Keith B Elkon

Keith B Elkon

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Keith B Elkon

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Aspirin meets cGAS.

Authors:
Keith B Elkon

Nat Rev Rheumatol 2019 05;15(5):254-255

Departments of Medicine and Immunology, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1038/s41584-019-0205-yDOI Listing
May 2019

Review: Cell Death, Nucleic Acids, and Immunity: Inflammation Beyond the Grave.

Authors:
Keith B Elkon

Arthritis Rheumatol 2018 06 18;70(6):805-816. Epub 2018 Apr 18.

University of Washington, Seattle.

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http://dx.doi.org/10.1002/art.40452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984680PMC
June 2018

TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA.

J Exp Med 2017 Jul 12;214(7):2103-2119. Epub 2017 Jun 12.

Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA 98109

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http://dx.doi.org/10.1084/jem.20161512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502427PMC
July 2017

Expression of Cyclic GMP-AMP Synthase in Patients With Systemic Lupus Erythematosus.

Arthritis Rheumatol 2017 04 7;69(4):800-807. Epub 2017 Mar 7.

University of Washington, Seattle.

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http://dx.doi.org/10.1002/art.40002DOI Listing
April 2017

Antimalarial Drugs as Immune Modulators: New Mechanisms for Old Drugs.

Annu Rev Med 2017 01 21;68:317-330. Epub 2016 Oct 21.

Division of Rheumatology, Department of Medicine, University of Washington, Seattle, Washington 98195; email

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http://dx.doi.org/10.1146/annurev-med-043015-123453DOI Listing
January 2017

Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity.

Annu Rev Med 2016 2;67:323-36. Epub 2015 Nov 2.

Program in Innate Immunity, University of Massachusetts Medical School, Worcester, Massachusetts 01605.

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http://dx.doi.org/10.1146/annurev-med-052814-023338DOI Listing
October 2016

Citrullination in Rheumatoid Arthritis-A Process Promoted by Neutrophil Lysis?

Rambam Maimonides Med J 2016 Oct 31;7(4). Epub 2016 Oct 31.

Division of Rheumatology, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.5041/RMMJ.10254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101001PMC
October 2016

Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity.

Cell 2016 Jun 9;166(1):88-101. Epub 2016 Jun 9.

Department of Pathology, New York University School of Medicine, New York, NY 10016, USA; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA; Department of Medicine, New York University School of Medicine, New York, NY 10016, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(16)30585-2.pdf
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http://dx.doi.org/10.1016/j.cell.2016.05.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030815PMC
June 2016

Uncoupling complement C1s activation from C1q binding in apoptotic cell phagocytosis and immunosuppressive capacity.

Clin Immunol 2016 Feb 6;163:84-90. Epub 2016 Jan 6.

University of Washington, Division of Rheumatology, 750 Republican Street, Box 358060, Seattle, WA 98109, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15216616153008
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http://dx.doi.org/10.1016/j.clim.2015.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753131PMC
February 2016

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease.

Nat Med 2016 Feb 18;22(2):146-53. Epub 2016 Jan 18.

Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health (NIH), Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/nm.4027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742415PMC
February 2016

Cutting edge: Antimalarial drugs inhibit IFN-β production through blockade of cyclic GMP-AMP synthase-DNA interaction.

J Immunol 2015 May 27;194(9):4089-93. Epub 2015 Mar 27.

Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA 98109; Department of Immunology, University of Washington, Seattle, WA 98109

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1402793
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http://dx.doi.org/10.4049/jimmunol.1402793DOI Listing
May 2015

Beyond apoptosis in lupus.

Curr Opin Rheumatol 2014 Sep;26(5):459-66

Division of Rheumatology, University of Washington, Seattle, Washington, USA *Lucrezia Colonna and Christian Lood contributed equally to the writing of this article.

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http://dx.doi.org/10.1097/BOR.0000000000000083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272326PMC
September 2014

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus.

J Exp Med 2014 Sep 1;211(10):1969-76. Epub 2014 Sep 1.

Department of Microbiology and Immunology and Department of Pathology, Columbia University Medical Center, New York, NY 10032

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http://dx.doi.org/10.1084/jem.20132522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172218PMC
September 2014

Reply: To PMID 23840006.

Arthritis Rheumatol 2014 Aug;66(8):2309-10

University of Washington, Seattle, WA.

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http://dx.doi.org/10.1002/art.38684DOI Listing
August 2014

Editorial: toll-like receptor 7: more than skin deep?

Arthritis Rheumatol 2014 Mar;66(3):481-4

University of Washington, Seattle.

