Ken Inoki

Ken Inoki

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Ken Inoki

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Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR.

PLoS Biol 2019 May 21;17(5):e3000252. Epub 2019 May 21.

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.3000252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528971PMC
May 2019

Macropinocytosis, mTORC1 and cellular growth control.

Cell Mol Life Sci 2018 Apr 8;75(7):1227-1239. Epub 2017 Nov 8.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109-5620, USA.

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http://dx.doi.org/10.1007/s00018-017-2710-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843684PMC
April 2018

Microphthalmia-associated transcription factors activate mTORC1 through RagD GTPase gene expression.

Transl Cancer Res 2017 Oct;6(Suppl 7):S1234-S1238

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.21037/tcr.2017.09.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557429PMC
October 2017

Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells.

Biomolecules 2017 07 7;7(3). Epub 2017 Jul 7.

Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA.

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http://www.mdpi.com/2218-273X/7/3/51
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http://dx.doi.org/10.3390/biom7030051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618232PMC
July 2017

Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress.

Cell Rep 2017 07;20(4):895-908

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.06.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586494PMC
July 2017

mTOR: Pumping Nutrients into Tubules.

Authors:
Ken Inoki

J Am Soc Nephrol 2017 01 27;28(1):3-5. Epub 2016 Oct 27.

Life Sciences Institute, Department of Molecular and Integrative Physiology, Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan

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http://dx.doi.org/10.1681/ASN.2016080924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198299PMC
January 2017

Aberrant mTORC1 activation kills tubular cells by inactivating miR148b-3p.

Authors:
Ken Inoki

Kidney Int 2016 12;90(6):1146-1148

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Division of Nephrology, Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.07.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542052PMC
December 2016

The role of mechanistic target of rapamycin in maintenance of glomerular epithelial cells.

Authors:
Yao Yao Ken Inoki

Curr Opin Nephrol Hypertens 2016 Jan;25(1):28-34

aLife Sciences Institute bDepartment of Molecular and Integrative Physiology cDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1097/MNH.0000000000000181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911704PMC
January 2016

Growth factor signaling to mTORC1 by amino acid-laden macropinosomes.

J Cell Biol 2015 Oct 5;211(1):159-72. Epub 2015 Oct 5.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109

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http://dx.doi.org/10.1083/jcb.201504097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602043PMC
October 2015

GSK3β-dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury.

Am J Physiol Lung Cell Mol Physiol 2014 Nov 19;307(10):L735-45. Epub 2014 Sep 19.

Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama;

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http://dx.doi.org/10.1152/ajplung.00165.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233296PMC
November 2014

Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling.

J Biol Chem 2014 Sep 25;289(37):25925-35. Epub 2014 Jul 25.

From the Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109

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http://dx.doi.org/10.1074/jbc.M114.567628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162191PMC
September 2014

mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases.

Sci Signal 2014 Feb 25;7(314):ra18. Epub 2014 Feb 25.

1Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1126/scisignal.2004809DOI Listing
February 2014

mTOR signaling in autophagy regulation in the kidney.

Authors:
Ken Inoki

Semin Nephrol 2014 Jan 21;34(1):2-8. Epub 2013 Nov 21.

Life Sciences Institute, Department of Molecular and Integrative Physiology, Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI. Electronic address:

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http://dx.doi.org/10.1016/j.semnephrol.2013.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911697PMC
January 2014

LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST8.

Obes Res Clin Pract 2012 Jul-Sep;6(3):e175-262

Department of Medical Science, Graduate School of Medicine, University of Hiroshima, 1-2-3 Kasumi, Minami-ku, Hiroshima City 734-8553, Hiroshima, Japan. Electronic

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http://dx.doi.org/10.1016/j.orcp.2011.10.002DOI Listing
December 2013

Proximal tubules forget "self-eating" when they meet Western meals.

Authors:
Ken Inoki

J Am Soc Nephrol 2013 Nov 3;24(11):1711-3. Epub 2013 Oct 3.

Life Sciences Institute, Department of Molecular and Integrative Physiology, Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1681/ASN.2013070794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810096PMC
November 2013

Inhibition of AMPK catabolic action by GSK3.

Mol Cell 2013 May 25;50(3):407-19. Epub 2013 Apr 25.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.molcel.2013.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654099PMC
May 2013

Rags connect mTOR and autophagy.

