Publications

Interstitial pneumonia induced by bleomycin treatment is exacerbated in Angptl2-deficient mice.
Am J Physiol Lung Cell Mol Physiol 2016 Oct 19;311(4):L704-L713. Epub 2016 Aug 19.
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.




The exacerbating roles of CCAAT/enhancer-binding protein homologous protein (CHOP) in the development of bleomycin-induced pulmonary fibrosis and the preventive effects of tauroursodeoxycholic acid (TUDCA) against pulmonary fibrosis in mice.
Pharmacol Res 2015 Sep 22;99:52-62. Epub 2015 May 22.
Department of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan; Center for Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.

A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling.
Nat Commun 2015 Apr 1;6:6693. Epub 2015 Apr 1.
1] Department of Rheumatology and Allergy, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan [2] Division of Rheumatology, Center for Antibody and Vaccine, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.


ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling.
Sci Rep 2015 Mar 16;5:9170. Epub 2015 Mar 16.
1] Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan [2] Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan.

Effects of Seijo-bofu-to, a traditional Japanese herbal medicine containing furanocoumarin derivatives, on the drug-metabolizing enzyme activities in healthy male volunteers.
Basic Clin Pharmacol Toxicol 2014 Oct 21;115(4):360-5. Epub 2014 Mar 21.
Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.

Serum ANGPTL2 levels reflect clinical features of breast cancer patients: implications for the pathogenesis of breast cancer metastasis.
Int J Biol Markers 2014 Sep 30;29(3):e239-45. Epub 2014 Sep 30.
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto - Japan.

The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.
Cell Metab 2014 Jul 5;20(1):119-32. Epub 2014 Jun 5.
Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan; CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. Electronic address:

Diverse roles of ANGPTL2 in physiology and pathophysiology.
Trends Endocrinol Metab 2014 May 17;25(5):245-54. Epub 2014 Apr 17.
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Chiyoda-ku, Tokyo 102-0075, Japan. Electronic address:

Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression.
Arterioscler Thromb Vasc Biol 2014 Apr 13;34(4):790-800. Epub 2014 Feb 13.
From the Department of Molecular Genetics (E.H., T.K., K.M., H.H., M.E., M. Tabata, H.T., Z.T., O.T., K.T., Y.O.), Department of Cardiovascular Medicine (E.H., H.O., K.K.), and Department of Cell Pathology (M. Takeya), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Division of Geriatric Medicine, Department of Internal Medicine (Y.A., N.H.) and Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine (K.H., T.S.), Keio University School of Medicine, Tokyo, Japan; Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (Y.D., T.N., Y.K.); Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan (H.H.); Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan (T.M.); and Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan (Y.O.).


Angiopoietin-like protein 2 accelerates carcinogenesis by activating chronic inflammation and oxidative stress.
Mol Cancer Res 2014 Feb 20;12(2):239-49. Epub 2013 Nov 20.
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.







Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis.
Cancer Res 2011 Dec 31;71(24):7502-12. Epub 2011 Oct 31.
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques.
Arterioscler Thromb Vasc Biol 2010 Oct 22;30(10):1925-32. Epub 2010 Jul 22.
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity.
Cell Metab 2010 Jun;11(6):479-92
Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.

Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity.
J Biol Chem 2010 May 26;285(20):15538-47. Epub 2010 Feb 26.
Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan.

Synoviocyte-derived angiopoietin-like protein 2 contributes to synovial chronic inflammation in rheumatoid arthritis.
Am J Pathol 2010 May 19;176(5):2309-19. Epub 2010 Mar 19.
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.


Angiopoietins contribute to lung development by regulating pulmonary vascular network formation.
Biochem Biophys Res Commun 2009 Apr 13;381(2):218-23. Epub 2009 Feb 13.
Department of Cell Differentiation, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo 160-8556, Japan.


Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages.
Circulation 2009 Jan 22;119(1):28-36. Epub 2008 Dec 22.
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto City, Japan.

Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model.
Arterioscler Thromb Vasc Biol 2008 May 7;28(5):827-34. Epub 2008 Feb 7.
Laboratory of Vascular Biology and Metabolism, Center for Integrated Medical Research, Department of Cell Differentiation, School of Medicine, Keio University, Tokyo, Japan.

Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha/beta hydrolase domain containing 2 gene.
Biochem Biophys Res Commun 2005 Apr;329(1):296-304
Department of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, 4-24-1 Kuhonji, Kumamoto 862-0976, Japan.

Angiopoietin-related growth factor antagonizes obesity and insulin resistance.
Nat Med 2005 Apr 20;11(4):400-8. Epub 2005 Mar 20.
Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.





Macrophage-Derived Angiopoietin-Like Protein 2 Exacerbates Brain Damage by Accelerating Acute Inflammation after Ischemia-Reperfusion.
PLoS One 2016 18;11(11):e0166285. Epub 2016 Nov 18.
Department of Molecular Genetics, