Keith W Caldecott

Keith W Caldecott

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Keith W Caldecott

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Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation.

Viruses 2020 Jan 31;12(2). Epub 2020 Jan 31.

Department of Microbiology & Molecular Genetics and Center for Virus Research, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.3390/v12020166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077319PMC
January 2020

Homozygous pathogenic variant in associated with nonprogressive cerebellar ataxia.

Neurol Genet 2019 Oct 4;5(5):e359. Epub 2019 Sep 4.

Division of Neurology (A.M., G.Y.), Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Canada; Department of Genome Dynamics (Z.C., K.W.C., H.H.), Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Science (Z.C.), Charles University in Prague, Czech Republic; Department of Neuroscience (M.T.), Université de Montréal, CHUM, Montréal, Québec, Canada; Department of Paediatric Laboratory Medicine (L.M.), Hospital for Sick Children; Department of Lab Medicine and Pathobiology (L.M.), University of Toronto, Ontario, Canada; Program in Genetics and Genome Biology (N.S.), SickKids Research Institute, Toronto, Ontario, Canada; Division of Clinical and Metabolic Genetics (N.S., G.Y.), Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Canada; and Genome Damage and Stability Centre (K.W.C., H.H.), School of Life Sciences, University of Sussex, Falmer, Brighton, UK.

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http://dx.doi.org/10.1212/NXG.0000000000000359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773431PMC
October 2019

XRCC1 protein; Form and function.

DNA Repair (Amst) 2019 09 8;81:102664. Epub 2019 Jul 8.

Genome Damage and Stability Centre, School of Life Sciences, Falmer, Brighton, BN1 9RQ, United Kingdom; Department of Genome Dynamics, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20, Prague, 4, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2019.102664DOI Listing
September 2019

Perspectives on PARPs in S Phase.

Trends Genet 2019 Jun 26;35(6):412-422. Epub 2019 Apr 26.

Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK; Department of Genome Dynamics, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague, 4, Czech Republic. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01689525193005
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http://dx.doi.org/10.1016/j.tig.2019.03.008DOI Listing
June 2019

Deazaflavin Inhibitors of TDP2 with Cellular Activity Can Affect Etoposide Influx and/or Efflux.

ACS Chem Biol 2019 06 16;14(6):1110-1114. Epub 2019 May 16.

Genome Damage and Stability Centre, School of Life Sciences , University of Sussex , Falmer, Brighton , BN1 9RQ , United Kingdom.

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http://dx.doi.org/10.1021/acschembio.9b00144DOI Listing
June 2019

Novel PNKP mutations causing defective DNA strand break repair and PARP1 hyperactivity in MCSZ.

Neurol Genet 2019 Apr 25;5(2):e320. Epub 2019 Mar 25.

Department of Genome Dynamics (I.K., H.H., K.W.C.), Institute of Molecular Genetics of the Czech Academy of Sciences, Czech Republic; Genome Damage and Stability Centre (H.H., K.W.C.), School of Life Sciences, University of Sussex, Falmer, Brighton, UK; Institute of Human Genetics (Y.L., B.W., G.Y.), University Medical Center Göttingen, Germany; Cologne Center for Genomics (J.A.), University of Cologne, Germany; Institute of Cancer and Genomic Sciences (J.J.R., G.S.S.), College of Medical and Dental Sciences, University of Birmingham, UK; and Division of Genetics (N.G.), Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1212/NXG.0000000000000320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454307PMC
April 2019

Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1.

Cell Rep 2019 01;26(3):573-581.e5

Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RQ, UK; Division of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW1E 6BT, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183204
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http://dx.doi.org/10.1016/j.celrep.2018.12.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334254PMC
January 2019

Nonsyndromic cerebellar ataxias associated with disorders of DNA single-strand break repair.

Handb Clin Neurol 2018 ;155:105-115

Genome Damage and Stability Centre, University of Sussex, Brighton, United Kingdom.

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http://dx.doi.org/10.1016/B978-0-444-64189-2.00007-XDOI Listing
October 2018

Confirming TDP2 mutation in spinocerebellar ataxia autosomal recessive 23 (SCAR23).

Neurol Genet 2018 08 1;4(4):e262. Epub 2018 Aug 1.