Small GTPases 2012 Apr-Jun;3(2):111-4

Cancer Research; UK Cambridge Research Institute, Cambridge, UK.

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http://dx.doi.org/10.4161/sgtp.19422DOI Listing
April 2013

Retrograde changes in presynaptic function driven by dendritic mTORC1.

J Neurosci 2012 Nov;32(48):17128-42

Neuroscience Graduate Program, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.2149-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518308PMC
November 2012

Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1.

Mol Biol Cell 2012 Aug 13;23(15):2955-62. Epub 2012 Jun 13.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1091/mbc.E11-12-1034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408421PMC
August 2012

Growth-dependent podocyte failure causes glomerulosclerosis.

J Am Soc Nephrol 2012 Aug 5;23(8):1351-63. Epub 2012 Jul 5.

Nephrology Division, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1681/ASN.2012030271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402293PMC
August 2012

Rab5 proteins regulate activation and localization of target of rapamycin complex 1.

J Biol Chem 2012 Jun 30;287(25):20913-21. Epub 2012 Apr 30.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/jbc.M111.334060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375515PMC
June 2012

AMPK and mTOR in cellular energy homeostasis and drug targets.

Annu Rev Pharmacol Toxicol 2012 17;52:381-400. Epub 2011 Oct 17.

Life Sciences Institute and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1146/annurev-pharmtox-010611-134537DOI Listing
May 2012

Mammalian target of rapamycin signaling in the podocyte.

Curr Opin Nephrol Hypertens 2012 May;21(3):251-7

Life Sciences Institute, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1097/MNH.0b013e3283520f38DOI Listing
May 2012

Guidelines for the use and interpretation of assays for monitoring autophagy.

