Keith Stewart

Keith Stewart

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Whole Genome Mate-pair Sequencing of Plasma Cell Neoplasm as a Novel Diagnostic Strategy: A Case of Unrecognized t(2;11) Structural Variation.

Clin Lymphoma Myeloma Leuk 2019 Sep 18;19(9):598-602. Epub 2019 Jun 18.

Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2019.06.006DOI Listing
September 2019

Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma.

N Engl J Med 2019 08;381(8):727-738

From the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai (A.C., S.P., S.J.), and New York University Langone Medical Center (D.K.) - both in New York; the Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia (D.T.V.); the School of Medicine, National and Kapodistrian University of Athens, Athens (M.G., M. Dimopoulos); the Winship Cancer Institute, Emory University, Atlanta (A.K.N., S.L.); Massachusetts General Hospital Cancer Center (A.J.Y.), Tufts Medical Center (R.L.C.), and the Dana-Farber Cancer Institute (P.G.R.), Boston, and Karyopharm Therapeutics, Newton (M.G.K., S.S., L.L., S. Tang, C.P., J.-R.S.-M., M.C., H.C., Y.L., J.S.) - all in Massachusetts; Johns Hopkins University, Baltimore (C.A.H.); the University of Nantes, Nantes (P.M.), Hôpital Necker (L.F.), Hôpital Saint-Antoine (M.M.), and La Pitié-Salpêtrière Hospital (S.C.), Paris, University Hospital, Lille (T.F.), Centre Hospitalier Lyon Sud, Pierre-Benite (L.K.), and Centre Hospitalo-Universitaire Vandoeuvre-lès-Nancy, Nancy (A.P.) - all in France; the Mayo Clinic, Rochester, MN (D.D.); the University of Michigan, Ann Arbor (C.C.); the Mayo Clinic of Arizona, Phoenix (A.K.S.); Hackensack University Medical Center, Hackensack, NJ (J.R.); Washington University School of Medicine, St. Louis (R.V.); Lineberger Comprehensive Cancer Center at University of North Carolina-Chapel Hill, Chapel Hill (S. Tuchman); the University of Heidelberg, Heidelberg (M.S.R.), University Medical Center Hamburg-Eppendorf, Hamburg (K.C.W.), the University of Tübingen, Tübingen (K.C.W.), University Hospital Würzburg, Würzburg (M.S.), the University of Freiburg, Freiburg (M.E.), and Gemeinschaftspraxis Hämatologie-Onkologie, Dresden (T.I.) - all in Germany; the University of Leuven, Leuven (M. Delforge), Institut Jules Bordet, Université Libre de Bruxelles, Brussels (N.M.), University Hospital Ghent, Ghent (P.V.), and Centre Hospitalier Universitaire Université Catholique de Louvain Namur, Yvoir (C.D.) - all in Belgium; Vanderbilt University Medical Center, Nashville (R.F.C.); Sylvester Cancer Center, University of Miami, Miami (J.E.H.); the University of Alabama at Birmingham, Birmingham (L.J.C.); Yale School of Medicine, New Haven, CT (T.L.P.); Baylor University Medical Center, Dallas (M.L.); the David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (G.S.); and University Hospital Krems, Karl Landsteiner University of Health Sciences, Krems an der Donau, Austria (K.P.).

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http://www.nejm.org/doi/10.1056/NEJMoa1903455
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http://dx.doi.org/10.1056/NEJMoa1903455DOI Listing
August 2019

Concurrent progressive multifocal leukoencephalopathy and central nervous system infiltration by multiple myeloma: A case report.

J Oncol Pharm Pract 2019 Jun 24;25(4):998-1002. Epub 2018 Apr 24.

1 Department of Hematology, Hospital Universitario 12 de Octubre, Hematological Malignancies Clinical Research Unit H120-CNIO, Madrid, Spain.

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http://dx.doi.org/10.1177/1078155218769367DOI Listing
June 2019

Improvement in Overall Survival With Carfilzomib, Lenalidomide, and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma.

J Clin Oncol 2018 03 17;36(8):728-734. Epub 2018 Jan 17.