Genome Damage and Stability Centre (G.Z-V., K.W.C.), University of Sussex, Falmer, Brighton, United Kingdom; Wellcome Centre for Mitochondrial Research (F.B., K.T., L.H., R.T.), Institute of Neuroscience, Newcastle University, Tyne, United Kingdom; Sussex Drug Discovery Centre (S.W.), University of Sussex, Falmer, Brighton, United Kingdom; Department of Human Genetics (A.P.M.d.B.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands; and Medical Genetics (A.P.M.d.B., D.N.), Ochsner Health Center for Children, New Orleans, LA.

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http://dx.doi.org/10.1212/NXG.0000000000000262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089694PMC
August 2018

The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication.

Mol Cell 2018 07 5;71(2):319-331.e3. Epub 2018 Jul 5.

Genome Damage and Stability Centre & Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RQ, UK; Department of Genome Dynamics, Institute of Molecular Genetics of the ASCR, v.v.i., 142 20 Prague 4, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060609PMC
July 2018

TDP2, TOP2, and SUMO: what is ZATT about?

Cell Res 2017 12 21;27(12):1405-1406. Epub 2017 Nov 21.

Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, BN1 9RQ, United Kingdom.

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http://dx.doi.org/10.1038/cr.2017.147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717409PMC
December 2017

Acylpeptide hydrolase is a component of the cellular response to DNA damage.

DNA Repair (Amst) 2017 10 24;58:52-61. Epub 2017 Aug 24.

Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.08.008DOI Listing
October 2017

The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair.

J Biol Chem 2017 09 16;292(39):16024-16031. Epub 2017 Aug 16.

From the Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Science Park Road, Falmer, Brighton BN19RQ, United Kingdom,

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http://dx.doi.org/10.1074/jbc.M117.806638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625035PMC
September 2017

TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription.

Nat Commun 2017 08 10;8(1):233. Epub 2017 Aug 10.

Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9RQ, UK.

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http://dx.doi.org/10.1038/s41467-017-00307-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550487PMC
August 2017

Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin.

Nucleic Acids Res 2017 03;45(5):2546-2557

Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9RQ, UK.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkw1246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389470PMC
March 2017

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2).

Nat Commun 2016 08 17;7:12404. Epub 2016 Aug 17.

Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK.

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http://dx.doi.org/10.1038/ncomms12404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992063PMC
August 2016

Does Tyrosyl DNA Phosphodiesterase-2 Play a Role in Hepatitis B Virus Genome Repair?

PLoS One 2015 16;10(6):e0128401. Epub 2015 Jun 16.

Department of Microbiology and Immunology, Hershey, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128401PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469307PMC
April 2016

The Yin and Yang of DAXX regulation.

Cell Cycle 2015 ;14(3):295-6

a Genome Damage and Stability Centre ; Falmer ; Brighton , UK.

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http://dx.doi.org/10.1080/15384101.2015.1006552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353225PMC
December 2015

Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections.

mBio 2015 Dec 29;7(1):e01931-15. Epub 2015 Dec 29.

Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California, USA

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http://escholarship.org/uc/item/66z231vq.pdf
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http://mbio.asm.org/lookup/doi/10.1128/mBio.01931-15
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http://dx.doi.org/10.1128/mBio.01931-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725011PMC
December 2015

Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains.

DNA Repair (Amst) 2015 Nov 23;35:116-25. Epub 2015 Oct 23.

Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW7 1AA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2015.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655838PMC
November 2015

The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function.

Nucleic Acids Res 2015 Aug 29;43(14):6934-44. Epub 2015 Jun 29.

Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RQ, UK

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http://dx.doi.org/10.1093/nar/gkv623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538820PMC
August 2015

Identification and Functional Characterizations of N-Terminal α-N-Methylation and Phosphorylation of Serine 461 in Human Poly(ADP-ribose) Polymerase 3.

J Proteome Res 2015 Jun 27;14(6):2575-82. Epub 2015 Apr 27.

†Department of Chemistry, University of California, Riverside, California 92521-0403, United States.

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http://dx.doi.org/10.1021/acs.jproteome.5b00126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703312PMC
June 2015

DNA single-strand break repair.

