Ken S Lau

Ken S Lau

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Ken S Lau

Ken S Lau

Publications by authors named "Ken S Lau"

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Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response.

Diabetes 2020 Apr 3. Epub 2020 Apr 3.

Vanderbilt Program in Developmental Biology, Vanderbilt Center for Stem Cell Biology, Department of Cell & Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, 37232

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http://dx.doi.org/10.2337/db19-0721DOI Listing
April 2020

scRNABatchQC: multi-samples quality control for single cell RNA-seq data.

Bioinformatics 2019 Dec;35(24):5306-5308

Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1093/bioinformatics/btz601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954654PMC
December 2019

mPGES-1-Mediated Production of PGE and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation.

Front Immunol 2018 14;9:2954. Epub 2018 Dec 14.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02954
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http://dx.doi.org/10.3389/fimmu.2018.02954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302013PMC
October 2019

pyNVR: investigating factors affecting feature selection from scRNA-seq data for lineage reconstruction.

Bioinformatics 2019 Jul;35(13):2335-2337

Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1093/bioinformatics/bty950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596893PMC
July 2019

Single-Cell Mass Cytometry of Archived Human Epithelial Tissue for Decoding Cancer Signaling Pathways.

Methods Mol Biol 2019 ;1884:215-229

Epithelial Biology Center and the Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1007/978-1-4939-8885-3_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282860PMC
June 2019

Not All Insults Are Created Equal for Awakening Dormant Stem Cell Abilities.

Cell Mol Gastroenterol Hepatol 2019 7;7(3):619-621. Epub 2019 Jan 7.

Department of Cell and Developmental Biology, Epithelial Biology Center, Department of Surgery, Vanderbilt University School of Medicine, Nashville VA Medical Center, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2018.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411908PMC
May 2019

Novel kidney dissociation protocol and image-based flow cytometry facilitate improved analysis of injured proximal tubules.

Am J Physiol Renal Physiol 2019 05 13;316(5):F847-F855. Epub 2019 Feb 13.

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center , Nashville, Tennessee.

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http://dx.doi.org/10.1152/ajprenal.00354.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580245PMC
May 2019

Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities.

Cell 2019 05 25;177(4):1035-1049.e19. Epub 2019 Apr 25.

Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193029
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http://dx.doi.org/10.1016/j.cell.2019.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768830PMC
May 2019

DSS-induced damage to basement membranes is repaired by matrix replacement and crosslinking.

J Cell Sci 2019 04 8;132(7). Epub 2019 Apr 8.

Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240-7935, USA

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http://jcs.biologists.org/lookup/doi/10.1242/jcs.226860
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http://dx.doi.org/10.1242/jcs.226860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467488PMC
April 2019

Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity.

Dev Cell 2019 01;48(1):49-63.e7

Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Program in Developmental Biology and Center for Stem Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.11.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327977PMC
January 2019

Quantitative assessment of cell population diversity in single-cell landscapes.

PLoS Biol 2018 10 22;16(10):e2006687. Epub 2018 Oct 22.

Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.2006687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211764PMC
October 2018

Interpreting heterogeneity in intestinal tuft cell structure and function.

J Clin Invest 2018 05 1;128(5):1711-1719. Epub 2018 May 1.

Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1172/JCI120330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919882PMC
May 2018

Single-Cell Computational Strategies for Lineage Reconstruction in Tissue Systems.

Cell Mol Gastroenterol Hepatol 2018 13;5(4):539-548. Epub 2018 Feb 13.

Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1016/j.jcmgh.2018.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924749PMC
February 2018

Unsupervised Trajectory Analysis of Single-Cell RNA-Seq and Imaging Data Reveals Alternative Tuft Cell Origins in the Gut.

Cell Syst 2018 01 15;6(1):37-51.e9. Epub 2017 Nov 15.

Epithelial Biology Center, Vanderbilt University Medical Center, 2213 Garland Avenue, 10475 MRB IV, Nashville, TN 37232, USA; Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Center for Quantitative Sciences, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2017.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799016PMC
January 2018

Deciphering tumor heterogeneity from FFPE tissues: Its promise and challenges.

Mol Cell Oncol 2017 18;4(1):e1260191. Epub 2016 Nov 18.

Epithelial Biology Center and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine , Nashville, TN, USA.

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http://dx.doi.org/10.1080/23723556.2016.1260191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286981PMC
November 2016

Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks.

Sci Signal 2016 10 11;9(449):rs11. Epub 2016 Oct 11.

Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Chemical and Physical Biology Program, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1126/scisignal.aah4413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111815PMC
October 2016

Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium.

Sci Signal 2015 Dec 15;8(407):ra129. Epub 2015 Dec 15.

Cancer Research Institute, Beth Israel Deaconess Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1126/scisignal.aac7235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812576PMC
December 2015

Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-α-induced apoptosis in vivo.

Mol Syst Biol 2015 Oct 30;11(10):835. Epub 2015 Oct 30.

Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA Department of Chemical and Physical Biology, Vanderbilt University Medical Center, Nashville, TN, USA

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631206PMC
http://dx.doi.org/10.15252/msb.20156282DOI Listing
October 2015

Multiscale analysis of the murine intestine for modeling human diseases.

Integr Biol (Camb) 2015 Jul;7(7):740-57

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1039/c5ib00030kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569017PMC
July 2015

Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α.

Integr Biol (Camb) 2013 Nov 2;5(11):1355-65. Epub 2013 Oct 2.

Molecular Pathology Unit, Center for Cancer Research, and Center for Systems Biology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1039/c3ib40062jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966991PMC
November 2013

Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium.

PLoS Biol 2012 25;10(9):e1001393. Epub 2012 Sep 25.

Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1001393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463506PMC
June 2013

BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner.

PLoS One 2012 18;7(7):e41343. Epub 2012 Jul 18.

Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041343PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399817PMC
January 2013

In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs.

Sci Signal 2011 Mar 22;4(165):ra16. Epub 2011 Mar 22.

Molecular Pathology Unit, Center for Cancer Research, and Center for Systems Biology, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1126/scisignal.2001338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963028PMC
March 2011

Adaptive regulation at the cell surface by N-glycosylation.

Traffic 2009 Nov 2;10(11):1569-78. Epub 2009 Sep 2.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue R988, Toronto, ON, Canada M5G 1X5.

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http://doi.wiley.com/10.1111/j.1600-0854.2009.00981.x
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http://dx.doi.org/10.1111/j.1600-0854.2009.00981.xDOI Listing
November 2009

Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer.

Mol Cells 2009 Oct 30;28(4):315-20. Epub 2009 Sep 30.

Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital and Department of Pathology, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1007/s10059-009-0143-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976423PMC
October 2009

N-Glycans in cancer progression.

Glycobiology 2008 Oct 13;18(10):750-60. Epub 2008 Aug 13.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/glycob/cwn071DOI Listing
October 2008

Genome-scale identification of UDP-GlcNAc-dependent pathways.

Proteomics 2008 Aug;8(16):3294-302

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, ON, Canada.

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http://doi.wiley.com/10.1002/pmic.200800208
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http://dx.doi.org/10.1002/pmic.200800208DOI Listing
August 2008

Production of activated carbons from waste tire--process design and economical analysis.

Waste Manag 2004 ;24(9):875-88

Department of Chemical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.

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http://dx.doi.org/10.1016/j.wasman.2004.03.006DOI Listing
March 2005