Dr. Ken Ishii, M.D., Ph.D. - National Institute of Biomedical Innovation, Health and Nutrition - Director

Dr. Ken Ishii

M.D., Ph.D.

National Institute of Biomedical Innovation, Health and Nutrition

Director

Osaka | Japan

ORCID logohttps://orcid.org/0000-0002-6728-3872

Dr. Ken Ishii, M.D., Ph.D. - National Institute of Biomedical Innovation, Health and Nutrition - Director

Dr. Ken Ishii

M.D., Ph.D.

Introduction

Primary Affiliation: National Institute of Biomedical Innovation, Health and Nutrition - Osaka , Japan

Publications

63Publications

1924Reads

67Profile Views

1106PubMed Central Citations

The early activation of CD8+ T cells is dependent on type I IFN signaling following intramuscular vaccination of adenovirus vector.

Biomed Res Int 2014 27;2014:158128. Epub 2014 May 27.

Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan ; iPS Cell-Based Research Project on Hepatic Toxicity and Metabolism, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan ; Laboratory of Hepatocyte Differentiation, National Institute of Biomedical Innovation, 7-6-8 Asagi, Saito, Ibaraki, Osaka 567-0085, Japan ; The Center for Advanced Medical Engineering and Informatics, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1155/2014/158128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058243PMC
May 2016
48 Reads
4 Citations

TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN.

Eur J Immunol 2015 Apr 5;45(4):1159-69. Epub 2015 Feb 5.

Laboratory of Vaccine Science, WPI Immunology Frontier Research Center (iFReC), Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1002/eji.201445132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671267PMC
April 2015
57 Reads
13 Citations
4.034 Impact Factor

Genome-derived cytosolic DNA mediates type I interferon-dependent rejection of B cell lymphoma cells.

Cell Rep 2015 Apr 9;11(3):460-73. Epub 2015 Apr 9.

Immunology Programme and Department of Microbiology, Centre for Life Sciences, National University of Singapore, Singapore 117456, Singapore; NUS Graduate School for Integrative Sciences & Engineering, National University of Singapore, Singapore 117456, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.041DOI Listing
April 2015
35 Reads
24 Citations
7.210 Impact Factor

Hydroxypropyl-β-cyclodextrin spikes local inflammation that induces Th2 cell and T follicular helper cell responses to the coadministered antigen.

J Immunol 2015 Mar 13;194(6):2673-82. Epub 2015 Feb 13.

Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation, Osaka 567-0085, Japan; Laboratory of Vaccine Science, Immunology Frontier Research Center, World Premier Institute, Osaka University, Osaka 565-0871, Japan;

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http://dx.doi.org/10.4049/jimmunol.1402027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470223PMC
March 2015
27 Reads
7 Citations
4.922 Impact Factor

RNA polymerase III regulates cytosolic RNA:DNA hybrids and intracellular microRNA expression.

J Biol Chem 2015 Mar 26;290(12):7463-73. Epub 2015 Jan 26.

the Laboratory of Adjuvant Innovation and the Laboratory of Vaccine Science, World Premier International Immunology Frontier Research Center (iFREC), Osaka University, Suita, Osaka 565-0871, Japan

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http://dx.doi.org/10.1074/jbc.M115.636365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367256PMC
March 2015
38 Reads
7 Citations
4.573 Impact Factor

System vaccinology for the evaluation of influenza vaccine safety by multiplex gene detection of novel biomarkers in a preclinical study and batch release test.

PLoS One 2014 10;9(7):e101835. Epub 2014 Jul 10.

Laboratory of Blood and Vaccine safety, Department of Safety Research on Blood and Biologicals, National Institute of Infectious Diseases, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101835PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092028PMC
March 2015
52 Reads
5 Citations
3.234 Impact Factor

Development and application of next generation SE36 malaria vaccine formulated with a novel adjuvant: approach to travelers' vaccine.

Yakugaku Zasshi 2013 ;133(11):1153-7

Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University.

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http://dx.doi.org/10.1248/yakushi.13-00212-2DOI Listing
November 2014
10 Reads
0.310 Impact Factor

Hemozoin as a novel adjuvant for inactivated whole virion influenza vaccine.

Vaccine 2014 Sep 6;32(41):5295-300. Epub 2014 Aug 6.

Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53711, USA; ERATO Infection-Induced Host Responses Project (JST), Saitama 332-0012, Japan; Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2014.07.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312188PMC
September 2014
36 Reads
2 Citations
3.624 Impact Factor

Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria.

