Keith A Sharkey

Keith A Sharkey

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Keith A Sharkey

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Insights into the role of cannabis in the management of inflammatory bowel disease.

Therap Adv Gastroenterol 2019 3;12:1756284819870977. Epub 2019 Sep 3.

Inflammatory Bowel Disease Unit, Department of Gastroenterology, Cumming School of Medicine, University of Calgary, AB, Canada.

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http://dx.doi.org/10.1177/1756284819870977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727090PMC
September 2019

The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice.

Front Immunol 2019 12;10:803. Epub 2019 Apr 12.

Liver Unit, Snyder Institute for Chronic Disease, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.3389/fimmu.2019.00803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474187PMC
April 2019

Nausea-Induced 5-HT Release in the Interoceptive Insular Cortex and Regulation by Monoacylglycerol Lipase (MAGL) Inhibition and Cannabidiol.

eNeuro 2018 Jul-Aug;5(4). Epub 2018 Jul 31.

Department of Psychology and Neuroscience Program, University of Guelph, Guelph, Ontario N1G 2W1, Canada.

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http://dx.doi.org/10.1523/ENEURO.0256-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071201PMC
March 2019

Antibiotic treatment affects the expression levels of copper transporters and the isotopic composition of copper in the colon of mice.

Proc Natl Acad Sci U S A 2019 03 8;116(13):5955-5960. Epub 2019 Mar 8.

Department of Physics and Astronomy, University of Calgary, Calgary, AB, Canada T2N 1N4.

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http://dx.doi.org/10.1073/pnas.1814047116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442602PMC
March 2019

Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium.

Nat Rev Gastroenterol Hepatol 2018 12;15(12):765-784

Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1038/s41575-018-0051-4DOI Listing
December 2018

Helminth Antigen-Conditioned Dendritic Cells Generate Anti-Inflammatory Cd4 T Cells Independent of Antigen Presentation via Major Histocompatibility Complex Class II.

Am J Pathol 2018 11 17;188(11):2589-2604. Epub 2018 Aug 17.

Gastrointestinal Research Group and Inflammation Research Network, Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.07.008DOI Listing
November 2018

Modulation of the immune response by helminths: a role for serotonin?

Biosci Rep 2018 10 20;38(5). Epub 2018 Sep 20.

Gastrointestinal Research Group and Inflammation Research Network, Department of Physiology and Pharmacology, Calvin, Joan and Phoebe Snyder Institute for Chronic Diseases, Cumming School of Medicine, Calgary, Alberta, Canada

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http://dx.doi.org/10.1042/BSR20180027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148219PMC
October 2018

The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics.

Brain 2018 07;141(7):1900-1916

Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1093/brain/awy131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022557PMC
July 2018

Alterations in melatonin and 5-HT signalling in the colonic mucosa of mice with dextran-sodium sulfate-induced colitis.

Br J Pharmacol 2018 05 25;175(9):1535-1547. Epub 2018 Mar 25.

School of Pharmacy and Biomolecular Sciences, University of Brighton, Huxley Building, Brighton, UK.

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http://dx.doi.org/10.1111/bph.14163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900989PMC
May 2018

Altered Brain Excitability and Increased Anxiety in Mice With Experimental Colitis: Consideration of Hyperalgesia and Sex Differences.

Front Behav Neurosci 2018 3;12:58. Epub 2018 Apr 3.

Hotchkiss Brain Institute, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.3389/fnbeh.2018.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893896PMC
April 2018

The role of enteric neurons in the development and progression of colorectal cancer.

Biochim Biophys Acta Rev Cancer 2017 Dec 25;1868(2):420-434. Epub 2017 Aug 25.

Department of Pathology, GROW - School for Oncology & Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands; Department of Clinical Genetics, University of Rotterdam, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.08.003DOI Listing
December 2017

Primary Biliary Cholangitis Alters Functional Connections of the Brain's Deep Gray Matter.

Clin Transl Gastroenterol 2017 Jul 27;8(7):e107. Epub 2017 Jul 27.

Seaman Family MR Research Centre, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1038/ctg.2017.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539342PMC
July 2017

The Intrinsic Reflex Circuitry of the Inflamed Colon.

