Keith A Youker

Keith A Youker

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Keith A Youker

Keith A Youker

Publications by authors named "Keith A Youker"

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49Publications

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Functionally redundant control of cardiac hypertrophic signaling by inositol 1,4,5-trisphosphate receptors.

J Mol Cell Cardiol 2017 11 18;112:95-103. Epub 2017 Sep 18.

Department of Biochemistry and Molecular Biology, McGovern Medical School at UTHealth, Houston, TX 77030, United States. Electronic address:

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November 2017

AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling.

Circ Res 2017 May 21;120(11):1727-1739. Epub 2017 Mar 21.

From the Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences (R.M., S.M., Q.G., R.A.-G., Q.Y., J.P.C., L.F.), Houston Methodist DeBakey Heart and Vascular Center, Department of Cardiology (R.A.-G., K.A.Y.), Department of Bioenergetics (H.J.P.), Houston Methodist Research Institute, TX; Department of Ophthalmology, Baylor College of Medicine, Houston, TX (S.K., Y.F.); and Department of Medicine, University of California, San Diego, La Jolla (F.A., Y.I.M.).

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May 2017

MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes.

Sci Rep 2016 11 9;6:36207. Epub 2016 Nov 9.

Department of Cardiovascular Sciences, Centre for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX 77030, USA.

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November 2016

Combination of angiotensin II and l-NG-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure.

Am J Physiol Heart Circ Physiol 2016 Mar 8;310(6):H667-80. Epub 2016 Jan 8.

Center for Bioenergetics, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, Texas;

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March 2016

Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis.

Hypertension 2016 Mar 18;67(3):597-605. Epub 2016 Jan 18.

From the Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (X.Y., Y.Y.); Texas A&M University Health Science Center, Institute of Biosciences and Technology, Houston (X.Y., X.L., T.Y., X.Y., Y.D., K.C.A., J.C.); Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China (X.Y., X.J., X.L.); Cardiovascular Disease and Research Institute, Affiliated Hospital of Hainan Medical College, Haikou, Hainan, China (T.L., J.G.); Department of Pediatrics, Indiana University School of Medicine, Indianapolis (J.S., L.W.); and Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX (K.A.Y., G.T.-A.).

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March 2016

MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1.

Biochem Biophys Res Commun 2016 Mar 17;471(4):423-9. Epub 2016 Feb 17.

Department of Cardiovascular Sciences, Centre for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX 77030, USA; Cell and Developmental Biology, Department of Cardiothoracic Surgery, Weill Cornell Medical College of Cornell University, New York, NY, USA. Electronic address:

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March 2016

Differential Mitochondrial Function in Remodeled Right and Nonremodeled Left Ventricles in Pulmonary Hypertension.

J Card Fail 2016 Jan 12;22(1):73-81. Epub 2015 Sep 12.

Bioenergetics Program, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, Texas; Department of Medicine, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, Texas. Electronic address:

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January 2016

Full Expression of Cardiomyopathy Is Partly Dependent on B-Cells: A Pathway That Involves Cytokine Activation, Immunoglobulin Deposition, and Activation of Apoptosis.

J Am Heart Assoc 2016 Jan 14;5(1). Epub 2016 Jan 14.

Houston Methodist DeBakey Heart & Vascular Center, Houston, TX (A.M.C.R., K.A.Y., J.H.F.A., C.M.O., A.B., J.D.E., G.T.A.) Houston Methodist Hospital Research Institute, Houston, TX (A.M.C.R., K.A.Y., D.J.H., J.D.E., G.T.A.) Catedra de Cardiologia y Medicina Vascular, Tecnológico de Monterrey, Mexico (G.T.A.).

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January 2016

Enhanced Cardiac Regenerative Ability of Stem Cells After Ischemia-Reperfusion Injury: Role of Human CD34+ Cells Deficient in MicroRNA-377.

J Am Coll Cardiol 2015 11;66(20):2214-2226

Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, Texas; Department of Cell and Developmental Biology, Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, New York. Electronic address:

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November 2015

Mechanical unloading promotes myocardial energy recovery in human heart failure.

Circ Cardiovasc Genet 2014 Jun 13;7(3):266-76. Epub 2014 May 13.