Cell Host Microbe 2014 May;15(5):551-63

Laboratory of Malaria Immunology, Immunology Frontier Research Center (IFReC), Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2014.04.008DOI Listing
May 2014
42 Reads
22 Citations
12.330 Impact Factor

Hemozoin is a potent adjuvant for hemagglutinin split vaccine without pyrogenicity in ferrets.

Vaccine 2014 May 8;32(25):3004-9. Epub 2014 Apr 8.

Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation (NIBIO), Osaka, Japan; Laboratory of Vaccine Science, Immunology Frontier Research Center (IFREC), World Premier Institute (WPI), Osaka University, Osaka, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2014.03.072DOI Listing
May 2014
18 Reads
1 Citation
3.624 Impact Factor

Nucleic acid sensing by T cells initiates Th2 cell differentiation.

Nat Commun 2014 Apr 10;5:3566. Epub 2014 Apr 10.

1] Laboratory for Cell Signaling, RCAI, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Yokohama, Kanagawa 230-0045, Japan [2] Laboratory for Cell Signaling, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1038/ncomms4566DOI Listing
April 2014
49 Reads
5 Citations
10.742 Impact Factor

RAE1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma.

Cancer Res 2014 Apr 3;74(8):2193-2203. Epub 2014 Mar 3.

Immunology Programme and Department of Microbiology, Centre for Life Sciences, National University of Singapore, 117456, Singapore.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229084PMC
April 2014
61 Reads
22 Citations
9.330 Impact Factor

Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.

Nat Commun 2014 Mar 18;5:3492. Epub 2014 Mar 18.

Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccines, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://www.nature.com/articles/ncomms4492
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http://dx.doi.org/10.1038/ncomms4492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959210PMC
March 2014
92 Reads
22 Citations
10.742 Impact Factor

Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells.

J Virol 2014 Feb 11;88(4):2157-67. Epub 2013 Dec 11.

Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1128/JVI.03055-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911546PMC
February 2014
42 Reads
6 Citations
4.440 Impact Factor

Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist.

Proc Natl Acad Sci U S A 2014 Feb 10;111(8):3086-91. Epub 2014 Feb 10.

Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation, Osaka 567-0085, Japan.

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http://dx.doi.org/10.1073/pnas.1319268111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939924PMC
February 2014
39 Reads
19 Citations
9.810 Impact Factor

In vitro and in vivo antimicrobial properties of silver-containing hydroxyapatite prepared via ultrasonic spray pyrolysis route.

Mater Sci Eng C Mater Biol Appl 2013 Dec 7;33(8):5008-18. Epub 2013 Sep 7.

Aizawa "Next-generation Bioceramics" Project, Kanagawa Academy of Science and Technology (KAST), 3-2-1 Sakado, Takatsu-ku, Kawasaki, Kanagawa 213-0012, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.msec.2013.08.026DOI Listing
December 2013
32 Reads
2 Citations
3.090 Impact Factor

Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination.

Front Cell Infect Microbiol 2012 8;2:168. Epub 2013 Jan 8.

Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation Osaka, Japan ; Laboratory of Vaccine Science, WPI Immunology Frontier Research Center, Osaka University Osaka, Japan.

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http://dx.doi.org/10.3389/fcimb.2012.00168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539075PMC
December 2013
41 Reads
25 Citations
2.620 Impact Factor

DNA vaccines: a simple DNA sensing matter?

Hum Vaccin Immunother 2013 Oct 2;9(10):2216-21. Epub 2013 Aug 2.

Laboratory of Adjuvant Innovation; National Institute of Biomedical Innovation; Osaka, Japan; Laboratory of Vaccine Science; IFReC; Osaka University; Osaka, Japan.

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http://dx.doi.org/10.4161/hv.25893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906407PMC
October 2013
33 Reads
9 Citations
2.131 Impact Factor

Retinal cell type-specific prevention of ischemia-induced damages by LPS-TLR4 signaling through microglia.

J Neurochem 2013 Jul 13;126(2):243-60. Epub 2013 May 13.

Department of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

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http://dx.doi.org/10.1111/jnc.12262DOI Listing
July 2013
28 Reads
9 Citations
4.281 Impact Factor

Role of Extrachromosomal Histone H2B on Recognition of DNA Viruses and Cell Damage.

Front Genet 2013 23;4:91. Epub 2013 May 23.

Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation Ibaraki, Osaka, Japan ; Laboratory of Vaccine Science, Immunology Frontier Research Center, World Premier International Research Center, Osaka University Suita, Osaka, Japan.

