Publications by authors named "Keith Mansfield"

124Publications

A Recombinant Protein SARS-CoV-2 Candidate Vaccine Elicits High-titer Neutralizing Antibodies in Macaques.

Authors:
Gary Baisa David Rancour Keith Mansfield Monika Burns Lori Martin Daise Cunha Jessica Fischer Frauke Muecksch Theodora Hatziioannou Paul D Bieniasz Fritz Schomburg Kimberly Luke

Res Sq 2021 Jan 5. Epub 2021 Jan 5.

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January 2021

A recombinant protein SARS-CoV-2 candidate vaccine elicits high-titer neutralizing antibodies in macaques.

Authors:
Gary Baisa David Rancour Keith Mansfield Monika Burns Lori Martin Daise Cunha Jessica Fischer Frauke Muecksch Theodora Hatziioannou Paul Bieniasz Frtiz Schomburg Kimberly Luke

bioRxiv 2020 Dec 21. Epub 2020 Dec 21.

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December 2020

Imaging Mass Cytometry and Single-Cell Genomics Reveal Differential Depletion and Repletion of B-Cell Populations Following Ofatumumab Treatment in Cynomolgus Monkeys.

Authors:
Diethilde Theil Paul Smith Catherine Huck Yoann Gilbart Algirdas Kakarieka David Leppert Celine Rauld Cindy Schmid Reto Baumgartner Nathalie Stuber Francisco Cordoba Valerie Dubost Katy Darribat Magali Jivkov Wilfried Frieauff Rainer Kneuer Markus Stoeckli Stefan Reinker Keith Mansfield José M Carballido Philippe Couttet Gisbert Weckbecker

Front Immunol 2019 20;10:1340. Epub 2019 Jun 20.

Novartis Pharma AG, Basel, Switzerland.

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October 2020

Pre-clinical validation of B cell maturation antigen (BCMA) as a target for T cell immunotherapy of multiple myeloma.

Authors:
De-Xiu Bu Reshma Singh Eugene E Choi Marco Ruella Selene Nunez-Cruz Keith G Mansfield Paul Bennett Nathanial Barton Qilong Wu Jiquan Zhang Yongqiang Wang Lai Wei Shawn Cogan Tucker Ezell Shree Joshi Kellie J Latimer Brian Granda William R Tschantz Regina M Young Heather A Huet Celeste J Richardson Michael C Milone

Oncotarget 2018 May 25;9(40):25764-25780. Epub 2018 May 25.

Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

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May 2018

Preclinical Antitumor Activity of a Novel Anti-c-KIT Antibody-Drug Conjugate against Mutant and Wild-type c-KIT-Positive Solid Tumors.

Authors:
Tinya Abrams Anu Connor Christie Fanton Steven B Cohen Thomas Huber Kathy Miller E Erica Hong Xiaohong Niu Janine Kline Marjorie Ison-Dugenny Sarah Harris Dana Walker Klaus Krauser Francesco Galimi Zhen Wang Majid Ghoddusi Keith Mansfield Si Tuen Lee-Hoeflich Jocelyn Holash Nancy Pryer William Kluwe Seth A Ettenberg William R Sellers Emma Lees Paul Kwon Judith A Abraham Siew C Schleyer

Clin Cancer Res 2018 09 15;24(17):4297-4308. Epub 2018 May 15.

Novartis Institutes of Biomedical Research, Emeryville, California.

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September 2018

An OX40/OX40L interaction directs successful immunity to hepatitis B virus.

Authors:
Jean Publicover Anuj Gaggar Jillian M Jespersen Ugur Halac Audra J Johnson Amanda Goodsell Lia Avanesyan Stephen L Nishimura Meghan Holdorf Keith G Mansfield Joyce Bousquet Judge Arya Koshti Michael Croft Adil E Wakil Philip Rosenthal Eric Pai Stewart Cooper Jody L Baron

Sci Transl Med 2018 03;10(433)

Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA 94143, USA.

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March 2018

Cytokine release syndrome associated with chimeric-antigen receptor T-cell therapy: clinicopathological insights.