Adv Exp Med Biol 2016 ;891:153-7

Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1007/978-3-319-27592-5_15DOI Listing
June 2017

The Endocannabinoid System and Its Role in Regulating the Intrinsic Neural Circuitry of the Gastrointestinal Tract.

Int Rev Neurobiol 2015 6;125:85-126. Epub 2015 Nov 6.

Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/bs.irn.2015.10.002DOI Listing
September 2016

The Role of the Endocannabinoid System in the Brain-Gut Axis.

Gastroenterology 2016 08 29;151(2):252-66. Epub 2016 Apr 29.

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1053/j.gastro.2016.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961581PMC
August 2016

Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment.

J Inflamm (Lond) 2016 14;13:21. Epub 2016 Jul 14.

Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, AB Canada ; Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB Canada ; Division of Gastroenterology, Department of Medicine, Ludwig Maximilians University of Munich, Marchioninistrasse 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1186/s12950-016-0129-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944257PMC
July 2016

Prevention of Diet-Induced Obesity Effects on Body Weight and Gut Microbiota in Mice Treated Chronically with Δ9-Tetrahydrocannabinol.

PLoS One 2015 3;10(12):e0144270. Epub 2015 Dec 3.

Hotchkiss Brain Institute and Snyder Institute of Chronic Diseases, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144270PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669115PMC
June 2016

Malabsorption plays a major role in the effects of the biliopancreatic diversion with duodenal switch on energy metabolism in rats.

Surg Obes Relat Dis 2015 Mar-Apr;11(2):356-66. Epub 2014 Aug 12.

Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.soard.2014.07.020DOI Listing
February 2016

Intestinal microbiota: a regulator of intestinal inflammation and cardiac ischemia?

Curr Drug Targets 2015 ;16(3):199-208

Department of Internal Medicine, Texas Tech University, Health Sciences Center, Paul L. Foster School of Medicine, 4800 Alberta Ave, El Paso, TX 79905, USA.

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http://dx.doi.org/10.2174/1389450116666150120104012DOI Listing
January 2016

Cannabinoids alleviate experimentally induced intestinal inflammation by acting at central and peripheral receptors.

PLoS One 2014 2;9(10):e109115. Epub 2014 Oct 2.

Snyder Institute for Chronic Disease, Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Division of Gastroenterology, Department of Medicine, University of Munich, Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109115PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183544PMC
December 2015

Adoptive transfer of helminth antigen-pulsed dendritic cells protects against the development of experimental colitis in mice.

Eur J Immunol 2015 Nov 25;45(11):3126-39. Epub 2015 Sep 25.

Department of Physiology and Pharmacology, Gastrointestinal Research Group and Inflammation Research Network, Calvin, Joan and Phoebe Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://doi.wiley.com/10.1002/eji.201545579
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http://dx.doi.org/10.1002/eji.201545579DOI Listing
November 2015

Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis.

Gastroenterology 2015 Aug 9;149(2):445-55.e3. Epub 2015 Apr 9.

Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516675PMC
August 2015

Orally administered indomethacin acutely reduces cellular prion protein in the small intestine and modestly increases survival of mice exposed to infectious prions.

Scand J Gastroenterol 2015 May 19;50(5):542-9. Epub 2015 Jan 19.

Hotchkiss Brain Institute, University of Calgary , Calgary, AB , Canada.

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http://dx.doi.org/10.3109/00365521.2014.1003400DOI Listing
May 2015

Interactive effects of oligofructose and obesity predisposition on gut hormones and microbiota in diet-induced obese rats.

Obesity (Silver Spring) 2015 Apr;23(4):769-78

Department of Physiology and Pharmacology, Hotchkiss Brain Institute and Snyder Institute of Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.

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http://doi.wiley.com/10.1002/oby.21017
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http://dx.doi.org/10.1002/oby.21017DOI Listing
April 2015

Emerging roles for enteric glia in gastrointestinal disorders.

Authors:
Keith A Sharkey

J Clin Invest 2015 Mar 17;125(3):918-25. Epub 2015 Feb 17.

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http://dx.doi.org/10.1172/JCI76303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362226PMC
March 2015

Microglia-dependent alteration of glutamatergic synaptic transmission and plasticity in the hippocampus during peripheral inflammation.