Exp Cell Res 2014 Nov 28;329(1):2-8. Epub 2014 Aug 28.

Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2014.08.027DOI Listing
November 2014

One ring to bring them all--the role of Ku in mammalian non-homologous end joining.

DNA Repair (Amst) 2014 May 26;17:30-8. Epub 2014 Mar 26.

Genome Damage and Stability Centre, Science Park Road, Falmer, Brighton BN1 9RQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2014.02.019DOI Listing
May 2014

PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.

Nucleic Acids Res 2014 Jan 18;42(1):307-14. Epub 2013 Sep 18.

Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9RQ, UK and School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG.

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http://dx.doi.org/10.1093/nar/gkt835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874156PMC
January 2014

Molecular biology. Ribose--an internal threat to DNA.

Science 2014 Jan;343(6168):260-1

Genome Damage and Stability Centre, University of Sussex, Falmer, UK.

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http://dx.doi.org/10.1126/science.1248234DOI Listing
January 2014

DNA strand break repair and neurodegeneration.

DNA Repair (Amst) 2013 Aug 24;12(8):558-67. Epub 2013 May 24.

Genome Damage and Stability Centre, Science Park Road, Falmer, Brighton BN1 9RQ, UK.

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http://dx.doi.org/10.1016/j.dnarep.2013.04.008DOI Listing
August 2013

Tyrosyl DNA phosphodiesterase 2, an enzyme fit for purpose.

Nat Struct Mol Biol 2012 Dec;19(12):1212-3

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http://dx.doi.org/10.1038/nsmb.2455DOI Listing
December 2012

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

Nucleic Acids Res 2012 Sep 26;40(17):8371-80. Epub 2012 Jun 26.

School of Life Sciences, Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK.

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http://dx.doi.org/10.1093/nar/gks622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458563PMC
September 2012

Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair.

Nucleic Acids Res 2012 Aug 15;40(14):6608-19. Epub 2012 Apr 15.

Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton, BN1 9RQ, UK.

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http://dx.doi.org/10.1093/nar/gks318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413127PMC
August 2012

TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.

J Biol Chem 2011 Jan 28;286(1):403-9. Epub 2010 Oct 28.

Genome Damage and Stability Centre, Science Park Road, University of Sussex, Falmer, Brighton, BN1 9RQ, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.181016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012998PMC
January 2011

PARP-3 and APLF function together to accelerate nonhomologous end-joining.

Mol Cell 2011 Jan;41(1):33-45

Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK.

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http://dx.doi.org/10.1016/j.molcel.2010.12.006DOI Listing
January 2011

Mutations in PNKP cause microcephaly, seizures and defects in DNA repair.

Nat Genet 2010 Mar 31;42(3):245-9. Epub 2010 Jan 31.

[1] Howard Hughes Medical Institute, Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA. [2] These authors contributed equally to the work.

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http://dx.doi.org/10.1038/ng.526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835984PMC
March 2010

A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage.

Nature 2009 Oct;461(7264):674-8

Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton, Sussex BN1 9RQ, UK.

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http://dx.doi.org/10.1038/nature08444DOI Listing
October 2009

DNA 3'-phosphatase activity is critical for rapid global rates of single-strand break repair following oxidative stress.

Mol Cell Biol 2009 Sep 22;29(17):4653-62. Epub 2009 Jun 22.

Genome Damage and Stability Centre, University of Sussex, Brighton, United Kingdom.

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http://dx.doi.org/10.1128/MCB.00677-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725712PMC
September 2009

The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1.

Nat Neurosci 2009 Aug 26;12(8):973-80. Epub 2009 Jul 26.

Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nn.2375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831284PMC
August 2009

Short-patch single-strand break repair in ataxia oculomotor apraxia-1.

Biochem Soc Trans 2009 Jun;37(Pt 3):577-81

Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, UK.

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http://dx.doi.org/10.1042/BST0370577DOI Listing
June 2009

Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1.

Mol Cell Biol 2009 Mar 22;29(5):1354-62. Epub 2008 Dec 22.

Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, United Kingdom.

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http://dx.doi.org/10.1128/MCB.01471-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643831PMC
March 2009

Single-strand break repair and genetic disease.

