression.

Psychopharmacology (Berl) 2015 Dec 4;232(23):4325-35. Epub 2015 Sep 4.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.1007/s00213-015-4062-3DOI Listing
December 2015
68 Reads
27 Citations
3.880 Impact Factor

Early Intervention for Psychosis with N-Methyl-D-Aspartate Receptor Modulators.

Clin Psychopharmacol Neurosci 2015 Dec;13(3):328-9

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.9758/cpn.2015.13.3.328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662175PMC
December 2015
7 Reads
2 Citations

Glutamatergic system abnormalities in posttraumatic stress disorder.

Psychopharmacology (Berl) 2015 Dec 22;232(23):4261-8. Epub 2015 Aug 22.

Department of Psychiatry, National Disaster Medical Center, 3256 Midoricho, Tachikawa, Tokyo, 190-0014, Japan.

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http://dx.doi.org/10.1007/s00213-015-4052-5DOI Listing
December 2015
4 Reads
4 Citations
3.880 Impact Factor

Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist.

Eur Neuropsychopharmacol 2015 Dec 9;25(12):2449-58. Epub 2015 Sep 9.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2015.09.002DOI Listing
December 2015
45 Reads
16 Citations
4.370 Impact Factor

G protein-coupled receptor kinase 6/β-arrestin 2 system in a rat model of dopamine supersensitivity psychosis.

J Psychopharmacol 2015 Dec 14;29(12):1308-13. Epub 2015 Jul 14.

Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.

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http://dx.doi.org/10.1177/0269881115593903DOI Listing
December 2015
11 Reads
2 Citations
3.593 Impact Factor

Minocycline and St. John's wort as therapeutic drugs for human tauopathy.

Authors:
Kenji Hashimoto

Biol Psychiatry 2015 Nov 6;78(10):e39. Epub 2015 May 6.

Division of Clinical Neuroscience, Center for Forensic Mental Health, Chiba UniversityChiba, Japan.. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2015.04.025DOI Listing
November 2015
1 Read
10.260 Impact Factor

Peripheral IL-6 signaling: a promising therapeutic target for depression?

Expert Opin Investig Drugs 2015 4;24(7):989-90. Epub 2015 Jun 4.

Chiba University Center for Forensic Mental Health, Division of Clinical Neuroscience , Chiba 260-8670 , Japan +81 43 226 2517 ; +81 43 226 2561 ;

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http://dx.doi.org/10.1517/13543784.2015.1055669DOI Listing
November 2015
5 Reads
5 Citations
5.530 Impact Factor

Peripheral interleukin-6 promotes resilience versus susceptibility to inescapable electric stress.

Acta Neuropsychiatr 2015 Oct 28;27(5):312-6. Epub 2015 May 28.

1Division of Clinical Neuroscience,Chiba University Center for Forensic Mental Health,Chiba,Japan.

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http://dx.doi.org/10.1017/neu.2015.36DOI Listing
October 2015
15 Reads
10 Citations

Opposite roles for neuropeptide S in the nucleus accumbens and bed nucleus of the stria terminalis in learned helplessness rats.

Behav Brain Res 2015 Sep 16;291:67-71. Epub 2015 May 16.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.1016/j.bbr.2015.05.007DOI Listing
September 2015
8 Reads
3.030 Impact Factor

Effects of amycenone on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration.

Pharmacol Biochem Behav 2015 Sep 4;136:7-12. Epub 2015 Jul 4.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2015.06.012DOI Listing
September 2015
28 Reads
4 Citations
2.781 Impact Factor

Docosahexaenoic acid for selective prevention of posttraumatic stress disorder among severely injured patients: a randomized, placebo-controlled trial.

J Clin Psychiatry 2015 08;76(8):e1015-22

Department of Psychiatry, National Disaster Medical Center, 3256 Midoricho, Tachikawa, Tokyo 190-0014, Japan

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http://dx.doi.org/10.4088/JCP.14m09260DOI Listing
August 2015
7 Reads
4 Citations
5.500 Impact Factor

Role of EphA4 signaling in the pathogenesis of amyotrophic lateral sclerosis and therapeutic potential of traditional Chinese medicine rhynchophylline.

Authors:
Kenji Hashimoto

Psychopharmacology (Berl) 2015 Aug 5;232(15):2873-5. Epub 2015 Jul 5.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba, 260-8670, Japan,

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http://dx.doi.org/10.1007/s00213-015-4013-zDOI Listing
August 2015
11 Reads
2 Citations
3.880 Impact Factor

Genetic association between G protein-coupled receptor kinase 6/β-arrestin 2 and dopamine supersensitivity psychosis in schizophrenia.

Neuropsychiatr Dis Treat 2015 29;11:1845-51. Epub 2015 Jul 29.

Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.

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http://dx.doi.org/10.2147/NDT.S86042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524575PMC
August 2015
7 Reads
3 Citations
2.154 Impact Factor

Decreased levels of serum oxytocin in pediatric patients with Attention Deficit/Hyperactivity Disorder.

Psychiatry Res 2015 Aug 15;228(3):746-51. Epub 2015 Jun 15.

Department of Child Psychiatry, Chiba University Hospital, Japan; Department of Psychiatry, Chiba University Graduate School of Medicine, Japan; Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Japan; Division of Medical Treatment and Rehabilitation, Chiba University Center for Forensic Mental Health, Japan.

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http://dx.doi.org/10.1016/j.psychres.2015.05.029DOI Listing
August 2015
71 Reads
4 Citations
2.470 Impact Factor

Nitrate sensing and uptake in Arabidopsis are enhanced by ABI2, a phosphatase inactivated by the stress hormone abscisic acid.

Sci Signal 2015 May 5;8(375):ra43. Epub 2015 May 5.

Laboratoire de Biochimie et Physiologie Moléculaire des Plantes, UMR CNRS/INRA/SupAgro/UM, Institut de Biologie Intégrative des Plantes "Claude Grignon," Place Viala, 34060 Montpellier Cedex, France.

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http://dx.doi.org/10.1126/scisignal.aaa4829DOI Listing
May 2015
30 Reads
23 Citations
6.280 Impact Factor

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