Ken Op de Beeck

Collaborative Antwerp Psychiatric Research Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; University Psychiatric Hospital Antwerp, Campus Duffel, Duffel, Belgium.

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March 2019

Cell-Free DNA From Metastatic Pancreatic Neuroendocrine Tumor Patients Contains Tumor-Specific Mutations and Copy Number Variations.

Authors:

Gitta Boons Timon Vandamme Marc Peeters Matthias Beyens Ann Driessen Katrien Janssens Karen Zwaenepoel Geert Roeyen Guy Van Camp Ken Op de Beeck

Front Oncol 2018 1;8:467. Epub 2018 Nov 1.

Center for Oncological Research, University of Antwerp, Antwerp, Belgium.

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November 2018

Tumor-specific genetic variants can be detected in circulating cell-free DNA of malignant pleural mesothelioma patients.

Authors:

Marieke Hylebos Ken Op de Beeck Patrick Pauwels Karen Zwaenepoel Jan P van Meerbeeck Guy Van Camp

Lung Cancer 2018 10 21;124:19-22. Epub 2018 Jul 21.

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Prins Boudewijnlaan 43, 2650 Antwerp, Belgium; Center for Oncological Research, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.

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October 2018

Molecular analysis of an asbestos-exposed Belgian family with a high prevalence of mesothelioma.

Authors:

Marieke Hylebos Ken Op de Beeck Jenneke van den Ende Patrick Pauwels Martin Lammens Jan P van Meerbeeck Guy Van Camp

Fam Cancer 2018 10;17(4):569-576

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Prins Boudewijnlaan 43, 2650, Antwerp, Belgium.

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October 2018

Large-scale analysis of methylation reveals its potential as biomarker for breast cancer.

Authors:

Lieselot Croes Matthias Beyens Erik Fransen Joe Ibrahim Wim Vanden Berghe Arvid Suls Marc Peeters Patrick Pauwels Guy Van Camp Ken Op de Beeck

Clin Epigenetics 2018 11;10:51. Epub 2018 Apr 11.

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Prins Boudewijnlaan 43/6, BE-2650 Edegem, Antwerp Belgium.

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May 2019

Effect of Primary Tumor Location on Second- or Later-line Treatment Outcomes in Patients With RAS Wild-type Metastatic Colorectal Cancer and All Treatment Lines in Patients With RAS Mutations in Four Randomized Panitumumab Studies.

Authors:

Nele Boeckx Reija Koukakis Ken Op de Beeck Christian Rolfo Guy Van Camp Salvatore Siena Josep Tabernero Jean-Yves Douillard Thierry André Marc Peeters

Clin Colorectal Cancer 2018 09 8;17(3):170-178.e3. Epub 2018 Mar 8.

Center for Oncological Research, University of Antwerp, Wilrijk, Belgium; Department of Oncology, Antwerp University Hospital, Edegem, Belgium. Electronic address:

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September 2018

Mutation and Methylation Analysis of Circulating Tumor DNA Can Be Used for Follow-up of Metastatic Colorectal Cancer Patients.

Authors:

Nele Boeckx Ken Op de Beeck Matthias Beyens Vanessa Deschoolmeester Christophe Hermans Peggy De Clercq Sonia Garrigou Corinne Normand Els Monsaert Konstantinos Papadimitriou Pierre Laurent-Puig Patrick Pauwels Guy Van Camp Valerie Taly Marc Peeters

Clin Colorectal Cancer 2018 06 22;17(2):e369-e379. Epub 2018 Feb 22.

Center for Oncological Research (CORE), University of Antwerp, Antwerp, Belgium; Department of Oncology, Antwerp University Hospital, Antwerp, Belgium. Electronic address:

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June 2018

Large-scale copy number analysis reveals variations in genes not previously associated with malignant pleural mesothelioma.

Authors:

Marieke Hylebos Guy Van Camp Geert Vandeweyer Erik Fransen Matthias Beyens Robin Cornelissen Arvid Suls Patrick Pauwels Jan P van Meerbeeck Ken Op de Beeck

Oncotarget 2017 Dec 1;8(69):113673-113686. Epub 2017 Dec 1.

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, 2650 Antwerp, Belgium.

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December 2017

The predictive value of primary tumor location in patients with metastatic colorectal cancer: A systematic review.

Authors:

Nele Boeckx Katleen Janssens Guy Van Camp Marika Rasschaert Konstantinos Papadimitriou Marc Peeters Ken Op de Beeck

Crit Rev Oncol Hematol 2018 Jan 7;121:1-10. Epub 2017 Nov 7.

Center of Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium; Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Prins Boudewijnlaan 43/6, 2650 Edegem, Belgium. Electronic address:

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January 2018

pyAmpli: an amplicon-based variant filter pipeline for targeted resequencing data.

Authors:

Matthias Beyens Nele Boeckx Guy Van Camp Ken Op de Beeck Geert Vandeweyer

BMC Bioinformatics 2017 Dec 14;18(1):554. Epub 2017 Dec 14.