J Neurosci 2015 Mar;35(12):4942-52

Hotchkiss Brain Institute and Snyder Institute for Chronic Diseases, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1

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http://dx.doi.org/10.1523/JNEUROSCI.4485-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705378PMC
March 2015

The past 10 years of gastroenterology and hepatology-reflections and predictions.

Nat Rev Gastroenterol Hepatol 2014 Nov 7;11(11):692-700. Epub 2014 Oct 7.

Department of Medicine, Cell Biology &Molecular Physiology and Human Genetics, University of Pittsburgh and UPMC, Room 401.4, 3708 Fifth Avenue, Pittsburgh, PA 15231, USA.

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http://dx.doi.org/10.1038/nrgastro.2014.167DOI Listing
November 2014

Gastrointestinal viral load and enteroendocrine cell number are associated with altered survival in HIV-1 infected individuals.

PLoS One 2013 16;8(10):e75967. Epub 2013 Oct 16.

Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada ; Department of Microbiology, Immunology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075967PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797816PMC
July 2014

Neurohormonal signalling in the gastrointestinal tract: new frontiers.

J Physiol 2014 Jul 13;592(14):2923-5. Epub 2014 Jun 13.

Department of Neurological Sciences, University of Vermont, Burlington, VT, USA.

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http://dx.doi.org/10.1113/jphysiol.2014.275487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214648PMC
July 2014

Reprint of: Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract.

Auton Neurosci 2014 May 15;182:70-82. Epub 2014 Mar 15.

Texas Children's Microbiome Center, Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1016/j.autneu.2014.03.004DOI Listing
May 2014

Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract.

Auton Neurosci 2014 Apr 22;181:94-106. Epub 2013 Dec 22.

Texas Children's Microbiome Center, Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1016/j.autneu.2013.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944077PMC
April 2014

The subfornical organ: a novel site of action of cholecystokinin.

Am J Physiol Regul Integr Comp Physiol 2014 Mar 15;306(5):R363-73. Epub 2014 Jan 15.

Hotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada; and.

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http://dx.doi.org/10.1152/ajpregu.00462.2013DOI Listing
March 2014

Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system.

Eur J Pharmacol 2014 Jan 1;722:134-46. Epub 2013 Nov 1.

Department of Psychology, University of Guelph, Guelph, ON, Canada.

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http://dx.doi.org/10.1016/j.ejphar.2013.09.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883513PMC
January 2014

A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice.

Neuropharmacology 2013 Aug 18;71:255-63. Epub 2013 Apr 18.

Snyder Institute for Chronic Diseases, Division of Gastroenterology, Department of Medicine, University of Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.neuropharm.2013.03.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677091PMC
August 2013

Oxidative stress disrupts purinergic neuromuscular transmission in the inflamed colon.

J Physiol 2013 Aug 3;591(15):3725-37. Epub 2013 Jun 3.

Department of Neurological Sciences, University of Vermont, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1113/jphysiol.2013.254136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752453PMC
August 2013

Cannabinoid 1 receptors are critical for the innate immune response to TLR4 stimulation.

Am J Physiol Regul Integr Comp Physiol 2013 Aug 5;305(3):R224-31. Epub 2013 Jun 5.

Hotchkiss Brain Institute and Snyder Institute for Chronic Diseases, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1152/ajpregu.00104.2013DOI Listing
August 2013

Murine autoimmune arthritis is exaggerated by infection with the rat tapeworm, Hymenolepis diminuta.

Int J Parasitol 2013 Jun 11;43(7):593-601. Epub 2013 Apr 11.

Gastrointestinal Research Group, Department of Physiology & Pharmacology, The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.ijpara.2013.02.006DOI Listing
June 2013

Cannabis and Δ9-tetrahydrocannabinol (THC) for weight loss?

Med Hypotheses 2013 May 11;80(5):564-7. Epub 2013 Feb 11.

Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.mehy.2013.01.019DOI Listing
May 2013

Urinary phenotyping indicates weight loss-independent metabolic effects of Roux-en-Y gastric bypass in mice.

J Proteome Res 2013 Mar 11;12(3):1245-53. Epub 2013 Feb 11.

Department of General- and Visceral, Vascular- and Pediatric Surgery, University Hospital of Wuerzburg, Germany.

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http://dx.doi.org/10.1021/pr300909vDOI Listing
March 2013

The roles of purinergic signaling during gastrointestinal inflammation.