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http://dx.doi.org/10.3389/fgene.2013.00091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661947PMC
June 2013
42 Reads
3 Citations

Particulate adjuvant and innate immunity: past achievements, present findings, and future prospects.

Int Rev Immunol 2013 Apr;32(2):209-20

Laboratory of Vaccine Science, WPI Immunology Frontier Research Center (IFReC), Osaka University, Suita, Osaka, Japan.

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http://dx.doi.org/10.3109/08830185.2013.773326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632271PMC
April 2013
19 Reads
27 Citations
4.103 Impact Factor

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.

Proc Natl Acad Sci U S A 2013 Feb 6;110(8):2969-74. Epub 2013 Feb 6.

Laboratory of Host Defense, World Premier International Research Center Initiative (WPI) Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1073/pnas.1222694110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581880PMC
February 2013
27 Reads
74 Citations
9.810 Impact Factor

Hydrophobic blocks of PEG-conjugates play a significant role in the accelerated blood clearance (ABC) phenomenon.

J Control Release 2013 Feb 3;165(3):183-90. Epub 2012 Dec 3.

Medical Engineering Laboratory, Research Center for Medical Science, The Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan.

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http://dx.doi.org/10.1016/j.jconrel.2012.11.016DOI Listing
February 2013
8 Reads
9 Citations
7.705 Impact Factor

TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36/AHG malaria vaccine in nonhuman primate models.

Hum Vaccin Immunother 2013 Feb 4;9(2):283-90. Epub 2013 Jan 4.

Department of Molecular Protozoology; Research Institute for Microbial Diseases; Osaka University at Suita; Osaka, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859748PMC
http://dx.doi.org/10.4161/hv.22950DOI Listing
February 2013
28 Reads
7 Citations
2.131 Impact Factor

Adjuvants in influenza vaccines.

Vaccine 2012 Dec 19;30(52):7658-61. Epub 2012 Oct 19.

Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation, Japan.

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http://dx.doi.org/10.1016/j.vaccine.2012.10.007DOI Listing
December 2012
17 Reads
11 Citations
3.624 Impact Factor

Alum-adjuvanted H5N1 whole virion inactivated vaccine (WIV) induced IgG1 and IgG4 antibody responses in young children.

Vaccine 2012 Dec 24;30(52):7662-6. Epub 2012 Oct 24.

Kitasato Institute for Life Sciences, Laboratory of Viral Infection, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.vaccine.2012.10.006DOI Listing
December 2012
9 Reads
1 Citation
3.624 Impact Factor

Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism.

Cell Host Microbe 2012 Nov;12(5):705-16

Laboratory of Malaria Immunology, Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1016/j.chom.2012.10.010DOI Listing
November 2012
21 Reads
12 Citations
12.330 Impact Factor

Differential diagnosis between intracranial dissemination of spinal cord astrocytoma and paraneoplastic limbic encephalitis.

Intern Med 2012 1;51(3):321-4. Epub 2012 Feb 1.

Department of Neurology, School of Medicine, Keio University, Japan.

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http://dx.doi.org/10.2169/internalmedicine.51.5568DOI Listing
September 2012
5 Reads
1 Citation
0.970 Impact Factor

Type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell responses by adenovirus vector vaccine in the gut-mucosa.

Biochem Biophys Res Commun 2012 Aug 20;425(1):89-93. Epub 2012 Jul 20.

Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2012.07.056DOI Listing
August 2012
10 Reads
4 Citations
2.300 Impact Factor

A critical role of IL-33 in experimental allergic rhinitis.

J Allergy Clin Immunol 2012 Jul 27;130(1):184-94.e11. Epub 2012 Mar 27.

Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

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http://dx.doi.org/10.1016/j.jaci.2012.02.013DOI Listing
July 2012
40 Reads
32 Citations
11.480 Impact Factor

Alum-adjuvanted H5N1 whole virion inactivated vaccine (WIV) enhanced inflammatory cytokine productions.

Vaccine 2012 Jun 13;30(26):3885-90. Epub 2012 Apr 13.

Kitasato Institute for Life Sciences, Laboratory of Viral Infection, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.vaccine.2012.04.004DOI Listing
June 2012
53 Reads
3 Citations
3.624 Impact Factor

Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination.

Nat Rev Immunol 2012 Jun 22;12(7):479-91. Epub 2012 Jun 22.