Authors:
Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizuo Akira Hesham M Al-Younes Munir A Al-Zeer Matthew L Albert Roger L Albin Javier Alegre-Abarrategui Maria Francesca Aleo Mehrdad Alirezaei Alexandru Almasan Maylin Almonte-Becerril Atsuo Amano Ravi Amaravadi Shoba Amarnath Amal O Amer Nathalie Andrieu-Abadie Vellareddy Anantharam David K Ann Shailendra Anoopkumar-Dukie Hiroshi Aoki Nadezda Apostolova Giuseppe Arancia John P Aris Katsuhiko Asanuma Nana Y O Asare Hisashi Ashida Valerie Askanas David S Askew Patrick Auberger Misuzu Baba Steven K Backues Eric H Baehrecke Ben A Bahr Xue-Yuan Bai Yannick Bailly Robert Baiocchi Giulia Baldini Walter Balduini Andrea Ballabio Bruce A Bamber Edward T W Bampton Gábor Bánhegyi Clinton R Bartholomew Diane C Bassham Robert C Bast Henri Batoko Boon-Huat Bay Isabelle Beau Daniel M Béchet Thomas J Begley Christian Behl Christian Behrends Soumeya Bekri Bryan Bellaire Linda J Bendall Luca Benetti Laura Berliocchi Henri Bernardi Francesca Bernassola Sébastien Besteiro Ingrid Bhatia-Kissova Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Lawrence H Boise Paolo Bonaldo David L Boone Beat C Bornhauser Karina R Bortoluci Ioannis Bossis Frédéric Bost Jean-Pierre Bourquin Patricia Boya Michaël Boyer-Guittaut Peter V Bozhkov Nathan R Brady Claudio Brancolini Andreas Brech Jay E Brenman Ana Brennand Emery H Bresnick Patrick Brest Dave Bridges Molly L Bristol Paul S Brookes Eric J Brown John H Brumell Nicola Brunetti-Pierri Ulf T Brunk Dennis E Bulman Scott J Bultman Geert Bultynck Lena F Burbulla Wilfried Bursch Jonathan P Butchar Wanda Buzgariu Sergio P Bydlowski Ken Cadwell Monika Cahová Dongsheng Cai Jiyang Cai Qian Cai Bruno Calabretta Javier Calvo-Garrido Nadine Camougrand Michelangelo Campanella Jenny Campos-Salinas Eleonora Candi Lizhi Cao Allan B Caplan Simon R Carding Sandra M Cardoso Jennifer S Carew Cathleen R Carlin Virginie Carmignac Leticia A M Carneiro Serena Carra Rosario A Caruso Giorgio Casari Caty Casas Roberta Castino Eduardo Cebollero Francesco Cecconi Jean Celli Hassan Chaachouay Han-Jung Chae Chee-Yin Chai David C Chan Edmond Y Chan Raymond Chuen-Chung Chang Chi-Ming Che Ching-Chow Chen Guang-Chao Chen Guo-Qiang Chen Min Chen Quan Chen Steve S-L Chen WenLi Chen Xi Chen Xiangmei Chen Xiequn Chen Ye-Guang Chen Yingyu Chen Yongqiang Chen Yu-Jen Chen Zhixiang Chen Alan Cheng Christopher H K Cheng Yan Cheng Heesun Cheong Jae-Ho Cheong Sara Cherry Russ Chess-Williams Zelda H Cheung Eric Chevet Hui-Ling Chiang Roberto Chiarelli Tomoki Chiba Lih-Shen Chin Shih-Hwa Chiou Francis V Chisari Chi Hin Cho Dong-Hyung Cho Augustine M K Choi DooSeok Choi Kyeong Sook Choi Mary E Choi Salem Chouaib Divaker Choubey Vinay Choubey Charleen T Chu Tsung-Hsien Chuang Sheau-Huei Chueh Taehoon Chun Yong-Joon Chwae Mee-Len Chye Roberto Ciarcia Maria R Ciriolo Michael J Clague Robert S B Clark Peter G H Clarke Robert Clarke Patrice Codogno Hilary A Coller María I Colombo Sergio Comincini Maria Condello Fabrizio Condorelli Mark R Cookson Graham H Coombs Isabelle Coppens Ramon Corbalan Pascale Cossart Paola Costelli Safia Costes Ana Coto-Montes Eduardo Couve Fraser P Coxon James M Cregg José L Crespo Marianne J Cronjé Ana Maria Cuervo Joseph J Cullen Mark J Czaja Marcello D'Amelio Arlette Darfeuille-Michaud Lester M Davids Faith E Davies Massimo De Felici John F de Groot Cornelis A M de Haan Luisa De Martino Angelo De Milito Vincenzo De Tata Jayanta Debnath Alexei Degterev Benjamin Dehay Lea M D Delbridge Francesca Demarchi Yi Zhen Deng Jörn Dengjel Paul Dent Donna Denton Vojo Deretic Shyamal D Desai Rodney J Devenish Mario Di Gioacchino Gilbert Di Paolo Chiara Di Pietro Guillermo Díaz-Araya Inés Díaz-Laviada Maria T Diaz-Meco Javier Diaz-Nido Ivan Dikic Savithramma P Dinesh-Kumar Wen-Xing Ding Clark W Distelhorst Abhinav Diwan Mojgan Djavaheri-Mergny Svetlana Dokudovskaya