Curr Opin Pharmacol 2012 Dec 11;12(6):659-66. Epub 2012 Oct 11.

Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT, USA.

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http://dx.doi.org/10.1016/j.coph.2012.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515696PMC
December 2012

Novel functional roles for enteric glia in the gastrointestinal tract.

Nat Rev Gastroenterol Hepatol 2012 Nov 14;9(11):625-32. Epub 2012 Aug 14.

Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive North West Calgary, AB T2N 4N1, Canada.

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http://dx.doi.org/10.1038/nrgastro.2012.138DOI Listing
November 2012

Glucagon-like peptide 2 induces vasoactive intestinal polypeptide expression in enteric neurons via phophatidylinositol 3-kinase-γ signaling.

Am J Physiol Endocrinol Metab 2012 Oct 14;303(8):E994-1005. Epub 2012 Aug 14.

Gastrointestinal Research Group, Snyder Institute for Chronic Diseases.

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http://dx.doi.org/10.1152/ajpendo.00291.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469609PMC
October 2012

Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes.

ACS Med Chem Lett 2012 Sep 15;3(9):759-763. Epub 2012 Aug 15.

A.B. Hancock Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine , Nashville, Tennessee, United States.

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http://dx.doi.org/10.1021/ml3001616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441040PMC
September 2012

Cannabinoid signalling regulates inflammation and energy balance: the importance of the brain-gut axis.

Brain Behav Immun 2012 Jul 17;26(5):691-8. Epub 2012 Jan 17.

Hotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S088915911200006
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http://dx.doi.org/10.1016/j.bbi.2012.01.004DOI Listing
July 2012

Cytokines and irritable bowel syndrome: where do we stand?

Cytokine 2012 Feb 16;57(2):201-9. Epub 2011 Dec 16.

Gastrointestinal Research Group, Snyder Institute of Infection, Immunity and Inflammation and Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1016/j.cyto.2011.11.019DOI Listing
February 2012

Neurogastroenterology in 2011: Emerging concepts in neurogastroenterology and motility.

Nat Rev Gastroenterol Hepatol 2011 Dec 13;9(2):74-6. Epub 2011 Dec 13.

Hotchkiss Brain Institute & Snyder Institute of Infection, Immunity and Inflammation, Department of Physiology & Pharmacology, University of Calgary, AB T2N 4N1, Canada.

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http://dx.doi.org/10.1038/nrgastro.2011.247DOI Listing
December 2011

Endogenous prion protein attenuates experimentally induced colitis.

Am J Pathol 2011 Nov 13;179(5):2290-301. Epub 2011 Sep 13.

Department of Biochemistry and Molecular Biology and the McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.ajpath.2011.07.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204082PMC
November 2011

The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment.

Inflamm Bowel Dis 2011 Aug 15;17(8):1651-64. Epub 2010 Nov 15.

Division of Gastroenterology, Department of Medicine, Snyder Institute of Infection, Immunity and Inflammation (III), Alberta, Canada.

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http://dx.doi.org/10.1002/ibd.21538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116968PMC
August 2011

Nitric oxide regulation of colonic epithelial ion transport: a novel role for enteric glia in the myenteric plexus.

J Physiol 2011 Jul 9;589(Pt 13):3333-48. Epub 2011 May 9.

Hotchkiss Brain Institute and Snyder Institute of Infection, Immunity and Inflammation, Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive, Calgary, Alberta, Canada, T2N 4N1.

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http://dx.doi.org/10.1113/jphysiol.2011.207902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145943PMC
July 2011

Helminth parasites and the modulation of joint inflammation.

J Parasitol Res 2011 18;2011:942616. Epub 2011 Apr 18.

Gastrointestinal Research Group, Department of Physiology and Pharmacology, The Calvin, Phoebe and Joan Snyder Institute of Infection Immunity and Inflammation, 1877 HSC University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1.

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http://dx.doi.org/10.1155/2011/942616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092582PMC
July 2011

Ectonucleotidases in the digestive system: focus on NTPDase3 localization.

Am J Physiol Gastrointest Liver Physiol 2011 Apr 13;300(4):G608-20. Epub 2011 Jan 13.

Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Québec, QC, Canada.