Authors:
Amrom E Obstfeld Noelle V Frey Keith Mansfield Simon F Lacey Carl H June David L Porter Jan J Melenhorst Mariusz A Wasik

Blood 2017 12 26;130(23):2569-2572. Epub 2017 Oct 26.

Department of Pathology and Laboratory Medicine.

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December 2017

A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia.

Authors:
Thomas Suply Sébastien Hannedouche Nathalie Carte Jianping Li Bianka Grosshans Michael Schaefer Layla Raad Valérie Beck Solange Vidal Agnès Hiou-Feige Noémie Beluch Samuel Barbieri Johann Wirsching Nadine Lageyre Frank Hillger Corinne Debon Janet Dawson Philip Smith Vincent Lannoy Michel Detheux Francis Bitsch Rocco Falchetto Tewis Bouwmeester Jeffrey Porter Birgit Baumgarten Keith Mansfield José M Carballido Klaus Seuwen Frédéric Bassilana

Sci Signal 2017 Sep 12;10(496). Epub 2017 Sep 12.

Novartis Institutes for BioMedical Research, CH-4056 Basel, Switzerland.

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September 2017

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

Authors:
Donald M O'Rourke MacLean P Nasrallah Arati Desai Jan J Melenhorst Keith Mansfield Jennifer J D Morrissette Maria Martinez-Lage Steven Brem Eileen Maloney Angela Shen Randi Isaacs Suyash Mohan Gabriela Plesa Simon F Lacey Jean-Marc Navenot Zhaohui Zheng Bruce L Levine Hideho Okada Carl H June Jennifer L Brogdon Marcela V Maus

Sci Transl Med 2017 07;9(399)

Cellular Immunotherapy Program, Cancer Center and Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA.

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July 2017

Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers.

Authors:
Carl U Bialucha Scott D Collins Xiao Li Parmita Saxena Xiamei Zhang Clemens Dürr Bruno Lafont Pierric Prieur Yeonju Shim Rebecca Mosher David Lee Lance Ostrom Tiancen Hu Sanela Bilic Ivana Liric Rajlic Vladimir Capka Wei Jiang Joel P Wagner GiNell Elliott Artur Veloso Jessica C Piel Meghan M Flaherty Keith G Mansfield Emily K Meseck Tina Rubic-Schneider Anne Serdakowski London William R Tschantz Markus Kurz Duc Nguyen Aaron Bourret Matthew J Meyer Jason E Faris Mary J Janatpour Vivien W Chan Nicholas C Yoder Kalli C Catcott Molly A McShea Xiuxia Sun Hui Gao Juliet Williams Francesco Hofmann Jeffrey A Engelman Seth A Ettenberg William R Sellers Emma Lees

Cancer Discov 2017 09 19;7(9):1030-1045. Epub 2017 May 19.

Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.

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September 2017

Feasibility of intravitreal injections and ophthalmic safety assessment in marmoset () monkeys.

Authors:
Birgit Korbmacher Jenny Atorf Stephanie Fridrichs-Gromoll Marilyn Hill Sven Korte Jan Kremers Keith Mansfield Lars Mecklenburg Andrew Pilling Andreas Wiederhold

Primate Biol 2017 28;4(1):93-100. Epub 2017 Apr 28.

Covance Preclinical Services GmbH, Kesselfeld 29, 48163 Münster, Germany.

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April 2017

The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey.

Authors:
Heidi A Schoenfeld Tim West Philip B Verghese Mary Holubasch Neeta Shenoy David Kagan Chiara Buono Wei Zhou Marc DeCristofaro Julie Douville Geoffrey G Goodrich Keith Mansfield Chandra Saravanan Frederic Cumin Randy L Webb Randall J Bateman

Toxicol Appl Pharmacol 2017 05 15;323:53-65. Epub 2017 Mar 15.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

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May 2017

From the Cover: Drug-Induced Taste Disorders in Clinical Practice and Preclinical Safety Evaluation.

Authors:
Tao Wang John Glendinning Miriam Grushka Thomas Hummel Keith Mansfield

Toxicol Sci 2017 04;156(2):315-324

Preclinical Safety, Novartis Institutes for BioMedical Research, Cambridge, Massacheusetts.

