Keisuke Hirai

Keisuke Hirai

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Keisuke Hirai

Keisuke Hirai

Publications by authors named "Keisuke Hirai"

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36Publications

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Determinants of high device cost in current percutaneous coronary interventions.

Cardiovasc Revasc Med 2018 Jul - Aug;19(5 Pt B):607-612. Epub 2017 Dec 23.

Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Japan.

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http://dx.doi.org/10.1016/j.carrev.2017.12.007DOI Listing
July 2019

Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia.

ACS Med Chem Lett 2017 Dec 20;8(12):1281-1286. Epub 2017 Nov 20.

Medicinal Chemistry Research Laboratories, Exploratory Research Laboratories, and Discovery Research Laboratories, ONO Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan.

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http://dx.doi.org/10.1021/acsmedchemlett.7b00383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733272PMC
December 2017

Characterization of CRF receptor antagonists with differential peripheral vs central actions in CRF challenge in rats.

Peptides 2017 Sep 6;95:40-50. Epub 2017 Jul 6.

CNS Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2017.06.009DOI Listing
September 2017

In vitro comparison of duration of action of melatonin agonists on melatonin MT1 receptor: possible link between duration of action and dissociation rate from receptor.

Eur J Pharmacol 2015 Jun 20;757:42-52. Epub 2015 Mar 20.

CNS Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.03.009DOI Listing
June 2015

The melatonin agonist ramelteon induces duration-dependent clock gene expression through cAMP signaling in pancreatic INS-1 β-cells.

PLoS One 2014 11;9(7):e102073. Epub 2014 Jul 11.

CNS Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102073PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094524PMC
March 2015

Pharmacological characterization of M-II, the major human metabolite of ramelteon.

Pharmacology 2014 6;93(3-4):197-201. Epub 2014 Jun 6.

CNS Drug Discovery Unit, Takeda Pharmaceutical Company Ltd., Fujisawa, Japan.

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http://dx.doi.org/10.1159/000362459DOI Listing
January 2015

Discovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonists.

Bioorg Med Chem Lett 2011 Nov 30;21(21):6414-6. Epub 2011 Aug 30.

Medicinal Chemistry Research Laboratories, Takeda Pharmaceutical Company, 26-1, Muraokahigashi 2-Chome, Fujisawa, Kanagawa 251-1238, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X110119
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http://dx.doi.org/10.1016/j.bmcl.2011.08.093DOI Listing
November 2011

Synthesis of a novel series of tricyclic dihydrofuran derivatives: discovery of 8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as melatonin receptor (MT1/MT2) ligands.

J Med Chem 2011 Jun 24;54(12):4207-18. Epub 2011 May 24.

Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 17-85 Jusohonmachi, 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan.

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http://dx.doi.org/10.1021/jm200385uDOI Listing
June 2011

1,6-Dihydro-2H-indeno[5,4-b]furan derivatives: design, synthesis, and pharmacological characterization of a novel class of highly potent MT₂-selective agonists.

J Med Chem 2011 May 7;54(9):3436-44. Epub 2011 Apr 7.

Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , 17-85 Jusohonmachi, 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan.

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http://dx.doi.org/10.1021/jm200221qDOI Listing
May 2011

Discovery of orally available spirodiketopiperazine-based CCR5 antagonists.

Bioorg Med Chem 2010 Jul 25;18(14):5208-23. Epub 2010 May 25.

Minase Research Institute, Ono Pharmaceutical Co., Ltd, Shimamoto, Mishima, Osaka 618-8585, Japan.

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http://dx.doi.org/10.1016/j.bmc.2010.05.057DOI Listing
July 2010

Oxidative damage to RNA in neurodegenerative diseases.

J Biomed Biotechnol 2006 ;2006(3):82323

Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa 078-8510, Japan.

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http://www.hindawi.com/journals/bmri/2006/082323/abs/
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http://dx.doi.org/10.1155/JBB/2006/82323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559934PMC
June 2010

Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles.