Laboratory of Cellular and Molecular Immunology, GIGA-Research and Faculty of Veterinary Medicine, B34, University of Liege, 1 Avenue de l'Hopital, B-4000 Liège, Belgium.

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http://dx.doi.org/10.1038/nri3247DOI Listing
June 2012
59 Reads
92 Citations
34.985 Impact Factor

Long-term surgical outcomes of spinal meningiomas.

Spine (Phila Pa 1976) 2012 May;37(10):E617-23

Department of Orthopaedic Surgery, Keio University, Tokyo, Japan.

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http://pdfs.journals.lww.com/spinejournal/2012/05010/Long_Te
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/BRS.0b013e31824167f1DOI Listing
May 2012
43 Reads
11 Citations
2.300 Impact Factor

Pathogenic anti-desmoglein 3 mAbs cloned from a paraneoplastic pemphigus patient by phage display.

J Invest Dermatol 2012 Apr 26;132(4):1141-8. Epub 2012 Jan 26.

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1038/jid.2011.449DOI Listing
April 2012
1 Read
7 Citations
7.220 Impact Factor

Morphologic evaluation of the thoracic vertebrae for safe free-hand pedicle screw placement in adolescent idiopathic scoliosis: a CT-based anatomical study.

Surg Radiol Anat 2012 Apr 8;34(3):209-16. Epub 2011 Jul 8.

Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.

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http://link.springer.com/content/pdf/10.1007/s00276-011-0849
Web Search
http://link.springer.com/10.1007/s00276-011-0849-z
Publisher Site
http://dx.doi.org/10.1007/s00276-011-0849-zDOI Listing
April 2012
20 Reads
6 Citations
1.333 Impact Factor

Management of chronic atlantoaxial rotatory fixation.

Spine (Phila Pa 1976) 2012 Mar;37(5):E278-85

Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan.

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http://dx.doi.org/10.1097/BRS.0b013e31823cc2eaDOI Listing
March 2012
18 Reads
4 Citations
2.300 Impact Factor

Sterility of posterior elements of the spine in posterior correction surgery.

Spine (Phila Pa 1976) 2012 Mar;37(6):523-6

Department of Orthopaedic Surgery, Keio University, Tokyo, Japan.

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http://dx.doi.org/10.1097/BRS.0b013e318224d7b2DOI Listing
March 2012
11 Reads
6 Citations
2.300 Impact Factor

Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice.

Proc Natl Acad Sci U S A 2012 Feb 13;109(9):3451-6. Epub 2012 Feb 13.

Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan.

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http://dx.doi.org/10.1073/pnas.1201042109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295287PMC
February 2012
16 Reads
81 Citations
9.810 Impact Factor

Establishment of a real-time, quantitative, and reproducible mouse model of Staphylococcus osteomyelitis using bioluminescence imaging.

Infect Immun 2012 Feb 21;80(2):733-41. Epub 2011 Nov 21.

Department of Orthopaedic Surgery, School of Medicine, Keio University, Shinjuku, Tokyo, Japan.

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http://dx.doi.org/10.1128/IAI.06166-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264289PMC
February 2012
13 Reads
17 Citations
3.731 Impact Factor

Novel strategies to improve DNA vaccine immunogenicity.

Curr Gene Ther 2011 Dec;11(6):479-84

Laboratory of Malaria Immunology, Immunology Frontier Research Center, World Premier Institute for Immunology, Osaka University, Japan.

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December 2011
35 Reads
25 Citations
2.542 Impact Factor

Matrix metalloproteinase 13 in the ligamentum flavum from lumbar spinal canal stenosis patients with and without diabetes mellitus.

J Orthop Sci 2011 Nov 10;16(6):785-90. Epub 2011 Aug 10.

Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.1007/s00776-011-0135-2DOI Listing
November 2011
7 Reads
3 Citations
1.010 Impact Factor

Cervical intramedullary ependymoma masquerading as cervical spondylotic myelopathy on MRI analysis.

J Orthop Sci 2011 Oct 6. Epub 2011 Oct 6.

Department of Orthopaedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.1007/s00776-011-0165-9DOI Listing
October 2011
22 Reads
1.010 Impact Factor

Innate and adaptive immune responses to viral infection and vaccination.

Curr Opin Virol 2011 Oct 30;1(4):226-32. Epub 2011 Jul 30.

Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation, Osaka, Japan.

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http://dx.doi.org/10.1016/j.coviro.2011.07.002DOI Listing
October 2011
26 Reads
35 Citations
6.300 Impact Factor

[Vaccine adjuvant].