Zheng Dong Frank C Dorsey Victor Dosenko James J Dowling Stephen Doxsey Marlène Dreux Mark E Drew Qiuhong Duan Michel A Duchosal Karen Duff Isabelle Dugail Madeleine Durbeej Michael Duszenko Charles L Edelstein Aimee L Edinger Gustavo Egea Ludwig Eichinger N Tony Eissa Suhendan Ekmekcioglu Wafik S El-Deiry Zvulun Elazar Mohamed Elgendy Lisa M Ellerby Kai Er Eng Anna-Mart Engelbrecht Simone Engelender Jekaterina Erenpreisa Ricardo Escalante Audrey Esclatine Eeva-Liisa Eskelinen Lucile Espert Virginia Espina Huizhou Fan Jia Fan Qi-Wen Fan Zhen Fan Shengyun Fang Yongqi Fang Manolis Fanto Alessandro Fanzani Thomas Farkas Jean-Claude Farré Mathias Faure Marcus Fechheimer Carl G Feng Jian Feng Qili Feng Youji Feng László Fésüs Ralph Feuer Maria E Figueiredo-Pereira Gian Maria Fimia Diane C Fingar Steven Finkbeiner Toren Finkel Kim D Finley Filomena Fiorito Edward A Fisher Paul B Fisher Marc Flajolet Maria L Florez-McClure Salvatore Florio Edward A Fon Francesco Fornai Franco Fortunato Rati Fotedar Daniel H Fowler Howard S Fox Rodrigo Franco Lisa B Frankel Marc Fransen José M Fuentes Juan Fueyo Jun Fujii Kozo Fujisaki Eriko Fujita Mitsunori Fukuda Ruth H Furukawa Matthias Gaestel Philippe Gailly Malgorzata Gajewska Brigitte Galliot Vincent Galy Subramaniam Ganesh Barry Ganetzky Ian G Ganley Fen-Biao Gao George F Gao Jinming Gao Lorena Garcia Guillermo Garcia-Manero Mikel Garcia-Marcos Marjan Garmyn Andrei L Gartel Evelina Gatti Mathias Gautel Thomas R Gawriluk Matthew E Gegg Jiefei Geng Marc Germain Jason E Gestwicki David A Gewirtz Saeid Ghavami Pradipta Ghosh Anna M Giammarioli Alexandra N Giatromanolaki Spencer B Gibson Robert W Gilkerson Michael L Ginger Henry N Ginsberg Jakub Golab Michael S Goligorsky Pierre Golstein Candelaria Gomez-Manzano Ebru Goncu Céline Gongora Claudio D Gonzalez Ramon Gonzalez Cristina González-Estévez Rosa Ana González-Polo Elena Gonzalez-Rey Nikolai V Gorbunov Sharon Gorski Sandro Goruppi Roberta A Gottlieb Devrim Gozuacik Giovanna Elvira Granato Gary D Grant Kim N Green Aleš Gregorc Frédéric Gros Charles Grose Thomas W Grunt Philippe Gual Jun-Lin Guan Kun-Liang Guan Sylvie M Guichard Anna S Gukovskaya Ilya Gukovsky Jan Gunst Asa B Gustafsson Andrew J Halayko Amber N Hale Sandra K Halonen Maho Hamasaki Feng Han Ting Han Michael K Hancock Malene Hansen Hisashi Harada Masaru Harada Stefan E Hardt J Wade Harper Adrian L Harris James Harris Steven D Harris Makoto Hashimoto Jeffrey A Haspel Shin-ichiro Hayashi Lori A Hazelhurst Congcong He You-Wen He Marie-Joseé Hébert Kim A Heidenreich Miep H Helfrich Gudmundur V Helgason Elizabeth P Henske Brian Herman Paul K Herman Claudio Hetz Sabine Hilfiker Joseph A Hill Lynne J Hocking Paul Hofman Thomas G Hofmann Jörg Höhfeld Tessa L Holyoake Ming-Huang Hong David A Hood Gökhan S Hotamisligil Ewout J Houwerzijl Maria Høyer-Hansen Bingren Hu Chien-An A Hu Hong-Ming Hu Ya Hua Canhua Huang Ju Huang Shengbing Huang Wei-Pang Huang Tobias B Huber Won-Ki Huh Tai-Ho Hung Ted R Hupp Gang Min Hur James B Hurley Sabah N A Hussain Patrick J Hussey Jung Jin Hwang Seungmin Hwang Atsuhiro Ichihara Shirin Ilkhanizadeh Ken Inoki Takeshi Into Valentina Iovane Juan L Iovanna Nancy Y Ip Yoshitaka Isaka Hiroyuki Ishida Ciro Isidoro Ken-ichi Isobe Akiko Iwasaki Marta Izquierdo Yotaro Izumi Panu M Jaakkola Marja Jäättelä George R Jackson William T Jackson Bassam Janji Marina Jendrach Ju-Hong Jeon Eui-Bae Jeung Hong Jiang Hongchi Jiang Jean X Jiang Ming Jiang Qing Jiang Xuejun Jiang Xuejun Jiang Alberto Jiménez Meiyan Jin Shengkan Jin Cheol O Joe Terje Johansen Daniel E Johnson Gail V W Johnson Nicola L Jones Bertrand Joseph Suresh K Joseph Annie M Joubert Gábor Juhász Lucienne Juillerat-Jeanneret Chang Hwa Jung Yong-Keun Jung Kai Kaarniranta Allen Kaasik Tomohiro Kabuta Motoni Kadowaki Katarina Kagedal Yoshiaki Kamada Vitaliy O Kaminskyy Harm H Kampinga