David S. Siegel, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ; Meletios A. Dimopoulos, National and Kapodistrian University of Athens, Athens, Greece; Heinz Ludwig, Wilhelminen Cancer Research Institute, Wilhelminenspital, Vienna, Austria; Thierry Facon, Hôpital Claude Huriez, Centre Hospitalier Régional Universitaire de Lille, Lille, France; Hartmut Goldschmidt, Heidelberg Medical University and National Center of Tumor Diseases, Heidelberg, Germany; Andrzej Jakubowiak, University of Chicago Medicine, Chicago, IL; Jesus San-Miguel, Clinica Universidad de Navarra-Centro de Investigación Médica Aplicada, Instituto de Investigación Sanitaria de Navarra, Centro de Investigación Biomédica en Red de Cáncer, Pamplona, Spain; Mihaela Obreja and Julie Blaedel, Amgen, Thousand Oaks, CA; and A. Keith Stewart, Mayo Clinic, Scottsdale, AZ.

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http://dx.doi.org/10.1200/JCO.2017.76.5032DOI Listing
March 2018

Selective Inhibition of Nuclear Export With Oral Selinexor for Treatment of Relapsed or Refractory Multiple Myeloma.

J Clin Oncol 2018 03 30;36(9):859-866. Epub 2018 Jan 30.

Dan T. Vogl, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; David Dingli, Mayo Clinic, Rochester, MN; Robert Frank Cornell, Vanderbilt University Medical Center, Nashville, TN; Carol Ann Huff, Johns Hopkins University, Baltimore, MD; Sundar Jagannath, Tisch Cancer Institute, Mount Sinai School of Medicine; David Kaminetzky, New York University Langone Medical Center; Ajai Chari, Icahn School of Medicine at Mount Sanai, New York, NY; Divaya Bhutani and Jeffrey Zonder, Karmanos Cancer Institute, Wayne State University, Detroit; Craig Cole, University of Michigan, Ann Arbor, MI; Rachid Baz, H. Lee Moffitt Cancer Center and Research Institute, Tampa; James E. Hoffman, Sylvester Cancer Center, University of Miami, Miami, FL; Ajay Nooka, Winship Cancer Institute, Emory University, Atlanta, GA; Joshua Richter and David Siegel, John Theurer Cancer Center at the Hackensack University Medical Center, Hackensack, NJ; Ravi Vij, Washington University School of Medicine, St Louis, MO; Andrzej Jakubowiak, University of Chicago Medical Center, Chicago, IL; Rafat Abonour, Indiana University Cancer Center, Indianapolis, IN; Gary Schiller, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA; Terri L. Parker, Yale School of Medicine, New Haven, CT; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Andrew J. Yee, Massachusetts General Hospital Cancer Center, Boston; Michael Kauffman, Sharon Shacham, Jean-Richard Saint-Martin, Carla D. Picklesimer, and Cassandra Choe-Juliak, Karyopharm Therapeutics, Newton, MA; Rafael Fonseca, Scott Van Wier, Gregory Ahmann, Ilsel Lopez, and A. Keith Stewart, Mayo Clinic of Arizona, Phoenix, AZ.

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http://dx.doi.org/10.1200/JCO.2017.75.5207DOI Listing
March 2018

Mouse Monoclonal Antibodies Generated from Full Length Human Cereblon: Detection of Cereblon Protein in Patients with Multiple Myeloma.

Int J Mol Sci 2017 Sep 17;18(9). Epub 2017 Sep 17.

Division of Hematology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.

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http://dx.doi.org/10.3390/ijms18091999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618648PMC
September 2017

Molecular Modeling and Functional Analysis of Exome Sequencing-Derived Variants of Unknown Significance Identify a Novel, Constitutively Active FGFR2 Mutant in Cholangiocarcinoma.

JCO Precis Oncol 2017 1;2017. Epub 2017 Aug 1.