Center of Medical Genetics, University of Antwerp, Prins Boudewijnlaan 43, 2650, Antwerp, Belgium.

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December 2017

SNP309 and SNP285 Act as Negative Prognostic Markers for Non-small Cell Lung Cancer Adenocarcinoma Patients.

Authors:

Christophe Deben Ken Op de Beeck Jolien Van den Bossche Julie Jacobs Filip Lardon An Wouters Marc Peeters Guy Van Camp Christian Rolfo Vanessa Deschoolmeester Patrick Pauwels

J Cancer 2017 15;8(12):2154-2162. Epub 2017 Jul 15.

Center for Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium.

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July 2017

Towards Prognostic Profiling of Non-Small Cell Lung Cancer: New Perspectives on the Relevance of Polo-Like Kinase 1 Expression, the Mutation Status and Hypoxia.

Authors:

Jolien Van den Bossche Christophe Deben Ken Op de Beeck Vanessa Deschoolmeester Christophe Hermans Ines De Pauw Julie Jacobs Paul Van Schil Jan Baptist Vermorken Patrick Pauwels Marc Peeters Filip Lardon An Wouters

J Cancer 2017 12;8(8):1441-1452. Epub 2017 May 12.

Center for Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.

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May 2017

DFNA5 promoter methylation a marker for breast tumorigenesis.

Authors:

Lieselot Croes Ken Op de Beeck Patrick Pauwels Wim Vanden Berghe Marc Peeters Erik Fransen Guy Van Camp

Oncotarget 2017 May;8(19):31948-31958

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Edegem B-2650, Belgium.

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May 2017

Deep sequencing of the TP53 gene reveals a potential risk allele for non-small cell lung cancer and supports the negative prognostic value of TP53 variants.

Authors:

Christophe Deben Jolien Van den Bossche Nele Van Der Steen Filip Lardon An Wouters Ken Op de Beeck Christophe Hermans Julie Jacobs Marc Peeters Guy Van Camp Christian Rolfo Vanessa Deschoolmeester Patrick Pauwels

Tumour Biol 2017 Feb;39(2):1010428317694327

1 Center for Oncological Research (CORE), University of Antwerp, Antwerp, Belgium.

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February 2017

The Genetic Landscape of Malignant Pleural Mesothelioma: Results from Massively Parallel Sequencing.

Authors:

Marieke Hylebos Guy Van Camp Jan P van Meerbeeck Ken Op de Beeck

J Thorac Oncol 2016 10 6;11(10):1615-26. Epub 2016 Jun 6.

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium; Center for Oncological Research, University of Antwerp, Antwerp, Belgium.

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October 2016

Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway.

Authors:

Karen Heyninck Linde Sabbe Chandra Sekhar Chirumamilla Katarzyna Szarc Vel Szic Pieter Vander Veken Kristien J A Lemmens Maija Lahtela-Kakkonen Stefan Naulaerts Ken Op de Beeck Kris Laukens Guy Van Camp Antje R Weseler Aalt Bast Guido R M M Haenen Guy Haegeman Wim Vanden Berghe

Biochem Pharmacol 2016 06 1;109:48-61. Epub 2016 Apr 1.

Laboratory of Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Biochemistry and Microbiology, Ghent University, Proeftuinstraat 86, Gent, Belgium; Laboratory of Protein Science, Proteomics and Epigenetic Signaling (PPES), Department of Biomedical Sciences, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, Wilrijk, Belgium.

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June 2016

Long-term acquired everolimus resistance in pancreatic neuroendocrine tumours can be overcome with novel PI3K-AKT-mTOR inhibitors.

Authors:

Timon Vandamme Matthias Beyens Ken Op de Beeck Fadime Dogan Peter M van Koetsveld Patrick Pauwels Geert Mortier Christel Vangestel Wouter de Herder Guy Van Camp Marc Peeters Leo J Hofland

Br J Cancer 2016 Mar;114(6):650-8

Section of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Dr Molewaterplein 40, 3015GD Rotterdam, The Netherlands.

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March 2016

APR-246 (PRIMA-1(MET)) strongly synergizes with AZD2281 (olaparib) induced PARP inhibition to induce apoptosis in non-small cell lung cancer cell lines.

Authors:

Christophe Deben Filip Lardon An Wouters Ken Op de Beeck Jolien Van den Bossche Julie Jacobs Nele Van Der Steen Marc Peeters Christian Rolfo Vanessa Deschoolmeester Patrick Pauwels

Cancer Lett 2016 Jun 11;375(2):313-322. Epub 2016 Mar 11.

Center for Oncological Research (CORE), University of Antwerp, Universiteitsplein 1 2610 Wilrijk, Antwerp, Belgium; Department of Pathology, Antwerp University Hospital, Wilrijkstraat 10 2650 Edegem, Antwerp, Belgium.

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June 2016