Publications by authors named "Keivan Keramati"

4 Publications

  • Page 1 of 1

Data for zonisamide effect on length and weight of 14 day-old rat pups and abortion rate and day in refractory epileptic pregnant rats.

Data Brief 2018 Apr 20;17:279-283. Epub 2018 Jan 20.

Department of Animal Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.

Length and weight of 14 day-old rat pups and also abortion rate and day on refractory epileptic pregnant rats after treatment with zonisamide (ZNS) are presented. Lamotrigine-resistant chemical kindling procedure was used for inducing of refractory epilepsy. For further interpretation follow the research article: Effect of zonisamide on refractory epilepsy during pregnancy in lamotrigine resistant kindled rats (Sani et al., 2017) [1].
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http://dx.doi.org/10.1016/j.dib.2018.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988214PMC
April 2018

Effect of zonisamide on refractory epilepsy during pregnancy in lamotrigine resistant kindled rats.

Neurosci Lett 2018 01 11;664:91-97. Epub 2017 Nov 11.

Department of Animal Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.

Drug-resistant epilepsy with uncontrolled severe seizures despite state-of-the-art medical treatment continues to be a major clinical problem. Pregnancy is a state where drug pharmacokinetic changes are more pronounced and more rapid than any other period of life. The current study investigated the effect of zonisamide (ZNS) on refractory epilepsy during pregnancy in lamotrigine-resistant kindled rats. Fifty-six lamotrigine (LTG)-resistant kindled Wistar rats were divided into five experimental (four pregnant and one non-pregnant) and 2 positive controls (pregnant and non-pregnant) groups and eight intact Wistar rats were put in the negative pregnant control group. Experimental groups received daily ZNS 50mg/kg by oral gavage and 30min later, pentylenetetrazol (PTZ) (30mg/kg) was injected intraperitoneal (i.p) on Gestational Days 10-15 (in rats with or without ZNS or methanol and ethyl acetate as a ZNS solvent challenge in days -5 to 0) or Days 15-20 and for six days in the non-pregnant group. The positive control groups received the ZNS solvent for the same number of days, but the negative pregnant control group did not receive any treatment. Epilepsy was significantly controlled by ZNS in the experimental groups compared to the positive control groups. It was concluded that ZNS can control refractory epilepsy during pregnancy and increase pregnancy survival in refractory epileptic rats.
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http://dx.doi.org/10.1016/j.neulet.2017.11.020DOI Listing
January 2018

Evaluation of the protective effect of pentoxifylline on carrageenan-induced chronic non-bacterial prostatitis in rats.

Inflammopharmacology 2017 Jun 9;25(3):343-350. Epub 2017 Mar 9.

Department of Clinical Sciences, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran.

Chronic non-bacterial prostatitis (CNP) is the most common type of prostatitis and oxidative stress (OS) was shown to be highly elevated in prostatitis patients. This study aimed to investigate the protective effect of pentoxifylline (PTX) on CNP induced by carrageenan in rats. Male adult Wistar rats (n = 30) were divided into control, CNP and three treatment groups (n = 6) including CNP + cernilton and CNP + PTX groups. CNP was induced by single intraprostatic injection of 1% carrageenan (100 µl). Rats in treatment groups received orally cernilton 100 mg/kg and PTX at 50 and 100 mg/kg 1 week after CNP induction for 21 days. Prostatic index (PI), prostatic specific antigen (PSA), tumor-necrosis factor alpha (TNF-α), serum lipid peroxidation (MDA), blood urea nitrogen, creatinine and histopathological changes were compared between groups. There were significant increase of PI, serum levels of PSA, TNF-α and MDA in CNP group at 29 day. In treatment groups, significant reduction in PI, serum levels of PSA, TNF-α, MDA and creatinine was observed especially in rats treated with dose of 50 mg/kg of PTX. In CNP group, histopathological changes of the prostate such as leucocyte infiltration, large involutions and projection into the lumen and reducing the volume of the lumen were observed as well. Whereas PTX, especially at dose of 50 mg/kg, could improve the above-mentioned changes remarkably in CNP treated rats. For the first time, our findings indicated that PTX improved CNP induced by carrageenan in rats.
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http://dx.doi.org/10.1007/s10787-017-0335-2DOI Listing
June 2017

Motor disturbances and thalamic electrical power of frequency bands' improve by grape seed extract in animal model of Parkinson's disease.

Avicenna J Phytomed 2012 ;2(4):222-32

Department of physiology, Medicine Faculty, Physiology Research Center (PRC), Ahvaz Jundishpur University of Medical Sciences, Ahvaz, I.R. Iran.

Objective: Previous studies showed that grape seed extract (GSE) is an excellent natural substance with potent antioxidant effect and free radical scavenger. This study aimed to evaluate the effect of GSE on motor dysfunctions and thalamic local Electroencephalography (EEG) frequency bands' powers in rats with Parkinson's disease (PD).

Materials And Methods: In this study 8 µg 6-hydroxydopamine (6-OHDA) dissolved in 2 µl normal saline containing 0.01% ascorbic acid was infused into right medial forebrain bundle (MFB) to make an animal model of PD. Rats with PD received four weeks GSE (100 mg/kg, p.o.) after apomorphine-induced rotation test. Spontaneous motor tests and also thalamic ventroanterior nucleus (AV) local EEG recording were done in freely moving rats in all groups.

Results: Chronic treatment of PD rats with GSE could influence potentially frequency bands' powers of thalamic VA and improve post-lesion motor dysfunctions significantly (p<0.05 and p<0.01, respectively).

Conclusion: Our findings suggest that GSE modulates the CNS function and has beneficial effects on the direct and indirect striato-thalamo-cortical pathways in PD. GSE acts as a new and potent natural free radical scavenger which removes oxidants produced by neurotoxin 6-OHDA in brain. Therefore, it reinforces electrical power of remained thalamic VA neurons and thereby improves post-lesion motor disorders.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075680PMC
July 2014
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