Publications by authors named "Kendell Clement"

39Publications

Technologies and Computational Analysis Strategies for CRISPR Applications.

Mol Cell 2020 07;79(1):11-29

Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA; Department of Pathology, Harvard Medical School, Boston, MA, USA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497852PMC
July 2020

Therapeutic base editing of human hematopoietic stem cells.

Nat Med 2020 04 16;26(4):535-541. Epub 2020 Mar 16.

Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Broad Institute, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41591-020-0790-yDOI Listing
April 2020

Assessment of computational methods for the analysis of single-cell ATAC-seq data.

Genome Biol 2019 11 18;20(1):241. Epub 2019 Nov 18.

Molecular Pathology Unit, Massachusetts General Hospital Research Institute, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1186/s13059-019-1854-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859644PMC
November 2019

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis.

Cell Stem Cell 2019 11 3;25(5):622-638.e13. Epub 2019 Oct 3.

Department of Molecular Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Harvard Stem Cell Institute, 1350 Massachusetts Avenue, Cambridge, MA 02138, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247364PMC
November 2019

An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities.

Nat Biotechnol 2018 11 30;36(10):977-982. Epub 2018 Jul 30.

Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.4199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181770PMC
November 2018

Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming.

Cell Stem Cell 2018 Aug 12;23(2):289-305.e5. Epub 2018 Jul 12.

Department of Molecular Biology, Cancer Center, and Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Harvard Stem Cell Institute, 1350 Massachusetts Avenue, Cambridge, MA 02138, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183029
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http://dx.doi.org/10.1016/j.stem.2018.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086589PMC
August 2018

AmpUMI: design and analysis of unique molecular identifiers for deep amplicon sequencing.

Bioinformatics 2018 07;34(13):i202-i210

Molecular Pathology Unit and Cancer Center, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1093/bioinformatics/bty264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022702PMC
July 2018

An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition.

Cell Stem Cell 2018 Jun 24;22(6):851-864.e5. Epub 2018 May 24.

Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Harvard Initiative for RNA Medicine, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990487PMC
June 2018

A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development.

Cell Stem Cell 2018 04;22(4):575-588.e7

Stem Cell Program, Division of Hematology/Oncology, Manton Center for Orphan Disease Research, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957284PMC
April 2018

Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".

Nat Methods 2018 04 30;15(4):238-239. Epub 2018 Mar 30.

Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.4541DOI Listing
April 2018

DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells.

Cell Stem Cell 2017 05 30;20(5):706-719.e7. Epub 2017 Mar 30.

Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Harvard Stem Cell Institute, 1350 Massachusetts Avenue, Cambridge, MA 02138, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524993PMC
May 2017

A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs.

Nat Biotechnol 2015 Nov 26;33(11):1173-81. Epub 2015 Oct 26.

Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.3388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847940PMC
November 2015

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.

Nat Genet 2015 May 30;47(5):469-78. Epub 2015 Mar 30.

1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [3] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414868PMC
May 2015

Age- and pregnancy-associated DNA methylation changes in mammary epithelial cells.

Stem Cell Reports 2015 Feb 22;4(2):297-311. Epub 2015 Jan 22.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://www.cell.com/stem-cell-reports/pdf/S2213-6711(14)0038
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http://www.cell.com/cms/attachment/2025101614/2044763771/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S221367111400386
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http://dx.doi.org/10.1016/j.stemcr.2014.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325231PMC
February 2015

Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia.

Cancer Cell 2014 Dec;26(6):813-825

Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Division of Hematology/Oncology, Children's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302418PMC
December 2014