Nihon Rinsho 2011 Sep;69(9):1547-53

National Institute of Biomedical Innovation.

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September 2011
8 Reads

Late instrumentation failure after total en bloc spondylectomy.

J Neurosurg Spine 2011 Sep 3;15(3):320-7. Epub 2011 Jun 3.

Department of Orthopaedic Surgery, Keio University, Tokyo, Japan.

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http://dx.doi.org/10.3171/2011.5.SPINE10813DOI Listing
September 2011
13 Reads
2 Citations

Plasmodium falciparum serine repeat antigen 5 (SE36) as a malaria vaccine candidate.

Vaccine 2011 Aug 28;29(35):5837-45. Epub 2011 Jun 28.

Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1016/j.vaccine.2011.06.052DOI Listing
August 2011
7 Reads
11 Citations
3.624 Impact Factor

DNA released from dying host cells mediates aluminum adjuvant activity.

Nat Med 2011 Jul 17;17(8):996-1002. Epub 2011 Jul 17.

Laboratory of Cellular and Molecular Physiology, Groupe Interdisciplinaire de Génoprotéomique Appliquée, University of Liège, Liège, Belgium.

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http://dx.doi.org/10.1038/nm.2403DOI Listing
July 2011
29 Reads
137 Citations
27.363 Impact Factor

A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity.

J Immunol 2011 Jun 27;186(11):6287-95. Epub 2011 Apr 27.

Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.

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http://dx.doi.org/10.4049/jimmunol.1004036DOI Listing
June 2011
68 Reads
51 Citations
4.922 Impact Factor

Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms.

Immunity 2011 Apr 14;34(4):514-26. Epub 2011 Apr 14.

Department of Immunology and Parasitology, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka 807-8555, Japan.

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http://dx.doi.org/10.1016/j.immuni.2011.03.019DOI Listing
April 2011
9 Reads
62 Citations
21.561 Impact Factor

Fragments of genomic DNA released by injured cells activate innate immunity and suppress endocrine function in the thyroid.

Endocrinology 2011 Apr 8;152(4):1702-12. Epub 2011 Feb 8.

Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4-2-1 Aoba-cho, Higashimurayama, Tokyo 189-0002, Japan.

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http://dx.doi.org/10.1210/en.2010-1132DOI Listing
April 2011
30 Reads
18 Citations
4.503 Impact Factor

Intranasal vaccination with pneumococcal surface protein A plus poly(I:C) protects against secondary pneumococcal pneumonia in mice.

Vaccine 2011 Feb 8;29(9):1754-61. Epub 2011 Jan 8.

Laboratory of Clinical Research on Infectious Diseases, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Japan.

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http://dx.doi.org/10.1016/j.vaccine.2010.12.117DOI Listing
February 2011
10 Reads
7 Citations
3.624 Impact Factor

Interpedicular graft using a titanium mesh cage in a patient with lumbar scoliosis associated with a congenital butterfly vertebra.

J Neurosurg Spine 2011 Feb 7;14(2):215-8. Epub 2011 Jan 7.

Department of Spinal Surgery, Beijing Jishuitan Hospital, Peking University, Beijing, People's Republic of China.

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http://dx.doi.org/10.3171/2010.10.SPINE10191DOI Listing
February 2011
33 Reads

NLRP4 negatively regulates autophagic processes through an association with beclin1.

J Immunol 2011 Feb 5;186(3):1646-55. Epub 2011 Jan 5.

Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.

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http://dx.doi.org/10.4049/jimmunol.1001654DOI Listing
February 2011
57 Reads
54 Citations
4.922 Impact Factor

[Intramedullary spinal cord cavernous hemangiomas: clinical features and surgical treatment].

Brain Nerve 2011 Jan;63(1):27-30

Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan.

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January 2011
17 Reads

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Shizuo Akira
Shizuo Akira

Laboratory of Host Defense

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Kouji Kobiyama
Kouji Kobiyama

Yokohama City University Graduate School of Medicine

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Taiki Aoshi
Taiki Aoshi

Hamamatsu University School of Medicine

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Cevayir Coban
Cevayir Coban

Osaka University

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Yoshiaki Toyama
Yoshiaki Toyama

Keio University

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Morio Matsumoto
Morio Matsumoto

Keio University

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Kazuhiro Chiba
Kazuhiro Chiba

Keio University

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Masaya Nakamura
Masaya Nakamura

Keio University

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Kota Watanabe
Kota Watanabe

Keio University

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Toshihiro Horii
Toshihiro Horii

Osaka University

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