Publications by authors named "Keith K Murai"

53Publications

Interpericyte tunnelling nanotubes regulate neurovascular coupling.

Nature 2020 09 12;585(7823):91-95. Epub 2020 Aug 12.

Department of Neuroscience, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/s41586-020-2589-xDOI Listing
September 2020

The McGill-Mouse-Miniscope platform: A standardized approach for high-throughput imaging of neuronal dynamics during behavior.

Genes Brain Behav 2020 Jul 21:e12686. Epub 2020 Jul 21.

Psychiatry Department, McGill University, Douglas Hospital Research Center, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1111/gbb.12686DOI Listing
July 2020

Depolarizing GABA Transmission Restrains Activity-Dependent Glutamatergic Synapse Formation in the Developing Hippocampal Circuit.

Front Cell Neurosci 2020 25;14:36. Epub 2020 Feb 25.

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, QC, Canada.

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http://dx.doi.org/10.3389/fncel.2020.00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053538PMC
February 2020

Human iPSC-derived Down syndrome astrocytes display genome-wide perturbations in gene expression, an altered adhesion profile, and increased cellular dynamics.

Hum Mol Genet 2020 Mar;29(5):785-802

Department of Neurology & Neurosurgery, Brain Repair and Integrative Neuroscience Program, Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, QC H3G 1A4, Canada.

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http://dx.doi.org/10.1093/hmg/ddaa003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104679PMC
March 2020

An Optogenetic Kindling Model of Neocortical Epilepsy.

Sci Rep 2019 03 27;9(1):5236. Epub 2019 Mar 27.

Brain Repair and Integrative Neuroscience Program, Centre for Research in Neuroscience, Departments of Medicine, and Neurology & Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, H3G 1A4, Canada.

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http://dx.doi.org/10.1038/s41598-019-41533-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437216PMC
March 2019

A Specialized Method to Resolve Fine 3D Features of Astrocytes in Nonhuman Primate (Marmoset, Callithrix jacchus) and Human Fixed Brain Samples.

Methods Mol Biol 2019 ;1938:85-95

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.

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http://dx.doi.org/10.1007/978-1-4939-9068-9_6DOI Listing
July 2019

Detection of activity-dependent vasopressin release from neuronal dendrites and axon terminals using sniffer cells.

J Neurophysiol 2018 09 5;120(3):1386-1396. Epub 2018 Jul 5.

Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre , Montréal, Québec , Canada.

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http://dx.doi.org/10.1152/jn.00467.2017DOI Listing
September 2018

SPARC and GluA1-Containing AMPA Receptors Promote Neuronal Health Following CNS Injury.

Front Cell Neurosci 2018 1;12:22. Epub 2018 Feb 1.

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, QC, Canada.

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http://dx.doi.org/10.3389/fncel.2018.00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799273PMC
February 2018

Plant-made virus-like particles bearing influenza hemagglutinin (HA) recapitulate early interactions of native influenza virions with human monocytes/macrophages.

Vaccine 2017 08 13;35(35 Pt B):4629-4636. Epub 2017 Jul 13.

Research Institute of McGill University Health Centre, Glen Site, 1001 Décarie Boul., Montréal, Québec H4A 3J1, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X173090
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http://dx.doi.org/10.1016/j.vaccine.2017.07.012DOI Listing
August 2017

High Resolution Dissection of Reactive Glial Nets in Alzheimer's Disease.

Sci Rep 2016 Apr 19;6:24544. Epub 2016 Apr 19.

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/srep24544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835751PMC
April 2016

Neurons diversify astrocytes in the adult brain through sonic hedgehog signaling.

Science 2016 Feb;351(6275):849-54

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1126/science.aab3103DOI Listing
February 2016

Regional expression and ultrastructural localization of EphA7 in the hippocampus and cerebellum of adult rat.

J Comp Neurol 2016 08 26;524(12):2462-78. Epub 2016 Feb 26.

Département de neurosciences and Groupe de recherche sur le système nerveux central (GRSNC), Université de Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1002/cne.23962DOI Listing
August 2016

Synergistic actions of microglia and astrocytes in the progression of Alzheimer's disease.

J Alzheimers Dis 2015 ;45(4):1001-14

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.3233/JAD-143156DOI Listing
March 2016

FXR1P limits long-term memory, long-lasting synaptic potentiation, and de novo GluA2 translation.

Cell Rep 2014 Nov 13;9(4):1402-1416. Epub 2014 Nov 13.

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, QC H3G 1A4, Canada.