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http://doi.wiley.com/10.1002/art.38301
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http://dx.doi.org/10.1002/art.38301DOI Listing
March 2014

Poking holes in rheumatoid joints.

Authors:
Keith B Elkon

Sci Transl Med 2013 Oct;5(209):209fs39

Division of Rheumatology, University of Washington, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1126/scitranslmed.3007515DOI Listing
October 2013

Cutting edge: Type I IFN drives emergency myelopoiesis and peripheral myeloid expansion during chronic TLR7 signaling.

J Immunol 2013 Feb 9;190(3):886-91. Epub 2013 Jan 9.

Department of Immunology, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.4049/jimmunol.1202739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552021PMC
February 2013

Complement, interferon and lupus.

Curr Opin Immunol 2012 Dec 20;24(6):665-70. Epub 2012 Sep 20.

Division of Rheumatology and Department of Immunology, University of Washington, Seattle, WA 98195, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S095279151200127
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http://dx.doi.org/10.1016/j.coi.2012.08.004DOI Listing
December 2012

Naturally occurring autoantibodies to apoptotic cells.

Adv Exp Med Biol 2012 ;750:14-26

Department of Medicine and Immunology, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1007/978-1-4614-3461-0_2DOI Listing
October 2012

Type I IFN system in the development and manifestations of SLE.

Curr Opin Rheumatol 2012 Sep;24(5):499-505

Division of Rheumatology and Department of Immunology, University of Washington, Seattle, Washington, USA.

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http://pdfs.journals.lww.com/co-rheumatology/2012/09000/Type
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/BOR.0b013e3283562c3eDOI Listing
September 2012

Plasmacytoid dendritic cells and C1q differentially regulate inflammatory gene induction by lupus immune complexes.

J Immunol 2012 Jan 5;188(2):902-15. Epub 2011 Dec 5.

Department of Immunology, School of Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.4049/jimmunol.1102797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238790PMC
January 2012

Type I interferon and systemic lupus erythematosus.

J Interferon Cytokine Res 2011 Nov 22;31(11):803-12. Epub 2011 Aug 22.

Division of Rheumatology, University of Washington, Seattle, USA.

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http://www.liebertpub.com/doi/10.1089/jir.2011.0045
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http://dx.doi.org/10.1089/jir.2011.0045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216059PMC
November 2011

Autoimmunity in MFG-E8-deficient mice is associated with altered trafficking and enhanced cross-presentation of apoptotic cell antigens.

J Clin Invest 2011 Jun 2;121(6):2221-41. Epub 2011 May 2.

Division of Rheumatology, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1172/JCI43254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104739PMC
June 2011

Increased BCMA expression in lupus marks activated B cells, and BCMA receptor engagement enhances the response to TLR9 stimulation.

Autoimmunity 2011 Mar 20;44(2):69-81. Epub 2011 Jan 20.

Division of Rheumatology, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.3109/08916934.2010.509122DOI Listing
March 2011

Cytokines as therapeutic targets in SLE.

Nat Rev Rheumatol 2010 Jun 4;6(6):339-47. Epub 2010 May 4.

Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala SE-751 85, Sweden.

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http://www.nature.com/articles/nrrheum.2010.64
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http://dx.doi.org/10.1038/nrrheum.2010.64DOI Listing
June 2010

Autoimmunity: apoptotic fats grease transcription.

Authors:
Keith B Elkon

Nat Med 2009 Nov;15(11):1246-8

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http://dx.doi.org/10.1038/nm1109-1246DOI Listing
November 2009

Splenic phagocytes promote responses to nucleosomes in (NZB x NZW) F1 mice.

J Immunol 2008 Oct;181(8):5264-71

Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704580PMC
http://dx.doi.org/10.4049/jimmunol.181.8.5264DOI Listing
October 2008

Peripheral CD8 T-cell responses to apoptotic cell proteins and peptides.

Crit Rev Immunol 2007 ;27(4):357-65

Rheumatology, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1615/critrevimmunol.v27.i4.50DOI Listing
February 2008

Innate and adaptive immune response to apoptotic cells.

J Autoimmun 2007 Dec 20;29(4):303-9. Epub 2007 Sep 20.

Division of Rheumatology, 1959 NE Pacific Avenue, Box 356428, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.jaut.2007.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2100400PMC
December 2007

A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes.

J Immunol 2007 Jul;179(2):1096-103

Department of Immunology, M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.4049/jimmunol.179.2.1096DOI Listing
July 2007

IL-1alpha responds to necrotic cell death.

Authors:
Keith B Elkon

Nat Med 2007 Jul;13(7):778-80

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http://dx.doi.org/10.1038/nm0707-778DOI Listing
July 2007

Shining light on lupus and UV.

