Publications

AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling.
Circ Res 2017 May 21;120(11):1727-1739. Epub 2017 Mar 21.
From the Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences (R.M., S.M., Q.G., R.A.-G., Q.Y., J.P.C., L.F.), Houston Methodist DeBakey Heart and Vascular Center, Department of Cardiology (R.A.-G., K.A.Y.), Department of Bioenergetics (H.J.P.), Houston Methodist Research Institute, TX; Department of Ophthalmology, Baylor College of Medicine, Houston, TX (S.K., Y.F.); and Department of Medicine, University of California, San Diego, La Jolla (F.A., Y.I.M.).


MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes.
Sci Rep 2016 Nov 9;6:36207. Epub 2016 Nov 9.
Department of Cardiovascular Sciences, Centre for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX 77030, USA.

Combination of angiotensin II and l-NG-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure.
Am J Physiol Heart Circ Physiol 2016 Mar 8;310(6):H667-80. Epub 2016 Jan 8.
Center for Bioenergetics, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, Texas;

Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis.
Hypertension 2016 Mar 18;67(3):597-605. Epub 2016 Jan 18.
From the Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (X.Y., Y.Y.); Texas A&M University Health Science Center, Institute of Biosciences and Technology, Houston (X.Y., X.L., T.Y., X.Y., Y.D., K.C.A., J.C.); Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China (X.Y., X.J., X.L.); Cardiovascular Disease and Research Institute, Affiliated Hospital of Hainan Medical College, Haikou, Hainan, China (T.L., J.G.); Department of Pediatrics, Indiana University School of Medicine, Indianapolis (J.S., L.W.); and Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX (K.A.Y., G.T.-A.).

MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1.
Biochem Biophys Res Commun 2016 Mar 17;471(4):423-9. Epub 2016 Feb 17.
Department of Cardiovascular Sciences, Centre for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX 77030, USA; Cell and Developmental Biology, Department of Cardiothoracic Surgery, Weill Cornell Medical College of Cornell University, New York, NY, USA. Electronic address:


Differential Mitochondrial Function in Remodeled Right and Nonremodeled Left Ventricles in Pulmonary Hypertension.
J Card Fail 2016 Jan 12;22(1):73-81. Epub 2015 Sep 12.
Bioenergetics Program, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, Texas; Department of Medicine, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, Texas. Electronic address:

Full Expression of Cardiomyopathy Is Partly Dependent on B-Cells: A Pathway That Involves Cytokine Activation, Immunoglobulin Deposition, and Activation of Apoptosis.
J Am Heart Assoc 2016 Jan 14;5(1). Epub 2016 Jan 14.
Houston Methodist DeBakey Heart & Vascular Center, Houston, TX (A.M.C.R., K.A.Y., J.H.F.A., C.M.O., A.B., J.D.E., G.T.A.) Houston Methodist Hospital Research Institute, Houston, TX (A.M.C.R., K.A.Y., D.J.H., J.D.E., G.T.A.) Catedra de Cardiologia y Medicina Vascular, Tecnológico de Monterrey, Mexico (G.T.A.).

Mechanical unloading promotes myocardial energy recovery in human heart failure.
Circ Cardiovasc Genet 2014 Jun 13;7(3):266-76. Epub 2014 May 13.
From the Methodist Diabetes and Metabolism Institute, Houston Methodist Research Institute, Houston, TX (A.A.G., D.J.H., C.J.L., W.A.H.); Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Houston, TX (Z.Y., S.T.C.W.); Center for Biostatistics, Houston Methodist Research Institute, Houston, TX (L.E.P.); Department of Medicine, Houston Methodist Hospital, Houston, TX (D.J.H., W.A.H.), Department of Radiology, Houston Methodist Hospital, Houston, TX (S.T.C.W.); Methodist DeBakey Heart and Vascular Institute, Houston, TX (A.M.C.-R., K.A.Y., J.D.E., M.L., G.T.-A.); Weill Cornell Medical College, New York, NY (A.A.G., D.J.H., A.M.C.-R., K.A.Y., Z.Y., J.D.E., M.L., L.E.P., C.J.L., S.T.C.W., G.T.-A., W.A.H.); Sarah W. Stedman Nutrition and Metabolism Center and Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center (R.D.S., B.W., O.L., C.B.N.); Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY (S.T.C.W.); Catedra de Cardiologia, Instituto Tecnologico de Monterrey, Monterrey, Mexico (G.T.-A.); The University of Texas Medical School at Houston, Houston, TX (H.T.).


Freshly isolated mitochondria from failing human hearts exhibit preserved respiratory function.
J Mol Cell Cardiol 2014 Mar 9;68:98-105. Epub 2014 Jan 9.
Bioenergetics Program, Houston Methodist Research Institute, Weill Cornell Medical College, USA; Houston Methodist Hospital Department of Medicine, Weill Cornell Medical College, USA. Electronic address:


Rad GTPase deficiency leads to cardiac hypertrophy.
Circulation 2007 Dec 3;116(25):2976-2983. Epub 2007 Dec 3.
Cardiovascular Center (L.C., J.Z., C.-Q.X., T.C., S.M.D., Y.E.C.), Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich; Joslin Diabetes Center (Y.-H.T., J.I., J.C.B., C.R.K.), Harvard Medical School, Boston, Mass; Institute of Molecular Medicine (Z.S., X.Z.), Peking University, Beijing, People's Republic of China; Department of Cardiology (K.A.Y.), The Methodist Hospital Research Institute, Houston, Tex; and Cardiovascular Research Institute (Q.Y.), Morehouse School of Medicine, Atlanta, Ga.

Fluorescence imaging microscopy of cellular markers in ischemic vs non-ischemic cardiomyopathy after left ventricular unloading.
J Heart Lung Transplant 2005 Apr;24(4):454-61
Department of Organ Transplantation Cardiovascular Pathology, Texas Heart Institute and St. Lukes Episcopal Hospital, Houston, Texas, USA.

Plasma neurohormone levels correlate with left ventricular functional and morphological improvement in LVAD patients.
J Surg Res 2005 Jan;123(1):25-32
Michael E. DeBakey Department of Surgery, Division of Transplant Surgery and Assist Devices, Baylor College of Medicine, Houston, Texas 77030, USA.


Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading.
Circulation 2003 Jul 21;108(4):407-13. Epub 2003 Jul 21.
Department of Molecular and Cellular Biology, Center for Cardiovascular Development, Methodist Hospital, Baylor College of Medicine, One Baylor Plaza, Houston, Tex 77030, USA.

Regulation of ICAM-1 and IL-6 in Myocardial Ischemia: Effect of Reperfusion a.
Ann N Y Acad Sci 1994 Jun;723(1):258-270
Section of Cardiovascular Sciences Department of Medicine Baylor College of Medicine One Baylor Plaza Houston, Texas 77030-3498Department of Pathology The University of Texas Medical Branch 11th & Texas Avenue Galveston, Texas 77555-0609Department of Medicine Section of Atherosclerosis Baylor College of Medicine One Baylor Plaza Houston, Texas 77030-3498Texas Children's Hospital Speros P. Martel, Section of Leukocyte Biology Clinical Care Center, Suite 1130 6621 Fannin, MC 3-2372 Houston, Texas 77030-2399.

Enhanced Cardiac Regenerative Ability of Stem Cells After Ischemia-Reperfusion Injury: Role of Human CD34+ Cells Deficient in MicroRNA-377.
J Am Coll Cardiol 2015 11;66(20):2214-2226
Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, Texas; Department of Cell and Developmental Biology, Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, New York. Electronic address:

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