Hiromitsu Kanamori Chanhee Kang Khong Bee Kang Kwang Il Kang Rui Kang Yoon-A Kang Tomotake Kanki Thirumala-Devi Kanneganti Haruo Kanno Anumantha G Kanthasamy Arthi Kanthasamy Vassiliki Karantza Gur P Kaushal Susmita Kaushik Yoshinori Kawazoe Po-Yuan Ke John H Kehrl Ameeta Kelekar Claus Kerkhoff David H Kessel Hany Khalil Jan A K W Kiel Amy A Kiger Akio Kihara Deok Ryong Kim Do-Hyung Kim Dong-Hou Kim Eun-Kyoung Kim Hyung-Ryong Kim Jae-Sung Kim Jeong Hun Kim Jin Cheon Kim John K Kim Peter K Kim Seong Who Kim Yong-Sun Kim Yonghyun Kim Adi Kimchi Alec C Kimmelman Jason S King Timothy J Kinsella Vladimir Kirkin Lorrie A Kirshenbaum Katsuhiko Kitamoto Kaio Kitazato Ludger Klein Walter T Klimecki Jochen Klucken Erwin Knecht Ben C B Ko Jan C Koch Hiroshi Koga Jae-Young Koh Young Ho Koh Masato Koike Masaaki Komatsu Eiki Kominami Hee Jeong Kong Wei-Jia Kong Viktor I Korolchuk Yaichiro Kotake Michael I Koukourakis Juan B Kouri Flores Attila L Kovács Claudine Kraft Dimitri Krainc Helmut Krämer Carole Kretz-Remy Anna M Krichevsky Guido Kroemer Rejko Krüger Oleg Krut Nicholas T Ktistakis Chia-Yi Kuan Roza Kucharczyk Ashok Kumar Raj Kumar Sharad Kumar Mondira Kundu Hsing-Jien Kung Tino Kurz Ho Jeong Kwon Albert R La Spada Frank Lafont Trond Lamark Jacques Landry Jon D Lane Pierre Lapaquette Jocelyn F Laporte Lajos László Sergio Lavandero Josée N Lavoie Robert Layfield Pedro A Lazo Weidong Le Laurent Le Cam Daniel J Ledbetter Alvin J X Lee Byung-Wan Lee Gyun Min Lee Jongdae Lee Ju-Hyun Lee Michael Lee Myung-Shik Lee Sug Hyung Lee Christiaan Leeuwenburgh Patrick Legembre Renaud Legouis Michael Lehmann Huan-Yao Lei Qun-Ying Lei David A Leib José Leiro John J Lemasters Antoinette Lemoine Maciej S Lesniak Dina Lev Victor V Levenson Beth Levine Efrat Levy Faqiang Li Jun-Lin Li Lian Li Sheng Li Weijie Li Xue-Jun Li Yan-bo Li Yi-Ping Li Chengyu Liang Qiangrong Liang Yung-Feng Liao Pawel P Liberski Andrew Lieberman Hyunjung J Lim Kah-Leong Lim Kyu Lim Chiou-Feng Lin Fu-Cheng Lin Jian Lin Jiandie D Lin Kui Lin Wan-Wan Lin Weei-Chin Lin Yi-Ling Lin Rafael Linden Paul Lingor Jennifer Lippincott-Schwartz Michael P Lisanti Paloma B Liton Bo Liu Chun-Feng Liu Kaiyu Liu Leyuan Liu Qiong A Liu Wei Liu Young-Chau Liu Yule Liu Richard A Lockshin Chun-Nam Lok Sagar Lonial Benjamin Loos Gabriel Lopez-Berestein Carlos López-Otín Laura Lossi Michael T Lotze Peter Lőw Binfeng Lu Bingwei Lu Bo Lu Zhen Lu Frédéric Luciano Nicholas W Lukacs Anders H Lund Melinda A Lynch-Day Yong Ma Fernando Macian Jeff P MacKeigan Kay F Macleod Frank Madeo Luigi Maiuri Maria Chiara Maiuri Davide Malagoli May Christine V Malicdan Walter Malorni Na Man Eva-Maria Mandelkow Stéphen Manon Irena Manov Kai Mao Xiang Mao Zixu Mao Philippe Marambaud Daniela Marazziti Yves L Marcel Katie Marchbank Piero Marchetti Stefan J Marciniak Mateus Marcondes Mohsen Mardi Gabriella Marfe Guillermo Mariño Maria Markaki Mark R Marten Seamus J Martin Camille Martinand-Mari Wim Martinet Marta Martinez-Vicente Matilde Masini Paola Matarrese Saburo Matsuo Raffaele Matteoni Andreas Mayer Nathalie M Mazure David J McConkey Melanie J McConnell Catherine McDermott Christine McDonald Gerald M McInerney Sharon L McKenna BethAnn McLaughlin Pamela J McLean Christopher R McMaster G Angus McQuibban Alfred J Meijer Miriam H Meisler Alicia Meléndez Thomas J Melia Gerry Melino Maria A Mena Javier A Menendez Rubem F S Menna-Barreto Manoj B Menon Fiona M Menzies Carol A Mercer Adalberto Merighi Diane E Merry Stefania Meschini Christian G Meyer Thomas F Meyer Chao-Yu Miao Jun-Ying Miao Paul A M Michels Carine Michiels Dalibor Mijaljica Ana Milojkovic Saverio Minucci Clelia Miracco Cindy K Miranti Ioannis Mitroulis Keisuke Miyazawa Noboru Mizushima Baharia Mograbi Simin Mohseni Xavier Molero Bertrand Mollereau Faustino Mollinedo Takashi Momoi Iryna Monastyrska Martha M Monick Mervyn J Monteiro Michael N