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http://dx.doi.org/10.1152/ajpgi.00207.2010DOI Listing
April 2011

The neutral cannabinoid CB₁ receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat.

Pharmacol Biochem Behav 2011 Jan 4;97(3):537-43. Epub 2010 Nov 4.

Hotchkiss Brain Institute and Snyder Institute of Infection, Immunity and Inflammation, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.pbb.2010.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023913PMC
January 2011

Antisecretory effects of neuropeptide Y in the mouse colon are region-specific and are lost in DSS-induced colitis.

Regul Pept 2010 Dec 8;165(2-3):138-45. Epub 2010 Jun 8.

Gastrointestinal Research Group, Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive, Calgary, Alberta, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S016701151000122
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http://dx.doi.org/10.1016/j.regpep.2010.05.014DOI Listing
December 2010

Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice.

J Pharmacol Exp Ther 2010 Sep 22;334(3):973-80. Epub 2010 Jun 22.

Hotchkiss Brain Institute and Snyder Institute of Infection, Immunity, and Inflammation, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1124/jpet.110.169946DOI Listing
September 2010

Cannabinoid CB(2) receptors in health and disease.

Curr Med Chem 2010 ;17(14):1393-410

Snyder Institute of Infection, Immunity & Inflammation, Department of Physiology and Pharmacology, University of Calgary, Canada.

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http://dx.doi.org/10.2174/092986710790980041DOI Listing
July 2010

Gastric bypass increases energy expenditure in rats.

Gastroenterology 2010 May 18;138(5):1845-53. Epub 2009 Nov 18.

Department of Investigative Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S001650850902002
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http://dx.doi.org/10.1053/j.gastro.2009.11.012DOI Listing
May 2010

Enteric glia are targets of the sympathetic innervation of the myenteric plexus in the guinea pig distal colon.

J Neurosci 2010 May;30(19):6801-9

Hotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1523/JNEUROSCI.0603-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632550PMC
May 2010

Cannabinoids and the gut: new developments and emerging concepts.

Pharmacol Ther 2010 Apr 1;126(1):21-38. Epub 2010 Feb 1.

Department of Experimental Pharmacology, University of Naples Federico II and Endocannabinoid Research Group, Naples, Italy.

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http://dx.doi.org/10.1016/j.pharmthera.2009.12.005DOI Listing
April 2010

Purinergic neuromuscular transmission is selectively attenuated in ulcerated regions of inflamed guinea pig distal colon.

J Physiol 2010 Mar 11;588(Pt 5):847-59. Epub 2010 Jan 11.

D403A Given Building, Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1113/jphysiol.2009.185082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834943PMC
March 2010

Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis.

Inflamm Bowel Dis 2009 Nov;15(11):1678-85

Division of Gastroenterology, Department of Medicine and Snyder Institute of Infection, Immunity & Inflammation, University Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1002/ibd.20960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531765PMC
November 2009

Differential adipokine response in genetically predisposed lean and obese rats during inflammation: a role in modulating experimental colitis?

Am J Physiol Gastrointest Liver Physiol 2009 Nov;297(5):G869-77

Snyder Institute of Infection, Immunity and Inflammation, Hotchkiss Brain Institute and Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, T2N 4N1, Canada.

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http://dx.doi.org/10.1152/ajpgi.00164.2009DOI Listing
November 2009

Alterations to enteric neural signaling underlie secretory abnormalities of the ileum in experimental colitis in the guinea pig.

Am J Physiol Gastrointest Liver Physiol 2009 Apr 12;296(4):G717-26. Epub 2009 Feb 12.

Snyder Institute of Infection, Immunity and Inflammation, Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive N.W., Calgary, AB T2N 4N1, Canada.

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http://www.physiology.org/doi/10.1152/ajpgi.90472.2008
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http://dx.doi.org/10.1152/ajpgi.90472.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670664PMC
April 2009

Purinergic neuron-to-glia signaling in the enteric nervous system.

Gastroenterology 2009 Apr 1;136(4):1349-58. Epub 2009 Jan 1.

Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1053/j.gastro.2008.12.058DOI Listing
April 2009

Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain?

Trends Pharmacol Sci 2009 Jan 29;30(1):1-7. Epub 2008 Nov 29.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.tips.2008.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748782PMC
January 2009

Distribution and function of monoacylglycerol lipase in the gastrointestinal tract.