Arthritis Res Ther 2007 ;9(1):101

Division of Dermatology, University of Washington School of Medicine, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1186/ar2100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860055PMC
April 2007

Interferon-gamma regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17.

Arthritis Rheum 2007 Apr;56(4):1145-51

Division of Rheumatology, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1002/art.22453DOI Listing
April 2007

Role of complement and other innate immune mechanisms in the removal of apoptotic cells.

Curr Dir Autoimmun 2006 ;9:120-42

Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA 98195-6428, USA.

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http://dx.doi.org/10.1159/000090776DOI Listing
February 2006

Autoantibodies make a U-turn: the toll hypothesis for autoantibody specificity.

J Exp Med 2005 Dec;202(11):1465-9

Department of Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1084/jem.20052228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213341PMC
December 2005

IGM is required for efficient complement mediated phagocytosis of apoptotic cells in vivo.

Autoimmunity 2005 Jun;38(4):259-64

Division of Rheumatology and Immunology, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1080/08916930500124452DOI Listing
June 2005

The role of IgM antibodies in the recognition and clearance of apoptotic cells.

Mol Immunol 2005 May 16;42(7):781-7. Epub 2005 Jan 16.

Division of Rheumatology, University of Washington, P.O. Box 356428, 1959 NE Pacific Street, Seattle, WA 98195-6428, USA.

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http://dx.doi.org/10.1016/j.molimm.2004.07.045DOI Listing
May 2005

Scleroderma fibroblasts demonstrate enhanced activation of Akt (protein kinase B) in situ.

J Invest Dermatol 2005 Feb;124(2):298-303

Division of Rheumatology, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle 98195, Washington, USA.

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http://dx.doi.org/10.1111/j.0022-202X.2004.23559.xDOI Listing
February 2005

Mature dendritic cells readily break tolerance in normal mice but do not lead to disease expression.

Arthritis Rheum 2005 Jan;52(1):225-38

Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA.

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http://dx.doi.org/10.1002/art.20759DOI Listing
January 2005

Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells.

Immunity 2004 Nov;21(5):643-53

Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.immuni.2004.09.009DOI Listing
November 2004

Mechanisms of apoptosis.

Rheum Dis Clin North Am 2004 Aug;30(3):441-54, vii

Division of Rheumatology, University of Washington, 1959 NE Pacific Avenue, Box 356428, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.rdc.2004.04.008DOI Listing
August 2004

Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-alpha induction pathway.

Proc Natl Acad Sci U S A 2004 Apr 7;101(16):6200-5. Epub 2004 Apr 7.

Molecular Biology Graduate Program, Department of Microbiology and Immunology, Hearst Research Foundation, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.0308368101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC395946PMC
April 2004

Fibroblast and endothelial apoptosis in systemic sclerosis.

Curr Opin Rheumatol 2003 Nov;15(6):756-60

Division of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University School of Medicine, Seoul, Republic of Korea.

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http://dx.doi.org/10.1097/00002281-200311000-00012DOI Listing
November 2003

Differential recruitment of caspase 8 to cFlip confers sensitivity or resistance to Fas-mediated apoptosis in a subset of familial lymphoma patients.

Leuk Res 2003 Sep;27(9):841-51

Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/s0145-2126(03)00018-3DOI Listing
September 2003

Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1.

Immunity 2003 Aug;19(2):243-55

Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1016/s1074-7613(03)00209-7DOI Listing
August 2003

Opsonization of apoptotic cells and its effect on macrophage and T cell immune responses.

Ann N Y Acad Sci 2003 Apr;987:68-78

Department of Microbiology and Immunology and Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York 10021, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2003.tb06034.xDOI Listing
April 2003

Use of GC clamps in DHPLC mutation scanning.

Clin Med Res 2003 Apr;1(2):111-8

Research Division, Hospital for Special Surgery, New York, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069033PMC
http://dx.doi.org/10.3121/cmr.1.2.111DOI Listing
April 2003

Apoptosis: a case where too much or too little can lead to autoimmunity.

Mt Sinai J Med 2002 Sep;69(4):208-19

Department of Medicine, Rheumatology Division, Hospital for Special Surgery-Weill Medical College of Cornell University, New York, NY, USA.

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September 2002

Necessary role of phosphatidylinositol 3-kinase in transforming growth factor beta-mediated activation of Akt in normal and rheumatoid arthritis synovial fibroblasts.

Arthritis Rheum 2002 Jun;46(6):1504-11

Division of Rheumatology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1002/art.10314DOI Listing
June 2002