Bioorg Med Chem Lett 2010 Jan 12;20(2):763-6. Epub 2009 Nov 12.

Minase Research Institute, Ono Pharmaceutical Co., Ltd, Shimamoto, Mishima, Osaka 618-8585, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2009.11.018DOI Listing
January 2010

Molecular cloning and pharmacological characterization of monkey MT1 and MT2 melatonin receptors showing high affinity for the agonist ramelteon.

J Pharmacol Exp Ther 2009 Sep 25;330(3):855-63. Epub 2009 Jun 25.

Pharmacology Research Laboratory, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd, 17-85, Jusohonmachi 2-chome, Yodogawa-ku, Osaka 532-8686, Japan.

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http://dx.doi.org/10.1124/jpet.109.155283DOI Listing
September 2009

Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease.

J Alzheimers Dis 2006 Jul;9(2):147-53

Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, Ohio 44106, USA.

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July 2006

Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats.

J Biol Rhythms 2005 Feb;20(1):27-37

Pharmacology Research Laboratories I, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Osaka, Japan.

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http://dx.doi.org/10.1177/0748730404269890DOI Listing
February 2005

Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist.

Neuropharmacology 2005 Feb;48(2):301-10

Pharmacology Research Laboratories I, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Osaka 532-8686, Japan.

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http://dx.doi.org/10.1016/j.neuropharm.2004.09.007DOI Listing
February 2005

The sleep-promoting action of ramelteon (TAK-375) in freely moving cats.

Sleep 2004 Nov;27(7):1319-25

Pharmacology Research Laboratories I, Takeda Pharmaceutical Company Ltd, Osaka, Japan.

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http://dx.doi.org/10.1093/sleep/27.7.1319DOI Listing
November 2004

Role of mitochondrial dysfunction in Alzheimer's disease.

J Neurosci Res 2002 Nov;70(3):357-60

Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1002/jnr.10389DOI Listing
November 2002

Synthesis of a novel series of benzocycloalkene derivatives as melatonin receptor agonists.

J Med Chem 2002 Sep;45(19):4212-21

Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., 17-85, Jusohonmachi 2-chome, Yodogawa-ku, Osaka 532-8686, Japan.

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http://dx.doi.org/10.1021/jm020114gDOI Listing
September 2002

Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists.

J Med Chem 2002 Sep;45(19):4222-39

Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., 17-85, Jusohonmachi 2-chome, Yodogawa-ku, Osaka 532-8686, Japan.

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http://dx.doi.org/10.1021/jm0201159DOI Listing
September 2002

Prospective trial of unilateral surgery for nonhereditary medullary thyroid carcinoma in patients without germline RET mutations.

World J Surg 2002 Aug 21;26(8):1023-8. Epub 2002 May 21.

Department of Surgery, Kuma Hospital, 8-2-35 Shimoyamate-dori, Chuo-ku, Kobe 650-0011, Japan.

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http://dx.doi.org/10.1007/s00268-002-6665-1DOI Listing
August 2002

Diagnostic utility of galectin-3 and CD26/DPPIV as preoperative diagnostic markers for thyroid nodules.

Diagn Cytopathol 2002 Jun;26(6):366-72

Department of Clinical Investigation, Miyazaki Medical College Hospital, Miyazaki, Japan.

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http://dx.doi.org/10.1002/dc.10111DOI Listing
June 2002

Expression of p57/Kip2 protein in normal and neoplastic thyroid tissues.

Int J Mol Med 2002 Apr;9(4):373-6

Kuma Hospital, 8-2-35 Shimoyamate-Dori, Chuo-ku, Kobe City 650-0011, Japan.

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April 2002

Reactive Oxygen Species Mediate Cellular Damage in Alzheimer Disease.

J Alzheimers Dis 1998 Mar;1(1):45-55

Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA.

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March 1998