Publications by authors named "Kelan G Tantisira"

100Publications

Enhancing the prediction of childhood asthma remission: Integrating clinical factors with microRNAs.

J Allergy Clin Immunol 2020 Sep 2. Epub 2020 Sep 2.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass; Division of Pulmonary and Critical Care, Brigham and Women's Hospital, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2020.08.019DOI Listing
September 2020

CASTER: Cross-Sectional Asthma STEroid Response Measurement.

J Pers Med 2020 Aug 20;10(3). Epub 2020 Aug 20.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.3390/jpm10030095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564544PMC
August 2020

Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD.

Eur Respir J 2020 Oct 29;56(4). Epub 2020 Oct 29.

Channing Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

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http://dx.doi.org/10.1183/13993003.02347-2019DOI Listing
October 2020

Genetic Signatures of Acute Asthma Exacerbation Related With Ineffective Response to Corticosteroid.

Allergy Asthma Immunol Res 2020 Jul;12(4):626-640

Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.

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http://dx.doi.org/10.4168/aair.2020.12.4.626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224997PMC
July 2020

Real-Life Patterns of Exacerbations While on Inhaled Corticosteroids and Long-Acting Beta Agonists for Asthma over 15 Years.

J Clin Med 2020 Mar 18;9(3). Epub 2020 Mar 18.

PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.3390/jcm9030819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141292PMC
March 2020

COMPSRA: a COMprehensive Platform for Small RNA-Seq data Analysis.

Sci Rep 2020 03 12;10(1):4552. Epub 2020 Mar 12.

The Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41598-020-61495-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067867PMC
March 2020

Genome-wide interaction study reveals age-dependent determinants of responsiveness to inhaled corticosteroids in individuals with asthma.

PLoS One 2020 2;15(3):e0229241. Epub 2020 Mar 2.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229241PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051058PMC
June 2020

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.

Genome Med 2020 03 2;12(1):25. Epub 2020 Mar 2.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13073-020-0716-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050134PMC
March 2020

A nuclease-polymerase chain reaction enables amplification of probes used for capture-based DNA target enrichment.

Nucleic Acids Res 2019 12;47(22):e147

Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/nar/gkz870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902007PMC
December 2019

DNA methylation is associated with inhaled corticosteroid response in persistent childhood asthmatics.

Clin Exp Allergy 2019 09 15;49(9):1225-1234. Epub 2019 Aug 15.

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1111/cea.13447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085934PMC
September 2019

MicroRNAs in COPD: small molecules with big potential.

Eur Respir J 2019 Apr 25;53(4). Epub 2019 Apr 25.

Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1183/13993003.00515-2019DOI Listing
April 2019

Reply.

J Allergy Clin Immunol 2019 05 12;143(5):1975. Epub 2019 Mar 12.

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2019.01.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065828PMC
May 2019

Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults.

J Allergy Clin Immunol 2019 04 20;143(4):1633-1635. Epub 2018 Dec 20.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Mass. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183277
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http://dx.doi.org/10.1016/j.jaci.2018.11.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451881PMC
April 2019

Pulmonary Neuroendocrine Cells Secrete γ-Aminobutyric Acid to Induce Goblet Cell Hyperplasia in Primate Models.

Am J Respir Cell Mol Biol 2019 06;60(6):687-694

6 Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1165/rcmb.2018-0179OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543741PMC
June 2019

Gene expression changes in lymphoblastoid cell lines and primary B cells by dexamethasone.

Pharmacogenet Genomics 2019 04;29(3):58-64

Department of Medicine, Channing Division of Network Medicine.

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http://dx.doi.org/10.1097/FPC.0000000000000365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172499PMC
April 2019

Remission of persistent childhood asthma: Early predictors of adult outcomes.

J Allergy Clin Immunol 2019 05 14;143(5):1752-1759.e6. Epub 2018 Nov 14.

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183159
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http://dx.doi.org/10.1016/j.jaci.2018.09.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061344PMC
May 2019

Whole genome sequencing identifies high-impact variants in well-known pharmacogenomic genes.

Pharmacogenomics J 2019 04 14;19(2):127-135. Epub 2018 Sep 14.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.

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http://dx.doi.org/10.1038/s41397-018-0048-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417988PMC
April 2019

Assessment of genetic factor and depression interactions for asthma symptom severity in cohorts of childhood and elderly asthmatics.

Exp Mol Med 2018 07 4;50(7):1-7. Epub 2018 Jul 4.

