Keith A Youker

Keith A Youker

UNVERIFIED PROFILE

Are you Keith A Youker?   Register this Author

Register author
Keith A Youker

Keith A Youker

Publications by authors named "Keith A Youker"

Are you Keith A Youker?   Register this Author

48Publications

416Reads

-Profile Views

Functionally redundant control of cardiac hypertrophic signaling by inositol 1,4,5-trisphosphate receptors.

J Mol Cell Cardiol 2017 11 18;112:95-103. Epub 2017 Sep 18.

Department of Biochemistry and Molecular Biology, McGovern Medical School at UTHealth, Houston, TX 77030, United States. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00222828173030
Publisher Site
http://dx.doi.org/10.1016/j.yjmcc.2017.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793903PMC
November 2017

AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling.

Circ Res 2017 May 21;120(11):1727-1739. Epub 2017 Mar 21.

From the Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences (R.M., S.M., Q.G., R.A.-G., Q.Y., J.P.C., L.F.), Houston Methodist DeBakey Heart and Vascular Center, Department of Cardiology (R.A.-G., K.A.Y.), Department of Bioenergetics (H.J.P.), Houston Methodist Research Institute, TX; Department of Ophthalmology, Baylor College of Medicine, Houston, TX (S.K., Y.F.); and Department of Medicine, University of California, San Diego, La Jolla (F.A., Y.I.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.116.309754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446274PMC
May 2017

MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes.

Sci Rep 2016 11 9;6:36207. Epub 2016 Nov 9.

Department of Cardiovascular Sciences, Centre for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep36207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101812PMC
November 2016

Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis.

Hypertension 2016 Mar 18;67(3):597-605. Epub 2016 Jan 18.

From the Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (X.Y., Y.Y.); Texas A&M University Health Science Center, Institute of Biosciences and Technology, Houston (X.Y., X.L., T.Y., X.Y., Y.D., K.C.A., J.C.); Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China (X.Y., X.J., X.L.); Cardiovascular Disease and Research Institute, Affiliated Hospital of Hainan Medical College, Haikou, Hainan, China (T.L., J.G.); Department of Pediatrics, Indiana University School of Medicine, Indianapolis (J.S., L.W.); and Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX (K.A.Y., G.T.-A.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752414PMC
March 2016

MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1.

Biochem Biophys Res Commun 2016 Mar 17;471(4):423-9. Epub 2016 Feb 17.

Department of Cardiovascular Sciences, Centre for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX 77030, USA; Cell and Developmental Biology, Department of Cardiothoracic Surgery, Weill Cornell Medical College of Cornell University, New York, NY, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2016.02.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818978PMC
March 2016

Differential Mitochondrial Function in Remodeled Right and Nonremodeled Left Ventricles in Pulmonary Hypertension.

J Card Fail 2016 Jan 12;22(1):73-81. Epub 2015 Sep 12.

Bioenergetics Program, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, Texas; Department of Medicine, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, Texas. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10719164150103
Publisher Site
http://dx.doi.org/10.1016/j.cardfail.2015.09.001DOI Listing
January 2016

Full Expression of Cardiomyopathy Is Partly Dependent on B-Cells: A Pathway That Involves Cytokine Activation, Immunoglobulin Deposition, and Activation of Apoptosis.

J Am Heart Assoc 2016 Jan 14;5(1). Epub 2016 Jan 14.

Houston Methodist DeBakey Heart & Vascular Center, Houston, TX (A.M.C.R., K.A.Y., J.H.F.A., C.M.O., A.B., J.D.E., G.T.A.) Houston Methodist Hospital Research Institute, Houston, TX (A.M.C.R., K.A.Y., D.J.H., J.D.E., G.T.A.) Catedra de Cardiologia y Medicina Vascular, Tecnológico de Monterrey, Mexico (G.T.A.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/JAHA.115.002484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859365PMC
January 2016

Enhanced Cardiac Regenerative Ability of Stem Cells After Ischemia-Reperfusion Injury: Role of Human CD34+ Cells Deficient in MicroRNA-377.

J Am Coll Cardiol 2015 11;66(20):2214-2226

Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, Texas; Department of Cell and Developmental Biology, Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, New York. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacc.2015.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644493PMC
November 2015

Mechanical unloading promotes myocardial energy recovery in human heart failure.

Circ Cardiovasc Genet 2014 Jun 13;7(3):266-76. Epub 2014 May 13.