Nat Rev Genet 2008 Aug;9(8):619-31

Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK.

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http://dx.doi.org/10.1038/nrg2380DOI Listing
August 2008

APLF (C2orf13) is a novel component of poly(ADP-ribose) signaling in mammalian cells.

Mol Cell Biol 2008 Jul 12;28(14):4620-8. Epub 2008 May 12.

Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, United Kingdom.

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http://dx.doi.org/10.1128/MCB.02243-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447129PMC
July 2008

DNA damage responses and neurological disease. Preface.

DNA Repair (Amst) 2008 Jul 2;7(7):1009. Epub 2008 Jun 2.

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http://dx.doi.org/10.1016/j.dnarep.2008.04.011DOI Listing
July 2008

Claspin promotes normal replication fork rates in human cells.

Mol Biol Cell 2008 Jun 19;19(6):2373-8. Epub 2008 Mar 19.

Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom.

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http://dx.doi.org/10.1091/mbc.e07-10-1035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397295PMC
June 2008

DNA strand break repair and human genetic disease.

Annu Rev Genomics Hum Genet 2007 ;8:37-55

Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1146/annurev.genom.7.080505.115648DOI Listing
December 2007

TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo.

EMBO J 2007 Nov 4;26(22):4720-31. Epub 2007 Oct 4.

Department Genetics and Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080805PMC
November 2007

TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks.

DNA Repair (Amst) 2007 Oct 28;6(10):1485-95. Epub 2007 Jun 28.

Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton, UK.

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http://dx.doi.org/10.1016/j.dnarep.2007.04.015DOI Listing
October 2007

XRCC1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from DNA repair intermediates.

J Biol Chem 2007 Sep 23;282(38):28004-13. Epub 2007 Jul 23.

Department of Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1074/jbc.M704867200DOI Listing
September 2007

Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase.

Mol Cell Biol 2007 Aug 4;27(15):5597-605. Epub 2007 Jun 4.

Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, United Kingdom.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.02248-06
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http://dx.doi.org/10.1128/MCB.02248-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952076PMC
August 2007

Chk1 regulates the density of active replication origins during the vertebrate S phase.

EMBO J 2007 Jun 10;26(11):2719-31. Epub 2007 May 10.

Faculty of Life Sciences, University of Manchester, MIB, Manchester, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888675PMC
June 2007

APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks.

Mol Cell Biol 2007 May 12;27(10):3793-803. Epub 2007 Mar 12.

Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, Sussex, United Kingdom.

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http://dx.doi.org/10.1128/MCB.02269-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900005PMC
May 2007

Mammalian single-strand break repair: mechanisms and links with chromatin.

DNA Repair (Amst) 2007 Apr 21;6(4):443-53. Epub 2006 Nov 21.

Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, United Kingdom.

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http://dx.doi.org/10.1016/j.dnarep.2006.10.006DOI Listing
April 2007

The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates.

Nature 2006 Oct 10;443(7112):713-6. Epub 2006 Sep 10.

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

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http://dx.doi.org/10.1038/nature05164DOI Listing
October 2006

Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase.

Cell Cycle 2006 Oct 1;5(19):2203-9. Epub 2006 Oct 1.

Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, UK.

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http://dx.doi.org/10.4161/cc.5.19.3256DOI Listing
October 2006

Measurement of chromosomal DNA single-strand breaks and replication fork progression rates.

Methods Enzymol 2006 ;409:410-25

Genome Damage and Stability Center, University of Sussex, Brighton, United Kingdom.

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http://dx.doi.org/10.1016/S0076-6879(05)09024-5DOI Listing
August 2006

TDP1-dependent DNA single-strand break repair and neurodegeneration.

Mutagenesis 2006 Jul 14;21(4):219-24. Epub 2006 Jun 14.

Genome Damage and Stability Centre, University of Sussex Falmer, Brighton BN1 9RQ, UK.

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http://dx.doi.org/10.1093/mutage/gel024DOI Listing
July 2006

An Achilles' heel for breast cancer?

Nat Struct Mol Biol 2005 May;12(5):387-8

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http://dx.doi.org/10.1038/nsmb0505-387DOI Listing
May 2005

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1.

Nature 2005 Mar;434(7029):108-13

Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK.

