Keith Wheatley

Keith Wheatley

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Keith Wheatley

Keith Wheatley

Publications by authors named "Keith Wheatley"

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100Publications

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High-Dose Chemotherapy and Blood Autologous Stem-Cell Rescue Compared With Standard Chemotherapy in Localized High-Risk Ewing Sarcoma: Results of Euro-E.W.I.N.G.99 and Ewing-2008.

J Clin Oncol 2018 Sep 6:JCO2018782516. Epub 2018 Sep 6.

Jeremy Whelan, University College Hospital; Ian Judson, Institute of Cancer Research, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Bruce Morland, Birmingham Children's Hospital; Keith Wheatley, University of Birmingham, Birmingham; Ian Lewis, Leeds Community Healthcare National Health Service Trust, Leeds; Alan Craft, Newcastle University, Newcastle upon Tyne, United Kingdom; Marie-Cecile Le Deley and Cyril Lervat, Centre Oscar Lambret, Lille; Gwénaël Le Teuff, Nathalie Gaspar, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Jean-Yves Blay, Centre Léon Bérard; Perrine Marec-Berard, Institute of Pediatric Onco-Haematology, Lyon; Marie-Pierre Castex, Centre Hospitalier Universitaire de Toulouse, Toulouse; Jean-Claude Gentet, Centre Hospitalier Universitaire La Timone, Marseille; Marta Jimenez, Unicancer; Valerie Laurence and Jean Michon, Institut Curie, Paris; France; Uta Dirksen, Sebastian Bauer, Andreas Ranft, University Hospital Essen, Essen; Susanne Amler, Institut für Biometrie und Klinische Forschung; Wolfgang Hartmann and Heribert Juergens, Universitätsklinikum, Münster, Münster; Stefan Bielack, Klinikum Stuttgart, Stuttgart; Stefan Burdach, Comprehensive Cancer Center, München; Dagmar Dilloo, University-Clinic Bonn, Bonn; Angelika Eggert, Charité University; Peter Reichardt, HELIOS Klinikum Berlin-Buch, Berlin; Wolf-Achim Hassenpflug, University Medical Center Hamburg-Eppendorf, Hamburg; Thomas Klingebiel, Childrens University Hospital, Frankfurt; Udo Kontny, University Medical Center Aachen, Aachen; Michael Paulussen, Children's and Adolescents' Hospital, Datteln; Germany; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Hans Gelderblom, Leiden University Medical Center, Leiden; Hendrik van den Berg, University of Amsterdam, Amsterdam, the Netherlands; Lars Hjorth, Skane University Hospital, Lund, Sweden; Jarmila Kruseova, Faculty Hospital Motol Prague, Prague, Czech Republic; Ruth Ladenstein, St Anna Children's Hospital and Children's Cancer Research Institute, Vienna, Austria; Sandrine Marreaud, European Organisation for Research and Treatment of Cancer, Brussels, Belgium.

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September 2018

Hydroxycarbamide Plus Aspirin Versus Aspirin Alone in Patients With Essential Thrombocythemia Age 40 to 59 Years Without High-Risk Features.

J Clin Oncol 2018 Aug 28:JCO2018788414. Epub 2018 Aug 28.

Anna L. Godfrey, Jacob Grinfeld, and Anthony R. Green, Cambridge University Hospitals National Health Service (NHS) Foundation Trust; Peter J. Campbell and Jyoti Nangalia, Wellcome Trust Sanger Institute, Hinxton; Cathy MacLean, Julia Cook, Julie Temple, and Anthony R. Green, University of Cambridge; Anthony R. Green, Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge; Georgina Buck, University of Oxford, Oxford; Bridget S. Wilkins and Claire N. Harrison, Guy's and St Thomas' NHS Foundation Trust, London; Keith Wheatley, University of Birmingham, Birmingham; Mary Frances McMullin, Queen's University Belfast, Belfast, United Kingdom; Cecily Forsyth, Gosford Hospital, Gosford, and Australasian Leukaemia and Lymphoma Group, Australia; and Jean-Jacques Kiladjian, Hôpital Saint-Louis, Paris, France.

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August 2018

Immunohistochemical evaluation of molecular radiotherapy target expression in neuroblastoma tissue.

Eur J Nucl Med Mol Imaging 2018 03 17;45(3):402-411. Epub 2017 Oct 17.

Department of Oncology, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London, NW1 2PG, UK.

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March 2018

Relapse-Free Survival as a Surrogate for Overall Survival in the Evaluation of Stage II-III Melanoma Adjuvant Therapy.

J Natl Cancer Inst 2018 Jan;110(1)

European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium; Gustave Roussy Cancer Campus Grand Paris, Villejuif, France; The Christie NHS Foundation Trust, Manchester, UK; University of Pittsburgh Cancer Institute and School of Medicine, Pittsburgh, PA; Mayo Clinic Rochester, Rochester, MN; University of Tubingen, Tubingen, Germany; University of Edinburgh, Western General Hospital, Edinburgh, UK; Bristol-Myers Squibb, Wallingford, CT; Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK; Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK; Universitas Brawijaya, Malang, Indonesia; IDDI, Louvain-la-Neuve, Belgium.

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January 2018

Adjuvant interferon-α for the treatment of high-risk melanoma: An individual patient data meta-analysis.

Eur J Cancer 2017 09 7;82:171-183. Epub 2017 Jul 7.

Cancer Research UK Clinical Trials Unit, College of Medical and Dental Sciences, Robert Aitken Institute, University of Birmingham, Birmingham, B15 2TT, UK. Electronic address:

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September 2017

Reply to response to Wheatley et al., "Surgical excision margins in primary cutaneous melanoma: A meta-analysis and Bayesian probability evaluation" Cancer Treatment Reviews April 2016;45:76.

Cancer Treat Rev 2017 04 15;55:225-229. Epub 2016 Jul 15.

FRCP Skin Oncology Service, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, United Kingdom.

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April 2017

Mutational analysis of disease relapse in patients allografted for acute myeloid leukemia.

Blood Adv 2016 Dec 14;1(3):193-204. Epub 2016 Dec 14.

Centre for Clinical Haematology, Queen Elizabeth Hospital University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.

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December 2016

Bortezomib for the treatment of multiple myeloma.

Cochrane Database Syst Rev 2016 Apr 20;4:CD010816. Epub 2016 Apr 20.

School of Nursing & Midwifery, Trinity College Dublin, 24 D'Olier St, Dublin, Ireland.

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April 2016

Surgical excision margins in primary cutaneous melanoma: A meta-analysis and Bayesian probability evaluation.

Cancer Treat Rev 2016 Jan 10;42:73-81. Epub 2015 Nov 10.

Skin Oncology Service, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, United Kingdom.

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January 2016

Comparing results from long and short form versions of the Parkinson's disease questionnaire in a longitudinal study.

Parkinsonism Relat Disord 2015 Nov 3;21(11):1312-6. Epub 2015 Sep 3.

Department of Neurology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

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November 2015

Systematic review and meta-analysis of hydrocarbon exposure and the risk of Parkinson's disease.

Parkinsonism Relat Disord 2015 Mar 26;21(3):243-8. Epub 2014 Dec 26.

School of Clinical and Experimental Medicine, College of Medicine and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK; Department of Neurology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK. Electronic address:

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March 2015

Comparison of anticipated and actual control group outcomes in randomised trials in paediatric oncology provides evidence that historically controlled studies are biased in favour of the novel treatment.

Trials 2014 Dec 10;15:481. Epub 2014 Dec 10.

Cancer Research UK Clinical Trials Unit, School of Cancer Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.

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December 2014

Cyclophosphamide compared with ifosfamide in consolidation treatment of standard-risk Ewing sarcoma: results of the randomized noninferiority Euro-EWING99-R1 trial.

J Clin Oncol 2014 Aug 30;32(23):2440-8. Epub 2014 Jun 30.

Odile Oberlin, Gustave Roussy Institute, Villejuif; Marie-Cécile Le Deley, Université Paris-Sud, Le Kremlin-Bicêtre; Jean Michon, Institut Curie, Paris; Perrine Marec-Bérard, Centre Léon-Bérard, Lyon, France; Michael Paulussen, Vestische Kinder-und Jugendklinik Datteln, Witten/Herdecke University, Datteln; Andreas Ranft, Heribert Juergens, and Uta Dirksen, University Hospital Münster, Münster, Germany; Ian Lewis, Alder Hey Children's National Health Service Foundation Trust, Liverpool; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Jeremy Whelan, University College London Hospital National Health Service Foundation Trust; Ian Judson, The Royal Marsden Hospital, London; Keith Wheatley, University of Birmingham, Birmingham; Alan Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Ruth Ladenstein, St Anna Children's Cancer Research Institute, Vienna, Austria; Henk van den Berg, Emma Children Hospital AMC, Amsterdam, the Netherlands; and Lars Hjorth, Skåne University Hospital, Lund University, Lund, Sweden.

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August 2014

Physiotherapy for Parkinson's disease: a comparison of techniques.

Cochrane Database Syst Rev 2014 Jun 17(6):CD002815. Epub 2014 Jun 17.

Birmingham Clinical Trials Unit, University of Birmingham, Robert Aitken Institute, Edgbaston, Birmingham, UK, B15 2TT.

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June 2014

A systematic review of 131I-meta iodobenzylguanidine molecular radiotherapy for neuroblastoma.

Eur J Cancer 2014 Mar 12;50(4):801-15. Epub 2013 Dec 12.

Department of Oncology, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PG, United Kingdom. Electronic address:

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March 2014

Optimization of chemotherapy for younger patients with acute myeloid leukemia: results of the medical research council AML15 trial.

J Clin Oncol 2013 Sep 12;31(27):3360-8. Epub 2013 Aug 12.

Alan K. Burnett and Robert K. Hills, Cardiff University School of Medicine, Cardiff; Nigel H. Russell, Nottingham University Hospital National Health Service Trust, Nottingham; Ann E. Hunter, Leicester Royal Infirmary, Leicester; John Yin, Manchester Royal Infirmary, Manchester Brenda E.S. Gibson, Royal Hospital for Sick Children, Yorkhill, Glasgow; Keith Wheatley, Cancer Research UK Clinical Trials Unit, University of Birmingham; and Donald Milligan, Birmingham Heartlands Hospital, Birmingham, United Kingdom; and Lars Kjeldsen, Rigshopitalet, Copenhagen, Denmark.

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September 2013

Physiotherapy versus placebo or no intervention in Parkinson's disease.

Cochrane Database Syst Rev 2013 Sep 10(9):CD002817. Epub 2013 Sep 10.

Birmingham Clinical Trials Unit, University of Birmingham, Robert Aitken Institute, Edgbaston, Birmingham, UK, B15 2TT.

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September 2013

Curability of patients with acute myeloid leukemia who did not undergo transplantation in first remission.

J Clin Oncol 2013 Apr 25;31(10):1293-301. Epub 2013 Feb 25.

Department of Haematology, Cardiff University School of Medicine, Heath Park, Cardiff, UK.

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April 2013

Intensity-modulated arc therapy to improve radiation dose delivery in the treatment of abdominal neuroblastoma.

Future Oncol 2013 Mar;9(3):439-49

Department of Oncology, University College London Hospitals NHS Foundation Trust, First Floor Central, 250 Euston Road, London NW1 2PG, UK.

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March 2013

Plasma exchange and glucocorticoid dosing in the treatment of anti-neutrophil cytoplasm antibody associated vasculitis (PEXIVAS): protocol for a randomized controlled trial.

Trials 2013 Mar 14;14:73. Epub 2013 Mar 14.

Departments of Medicine and Clinical Epidemiology & Biostatistics, Marian Wing, Division of Nephrology, McMaster University, St, Joseph's Hospital, 50 Charlton Ave East, Hamilton, ON L8S 4A6, Canada.

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March 2013

Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia.

J Clin Oncol 2012 Nov 30;30(32):3924-31. Epub 2012 Jul 30.

FMedSci, Department of Haematology, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN United Kingdom.

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November 2012

Physiotherapy versus placebo or no intervention in Parkinson's disease.

Cochrane Database Syst Rev 2012 Aug 15(8):CD002817. Epub 2012 Aug 15.

Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK.

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August 2012

Physiotherapy versus placebo or no intervention in Parkinson's disease.

Cochrane Database Syst Rev 2012 Jul 11(7):CD002817. Epub 2012 Jul 11.

Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK.

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July 2012

Bisphosphonates in multiple myeloma: a network meta-analysis.

Cochrane Database Syst Rev 2012 May 16(5):CD003188. Epub 2012 May 16.

Center for Evidence Based Medicine and Health Outcomes Research, University of South Florida, Tampa, Florida, USA.

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May 2012

Results of a randomized trial in children with Acute Myeloid Leukaemia: medical research council AML12 trial.

Br J Haematol 2011 Nov 9;155(3):366-76. Epub 2011 Sep 9.

Department of Haematology, Royal Hospital for Sick Children, Glasgow G3 8SJ, Scotland, UK.

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November 2011

PEPtalk: postexposure prophylaxis against varicella in children with cancer.

Arch Dis Child 2011 Sep 28;96(9):841-5. Epub 2011 Jun 28.

Division of Clinical Sciences, St George's, University of London, London, UK.

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September 2011

Should treatment for Parkinson's disease start immediately on diagnosis or delayed until functional disability develops?

Mov Disord 2011 Jun 14;26(7):1187-93. Epub 2011 Apr 14.

Department of Neurology, City Hospital, Sandwell and West Birmingham NHS Trust, Dudley Road, Birmingham, United Kingdom.

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June 2011

A randomised controlled trial of treatment for idiopathic intracranial hypertension.

J Neurol 2011 May 16;258(5):874-81. Epub 2010 Dec 16.

Department of Neurology, School of Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

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May 2011

Meta-analysis of the comparative efficacy and safety of adjuvant treatment to levodopa in later Parkinson's disease.

Mov Disord 2011 Mar 2;26(4):587-98. Epub 2011 Mar 2.

Birmingham Clinical Trials Unit, College of Medical & Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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March 2011

Evaluation of the efficacy and safety of adjuvant treatment to levodopa therapy in Parkinson s disease patients with motor complications.

Cochrane Database Syst Rev 2010 Jul 7(7):CD007166. Epub 2010 Jul 7.

Birmingham Clinical Trials Unit, University of Birmingham, Edgbaston, Birmingham, UK, B15 2TT.

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July 2010

Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12.

J Clin Oncol 2010 Jun 3;28(16):2674-81. Epub 2010 May 3.

Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Queen Victoria Road, Newcastle-upon-Tyne, UK.

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June 2010

Bisphosphonates in multiple myeloma.

Cochrane Database Syst Rev 2010 Mar 17(3):CD003188. Epub 2010 Mar 17.

Center for Evidence-based medicine and Health Outcomes Research, University of South Florida, Tampa, Florida, USA.

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March 2010

Balancing treatment allocations by clinician or center in randomized trials allows unacceptable levels of treatment prediction.

J Evid Based Med 2009 Aug;2(3):196-204

Department of Haematology, Cardiff University School of Medicine, Cardiff, UK.

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August 2009

Prognostic factor analysis of the survival of elderly patients with AML in the MRC AML11 and LRF AML14 trials.

Br J Haematol 2009 Jun 26;145(5):598-605. Epub 2009 Mar 26.

Birmingham Clinical Trials Unit, School of Cancer Sciences, Robert Aitken Institute, University of Birmingham, Edgbaston, Birmingham, UK.

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June 2009

Reticulin accumulation in essential thrombocythemia: prognostic significance and relationship to therapy.

J Clin Oncol 2009 Jun 13;27(18):2991-9. Epub 2009 Apr 13.

Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

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June 2009

Calcineurin inhibitor sparing with mycophenolate in kidney transplantation: a systematic review and meta-analysis.

Transplantation 2009 Feb;87(4):591-605

Department of Nephrology and Kidney Transplantation, Renal Institute of Birmingham, University Hospital Birmingham, Edgbaston, Birmingham, United Kingdom.

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February 2009

Bone marrow pathology in essential thrombocythemia: interobserver reliability and utility for identifying disease subtypes.

Blood 2008 Jan 20;111(1):60-70. Epub 2007 Sep 20.

Department of Cellular Pathology, Newcastle-upon-Tyne Hospitals National Health Service (NHS) Foundation Trust and Newcastle University, Newcastle-upon-Tyne, UK.

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January 2008

Chemotherapy compared with biochemotherapy for the treatment of metastatic melanoma: a meta-analysis of 18 trials involving 2,621 patients.

J Clin Oncol 2007 Dec;25(34):5426-34

Birmingham Clinical Trials Unit, Division of Medical Sciences, Robert Aitken Institute, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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December 2007

Problems with up-front randomization in clinical trials.

J Clin Oncol 2006 Dec;24(34):5471-2; author reply 5472-3

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December 2006

Long-term results of the MRC AML10 trial.

Clin Adv Hematol Oncol 2006 Jun;4(6):445-51

Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom.

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June 2006

Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia.

N Engl J Med 2005 Jul;353(1):33-45

Department of Haematology, University of Cambridge, and Addenbrooke's National Health Service Trust, Cambridge, United Kingdom.

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July 2005

Adjuvant interferon therapy for melanoma.

J Clin Oncol 2005 Apr;23(10):2431; author reply 2431-2

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April 2005

Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy.

Blood 2004 Dec 31;104(13):3872-7. Epub 2004 Aug 31.

Epidemiology and Genetics Unit, Department of Biology, University of York, York, United Kingdom, YO10 5YW.

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December 2004

Cabergoline versus levodopa monotherapy.

Mov Disord 2004 Jun;19(6):733-4; author reply 734-5

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June 2004

Commentary: Mendelian randomization--an update on its use to evaluate allogeneic stem cell transplantation in leukaemia.

Int J Epidemiol 2004 Feb;33(1):15-7

University of Birmingham Clinical Trials Unit, 1 Somerset Road, Birmingham B15 2RR, UK.

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February 2004

High-dose chemotherapy for breast cancer.

N Engl J Med 2003 Oct;349(15):1476-9; author reply 1476-9

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October 2003

Does adjuvant interferon-alpha for high-risk melanoma provide a worthwhile benefit? A meta-analysis of the randomised trials.

Cancer Treat Rev 2003 Aug;29(4):241-52

University of Birmingham Clinical Trials Unit, Park Grange, 1 Somerset Road, Edgbaston, Birmingham, B15 2RR, UK.

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August 2003