Moore Rodrigo Mora Kevin Moreau Paula I Moreira Yuji Moriyasu Jorge Moscat Serge Mostowy Jeremy C Mottram Tomasz Motyl Charbel E-H Moussa Sylke Müller Sylviane Muller Karl Münger Christian Münz Leon O Murphy Maureen E Murphy Antonio Musarò Indira Mysorekar Eiichiro Nagata Kazuhiro Nagata Aimable Nahimana Usha Nair Toshiyuki Nakagawa Kiichi Nakahira Hiroyasu Nakano Hitoshi Nakatogawa Meera Nanjundan Naweed I Naqvi Derek P Narendra Masashi Narita Miguel Navarro Steffan T Nawrocki Taras Y Nazarko Andriy Nemchenko Mihai G Netea Thomas P Neufeld Paul A Ney Ioannis P Nezis Huu Phuc Nguyen Daotai Nie Ichizo Nishino Corey Nislow Ralph A Nixon Takeshi Noda Angelika A Noegel Anna Nogalska Satoru Noguchi Lucia Notterpek Ivana Novak Tomoyoshi Nozaki Nobuyuki Nukina Thorsten Nürnberger Beat Nyfeler Keisuke Obara Terry D Oberley Salvatore Oddo Michinaga Ogawa Toya Ohashi Koji Okamoto Nancy L Oleinick F Javier Oliver Laura J Olsen Stefan Olsson Onya Opota Timothy F Osborne Gary K Ostrander Kinya Otsu Jing-hsiung James Ou Mireille Ouimet Michael Overholtzer Bulent Ozpolat Paolo Paganetti Ugo Pagnini Nicolas Pallet Glen E Palmer Camilla Palumbo Tianhong Pan Theocharis Panaretakis Udai Bhan Pandey Zuzana Papackova Issidora Papassideri Irmgard Paris Junsoo Park Ohkmae K Park Jan B Parys Katherine R Parzych Susann Patschan Cam Patterson Sophie Pattingre John M Pawelek Jianxin Peng David H Perlmutter Ida Perrotta George Perry Shazib Pervaiz Matthias Peter Godefridus J Peters Morten Petersen Goran Petrovski James M Phang Mauro Piacentini Philippe Pierre Valérie Pierrefite-Carle Gérard Pierron Ronit Pinkas-Kramarski Antonio Piras Natik Piri Leonidas C Platanias Stefanie Pöggeler Marc Poirot Angelo Poletti Christian Poüs Mercedes Pozuelo-Rubio Mette Prætorius-Ibba Anil Prasad Mark Prescott Muriel Priault Nathalie Produit-Zengaffinen Ann Progulske-Fox Tassula Proikas-Cezanne Serge Przedborski Karin Przyklenk Rosa Puertollano Julien Puyal Shu-Bing Qian Liang Qin Zheng-Hong Qin Susan E Quaggin Nina Raben Hannah Rabinowich Simon W Rabkin Irfan Rahman Abdelhaq Rami Georg Ramm Glenn Randall Felix Randow V Ashutosh Rao Jeffrey C Rathmell Brinda Ravikumar Swapan K Ray Bruce H Reed John C Reed Fulvio Reggiori Anne Régnier-Vigouroux Andreas S Reichert John J Reiners Russel J Reiter Jun Ren José L Revuelta Christopher J Rhodes Konstantinos Ritis Elizete Rizzo Jeffrey Robbins Michel Roberge Hernan Roca Maria C Roccheri Stephane Rocchi H Peter Rodemann Santiago Rodríguez de Córdoba Bärbel Rohrer Igor B Roninson Kirill Rosen Magdalena M Rost-Roszkowska Mustapha Rouis Kasper M A Rouschop Francesca Rovetta Brian P Rubin David C Rubinsztein Klaus Ruckdeschel Edmund B Rucker Assaf Rudich Emil Rudolf Nelson Ruiz-Opazo Rossella Russo Tor Erik Rusten Kevin M Ryan Stefan W Ryter David M Sabatini Junichi Sadoshima Tapas Saha Tatsuya Saitoh Hiroshi Sakagami Yasuyoshi Sakai Ghasem Hoseini Salekdeh Paolo Salomoni Paul M Salvaterra Guy Salvesen Rosa Salvioli Anthony M J Sanchez José A Sánchez-Alcázar Ricardo Sánchez-Prieto Marco Sandri Uma Sankar Poonam Sansanwal Laura Santambrogio Shweta Saran Sovan Sarkar Minnie Sarwal Chihiro Sasakawa Ausra 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Yoshikawa Tamotsu Yoshimori Kohki Yoshimoto Ho Jin You Richard J Youle Anas Younes Li Yu Long Yu Seong-Woon Yu Wai Haung Yu Zhi-Min Yuan Zhenyu Yue Cheol-Heui Yun Michisuke Yuzaki Olga Zabirnyk Elaine Silva-Zacarin David Zacks Eldad Zacksenhaus Nadia Zaffaroni Zahra Zakeri Herbert J Zeh Scott O Zeitlin Hong Zhang Hui-Ling Zhang Jianhua Zhang Jing-Pu Zhang Lin Zhang Long Zhang Ming-Yong Zhang Xu Dong Zhang Mantong Zhao Yi-Fang Zhao Ying Zhao Zhizhuang J Zhao Xiaoxiang Zheng Boris Zhivotovsky Qing Zhong Cong-Zhao Zhou Changlian Zhu Wei-Guo Zhu Xiao-Feng Zhu Xiongwei Zhu Yuangang Zhu Teresa Zoladek Wei-Xing Zong Antonio Zorzano Jürgen Zschocke Brian Zuckerbraun