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http://dx.doi.org/10.1016/j.celrep.2014.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254574PMC
November 2014

Activity-dependent structural plasticity of perisynaptic astrocytic domains promotes excitatory synapse stability.

Curr Biol 2014 Aug 17;24(15):1679-88. Epub 2014 Jul 17.

Department of Basic Neurosciences, Medical School, University of Geneva, Rue Michel-Servet 1, 1211 Geneva 4, Switzerland.

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https://linkinghub.elsevier.com/retrieve/pii/S09609822140074
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http://dx.doi.org/10.1016/j.cub.2014.06.025DOI Listing
August 2014

Imaging and monitoring astrocytes in health and disease.

Front Cell Neurosci 2014 12;8:74. Epub 2014 Mar 12.

Department of Neurology and Neurosurgery, Center for Research in Neuroscience Montreal, Canada.

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http://dx.doi.org/10.3389/fncel.2014.00074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950414PMC
March 2014

Increasing our understanding of human cognition through the study of Fragile X Syndrome.

Dev Neurobiol 2014 Feb 30;74(2):147-77. Epub 2013 Jul 30.

Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/dneu.22096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216185PMC
February 2014

In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse.

J Biol Chem 2013 Feb 26;288(7):5007-16. Epub 2012 Dec 26.

Glycobiology Unit, Tumor Microenvironment Program, Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://www.jbc.org/content/288/7/5007.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M112.433474
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http://dx.doi.org/10.1074/jbc.M112.433474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576103PMC
February 2013

Activity maintains structural plasticity of mossy fiber terminals in the hippocampus.

Mol Cell Neurosci 2012 Jul 10;50(3-4):260-71. Epub 2012 May 10.

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, QC, Canada H3G 1A4.

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http://dx.doi.org/10.1016/j.mcn.2012.05.004DOI Listing
July 2012

Glial glutamate transport modulates dendritic spine head protrusions in the hippocampus.

Glia 2012 Jul 4;60(7):1067-77. Epub 2012 Apr 4.

Department of Neurology and Neurosurgery, McGill University, Montréal, QC H3G 0B1, Canada.

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http://dx.doi.org/10.1002/glia.22335DOI Listing
July 2012

EphA signaling promotes actin-based dendritic spine remodeling through slingshot phosphatase.

J Biol Chem 2012 Mar 26;287(12):9346-59. Epub 2012 Jan 26.

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1074/jbc.M111.302802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308827PMC
March 2012

A neuron-astrocyte co-culture system to investigate astrocyte-secreted factors in mouse neuronal development.

Methods Mol Biol 2012 ;814:341-52

Centre for Research in Neuroscience, Montreal General Hospital, Montreal, QC, Canada.

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http://dx.doi.org/10.1007/978-1-61779-452-0_22DOI Listing
March 2012

Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus.

PLoS One 2011 11;6(10):e26120. Epub 2011 Oct 11.

Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026120PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191184PMC
February 2012

Astrocytes are endogenous regulators of basal transmission at central synapses.

Cell 2011 Sep;146(5):785-98

Département de physiologie, Université de Montréal, PO Box 6128, Station Centre-Ville, Montreal, QC H3C 3J7, Canada.

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http://dx.doi.org/10.1016/j.cell.2011.07.022DOI Listing
September 2011

Eph receptors and ephrins in neuron-astrocyte communication at synapses.

Glia 2011 Nov 17;59(11):1567-78. Epub 2011 Aug 17.

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal, Canada.

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http://dx.doi.org/10.1002/glia.21226DOI Listing
November 2011

Astrocytes display complex and localized calcium responses to single-neuron stimulation in the hippocampus.

J Neurosci 2011 Jun;31(24):8905-19

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada, H3G 1A4.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.6341-10.2
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http://dx.doi.org/10.1523/JNEUROSCI.6341-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622952PMC
June 2011

Astrocytes control glutamate receptor levels at developing synapses through SPARC-beta-integrin interactions.

J Neurosci 2011 Mar;31(11):4154-65

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec H3G 1A4, Canada.

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http://dx.doi.org/10.1523/JNEUROSCI.4757-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6623508PMC
March 2011

Restraining stem cell niche plasticity: a new talent of Eph receptors.

Cell Stem Cell 2010 Dec;7(6):647-8

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal General Hospital, QC, Canada.

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http://dx.doi.org/10.1016/j.stem.2010.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040214PMC
December 2010

EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain.

J Neurochem 2010 Apr 12;113(1):153-65. Epub 2010 Jan 12.

Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central, Université de Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06582.xDOI Listing
April 2010

Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport.