David L. Marks, Tara L. Hogenson, Anne M. Vrabel, Ashley N. Sigafoos, Ezequiel J. Tolosa, Ryan M. Carr, Stephanie L. Safgren, Elisa Enriquez Hesles, Luciana L. Almada, Paola A. Romecin-Duran, Eriko Iguchi, Aryan Ala'Aldeen, Jean-Pierre A. Kocher, Gavin R. Oliver, Naresh Prodduturi, David W. Mead, Asif Hossain, Norine E. Huneke, Colleen M. Tagtow, Sikander Ailawadhi, Stephen M. Ansell, Michaela S. Banck, Asher A. Chanan-Khan, Ronald S. Go, Thorvardur R. Halfdanarson, Richard W. Joseph, Prashant Kapoor, Aaron S. Mansfield, Amulya A. Nageswara Rao, Grzegorz S. Nowakowski, Animesh Pardanani, Sameer A. Parikh, John C. Cheville, Andrew L. Feldman, Ramesh K. Ramanathan, Steven I. Robinson, Heidi D. Finnes, Jennifer B. McCormick, Robert R. McWilliams, Aminah Jatoi, Mrinal M. Patnaik, Eric D. Wieben, Tammy M. McAllister, Kandelaria M. Rumilla, Sarah E. Kerr, Konstantinos N. Lazaridis, Gianrico Farrugia, Karl J. Clark, Eric W. Klee, and Martin E. Fernandez-Zapico, Mayo Clinic, Rochester; Ernesto Resnik, Bio-Techne, Minneapolis, MN; Sikander Ailawadhi, Asher A. Chanan-Khan, and Richard W. Joseph, Mayo Clinic, Jacksonville, FL; Jan B. Egan, Alan H. Bryce, Estrella M. Carballido, KellyK. Curtis, Chelsea D. Gawryletz, Thai H. Ho,Nathalie Meurice, Ramesh K. Ramanathan, Raoul Tibes, Alvin C. Silva, A. Keith Stewart, and Mitesh J. Borad, Mayo Clinic, Phoenix, AZ; and Eileen J. Kennedy, University of Georgia, Athens, GA.

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http://dx.doi.org/10.1200/PO.17.00018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369924PMC
August 2017

A Field Trial of TCE Phytoremediation by Genetically Modified Poplars Expressing Cytochrome P450 2E1.

Environ Sci Technol 2017 Jun 23;51(11):6090-6099. Epub 2017 May 23.

Department of Civil and Environmental Engineering, UW Box 355014, University of Washington , Seattle, Washington, United States.

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http://dx.doi.org/10.1021/acs.est.5b04758DOI Listing
June 2017

Introduction to the Symposium on Precision Medicine.

Mayo Clin Proc 2017 01;92(1):4-6

Center for Individualized Medicine, Mayo Clinic, Rochester, MN; Division of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic, Rochester, MN; Department of Clinical Genomics, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1016/j.mayocp.2016.10.027DOI Listing
January 2017

Phase II trial of nab-paclitaxel in patients with relapsed or refractory multiple myeloma.

Am J Hematol 2016 12 11;91(12):E504-E505. Epub 2016 Oct 11.

Division of Hematology and Oncology, Mayo Clinic, Phoenix, Arizona.

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http://dx.doi.org/10.1002/ajh.24548DOI Listing
December 2016

Health-Related Quality-of-Life Results From the Open-Label, Randomized, Phase III ASPIRE Trial Evaluating Carfilzomib, Lenalidomide, and Dexamethasone Versus Lenalidomide and Dexamethasone in Patients With Relapsed Multiple Myeloma.

