Publications by authors named "Ken Op de Beeck"

43 Publications

GSDME and its role in cancer: From behind the scenes to the front of the stage.

Int J Cancer 2020 Nov 13. Epub 2020 Nov 13.

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.

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November 2020

DNA Methylation Distinguishes Two Subtypes of Pancreatic Neuroendocrine Neoplasms with a Different Prognosis.

Cancers (Basel) 2020 Jun 4;12(6). Epub 2020 Jun 4.

Center for Oncological Research, University of Antwerp and Antwerp University Hospital, 2610 Antwerp, Belgium.

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June 2020

Resistance to targeted treatment of gastroenteropancreatic neuroendocrine tumors

Endocr Relat Cancer 2019 03 1;26(3):R109-R130. Epub 2019 Mar 1.

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.

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March 2019

The Gene Has Potential as a Pan-Cancer Biomarker, While Discriminating between Different Tumor Types.

Cancers (Basel) 2019 Nov 18;11(11). Epub 2019 Nov 18.

Centre of Medical Genetics, University of Antwerp and Antwerp University Hospital, Prins Boudewijnlaan 43, 2650 Edegem, Belgium.

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November 2019

Clinical applications of (epi)genetics in gastroenteropancreatic neuroendocrine neoplasms: Moving towards liquid biopsies.

Rev Endocr Metab Disord 2019 09;20(3):333-351

Center for Oncological Research (CORE), University of Antwerp and Antwerp University Hospital, Universiteitsplein 1, 2610, Wilrijk, Belgium.

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September 2019

Methylation analysis of Gasdermin E shows great promise as a biomarker for colorectal cancer.

Cancer Med 2019 05 16;8(5):2133-2145. Epub 2019 Apr 16.

Centre of Medical Genetics, University of Antwerp and Antwerp University Hospital, Edegem, Belgium.

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May 2019

State-associated changes in longitudinal [F]-PBR111 TSPO PET imaging of psychosis patients: Evidence for the accelerated ageing hypothesis?

Brain Behav Immun 2019 03 29;77:46-54. Epub 2018 Nov 29.

Collaborative Antwerp Psychiatric Research Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; University Psychiatric Hospital Antwerp, Campus Duffel, Duffel, Belgium.

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March 2019

Tumor-specific genetic variants can be detected in circulating cell-free DNA of malignant pleural mesothelioma patients.

Lung Cancer 2018 10 21;124:19-22. Epub 2018 Jul 21.

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Prins Boudewijnlaan 43, 2650 Antwerp, Belgium; Center for Oncological Research, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.

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October 2018

Molecular analysis of an asbestos-exposed Belgian family with a high prevalence of mesothelioma.

Fam Cancer 2018 10;17(4):569-576

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Prins Boudewijnlaan 43, 2650, Antwerp, Belgium.

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October 2018

Large-scale analysis of methylation reveals its potential as biomarker for breast cancer.

Clin Epigenetics 2018 11;10:51. Epub 2018 Apr 11.

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Prins Boudewijnlaan 43/6, BE-2650 Edegem, Antwerp Belgium.

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May 2019

Mutation and Methylation Analysis of Circulating Tumor DNA Can Be Used for Follow-up of Metastatic Colorectal Cancer Patients.

Clin Colorectal Cancer 2018 06 22;17(2):e369-e379. Epub 2018 Feb 22.

Center for Oncological Research (CORE), University of Antwerp, Antwerp, Belgium; Department of Oncology, Antwerp University Hospital, Antwerp, Belgium. Electronic address:

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June 2018

The predictive value of primary tumor location in patients with metastatic colorectal cancer: A systematic review.

Crit Rev Oncol Hematol 2018 Jan 7;121:1-10. Epub 2017 Nov 7.

Center of Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium; Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Prins Boudewijnlaan 43/6, 2650 Edegem, Belgium. Electronic address:

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January 2018

pyAmpli: an amplicon-based variant filter pipeline for targeted resequencing data.

BMC Bioinformatics 2017 Dec 14;18(1):554. Epub 2017 Dec 14.

Center of Medical Genetics, University of Antwerp, Prins Boudewijnlaan 43, 2650, Antwerp, Belgium.

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December 2017

DFNA5 promoter methylation a marker for breast tumorigenesis.

Oncotarget 2017 May;8(19):31948-31958

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Edegem B-2650, Belgium.

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May 2017

The Genetic Landscape of Malignant Pleural Mesothelioma: Results from Massively Parallel Sequencing.

J Thorac Oncol 2016 10 6;11(10):1615-26. Epub 2016 Jun 6.

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium; Center for Oncological Research, University of Antwerp, Antwerp, Belgium.

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October 2016

Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway.

Biochem Pharmacol 2016 06 1;109:48-61. Epub 2016 Apr 1.

Laboratory of Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Biochemistry and Microbiology, Ghent University, Proeftuinstraat 86, Gent, Belgium; Laboratory of Protein Science, Proteomics and Epigenetic Signaling (PPES), Department of Biomedical Sciences, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, Wilrijk, Belgium.

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June 2016

APR-246 (PRIMA-1(MET)) strongly synergizes with AZD2281 (olaparib) induced PARP inhibition to induce apoptosis in non-small cell lung cancer cell lines.

Cancer Lett 2016 Jun 11;375(2):313-322. Epub 2016 Mar 11.

Center for Oncological Research (CORE), University of Antwerp, Universiteitsplein 1 2610 Wilrijk, Antwerp, Belgium; Department of Pathology, Antwerp University Hospital, Wilrijkstraat 10 2650 Edegem, Antwerp, Belgium.

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June 2016

Role of DFNA5 in hearing loss and cancer - a comment on Rakusic et al.

Onco Targets Ther 2015 15;8:2613-5. Epub 2015 Sep 15.

Center of Medical Genetics (CMG), Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

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October 2015

Prognostic and Predictive Value of RAS Gene Mutations in Colorectal Cancer: Moving Beyond KRAS Exon 2.

Drugs 2015 Oct;75(15):1739-56

Center for Oncological Research Antwerp, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, Wilrijk, 2610, Antwerp, Belgium.

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October 2015

Next generation exome sequencing of pancreatic neuroendocrine tumor cell lines BON-1 and QGP-1 reveals different lineages.

Cancer Genet 2015 Oct 4;208(10):523. Epub 2015 Aug 4.

Department of Oncology, University of Antwerp, Antwerp, Belgium; Center of Medical Genetics, University of Antwerp, Antwerp, Belgium.

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October 2015