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http://dx.doi.org/10.1038/nature03314DOI Listing
March 2005

DNA single-strand breaks and neurodegeneration.

DNA Repair (Amst) 2004 Aug-Sep;3(8-9):875-82

Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK.

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http://dx.doi.org/10.1016/j.dnarep.2004.04.011DOI Listing
February 2005

Biophysical characterization of human XRCC1 and its binding to damaged and undamaged DNA.

Biochemistry 2004 Dec;43(51):16505-14

Department of Experimental Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta T6G 1Z2, Canada.

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http://dx.doi.org/10.1021/bi048615mDOI Listing
December 2004

XRCC1-DNA polymerase beta interaction is required for efficient base excision repair.

Nucleic Acids Res 2004 11;32(8):2550-5. Epub 2004 May 11.

Radiation and Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK.

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http://dx.doi.org/10.1093/nar/gkh567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419455PMC
June 2004

The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks.

Cell 2004 Apr;117(1):17-28

Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, United Kingdom.

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http://dx.doi.org/10.1016/s0092-8674(04)00206-5DOI Listing
April 2004

Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions.

DNA Repair (Amst) 2003 Oct;2(10):1087-100

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institute of Health, Building 37, Room 5068, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/s1568-7864(03)00116-2DOI Listing
October 2003

A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage.

Nucleic Acids Res 2003 Oct;31(19):5526-33

Genome Damage and Stability Centre, University of Sussex, Falmer Brighton BN1 9RQ, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC206461PMC
http://dx.doi.org/10.1093/nar/gkg761DOI Listing
October 2003

Cell signaling. The BRCT domain: signaling with friends?

Science 2003 Oct;302(5645):579-80

Genome Damage and Stability Center, University of Sussex, Brighton BN1 9RR, UK.

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http://dx.doi.org/10.1126/science.1091463DOI Listing
October 2003

Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time.

Nucleic Acids Res 2003 Sep;31(17):e104

Department of Environmental Sciences and Engineering, Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC212824PMC
http://dx.doi.org/10.1093/nar/gng105DOI Listing
September 2003

XRCC1 and DNA strand break repair.

DNA Repair (Amst) 2003 Sep;2(9):955-69

Genome Damage and Stability Centre, University of Sussex, Science Park Road, BN1 9RQ, Falmer Brighton, UK.

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http://dx.doi.org/10.1016/s1568-7864(03)00118-6DOI Listing
September 2003

Spatial and temporal cellular responses to single-strand breaks in human cells.

Mol Cell Biol 2003 Jun;23(11):3974-81

Department of Molecular Genetics, Institute of Development, Aging and Cancer, Tohoku University, 980-8575 Sendai, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC155230PMC
http://dx.doi.org/10.1128/mcb.23.11.3974-3981.2003DOI Listing
June 2003

XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes.

Mol Cell 2003 Apr;11(4):1109-17

School of Biological Sciences, University of Manchester, Stopford Building, Oxford Road, United Kingdom.

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http://dx.doi.org/10.1016/s1097-2765(03)00132-1DOI Listing
April 2003

DNA single-strand break repair and spinocerebellar ataxia.

Cell 2003 Jan;112(1):7-10

Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton, BN1 9RQ, United Kingdom.

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http://dx.doi.org/10.1016/s0092-8674(02)01247-3DOI Listing
January 2003

Interference of papillomavirus E6 protein with single-strand break repair by interaction with XRCC1.

EMBO J 2002 Sep;21(17):4741-8

Sektion Experimentelle Virologie, Universitätsklinikum Tuebingen, Elfriede-Aulhorn Strasse 6, D-72076 Tuebingen, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126183PMC
http://dx.doi.org/10.1093/emboj/cdf443DOI Listing
September 2002

Polynucleotide kinase: a versatile molecule makes a clean break.

Structure 2002 Sep;10(9):1151-2

Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, United Kingdom.

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http://dx.doi.org/10.1016/s0969-2126(02)00833-xDOI Listing
September 2002

Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair.

Mol Cell Biol 2002 Apr;22(8):2556-63

School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133733PMC
http://dx.doi.org/10.1128/mcb.22.8.2556-2563.2002DOI Listing
April 2002