J Clin Oncol 2016 11;34(32):3921-3930

A. Keith Stewart, Mayo Clinic, Scottsdale, AZ; Meletios A. Dimopoulos, Alexandra Hospital, Athens, Greece; Tamás Masszi, St. István and St. László Hospital, Semmelweis University, Budapest, Hungary; Ivan Špička, General University Hospital in Prague, Prague; Roman Hájek, University Hospital Brno and University of Ostrava, Brno, Czech Republic; Albert Oriol, Institut Català d'Oncologia, Institut Josep Carreras, Hospital Germans Trias i Pujol; Laura Rosiñol, Hospital Clínic de Barcelona, Barcelona; Jesus F. San-Miguel, Clinica Universidad de Navarra/El Centro de Investigacíon Médica Aplicada, Instituto de Investigacíon Sanitaria de Navarra, Pamplona, Spain; David S. Siegel, John Theurer Cancer Center at Hackensack University, Hackensack, NJ; Ruben Niesvizky, Weill Cornell Medical College, New York, NY; Andrzej J. Jakubowiak, University of Chicago Medicine, Chicago, IL; Heinz Ludwig, Wilhelminen Cancer Research Institute, Wilheminenspital, Vienna, Austria; Jacqui Buchanan, Xinqun Yang, Biao Xing, Naseem Zojwalla, and Margaret Tonda, Onyx Pharmaceuticals, South San Francisco, CA; Kim Cocks, KCStats Consultancy, Leeds, United Kingdom; Philippe Moreau, University of Nantes, Nantes, France; and Antonio Palumbo, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1200/JCO.2016.66.9648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791840PMC
November 2016

Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes.

Blood 2016 09 25;128(9):1226-33. Epub 2016 Jul 25.

Max-Eder Group "Experimental Therapies for Hematologic Malignancies," Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany; Department of Internal Medicine V, and.

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http://dx.doi.org/10.1182/blood-2016-02-698092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524534PMC
September 2016

A pharmacogenetic analysis of the Canadian Cancer Trials Group MY.10 clinical trial of maintenance therapy for multiple myeloma.

Blood 2016 08 23;128(5):732-5. Epub 2016 Jun 23.

Biology, University of New Brunswick, Saint John, NB, Canada; Department of Oncology, Saint John Regional Hospital, Dalhousie University and University of New Brunswick, Saint John, NB, Canada.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2016-06-71
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http://dx.doi.org/10.1182/blood-2016-06-716902DOI Listing
August 2016

Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival.

BMC Cancer 2016 May 3;16:297. Epub 2016 May 3.

Department of Biochemistry & Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, 13400 E. Shea Boulevard, Scottsdale, AZ, 85259, USA.

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http://dx.doi.org/10.1186/s12885-016-2331-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855823PMC
May 2016

Carfilzomib for the treatment of patients with relapsed and/or refractory multiple myeloma.

Authors:
A Keith Stewart

Future Oncol 2015 30;11(15):2121-36. Epub 2015 Jun 30.

Mayo Clinic, 13400 East Shea Blvd, Scottsdale, AZ 85259, USA.

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http://dx.doi.org/10.2217/fon.15.123DOI Listing
April 2016

The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice.

Blood 2016 Mar 29;127(13):1676-86. Epub 2016 Jan 29.

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, China.

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http://dx.doi.org/10.1182/blood-2015-07-658203DOI Listing
March 2016

SnapShot: Multiple Myeloma.

Cancer Cell 2015 Nov;28(5):678-678.e1

Division of Hematology-Oncology, Mayo Clinic, Scottsdale, AZ 85259, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15356108150039
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http://dx.doi.org/10.1016/j.ccell.2015.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864595PMC
November 2015

Proteasome inhibitors block Ikaros degradation by lenalidomide in multiple myeloma.

Haematologica 2015 Aug 14;100(8):e315-7. Epub 2015 May 14.

Division of Hematology-Oncology, Mayo Clinic, Scottsdale, AZ, USA

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http://dx.doi.org/10.3324/haematol.2015.124297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004433PMC
August 2015

Clinical Implementation of Cardiovascular Pharmacogenomics.

Mayo Clin Proc 2015 Jun;90(6):701-4

Center for Individualized Medicine, Division of Hematology/Oncology, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1016/j.mayocp.2015.04.011DOI Listing
June 2015

Treatment of relapsed multiple myeloma.

N Engl J Med 2015 04;372(18):1774-5

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http://dx.doi.org/10.1056/NEJMc1501348DOI Listing
April 2015

Activity of 129 single-agent drugs in 228 phase I and II clinical trials in multiple myeloma.

Clin Lymphoma Myeloma Leuk 2014 Aug 28;14(4):284-290.e5. Epub 2013 Dec 28.

Division of Hematology, Mayo Clinic, Scottsdale, AZ. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2013.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092053PMC
August 2014

Mechanism of immunomodulatory drugs' action in the treatment of multiple myeloma.