From the Methodist Diabetes and Metabolism Institute, Houston Methodist Research Institute, Houston, TX (A.A.G., D.J.H., C.J.L., W.A.H.); Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Houston, TX (Z.Y., S.T.C.W.); Center for Biostatistics, Houston Methodist Research Institute, Houston, TX (L.E.P.); Department of Medicine, Houston Methodist Hospital, Houston, TX (D.J.H., W.A.H.), Department of Radiology, Houston Methodist Hospital, Houston, TX (S.T.C.W.); Methodist DeBakey Heart and Vascular Institute, Houston, TX (A.M.C.-R., K.A.Y., J.D.E., M.L., G.T.-A.); Weill Cornell Medical College, New York, NY (A.A.G., D.J.H., A.M.C.-R., K.A.Y., Z.Y., J.D.E., M.L., L.E.P., C.J.L., S.T.C.W., G.T.-A., W.A.H.); Sarah W. Stedman Nutrition and Metabolism Center and Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center (R.D.S., B.W., O.L., C.B.N.); Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY (S.T.C.W.); Catedra de Cardiologia, Instituto Tecnologico de Monterrey, Monterrey, Mexico (G.T.-A.); The University of Texas Medical School at Houston, Houston, TX (H.T.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.113.000404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394989PMC
June 2014

Freshly isolated mitochondria from failing human hearts exhibit preserved respiratory function.

J Mol Cell Cardiol 2014 Mar 9;68:98-105. Epub 2014 Jan 9.

Bioenergetics Program, Houston Methodist Research Institute, Weill Cornell Medical College, USA; Houston Methodist Hospital Department of Medicine, Weill Cornell Medical College, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2013.12.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995348PMC
March 2014

The role of B-cells in heart failure.

Methodist Debakey Cardiovasc J 2013 Jan-Mar;9(1):15-9

Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600879PMC
September 2013

Cellular evidence of reverse cardiac remodeling induced by cardiac resynchronization therapy.

Congest Heart Fail 2011 May-Jun;17(3):140-6. Epub 2011 May 23.

Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1751-7133.2011.00227.xDOI Listing
September 2011

Therapeutic plasma exchange a potential strategy for patients with advanced heart failure.

J Clin Apher 2010 24;25(6):323-30. Epub 2010 Sep 24.

Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.20264DOI Listing
June 2011

Reversal of secondary pulmonary hypertension by axial and pulsatile mechanical circulatory support.

J Heart Lung Transplant 2010 Feb 26;29(2):195-200. Epub 2009 Sep 26.

The Department of Cardiology, The Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.healun.2009.05.030DOI Listing
February 2010

Mast cell burden and reticulin fibrosis in the myeloproliferative neoplasms: a computer-assisted image analysis study.

Pathol Res Pract 2009 14;205(9):634-8. Epub 2009 May 14.

The Department of Pathology and Laboratory Medicine, The Methodist Hospital and Research Institute, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prp.2009.04.003DOI Listing
October 2009

Increased expression of stem cell factor and its receptor after left ventricular assist device support: a potential novel target for therapeutic interventions in heart failure.

J Heart Lung Transplant 2008 Jul 2;27(7):701-9. Epub 2008 Jun 2.

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.healun.2008.03.021DOI Listing
July 2008

The role of mast cells after solid organ transplantation.

Transplantation 2008 May;85(10):1365-71

Michael E DeBakey Department of Surgery, Division of Transplant and Assist Devices, Baylor College of Medicine, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0b013e31816fc0a3DOI Listing
May 2008

Myocardial contrast echocardiography of radiofrequency ablation lesions.

Conf Proc IEEE Eng Med Biol Soc 2006 ;Suppl:6689-92

Center for Experimental Cardiac Electrophysiology, Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1109/IEMBS.2006.260922DOI Listing
April 2008

Rad GTPase deficiency leads to cardiac hypertrophy.

Circulation 2007 Dec 3;116(25):2976-2983. Epub 2007 Dec 3.

Cardiovascular Center (L.C., J.Z., C.-Q.X., T.C., S.M.D., Y.E.C.), Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich; Joslin Diabetes Center (Y.-H.T., J.I., J.C.B., C.R.K.), Harvard Medical School, Boston, Mass; Institute of Molecular Medicine (Z.S., X.Z.), Peking University, Beijing, People's Republic of China; Department of Cardiology (K.A.Y.), The Methodist Hospital Research Institute, Houston, Tex; and Cardiovascular Research Institute (Q.Y.), Morehouse School of Medicine, Atlanta, Ga.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.107.707257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207362PMC
December 2007

Mast cell-derived cathepsin g: a possible role in the adverse remodeling of the failing human heart.

J Surg Res 2007 Jun 9;140(2):199-203. Epub 2007 Apr 9.

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2007.02.040DOI Listing
June 2007

Mechanical unloading of the heart activates the calpain system.