From the Methodist Diabetes and Metabolism Institute, Houston Methodist Research Institute, Houston, TX (A.A.G., D.J.H., C.J.L., W.A.H.); Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Houston, TX (Z.Y., S.T.C.W.); Center for Biostatistics, Houston Methodist Research Institute, Houston, TX (L.E.P.); Department of Medicine, Houston Methodist Hospital, Houston, TX (D.J.H., W.A.H.), Department of Radiology, Houston Methodist Hospital, Houston, TX (S.T.C.W.); Methodist DeBakey Heart and Vascular Institute, Houston, TX (A.M.C.-R., K.A.Y., J.D.E., M.L., G.T.-A.); Weill Cornell Medical College, New York, NY (A.A.G., D.J.H., A.M.C.-R., K.A.Y., Z.Y., J.D.E., M.L., L.E.P., C.J.L., S.T.C.W., G.T.-A., W.A.H.); Sarah W. Stedman Nutrition and Metabolism Center and Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center (R.D.S., B.W., O.L., C.B.N.); Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY (S.T.C.W.); Catedra de Cardiologia, Instituto Tecnologico de Monterrey, Monterrey, Mexico (G.T.-A.); The University of Texas Medical School at Houston, Houston, TX (H.T.).

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June 2014

Freshly isolated mitochondria from failing human hearts exhibit preserved respiratory function.

J Mol Cell Cardiol 2014 Mar 9;68:98-105. Epub 2014 Jan 9.

Bioenergetics Program, Houston Methodist Research Institute, Weill Cornell Medical College, USA; Houston Methodist Hospital Department of Medicine, Weill Cornell Medical College, USA. Electronic address:

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March 2014

The role of B-cells in heart failure.

Methodist Debakey Cardiovasc J 2013 Jan-Mar;9(1):15-9

Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, USA.

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September 2013

Cellular evidence of reverse cardiac remodeling induced by cardiac resynchronization therapy.

Congest Heart Fail 2011 May-Jun;17(3):140-6. Epub 2011 May 23.

Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX 77030, USA.

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September 2011

Therapeutic plasma exchange a potential strategy for patients with advanced heart failure.

J Clin Apher 2010 24;25(6):323-30. Epub 2010 Sep 24.

Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, Texas, USA.

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June 2011

Reversal of secondary pulmonary hypertension by axial and pulsatile mechanical circulatory support.

J Heart Lung Transplant 2010 Feb 26;29(2):195-200. Epub 2009 Sep 26.

The Department of Cardiology, The Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, USA.

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February 2010

Mast cell burden and reticulin fibrosis in the myeloproliferative neoplasms: a computer-assisted image analysis study.

Pathol Res Pract 2009 14;205(9):634-8. Epub 2009 May 14.

The Department of Pathology and Laboratory Medicine, The Methodist Hospital and Research Institute, Houston, TX 77030, USA.

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October 2009

The role of mast cells after solid organ transplantation.

Transplantation 2008 May;85(10):1365-71

Michael E DeBakey Department of Surgery, Division of Transplant and Assist Devices, Baylor College of Medicine, Houston, TX 77030, USA.

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May 2008

Myocardial contrast echocardiography of radiofrequency ablation lesions.

Conf Proc IEEE Eng Med Biol Soc 2006 ;Suppl:6689-92

Center for Experimental Cardiac Electrophysiology, Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

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April 2008

Rad GTPase deficiency leads to cardiac hypertrophy.

Circulation 2007 Dec 3;116(25):2976-2983. Epub 2007 Dec 3.

Cardiovascular Center (L.C., J.Z., C.-Q.X., T.C., S.M.D., Y.E.C.), Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich; Joslin Diabetes Center (Y.-H.T., J.I., J.C.B., C.R.K.), Harvard Medical School, Boston, Mass; Institute of Molecular Medicine (Z.S., X.Z.), Peking University, Beijing, People's Republic of China; Department of Cardiology (K.A.Y.), The Methodist Hospital Research Institute, Houston, Tex; and Cardiovascular Research Institute (Q.Y.), Morehouse School of Medicine, Atlanta, Ga.

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December 2007

Mast cell-derived cathepsin g: a possible role in the adverse remodeling of the failing human heart.

J Surg Res 2007 Jun 9;140(2):199-203. Epub 2007 Apr 9.

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA.

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June 2007

Lack of NF-kappaB1 (p105/p50) attenuates unloading-induced downregulation of PPARalpha and PPARalpha-regulated gene expression in rodent heart.

Cardiovasc Res 2007 Apr 3;74(1):133-9. Epub 2007 Jan 3.

Division of Cardiology, University of Texas Houston-Medical School, Houston, Texas 77030, USA.

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April 2007

Mechanical unloading of the heart activates the calpain system.

J Mol Cell Cardiol 2007 Feb 4;42(2):449-52. Epub 2006 Oct 4.