Autophagy 2012 Apr;8(4):445-544

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.4161/auto.19496DOI Listing
April 2012

Evaluation of the nutrient-sensing mTOR pathway.

Methods Mol Biol 2012 ;821:29-44

Department of Molecular and Integrative Physiology, Life Sciences Institute, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1007/978-1-61779-430-8_3DOI Listing
March 2012

Deconvolution of mTORC2 "in Silico".

Sci Signal 2012 Mar 27;5(217):pe12. Epub 2012 Mar 27.

Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.

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March 2012

Spatial regulation of the mTORC1 system in amino acids sensing pathway.

Acta Biochim Biophys Sin (Shanghai) 2011 Sep 23;43(9):671-9. Epub 2011 Jul 23.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1093/abbs/gmr066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160786PMC
September 2011

Regulation of mTORC1 by the Rab and Arf GTPases.

J Biol Chem 2010 Jun 10;285(26):19705-9. Epub 2010 May 10.

Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, California 92093, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888380PMC
June 2010

Critical roles for the TSC-mTOR pathway in β-cell function.

Am J Physiol Endocrinol Metab 2009 Nov 18;297(5):E1013-22. Epub 2009 Aug 18.

Dept. of Pharmacology and Moores Cancer Center, Univ. of California San Diego, La Jolla, CA 92093-081, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781354PMC
November 2009

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential.

Biochem Biophys Res Commun 2009 Jul 5;384(4):471-5. Epub 2009 May 5.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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July 2009

Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy.

Proc Natl Acad Sci U S A 2009 Jun 20;106(22):8923-8. Epub 2009 May 20.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690031PMC
June 2009

Monitoring mammalian target of rapamycin (mTOR) activity.

Methods Enzymol 2009 ;452:165-80

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.

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April 2009

Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment.

