Kelly E Dooley

Kelly E Dooley

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Kelly E Dooley

Kelly E Dooley

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Alternative dosing guidelines to improve outcomes in childhood tuberculosis: a mathematical modelling study.

Lancet Child Adolesc Health 2019 Sep 16;3(9):636-645. Epub 2019 Jul 16.

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/S2352-4642(19)30196-8DOI Listing
September 2019

The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis.

Lancet Respir Med 2019 Sep;7(9):820-826

South African Medical Research Council Centre for Tuberculosis Research/Department of Science and Technology/ National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, Tygerberg, South Africa.

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http://dx.doi.org/10.1016/S2213-2600(19)30263-2DOI Listing
September 2019

Integrating pharmacokinetics and pharmacodynamics in operational research to End TB.

Clin Infect Dis 2019 Sep 27. Epub 2019 Sep 27.

Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy.

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http://dx.doi.org/10.1093/cid/ciz942DOI Listing
September 2019

Pharmacokinetic and pharmacodynamic considerations of rifamycin antibiotics for the treatment of tuberculosis.

Expert Opin Drug Metab Toxicol 2019 Aug 30;15(8):615-618. Epub 2019 Jul 30.

b Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore , USA.

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http://dx.doi.org/10.1080/17425255.2019.1648432DOI Listing
August 2019

Advancing the development of new tuberculosis treatment regimens: The essential role of translational and clinical pharmacology and microbiology.

PLoS Med 2019 Jul 5;16(7):e1002842. Epub 2019 Jul 5.

University of California San Francisco, San Francisco, California, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1002842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611566PMC
July 2019

Adverse outcome pathway for aminoglycoside ototoxicity in drug-resistant tuberculosis treatment.

Arch Toxicol 2019 May 8;93(5):1385-1399. Epub 2019 Apr 8.

Johns Hopkins University School of Nursing, 525 North Wolfe Street, Baltimore, MD, 21205, USA.

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http://link.springer.com/10.1007/s00204-019-02407-8
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http://dx.doi.org/10.1007/s00204-019-02407-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667179PMC
May 2019

Pharmacologic Research in Pregnant Women - Time to Get It Right.

N Engl J Med 2019 Apr;380(14):1293-1295

From the Divisions of Maternal Fetal Medicine (A.C.E., J.S.S.) and Clinical Pharmacology (A.C.E., K.E.D.), Johns Hopkins University School of Medicine, and the Doctoral Training Program and the Graduate Training Program in Clinical Investigation, Johns Hopkins University Bloomberg School of Public Health (A.C.E.) - all in Baltimore.

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http://dx.doi.org/10.1056/NEJMp1815325DOI Listing
April 2019

Intensified antibiotic treatment of tuberculosis meningitis.

Expert Rev Clin Pharmacol 2019 Mar 12;12(3):267-288. Epub 2019 Feb 12.

f Department of Internal Medicine and Radboud Center for Infectious Diseases , Radboud university medical center , Nijmegen , the Netherlands.

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https://www.tandfonline.com/doi/full/10.1080/17512433.2019.1
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http://dx.doi.org/10.1080/17512433.2019.1552831DOI Listing
March 2019

The Global Landscape of Tuberculosis Therapeutics.

Annu Rev Med 2019 01 7;70:105-120. Epub 2018 Nov 7.

Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA; email:

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https://www.annualreviews.org/doi/10.1146/annurev-med-040717
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http://dx.doi.org/10.1146/annurev-med-040717-051150DOI Listing
January 2019

State-of-the-Art Review of HIV-TB Coinfection in Special Populations.

Clin Pharmacol Ther 2018 12 26;104(6):1098-1109. Epub 2018 Oct 26.

Division of Clinical Pharmacology, Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/cpt.1221DOI Listing
December 2018

Challenges of TB and HIV co-treatment: updates and insights.

Curr Opin HIV AIDS 2018 11;13(6):486-491

Division of Clinical Pharmacology & Infectious Diseases, Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1097/COH.0000000000000495DOI Listing
November 2018

High-Dose Rifampin: Shall We Be Bolder?

Authors:
Kelly E Dooley

Am J Respir Crit Care Med 2018 09;198(5):558-560

1 Division of Clinical Pharmacology and.

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http://dx.doi.org/10.1164/rccm.201806-1140EDDOI Listing
September 2018

Long-acting injectables for tuberculosis prophylaxis and treatment: is now the time?

Authors:
Kelly E Dooley

Int J Tuberc Lung Dis 2018 08;22(8):833-834

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.5588/ijtld.18.0411DOI Listing
August 2018

The Global Neurological Burden of Tuberculosis.