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April 2017

Compound Property Optimization in Drug Discovery Using Quantitative Surface Sampling Micro Liquid Chromatography with Tandem Mass Spectrometry.

Authors:
Xiaohui Chen Panos Hatsis Joyce Judge Upendra A Argikar Xiaojun Ren Jason Sarber Keith Mansfield Guiqing Liang Adam Amaral Alexandre Catoire Adam Bentley Luis Ramos Paul Moench Samuel Hintermann David Carcache Jim Glick Jimmy Flarakos

Anal Chem 2016 12 16;88(23):11813-11820. Epub 2016 Nov 16.

Drug Metabolism & Pharmacokinetics, Novartis Institutes for BioMedical Research, Inc. 1 Health Plaza, East Hanover, New Jersey 07936 United States.

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December 2016

Antiviral Nucleotide Incorporation by Recombinant Human Mitochondrial RNA Polymerase Is Predictive of Increased In Vivo Mitochondrial Toxicity Risk.

Authors:
Martijn Fenaux Xiaodong Lin Fumiaki Yokokawa Zachary Sweeney Oliver Saunders Lili Xie Siew Pheng Lim Marianne Uteng Kyoko Uehara Robert Warne Wang Gang Christopher Jones Satya Yendluri Helen Gu Keith Mansfield Julie Boisclair Tycho Heimbach Alexandre Catoire Kathryn Bracken Margaret Weaver Heinz Moser Weidong Zhong

Antimicrob Agents Chemother 2016 12 21;60(12):7077-7085. Epub 2016 Nov 21.

Novartis Institutes for BioMedical Research, Emeryville, California, USA.

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December 2016

JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection.

Authors:
Keith A Wharton Catherine Quigley Marian Themeles Robert W Dunstan Kathryn Doyle Ellen Cahir-McFarland Jing Wei Alex Buko Carl E Reid Chao Sun Paul Carmillo Gargi Sur John P Carulli Keith G Mansfield Susan V Westmoreland Susan M Staugaitis Robert J Fox Werner Meier Susan E Goelz

PLoS One 2016 18;11(5):e0155897. Epub 2016 May 18.

Neurology, Biogen Inc, Cambridge, MA, United States of America.

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July 2017

Hyperhexosemia-Induced Retinal Vascular Pathology in a Novel Primate Model of Diabetic Retinopathy.

Authors:
Argyrios Chronopoulos Sumon Roy Ekaterina Beglova Keith Mansfield Lynn Wachtman Sayon Roy

Diabetes 2015 Jul 2;64(7):2603-8. Epub 2015 Mar 2.

Departments of Medicine and Ophthalmology, Boston University School of Medicine, Boston, MA

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July 2015

Biogeography of the intestinal mucosal and lumenal microbiome in the rhesus macaque.

Authors:
Koji Yasuda Keunyoung Oh Boyu Ren Timothy L Tickle Eric A Franzosa Lynn M Wachtman Andrew D Miller Susan V Westmoreland Keith G Mansfield Eric J Vallender Gregory M Miller James K Rowlett Dirk Gevers Curtis Huttenhower Xochitl C Morgan

Cell Host Microbe 2015 Mar 26;17(3):385-391. Epub 2015 Feb 26.

Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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March 2015

Limited dissemination and shedding of the UL128 complex-intact, UL/b'-defective rhesus cytomegalovirus strain 180.92.

Authors:
Basel T Assaf Keith G Mansfield Lisa Strelow Susan V Westmoreland Peter A Barry Amitinder Kaur

J Virol 2014 Aug 4;88(16):9310-20. Epub 2014 Jun 4.

Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, USA

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August 2014

SIV vpx is essential for macrophage infection but not for development of AIDS.

Authors:
Susan V Westmoreland A Peter Converse Kasia Hrecka Mollie Hurley Heather Knight Michael Piatak Jeffrey Lifson Keith G Mansfield Jacek Skowronski Ronald C Desrosiers

PLoS One 2014 21;9(1):e84463. Epub 2014 Jan 21.

Harvard Medical School, New England Primate Research Center, Division of Microbiology, Southborough, Massachusetts, United States of America.

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October 2014