Department of Medicine, Channing Division of Network of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s12276-018-0110-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031659PMC
July 2018

Circulating microRNAs and prediction of asthma exacerbation in childhood asthma.

Respir Res 2018 06 26;19(1):128. Epub 2018 Jun 26.

Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s12931-018-0828-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020199PMC
June 2018

Adrenal insufficiency and ICS: genetics takes a breath.

Lancet Respir Med 2018 06 15;6(6):407-408. Epub 2018 Mar 15.

Brigham and Women's Hospital, Department of Medicine, Channing Division of Network Medicine, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/S2213-2600(18)30101-2DOI Listing
June 2018

The phosphatidylinositide 3-kinase (PI3K) signaling pathway is a determinant of zileuton response in adults with asthma.

Pharmacogenomics J 2018 09 3;18(5):665-677. Epub 2018 Jan 3.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41397-017-0006-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150906PMC
September 2018

Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort.

PLoS One 2017 27;12(7):e0180329. Epub 2017 Jul 27.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180329PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531511PMC
October 2017

Differential connectivity of gene regulatory networks distinguishes corticosteroid response in asthma.

J Allergy Clin Immunol 2018 04 20;141(4):1250-1258. Epub 2017 Jul 20.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.05.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775928PMC
April 2018

Genetic Signatures of Asthma Exacerbation.

Allergy Asthma Immunol Res 2017 May;9(3):191-199

The Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.4168/aair.2017.9.3.191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352570PMC
May 2017

Asthma remission: Predicting future airways responsiveness using an miRNA network.

J Allergy Clin Immunol 2017 08 24;140(2):598-600.e8. Epub 2017 Feb 24.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2017.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546990PMC
August 2017

Whole genome prediction and heritability of childhood asthma phenotypes.

Immun Inflamm Dis 2016 12 28;4(4):487-496. Epub 2016 Nov 28.

Channing Division of Network Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts.

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http://dx.doi.org/10.1002/iid3.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134727PMC
December 2016

Circulating MicroRNAs: Association with Lung Function in Asthma.

PLoS One 2016 30;11(6):e0157998. Epub 2016 Jun 30.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157998PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928864PMC
July 2017

Bronchodilator response following methacholine-induced bronchoconstriction predicts acute asthma exacerbations.

Eur Respir J 2016 07 13;48(1):104-14. Epub 2016 Apr 13.

The Channing Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1183/13993003.00182-2016DOI Listing
July 2016

CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids.

Immun Inflamm Dis 2015 Dec 14;3(4):350-9. Epub 2015 Jul 14.

Channing Division of Network Medicine, Department of MedicineBrigham and Women's Hospital and Harvard Medical SchoolBostonMassachusetts02115; Center for Child Health Care Studies, Department of Population MedicineHarvard Pilgrim Health Care Institute and Harvard Medical SchoolBostonMassachusetts02115.

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http://dx.doi.org/10.1002/iid3.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693729PMC
December 2015

Personalized management of asthma exacerbations: lessons from genetic studies.

Expert Rev Precis Med Drug Dev 2016 20;1(6):487-495. Epub 2016 Dec 20.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.

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http://dx.doi.org/10.1080/23808993.2016.1269600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642928PMC
December 2016

Vitamin D Modulates Expression of the Airway Smooth Muscle Transcriptome in Fatal Asthma.

PLoS One 2015 24;10(7):e0134057. Epub 2015 Jul 24.

Partners Personalized Medicine, Boston, MA, United States of America; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134057PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514847PMC
May 2016

Airway Obstruction Worsens in Young Adults with Asthma Who Become Obese.

J Allergy Clin Immunol Pract 2015 Sep-Oct;3(5):765-71.e2. Epub 2015 Jul 9.

The Channing Division of Network Medicine and the Division of Pulmonary/Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaip.2015.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568157PMC
July 2016

Asthma Pharmacogenomics: 2015 Update.

Curr Allergy Asthma Rep 2015 Jul;15(7):42

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA,

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http://dx.doi.org/10.1007/s11882-015-0544-yDOI Listing
July 2015

Genome-Wide Association Study Identifies Novel Pharmacogenomic Loci For Therapeutic Response to Montelukast in Asthma.

PLoS One 2015 17;10(6):e0129385. Epub 2015 Jun 17.

Channing Division of Network Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, United States of America; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129385PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470685PMC
April 2016

Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts.