Am J Physiol Gastrointest Liver Physiol 2008 Dec 23;295(6):G1255-65. Epub 2008 Oct 23.

Hotchkiss Brain Institute and Snyder Institute of Infection, Immunity and Inflammation, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1152/ajpgi.90500.2008DOI Listing
December 2008

Microglial activation and TNFalpha production mediate altered CNS excitability following peripheral inflammation.

Proc Natl Acad Sci U S A 2008 Nov 27;105(44):17151-6. Epub 2008 Oct 27.

Hotchkiss Brain Institute and Snyder Institute of Infection, Immunity, and Inflammation, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1073/pnas.0806682105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579393PMC
November 2008

Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors.

J Mol Med (Berl) 2008 Aug 21;86(8):925-36. Epub 2008 May 21.

Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1007/s00109-008-0359-6DOI Listing
August 2008

Neuromuscular changes in a rat model of colitis.

Auton Neurosci 2008 Aug 4;141(1-2):10-21. Epub 2008 Jun 4.

Department of Cell Biology, Physiology and Immunology, Veterinary Faculty, Universitat Autònoma de Barcelona, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S156607020800063
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http://dx.doi.org/10.1016/j.autneu.2008.04.005DOI Listing
August 2008

Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study.

J Autism Dev Disord 2008 Jul 29;38(6):1066-71. Epub 2008 Feb 29.

Department of Pediatrics, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1007/s10803-007-0482-1DOI Listing
July 2008

Cannabinoid CB2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats.

Am J Physiol Gastrointest Liver Physiol 2008 Jul 15;295(1):G78-G87. Epub 2008 May 15.

Snyder Institute of Infection, Immunity and Inflammation and Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1152/ajpgi.90285.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494728PMC
July 2008

A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient.

J Transl Med 2008 Jan 18;6. Epub 2008 Jan 18.

Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA.

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http://dx.doi.org/10.1186/1479-5876-6-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2254379PMC
January 2008

The endocannabinoid system and gut-brain signalling.

Curr Opin Pharmacol 2007 Dec 29;7(6):575-82. Epub 2007 Sep 29.

Department of Medicine, Hotchkiss Brain Institute and Institute of Infection, Immunity and Inflammation, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.coph.2007.08.008DOI Listing
December 2007

A neutral CB1 receptor antagonist reduces weight gain in rat.

Am J Physiol Regul Integr Comp Physiol 2007 Dec 24;293(6):R2185-93. Epub 2007 Oct 24.

Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Alberta, Canada.

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http://dx.doi.org/10.1152/ajpregu.00663.2007DOI Listing
December 2007

Proliferative capacity of enterochromaffin cells in guinea-pigs with experimental ileitis.

Cell Tissue Res 2007 Sep 17;329(3):433-41. Epub 2007 May 17.

Gastrointestinal, Neuroscience and Mucosal Inflammation Research Groups, Department of Physiology and Biophysics, University of Calgary, Calgary, AB T2N 4N1, Canada.

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http://dx.doi.org/10.1007/s00441-007-0430-6DOI Listing
September 2007

Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2.

Am J Physiol Gastrointest Liver Physiol 2007 Jul 29;293(1):G211-21. Epub 2007 Mar 29.

Gastrointestinal Research Group, Institute of Infection, Immunity, and Inflammation, Faculty of Medicine, University of Calgary, Health Science Centre, 3330 Hospital Drive NW, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1152/ajpgi.00530.2006DOI Listing
July 2007

Synaptic plasticity in myenteric neurons of the guinea-pig distal colon: presynaptic mechanisms of inflammation-induced synaptic facilitation.

J Physiol 2007 Jun 15;581(Pt 2):787-800. Epub 2007 Mar 15.

Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT 05405, USA.

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http://doi.wiley.com/10.1113/jphysiol.2007.128082
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http://dx.doi.org/10.1113/jphysiol.2007.128082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075198PMC
June 2007

Expression of a functional metabotropic glutamate receptor 5 on enteric glia is altered in states of inflammation.

Glia 2007 Jun;55(8):859-72

Institute for Infection, Immunity and Inflammation, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada.