Acta Biochim Biophys Sin (Shanghai) 2014 Mar 29;46(3):240-53. Epub 2013 Dec 29.

Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.

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http://dx.doi.org/10.1093/abbs/gmt142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357794PMC
March 2014

Simultaneous characterization of somatic events and HPV-18 integration in a metastatic cervical carcinoma patient using DNA and RNA sequencing.

Int J Gynecol Cancer 2014 Feb;24(2):329-38

*Translational Genomics Research Institute; †Comprehensive Cancer Care, St Joseph's Hospital and Medical Center, Phoenix; ‡Mayo Clinic, Scottsdale; §Department of Obstetrics and Gynecology, St Joseph's Hospital and Medical Center, and ∥Division of Gynecologic Oncology, Creighton University School of Medicine, St Joseph's Hospital and Medical Center, University of Arizona Cancer Center, Phoenix, AZ.

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http://dx.doi.org/10.1097/IGC.0000000000000049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921261PMC
February 2014

International Myeloma Working Group consensus statement for the management, treatment, and supportive care of patients with myeloma not eligible for standard autologous stem-cell transplantation.

J Clin Oncol 2014 Feb 13;32(6):587-600. Epub 2014 Jan 13.

Antonio Palumbo and Alessandra Larocca, University of Torino, Torino; Michele Cavo, Seràgnoli Institute of Hematology, Bologna University School of Medicine, Bologna, Italy; S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Jesus F. San Miguel, University Hospital of Salamanca, Salamanca, Spain; Ruben Niesvizky, Weill Cornell Medical College, New York, NY; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Ola Landgren, National Cancer Institute, Bethesda, MD; Roman Hajek, University of Ostrava School of Medicine and University Hospital Ostrava, Ostrava, Czech Republic; Hermann Einsele, University of Wurzburg, Wurzburg, Germany; Kenneth C. Anderson and Paul G. Richardson, Dana-Farber Cancer Institute, Boston, MA; Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Andrew Spencer, Alfred Hospital, Melbourne, Victoria, Australia; A. Keith Stewart, Mayo Clinic, Scottsdale, AZ; Kazuyuki Shimizu, Aichi Gakuin Hospital, Nagoya, Japan; Sagar Lonial, Emory University, Atlanta, GA; Pieter Sonneveld, Erasmus Medical Centre, Rotterdam, the Netherlands; Brian G.M. Durie, Cedars-Sinai Comprehensive Cancer Center, Los Angeles, CA; Philippe Moreau, University Hospital, Nantes, France; and Robert Z. Orlowski, MD Anderson Cancer Center, Houston, TX.

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http://jco.ascopubs.org/content/32/6/587.full.pdf
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https://myeloma.org/pdfs/IMWG_Pub/2014%20JCO-%20Palumbo-%20I
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http://szpiczak.org/lang/aktualnosci/publikacje/rok_2013/LUD
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2013.48.7934
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http://dx.doi.org/10.1200/JCO.2013.48.7934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918540PMC
February 2014

Medicine. How thalidomide works against cancer.

Authors:
A Keith Stewart

Science 2014 Jan;343(6168):256-7

Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA.

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http://dx.doi.org/10.1126/science.1249543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084783PMC
January 2014

D(T)PACE as salvage therapy for aggressive or refractory multiple myeloma.

Br J Haematol 2013 Jun 18;161(6):802-10. Epub 2013 Apr 18.

Hematology, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/bjh.12325DOI Listing
June 2013

Carfilzomib.

Blood 2013 Feb;121(6):893-7

Division of Hematology-Oncology, Mayo Clinic, Scottsdale, AZ 85259-5494, USA.

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http://dx.doi.org/10.1182/blood-2012-10-459883DOI Listing
February 2013

Characterisation of tumour-infiltrating macrophages: impact on response and survival in patients receiving primary chemotherapy for breast cancer.

Breast Cancer Res Treat 2012 Sep 11;135(2):539-48. Epub 2012 Aug 11.

Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK.

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http://dx.doi.org/10.1007/s10549-012-2190-6DOI Listing
September 2012