J Mol Cell Cardiol 2007 Feb 4;42(2):449-52. Epub 2006 Oct 4.

Department of Internal Medicine, Division of Cardiology, University of Texas Houston-Medical School, 6431 Fannin, MSB 1.222, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2006.08.114DOI Listing
February 2007

Decorin-mediated transforming growth factor-beta inhibition ameliorates adverse cardiac remodeling.

J Heart Lung Transplant 2007 Jan 30;26(1):34-40. Epub 2006 Nov 30.

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.healun.2006.10.005DOI Listing
January 2007

Quantitative changes in mast cell populations after left ventricular assist device implantation.

ASAIO J 2005 May-Jun;51(3):275-80

Yuksek Ihtisas Hospital, Department of Cardiovascular Surgery, Ankara, Turkey.

View Article

Download full-text PDF

Source
August 2005

Fluorescence imaging microscopy of cellular markers in ischemic vs non-ischemic cardiomyopathy after left ventricular unloading.

J Heart Lung Transplant 2005 Apr;24(4):454-61

Department of Organ Transplantation Cardiovascular Pathology, Texas Heart Institute and St. Lukes Episcopal Hospital, Houston, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.healun.2004.02.003DOI Listing
April 2005

Placement of a left ventricular assist device in a patient with dextrocardia.

J Heart Lung Transplant 2005 Mar;24(3):338-9

Michael E. DeBakey Department of Surgery, Division of Transplant Surgery and Assist Devices, Baylor College of Medicine, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S105324980300989
Publisher Site
http://dx.doi.org/10.1016/j.healun.2003.11.404DOI Listing
March 2005

Plasma neurohormone levels correlate with left ventricular functional and morphological improvement in LVAD patients.

J Surg Res 2005 Jan;123(1):25-32

Michael E. DeBakey Department of Surgery, Division of Transplant Surgery and Assist Devices, Baylor College of Medicine, Houston, Texas 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2004.05.013DOI Listing
January 2005

Organ-specific regulation of pro-inflammatory molecules in heart, lung, and kidney following brain death.

J Surg Res 2005 Jan;123(1):118-25

Michael E. DeBakey Department of Surgery, Division of Transplant Surgery and Assist Devices, Baylor College of Medicine, Houston, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2004.07.245DOI Listing
January 2005

Localizing and quantifying ablation lesions in the left ventricle by myocardial contrast echocardiography.

J Cardiovasc Electrophysiol 2004 Sep;15(9):1078-87

Center for Experimental Cardiac Electrophysiology, Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1540-8167.2004.04087.xDOI Listing
September 2004

Role of mast cells and their mediators in failing myocardium under mechanical ventricular support.

J Heart Lung Transplant 2004 Jun;23(6):709-15

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.

View Article

Download full-text PDF

Source
June 2004

Interaction between isolated human myocardial mast cells and cultured fibroblasts.

J Surg Res 2004 May;118(1):66-70

Baylor College of Medicine, Michael E. DeBakey Department of Surgery, Division of Transplant Surgery and Assist Devices, Houstion, Texas 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2004.02.006DOI Listing
May 2004

Mechanical unloading of the failing human heart fails to activate the protein kinase B/Akt/glycogen synthase kinase-3beta survival pathway.

Cardiology 2003 ;100(1):17-22

Division of Cardiology, University of Texas-Houston Medical School, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000072387DOI Listing
January 2004

Apicoaortic conduit in a patient with severe hemolysis after three aortic valve replacements.

J Thorac Cardiovasc Surg 2004 Jan;127(1):270-2

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtcvs.2003.07.002DOI Listing
January 2004

Somatostatin receptor gene transfer inhibits established pancreatic cancer xenografts.

J Surg Res 2003 Nov;115(1):41-7

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.

View Article

Download full-text PDF

Source
November 2003

Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading.

Circulation 2003 Jul 21;108(4):407-13. Epub 2003 Jul 21.

Department of Molecular and Cellular Biology, Center for Cardiovascular Development, Methodist Hospital, Baylor College of Medicine, One Baylor Plaza, Houston, Tex 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/01.CIR.0000084502.02147.83DOI Listing
July 2003

Telomere attrition and Chk2 activation in human heart failure.

Proc Natl Acad Sci U S A 2003 Apr 17;100(9):5378-83. Epub 2003 Apr 17.

Center for Cardiovascular Development, and Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0836098100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154353PMC
April 2003

Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart.

Diabetes 2002 Aug;51(8):2587-95

Department of Internal Medicine, Division of Cardiology, University of Texas-Houston Medical School, Houston, Texas 77030, USA.

View Article

Download full-text PDF

Source
August 2002