Semin Neurol 2018 04 23;38(2):226-237. Epub 2018 May 23.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1055/s-0038-1651500DOI Listing
April 2018

Levofloxacin Population Pharmacokinetics in South African Children Treated for Multidrug-Resistant Tuberculosis.

Antimicrob Agents Chemother 2018 02 25;62(2). Epub 2018 Jan 25.

Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

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http://aac.asm.org/lookup/doi/10.1128/AAC.01521-17
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http://dx.doi.org/10.1128/AAC.01521-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786780PMC
February 2018

Rifampin vs. rifapentine: what is the preferred rifamycin for tuberculosis?

Expert Rev Clin Pharmacol 2017 Oct 18;10(10):1027-1036. Epub 2017 Aug 18.

b Department of Pharmacotherapy and Translational Research , University of Florida, College of Pharmacy , Gainesville , FL , USA.

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https://www.researchgate.net/profile/Mohammad_Al-Shaer/publi
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC163595/
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https://www.tandfonline.com/doi/full/10.1080/17512433.2017.1
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http://dx.doi.org/10.1080/17512433.2017.1366311DOI Listing
October 2017

Tuberculous meningitis.

Nat Rev Neurol 2017 Oct 8;13(10):581-598. Epub 2017 Sep 8.

Oxford University Clinical Research Unit, 764 Vo Van Kiet, Quan 5, Ho Chi Minh City, Vietnam.

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http://dx.doi.org/10.1038/nrneurol.2017.120DOI Listing
October 2017

In vitro and in vivo activity of biapenem against drug-susceptible and rifampicin-resistant Mycobacterium tuberculosis.

J Antimicrob Chemother 2017 08;72(8):2320-2325

Center for Tuberculosis Research, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1093/jac/dkx152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890701PMC
August 2017

Population Pharmacokinetics of Pyrazinamide in Patients with Tuberculosis.

Antimicrob Agents Chemother 2017 06 24;61(6). Epub 2017 May 24.

University of Florida, College of Pharmacy, Department of Pharmacotherapy and Translational Research, Gainesville, Florida, USA

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http://dx.doi.org/10.1128/AAC.02625-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444154PMC
June 2017

The time has come: sparing injectables in paediatric MDR-TB.

Lancet Respir Med 2017 Mar 15. Epub 2017 Mar 15.

The Johns Hopkins University School of Medicine, Department of Medicine, Divisions of Clinical Pharmacology & Infectious Disease, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/S2213-2600(17)30078-4DOI Listing
March 2017

Tuberculosis Associated with HIV Infection.

Microbiol Spectr 2017 01;5(1)

Johns Hopkins University School of Medicine, Divisions of Clinical Pharmacology & Infectious Diseases, Center for Tuberculosis Research, Baltimore, MD 21287.

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http://dx.doi.org/10.1128/microbiolspec.TNMI7-0028-2016DOI Listing
January 2017

Challenges in the clinical assessment of novel tuberculosis drugs.

Adv Drug Deliv Rev 2016 07 28;102:116-22. Epub 2016 Jan 28.

Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich (LMU), Leopoldstrasse 5, 80802 Munich, Germany; German Centre for Infection Research (DZIF), Leopoldstrasse 5, 80802 Munich, Germany; German Centre for Infection Research, Leopoldstrasse 5, 80802 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2016.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903928PMC
July 2016

Can the addition of verapamil to bedaquiline-containing regimens improve tuberculosis treatment outcomes? A novel approach to optimizing TB treatment.

Future Microbiol 2015 30;10(8):1257-60. Epub 2015 Jul 30.

Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Room 108, 1550 Orleans St, Baltimore, MD 21231, USA.

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https://www.futuremedicine.com/doi/10.2217/FMB.15.56
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http://dx.doi.org/10.2217/FMB.15.56DOI Listing
June 2016

Treatment Failure, Drug Resistance, and CD4 T-Cell Count Decline Among Postpartum Women on Antiretroviral Therapy in South Africa.

J Acquir Immune Defic Syndr 2016 Jan;71(1):31-7

*Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD;†Perinatal HIV Research Unit (PHRU), University of the Witwatersrand, Soweto, South Africa;‡Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa; and§Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.

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http://dx.doi.org/10.1097/QAI.0000000000000811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713347PMC
January 2016

Pharmacokinetics and Safety of Ofloxacin in Children with Drug-Resistant Tuberculosis.

Antimicrob Agents Chemother 2015 Oct 20;59(10):6073-9. Epub 2015 Jul 20.

Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

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http://dx.doi.org/10.1128/AAC.01404-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576031PMC
October 2015

Determination of [11C]rifampin pharmacokinetics within Mycobacterium tuberculosis-infected mice by using dynamic positron emission tomography bioimaging.

Antimicrob Agents Chemother 2015 Sep 13;59(9):5768-74. Epub 2015 Jul 13.

Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.01146-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538528PMC
September 2015

Rifampicin and rifapentine significantly reduce concentrations of bedaquiline, a new anti-TB drug.

J Antimicrob Chemother 2015 Apr 21;70(4):1106-14. Epub 2014 Dec 21.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1093/jac/dku504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356204PMC
April 2015

Designing drug trials: considerations for pregnant women.

Clin Infect Dis 2014 Dec;59 Suppl 7:S437-44

Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda.

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http://dx.doi.org/10.1093/cid/ciu709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303056PMC
December 2014

Impact of lopinavir-ritonavir or nevirapine on bedaquiline exposures and potential implications for patients with tuberculosis-HIV coinfection.

Antimicrob Agents Chemother 2014 Nov 11;58(11):6406-12. Epub 2014 Aug 11.

Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1128/AAC.03246-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249405PMC
November 2014

Induction of influx and efflux transporters and cytochrome P450 3A4 in primary human hepatocytes by rifampin, rifabutin, and rifapentine.

Antimicrob Agents Chemother 2013 Dec 23;57(12):6366-9. Epub 2013 Sep 23.

Department of Molecular and Clinical Pharmacology, The University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1128/AAC.01124-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837889PMC
December 2013

Pipeline of drugs for related diseases: tuberculosis.

Curr Opin HIV AIDS 2013 Nov;8(6):579-85

aJohns Hopkins University School of Medicine, Baltimore, Maryland, USA bStellenbosch University, Tygerberg, South Africa.

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http://dx.doi.org/10.1097/COH.0000000000000009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206795PMC
November 2013

TB and HIV Therapeutics: Pharmacology Research Priorities.

AIDS Res Treat 2012 5;2012:874083. Epub 2012 Jul 5.

Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Osler 527, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1155/2012/874083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398575PMC
August 2012

Activities of rifampin, Rifapentine and clarithromycin alone and in combination against mycobacterium ulcerans disease in mice.

PLoS Negl Trop Dis 2011 Jan 4;5(1):e933. Epub 2011 Jan 4.

Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0000933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014976PMC
January 2011

TMC207: the first compound of a new class of potent anti-tuberculosis drugs.

Future Microbiol 2010 Jun;5(6):849-58

Institute of Infectious & Tropical Diseases, University of Brescia, Italy.

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http://dx.doi.org/10.2217/fmb.10.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921705PMC
June 2010

Tuberculosis and diabetes mellitus: convergence of two epidemics.

Lancet Infect Dis 2009 Dec;9(12):737-46

Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S147330990970282
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http://dx.doi.org/10.1016/S1473-3099(09)70282-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945809PMC
December 2009

Impact of diabetes mellitus on treatment outcomes of patients with active tuberculosis.

Am J Trop Med Hyg 2009 Apr;80(4):634-9

Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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https://www.cap-tb.org/sites/default/files/documents/Gender.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750857PMC
April 2009

Drug interactions involving combination antiretroviral therapy and other anti-infective agents: repercussions for resource-limited countries.

J Infect Dis 2008 Oct;198(7):948-61

Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1086/591459DOI Listing
October 2008

Treatment of latent tuberculosis infection: challenges and prospects.

Clin Chest Med 2005 Jun;26(2):313-26, vii

Department of Medicine, Providence Portland Medical Center, 4805 NE Glissan Street, Portland, OR 97213, USA.

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http://dx.doi.org/10.1016/j.ccm.2005.02.003DOI Listing
June 2005

Fluoroquinolone resistance in patients with newly diagnosed tuberculosis.

Clin Infect Dis 2003 Dec 4;37(11):1448-52. Epub 2003 Nov 4.

Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1086/379328DOI Listing
December 2003

Empiric treatment of community-acquired pneumonia with fluoroquinolones, and delays in the treatment of tuberculosis.

Clin Infect Dis 2002 Jun 23;34(12):1607-12. Epub 2002 May 23.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1086/340618DOI Listing
June 2002

A 39-year-old man with hip pain and respiratory failure.

Chest 2002 Apr;121(4):1345-9

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224-6801, USA.

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http://dx.doi.org/10.1378/chest.121.4.1345DOI Listing
April 2002