J Allergy Clin Immunol 2015 Nov 27;136(5):1240-6.e1-8. Epub 2015 May 27.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749150057
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http://dx.doi.org/10.1016/j.jaci.2015.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641004PMC
November 2015

Measuring the corticosteroid responsiveness endophenotype in asthmatic patients.

J Allergy Clin Immunol 2015 Aug 5;136(2):274-81.e8. Epub 2015 May 5.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749150043
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http://dx.doi.org/10.1016/j.jaci.2015.03.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530065PMC
August 2015

A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma.

Hum Mol Genet 2015 Jun 12;24(11):3005-20. Epub 2015 Jan 12.

Center for Complex Networks Research, Department of Physics, Northeastern University, Boston, MA 02115, USA Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA Department of Theoretical Physics, Budapest University of Technology and Economics, H1111, Budapest, Hungary Center for Network Science, Central European University, Nador u. 9, 1051 Budapest, Hungary

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http://dx.doi.org/10.1093/hmg/ddv001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447811PMC
June 2015

Genomic architecture of pharmacological efficacy and adverse events.

Pharmacogenomics 2014 Dec;15(16):2025-48

Department of Bioengineering & Therapeutic Sciences, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.2217/pgs.14.144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308414PMC
December 2014

Pharmacogenomics in asthma therapy: where are we and where do we go?

Annu Rev Pharmacol Toxicol 2015 29;55:129-47. Epub 2014 Sep 29.

The Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115; email: , ,

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http://dx.doi.org/10.1146/annurev-pharmtox-010814-124543DOI Listing
September 2015

RNA-Seq transcriptome profiling identifies CRISPLD2 as a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells.

PLoS One 2014 13;9(6):e99625. Epub 2014 Jun 13.

Program in Molecular and Integrative Physiological Sciences, Departments of Environmental Health, and Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099625PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057123PMC
October 2015

Pharmacogenomics: novel loci identification via integrating gene differential analysis and eQTL analysis.

Hum Mol Genet 2014 Sep 25;23(18):5017-24. Epub 2014 Apr 25.

Channing Division of Network Medicine and Pulmonary Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston MA 02115, USA

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http://dx.doi.org/10.1093/hmg/ddu191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140460PMC
September 2014

The genomic origins of asthma.

Thorax 2014 May 25;69(5):481-7. Epub 2014 Mar 25.

Channing Division of Network Medicine, Brigham and Women's Hospital, , Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/thoraxjnl-2014-205166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343201PMC
May 2014

Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids.

J Allergy Clin Immunol 2014 Mar 31;133(3):664-9.e5. Epub 2014 Jan 31.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.12.1042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112383PMC
March 2014

Diagnostic accuracy of the bronchodilator response in children.

J Allergy Clin Immunol 2013 Sep 14;132(3):554-559.e5. Epub 2013 May 14.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2013.03.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759549PMC
September 2013

Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes.

Pharmacogenet Genomics 2013 Jun;23(6):324-8

Department of Medicine, Channing Division of Network Medicine, Brigham and Women’s Hospital, 181 Longwood Ave, Boston, MA 02115, USA.

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http://dx.doi.org/10.1097/FPC.0b013e3283607acfDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767309PMC
June 2013

Cotinine in human placenta predicts induction of gene expression in fetal tissues.

Drug Metab Dispos 2013 Feb 3;41(2):305-11. Epub 2012 Dec 3.

Division of Clinical Pharmacology and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1124/dmd.112.049999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558855PMC
February 2013

Maternal allergen exposure reprograms the developmental lung transcriptome in atopic and normoresponsive rat pups.

Am J Physiol Lung Cell Mol Physiol 2012 Nov 14;303(10):L899-911. Epub 2012 Sep 14.

Departments of Human Genetics, Montreal Children’s Hospital Research Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1152/ajplung.00179.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517678PMC
November 2012

Integrative systems biology approaches in asthma pharmacogenomics.

Pharmacogenomics 2012 Sep;13(12):1387-404

Channing Laboratory, Brigham & Women's Hospital & Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.2217/pgs.12.126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553555PMC
September 2012

Corticosteroid use and bone mineral accretion in children with asthma: effect modification by vitamin D.

J Allergy Clin Immunol 2012 Jul 16;130(1):53-60.e4. Epub 2012 May 16.

Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jaci.2012.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387323PMC
July 2012

Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus.

Am J Respir Crit Care Med 2012 Jun 26;185(12):1286-91. Epub 2012 Apr 26.

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1164/rccm.201111-2061OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381232PMC
June 2012

Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers.

BMC Med Genet 2011 Jun 30;12:90. Epub 2011 Jun 30.

Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/1471-2350-12-90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148549PMC
June 2011

Expression analysis of asthma candidate genes during human and murine lung development.

Respir Res 2011 Jun 23;12:86. Epub 2011 Jun 23.

Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/1465-9921-12-86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141421PMC
June 2011

Genome-wide association studies of family data in pharmacogenetics: a case study.

Curr Pharm Des 2009 ;15(32):3764-72

Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.2174/138161209789649493DOI Listing
January 2010

Pharmacogenetics of asthma therapy.

Curr Pharm Des 2009 ;15(32):3742-53

Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.2174/138161209789649510DOI Listing
January 2010

Novel approaches to pharmacogenomic investigations.

Curr Pharm Des 2009 ;15(32):3732-3

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http://dx.doi.org/10.2174/138161209789649501DOI Listing
January 2010

Transcriptomic analysis of human lung development.

Am J Respir Crit Care Med 2010 Jan 8;181(1):54-63. Epub 2009 Oct 8.

Children's Hospital Informatics Program, Harvard-MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1164/rccm.200907-1063OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797628PMC
January 2010

Genetics and pharmacogenetics of the leukotriene pathway.

J Allergy Clin Immunol 2009 Sep 8;124(3):422-7. Epub 2009 Aug 8.

Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02115, USA.

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http://dx.doi.org/10.1016/j.jaci.2009.06.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794036PMC
September 2009

PRKCA: a positional candidate gene for body mass index and asthma.

Am J Hum Genet 2009 Jul 2;85(1):87-96. Epub 2009 Jul 2.

Channing Laboratory, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ajhg.2009.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706964PMC
July 2009

In asthma, the apple falls faster than the pear.

J Allergy Clin Immunol 2009 May;123(5):1075-6

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http://dx.doi.org/10.1016/j.jaci.2009.03.037DOI Listing
May 2009

The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids.

J Allergy Clin Immunol 2009 Jun 28;123(6):1376-83.e7. Epub 2009 Feb 28.

Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1016/j.jaci.2009.01.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317788PMC
June 2009

5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci.

Pharmacogenet Genomics 2009 Mar;19(3):244-7

Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/FPC.0b013e328326e0b1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731688PMC
March 2009

Pharmacogenetics of asthma.

Curr Opin Pulm Med 2009 Jan;15(1):57-62

Centers for Pediatric Clinical Pharmacology and Pharmacogenetics, Nemours Children's Clinic, Jacksonville, Florida 32207, USA.

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http://dx.doi.org/10.1097/MCP.0b013e32831da8beDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754311PMC
January 2009

Clinical predictors and outcomes of consistent bronchodilator response in the childhood asthma management program.

J Allergy Clin Immunol 2008 Nov 10;122(5):921-928.e4. Epub 2008 Oct 10.

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jaci.2008.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947830PMC
November 2008

Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthma.

Pharmacogenet Genomics 2008 Aug;18(8):733-7

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1097/FPC.0b013e3282fe6ebfDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225071PMC
August 2008

CRHR1 polymorphisms predict bone density in survivors of acute lymphoblastic leukemia.

J Clin Oncol 2008 Jun;26(18):3031-7

Department of Radiology, Colleges of Pharmacy and Medicine, University of Tennessee, Memphis, TN, USA.

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http://dx.doi.org/10.1200/JCO.2007.14.6399DOI Listing
June 2008

Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history.

Am J Respir Crit Care Med 2008 Aug 17;178(4):325-31. Epub 2008 Apr 17.

Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1164/rccm.200708-1174OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542438PMC
August 2008

FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma.

J Allergy Clin Immunol 2007 Dec 5;120(6):1285-91. Epub 2007 Nov 5.

Channing Laboratory, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jaci.2007.09.005DOI Listing
December 2007

The pharmacogenetics of asthma therapy.

Curr Drug Targets 2006 Dec;7(12):1697-708

Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.2174/138945006779025374DOI Listing
December 2006

Bronchodilation and bronchoconstriction: predictors of future lung function in childhood asthma.

J Allergy Clin Immunol 2006 Jun 27;117(6):1264-71. Epub 2006 Apr 27.

Channing Laboratory, Pulmonary Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jaci.2006.01.050DOI Listing
June 2006