Proc Natl Acad Sci U S A 2009 Jul 10;106(30):12524-9. Epub 2009 Jul 10.

Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0903328106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718351PMC
July 2009

Subtype-specific oligodendrocyte dynamics in organotypic culture.

Glia 2009 Jul;57(9):1000-13

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/glia.20824DOI Listing
July 2009

Developmental course of EphA4 cellular and subcellular localization in the postnatal rat hippocampus.

J Comp Neurol 2009 Feb;512(6):798-813

Département de Pathologie et Biologie Cellulaire, Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, Montréal, Québec, Canada.

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http://doi.wiley.com/10.1002/cne.21922
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http://dx.doi.org/10.1002/cne.21922DOI Listing
February 2009

Localization of the Diaphanous-related formin Daam1 to neuronal dendrites.

Neurosci Lett 2008 Dec 25;447(1):62-7. Epub 2008 Sep 25.

Center for Research in Neuroscience, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.neulet.2008.09.051DOI Listing
December 2008

Reshaping neuron-glial communication at hippocampal synapses.

Neuron Glia Biol 2006 Feb;2(1):59-66

Centre for Research in Neuroscience, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Canada.

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http://dx.doi.org/10.1017/S1740925X06000032DOI Listing
February 2006

Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain.

J Neurochem 2008 Jul 12;106(2):682-95. Epub 2008 Apr 12.

Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central (GRSNC), Université de Montréal, Montréal, Quebéc, Canada.

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http://dx.doi.org/10.1111/j.1471-4159.2008.05416.xDOI Listing
July 2008

Neuroscience. Axons seek neighborly advice.

Science 2008 Apr;320(5873):185-6

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, Montreal, QC H3G 1A4, Canada.

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http://dx.doi.org/10.1126/science.1157605DOI Listing
April 2008

Neuron glial communication at synapses: insights from vertebrates and invertebrates.

Neuroscientist 2007 Dec 2;13(6):657-66. Epub 2007 Oct 2.

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University the Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1177/1073858407304393DOI Listing
December 2007

The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways.

J Cell Biol 2007 Sep 17;178(7):1295-307. Epub 2007 Sep 17.

Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1083/jcb.200610139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064660PMC
September 2007

EphA4 signaling regulates phospholipase Cgamma1 activation, cofilin membrane association, and dendritic spine morphology.

J Neurosci 2007 May;27(19):5127-38

Center for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada H3G 1A4.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.1170-07.2
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http://dx.doi.org/10.1523/JNEUROSCI.1170-07.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672384PMC
May 2007

Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus.

J Comp Neurol 2007 Apr;501(5):691-702

Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central, Université de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1002/cne.21263DOI Listing
April 2007

Cooperative astrocyte and dendritic spine dynamics at hippocampal excitatory synapses.

J Neurosci 2006 Aug;26(35):8881-91

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, H3G 1A4, Canada.

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http://dx.doi.org/10.1523/JNEUROSCI.1302-06.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675342PMC
August 2006

New exchanges in eph-dependent growth cone dynamics.

Neuron 2005 Apr;46(2):161-3

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A4.

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http://dx.doi.org/10.1016/j.neuron.2005.04.004DOI Listing
April 2005

Eph receptors, ephrins, and synaptic function.

Neuroscientist 2004 Aug;10(4):304-14

Centre for Research in Neuroscience, McGill University Health Centre, Montreal General Hospital, Montreal, Canada.

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http://dx.doi.org/10.1177/1073858403262221DOI Listing
August 2004

Targeting the EphA4 receptor in the nervous system with biologically active peptides.

Mol Cell Neurosci 2003 Dec;24(4):1000-11

The Burnham Institute, Neurobiology Program, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.mcn.2003.08.006DOI Listing
December 2003

'Eph'ective signaling: forward, reverse and crosstalk.

J Cell Sci 2003 Jul;116(Pt 14):2823-32

The Burnham Institute, Neurobiology Program, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1242/jcs.00625DOI Listing
July 2003

Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling.

Nat Neurosci 2003 Feb;6(2):153-60

The Burnham Institute, Neurobiology Program, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nn994DOI Listing
February 2003

Contactin supports synaptic plasticity associated with hippocampal long-term depression but not potentiation.

Curr Biol 2002 Feb;12(3):181-90

The Burnham Institute, Neurobiology Program, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/s0960-9822(02)00680-2DOI Listing
February 2002

Can Eph receptors stimulate the mind?

Neuron 2002 Jan;33(2):159-62

The Burnham Institute, Neurobiology Program, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/s0896-6273(02)00565-2DOI Listing
January 2002