Kellie R Machlus

Kellie R Machlus

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Kellie R Machlus

Kellie R Machlus

Publications by authors named "Kellie R Machlus"

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33Publications

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Teamwork makes the dream work in thrombopoiesis.

Blood 2019 Sep;134(10):791-792

Brigham and Women's Hospital; Harvard Medical School.

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http://dx.doi.org/10.1182/blood.2019002306DOI Listing
September 2019

New Insights Into the Differentiation of Megakaryocytes From Hematopoietic Progenitors.

Arterioscler Thromb Vasc Biol 2019 Jul 2;39(7):1288-1300. Epub 2019 May 2.

From the Division of Hematology, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/ATVBAHA.119.312129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594866PMC
July 2019

Modulation of megakaryopoiesis and platelet production during inflammation.

Thromb Res 2019 Jul 14;179:114-120. Epub 2019 May 14.

Division of Hematology, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2019.05.008DOI Listing
July 2019

Megakaryocyte modification of platelets in thrombocytopenia.

Curr Opin Hematol 2018 09;25(5):410-415

Division of Hematology, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Harvard Institutes of Medicine, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000451DOI Listing
September 2018

In vitro culture of murine megakaryocytes from fetal liver-derived hematopoietic stem cells.

Platelets 2018 Sep 26;29(6):583-588. Epub 2018 Jul 26.

a Division of Hematology , Brigham and Women's Hospital , Boston , MA , USA.

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http://dx.doi.org/10.1080/09537104.2018.1492107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323647PMC
September 2018

Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets.

Blood Adv 2017 Sep 8;1(20):1773-1785. Epub 2017 Sep 8.

Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/bloodadvances.2017007021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728336PMC
September 2017

RBCs pin platelets against the (thrombus) wall.

Blood 2017 05;129(18):2460-2461

BRIGHAM AND WOMEN'S HOSPITAL; HARVARD MEDICAL SCHOOL.

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http://dx.doi.org/10.1182/blood-2017-03-772079DOI Listing
May 2017

Tamoxifen Directly Inhibits Platelet Angiogenic Potential and Platelet-Mediated Metastasis.

Arterioscler Thromb Vasc Biol 2017 04 2;37(4):664-674. Epub 2017 Feb 2.

From the Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA (K.E.J., J.A.F., M.D.T., J.R.C., S.E.-H., R.K., K.R.M., J.E.I., E.M.B.); Department of Medicine, Harvard Medical School, Boston, MA (K.E.J., K.R.M., E.L.M., J.E.I., E.M.B.); Vascular Biology Program, Department of Surgery, Children's Hospital Boston, MA (J.E.I.); and Division of Hematology, Dana-Farber Cancer Institute, Boston, MA (E.L.M.).

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http://dx.doi.org/10.1161/ATVBAHA.116.308791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364056PMC
April 2017

Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation.

Blood 2016 Mar 7;127(11):1468-80. Epub 2016 Jan 7.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA; Vascular Biology Program, Department of Surgery, Children's Hospital Boston, Boston, MA.

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http://dx.doi.org/10.1182/blood-2015-08-663146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797023PMC
March 2016

Abnormal megakaryopoiesis and platelet function in cyclooxygenase-2-deficient mice.

Thromb Haemost 2015 Nov 13;114(6):1218-29. Epub 2015 Aug 13.

Silvia S. Barbieri, PhD, Centro Cardiologico Monzino, IRCCS, Via Parea 4, 20138 Milano, Italy, Tel.: +39 02 50318357, Fax: +39 02 50318250, E-mail:

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http://dx.doi.org/10.1160/TH14-10-0872DOI Listing
November 2015

Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation.

Br J Haematol 2014 Apr 6;165(2):227-36. Epub 2014 Feb 6.

Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/bjh.12758DOI Listing
April 2014

Elevated prothrombin promotes venous, but not arterial, thrombosis in mice.

Arterioscler Thromb Vasc Biol 2013 Aug 30;33(8):1829-36. Epub 2013 May 30.

Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, NC 27599-7525, USA.

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http://dx.doi.org/10.1161/ATVBAHA.113.301607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779620PMC
August 2013

The incredible journey: From megakaryocyte development to platelet formation.

J Cell Biol 2013 Jun;201(6):785-96

Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1083/jcb.201304054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678154PMC
June 2013

Procoagulant activity in hemostasis and thrombosis: Virchow's triad revisited.

Anesth Analg 2012 Feb 21;114(2):275-85. Epub 2011 Nov 21.

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599-7525, USA.

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http://dx.doi.org/10.1213/ANE.0b013e31823a088cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264782PMC
February 2012

Recombinant factor VIIa analog NN1731 (V158D/E296V/M298Q-FVIIa) enhances fibrin formation, structure and stability in lipidated hemophilic plasma.

Thromb Res 2011 Dec 10;128(6):570-6. Epub 2011 May 10.

Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599–7525, USA.

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http://dx.doi.org/10.1016/j.thromres.2011.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156970PMC
December 2011

Procoagulant activity induced by vascular injury determines contribution of elevated factor VIII to thrombosis and thrombus stability in mice.

Blood 2011 Oct 9;118(14):3960-8. Epub 2011 Aug 9.

Department of Pathology and Laboratory Medicine, North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1182/blood-2011-06-362814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193271PMC
October 2011

Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice.

Blood 2011 May 25;117(18):4953-63. Epub 2011 Feb 25.

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1182/blood-2010-11-316885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100702PMC
May 2011

Update on venous thromboembolism: risk factors, mechanisms, and treatments.

Arterioscler Thromb Vasc Biol 2011 Mar;31(3):476-8

Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7525, USA.

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http://dx.doi.org/10.1161/ATVBAHA.111.223008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044436PMC
March 2011

Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram.

Thromb Haemost 2009 Nov;102(5):936-44

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599-7525, USA.

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http://dx.doi.org/10.1160/TH09-03-0180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904819PMC
November 2009