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http://doi.wiley.com/10.1002/glia.20507
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http://dx.doi.org/10.1002/glia.20507DOI Listing
June 2007

Peptide YY containing enteroendocrine cells and peripheral tissue sensitivity to PYY and PYY(3-36) are maintained in diet-induced obese and diet-resistant rats.

Peptides 2007 Jun 30;28(6):1185-90. Epub 2007 Mar 30.

Institute of Infection, Immunity and Inflammation and Hotchkiss Brain Institute, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Alta., Canada.

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http://dx.doi.org/10.1016/j.peptides.2007.03.011DOI Listing
June 2007

Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation.

Gastroenterology 2007 May 25;132(5):1778-90. Epub 2007 Jan 25.

Gastrointestinal and Mucosal Inflammation Research Groups, Institute of Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1053/j.gastro.2007.01.032DOI Listing
May 2007

Ileitis alters neuronal and enteroendocrine signalling in guinea pig distal colon.

Gut 2007 Feb 24;56(2):186-94. Epub 2006 Aug 24.

Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1136/gut.2006.102780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856777PMC
February 2007

Persistent alterations to enteric neural signaling in the guinea pig colon following the resolution of colitis.

Am J Physiol Gastrointest Liver Physiol 2007 Feb 28;292(2):G482-91. Epub 2006 Sep 28.

Gastrointestinal Diseases Research Unit, Department of Medicine, Queen's University, Kingston, Ontario, Canada.

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http://dx.doi.org/10.1152/ajpgi.00355.2006DOI Listing
February 2007

Neonatal immune challenge exacerbates experimental colitis in adult rats: potential role for TNF-alpha.

Am J Physiol Regul Integr Comp Physiol 2007 Jan 14;292(1):R308-15. Epub 2006 Sep 14.

Hotchkiss Brain Institute and Institute of Infection, Immunity, and Inflammation, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1152/ajpregu.00398.2006DOI Listing
January 2007

Role of enteric glia in intestinal physiology: effects of the gliotoxin fluorocitrate on motor and secretory function.

Am J Physiol Gastrointest Liver Physiol 2006 Nov 22;291(5):G912-27. Epub 2006 Jun 22.

Institute for Infection, Immunity and Inflammation, University of Calgary, Alberta, Canada.

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http://dx.doi.org/10.1152/ajpgi.00067.2006DOI Listing
November 2006

Area postrema neurons are modulated by the adipocyte hormone adiponectin.

J Neurosci 2006 Sep;26(38):9695-702

Department of Physiology, Queen's University, Kingston, Ontario, Canada, K7L 3N6.

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http://dx.doi.org/10.1523/JNEUROSCI.2014-06.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6674457PMC
September 2006

From fat to full: peripheral and central mechanisms controlling food intake and energy balance: view from the chair.

Authors:
Keith A Sharkey

Obesity (Silver Spring) 2006 Aug;14 Suppl 5:239S-241S

Hotchkiss Brain Institute, Department of Physiology and Biophysics, 3330 Hospital Drive NW, University of Calgary, Calgary, Alberta, Canada T2N 4N1.

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http://doi.wiley.com/10.1038/oby.2006.316
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http://dx.doi.org/10.1038/oby.2006.316DOI Listing
August 2006

Effects of gastrointestinal inflammation on enteroendocrine cells and enteric neural reflex circuits.

Auton Neurosci 2006 Jun 17;126-127:250-7. Epub 2006 Apr 17.

Gastrointestinal Diseases Research Unit, Department of Medicine, Queen's University, Kingston, Ontario, Canada K7L 5G2, and Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.autneu.2006.02.015DOI Listing
June 2006

Distribution of adrenergic receptors in the enteric nervous system of the guinea pig, mouse, and rat.

J Comp Neurol 2006 Apr;495(5):529-53

Institute of Infection, Immunity and Inflammation and Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1002/cne.20898DOI Listing
April 2006

Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon.

Cell Microbiol 2006 Apr;8(4):646-60

Gastrointestinal Inflammation Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1111/j.1462-5822.2005.00657.xDOI Listing
April 2006

Prion diseases and the gastrointestinal tract.

Can J Gastroenterol 2006 Jan;20(1):18-24

Institute for Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538961PMC
http://dx.doi.org/10.1155/2006/184528DOI Listing
January 2006