Department of Internal Medicine, Division of Cardiology, University of Texas Houston-Medical School, 6431 Fannin, MSB 1.222, Houston, TX 77030, USA.

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February 2007

Decorin-mediated transforming growth factor-beta inhibition ameliorates adverse cardiac remodeling.

J Heart Lung Transplant 2007 Jan 30;26(1):34-40. Epub 2006 Nov 30.

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA.

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January 2007

Quantitative changes in mast cell populations after left ventricular assist device implantation.

ASAIO J 2005 May-Jun;51(3):275-80

Yuksek Ihtisas Hospital, Department of Cardiovascular Surgery, Ankara, Turkey.

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August 2005

Fluorescence imaging microscopy of cellular markers in ischemic vs non-ischemic cardiomyopathy after left ventricular unloading.

J Heart Lung Transplant 2005 Apr;24(4):454-61

Department of Organ Transplantation Cardiovascular Pathology, Texas Heart Institute and St. Lukes Episcopal Hospital, Houston, Texas, USA.

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April 2005

Placement of a left ventricular assist device in a patient with dextrocardia.

J Heart Lung Transplant 2005 Mar;24(3):338-9

Michael E. DeBakey Department of Surgery, Division of Transplant Surgery and Assist Devices, Baylor College of Medicine, Houston, TX 77030, USA.

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March 2005

Plasma neurohormone levels correlate with left ventricular functional and morphological improvement in LVAD patients.

J Surg Res 2005 Jan;123(1):25-32

Michael E. DeBakey Department of Surgery, Division of Transplant Surgery and Assist Devices, Baylor College of Medicine, Houston, Texas 77030, USA.

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January 2005

Organ-specific regulation of pro-inflammatory molecules in heart, lung, and kidney following brain death.

J Surg Res 2005 Jan;123(1):118-25

Michael E. DeBakey Department of Surgery, Division of Transplant Surgery and Assist Devices, Baylor College of Medicine, Houston, Texas, USA.

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January 2005

Localizing and quantifying ablation lesions in the left ventricle by myocardial contrast echocardiography.

J Cardiovasc Electrophysiol 2004 Sep;15(9):1078-87

Center for Experimental Cardiac Electrophysiology, Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

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September 2004

Role of mast cells and their mediators in failing myocardium under mechanical ventricular support.

J Heart Lung Transplant 2004 Jun;23(6):709-15

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.

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June 2004

Interaction between isolated human myocardial mast cells and cultured fibroblasts.

J Surg Res 2004 May;118(1):66-70

Baylor College of Medicine, Michael E. DeBakey Department of Surgery, Division of Transplant Surgery and Assist Devices, Houstion, Texas 77030, USA.

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May 2004

Apicoaortic conduit in a patient with severe hemolysis after three aortic valve replacements.

J Thorac Cardiovasc Surg 2004 Jan;127(1):270-2

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.

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January 2004

Somatostatin receptor gene transfer inhibits established pancreatic cancer xenografts.

J Surg Res 2003 Nov;115(1):41-7

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.

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November 2003

Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading.

Circulation 2003 Jul 21;108(4):407-13. Epub 2003 Jul 21.

Department of Molecular and Cellular Biology, Center for Cardiovascular Development, Methodist Hospital, Baylor College of Medicine, One Baylor Plaza, Houston, Tex 77030, USA.

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July 2003

Telomere attrition and Chk2 activation in human heart failure.

Proc Natl Acad Sci U S A 2003 Apr 17;100(9):5378-83. Epub 2003 Apr 17.

Center for Cardiovascular Development, and Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

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April 2003

Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart.

Diabetes 2002 Aug;51(8):2587-95

Department of Internal Medicine, Division of Cardiology, University of Texas-Houston Medical School, Houston, Texas 77030, USA.

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August 2002

Regulation of ICAM-1 and IL-6 in Myocardial Ischemia: Effect of Reperfusion a.

Ann N Y Acad Sci 1994 Jun;723(1):258-270

Section of Cardiovascular Sciences Department of Medicine Baylor College of Medicine One Baylor Plaza Houston, Texas 77030-3498Department of Pathology The University of Texas Medical Branch 11th & Texas Avenue Galveston, Texas 77555-0609Department of Medicine Section of Atherosclerosis Baylor College of Medicine One Baylor Plaza Houston, Texas 77030-3498Texas Children's Hospital Speros P. Martel, Section of Leukocyte Biology Clinical Care Center, Suite 1130 6621 Fannin, MC 3-2372 Houston, Texas 77030-2399.

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June 1994