Hum Mol Genet 2009 Apr;18(R1):R94-100

Department of Molecular and Integrative Physiology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1093/hmg/ddp032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657945PMC
April 2009

Role of TSC-mTOR pathway in diabetic nephropathy.

Authors:
Ken Inoki

Diabetes Res Clin Pract 2008 Nov 15;82 Suppl 1:S59-62. Epub 2008 Oct 15.

Life Sciences Institute, University of Michigan, 210 Washtenaw #6115, Ann Arbor, MI 48108-2216, USA.

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November 2008

A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression.

Am J Physiol Cell Physiol 2008 Sep 23;295(3):C836-43. Epub 2008 Jul 23.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-0680, USA.

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http://dx.doi.org/10.1152/ajpcell.00554.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544442PMC
September 2008

PTEN acetylation modulates its interaction with PDZ domain.

Cancer Res 2008 Sep;68(17):6908-12

Life Sciences Institute, University of Michigan, Ann Arbor, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1107DOI Listing
September 2008

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling.

EMBO J 2008 Jul 19;27(14):1919-31. Epub 2008 Jun 19.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1038/emboj.2008.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486275PMC
July 2008

Measurements of TSC2 GAP activity toward Rheb.

Methods Enzymol 2006 ;407:46-54

Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA.

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June 2008

mTOR pathway as a target in tissue hypertrophy.

Annu Rev Pharmacol Toxicol 2007 ;47:443-67

Life Science Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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April 2007

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.

Genes Dev 2006 Oct;20(20):2820-32

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1619946PMC
October 2006

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.

Proc Natl Acad Sci U S A 2006 May 20;103(18):6811-6. Epub 2006 Apr 20.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458976PMC
May 2006

Complexity of the TOR signaling network.

Trends Cell Biol 2006 Apr 3;16(4):206-12. Epub 2006 Mar 3.

Life Sciences Institute, Department of Biological Chemistry, Institute of Gerontology, University of Michigan, Ann Arbor, MI 48109, USA.

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April 2006

TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.

J Biol Chem 2006 Mar 7;281(13):8313-6. Epub 2006 Feb 7.

Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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March 2006

The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway.

J Biol Chem 2005 Mar 4;280(11):9769-72. Epub 2005 Jan 4.

Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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March 2005

Signaling by target of rapamycin proteins in cell growth control.

Microbiol Mol Biol Rev 2005 Mar;69(1):79-100

Life Science Institute, University of Michigan Medical School, 5450 Medical Science I Bldg., Ann Arbor, MI 48109-0606, USA.

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March 2005

Dysregulation of the TSC-mTOR pathway in human disease.

Nat Genet 2005 Jan;37(1):19-24

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

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January 2005

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.

Mol Cell Biol 2004 Sep;24(18):7965-75

Life Sciences Institute, Department of Biological Chemistry, University of Michigan, Ann Arbor 48109-0606, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC515062PMC
September 2004

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.

Genes Dev 2004 Jul;18(13):1533-8

Life Sciences Institute, Department of Biological Chemistry, and Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1101/gad.1199104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC443516PMC
July 2004

TSC2: filling the GAP in the mTOR signaling pathway.

Trends Biochem Sci 2004 Jan;29(1):32-8

Department of Biological Chemistry and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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January 2004

TSC2 mediates cellular energy response to control cell growth and survival.

Cell 2003 Nov;115(5):577-90

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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November 2003

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.

Genes Dev 2003 Aug 17;17(15):1829-34. Epub 2003 Jul 17.

Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC196227PMC
August 2003

The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.

J Biol Chem 2003 Apr 11;278(16):13663-71. Epub 2003 Feb 11.

Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109, USA.

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April 2003

Regulation of TSC2 by 14-3-3 binding.

J Biol Chem 2002 Nov 2;277(47):44593-6. Epub 2002 Oct 2.

Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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November 2002

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.

Nat Cell Biol 2002 Sep;4(9):648-57

Department of Biological Chemistry, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, MI 48109, USA.

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September 2002

15-Deoxy-Delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells.

Kidney Int 2002 Jun;61(6):1957-67

Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan.

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June 2002

Cyclic AMP inhibits stretch-induced overexpression of fibronectin in glomerular mesangial cells.

Eur J Pharmacol 2002 Feb;437(3):113-22

Third Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.

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February 2002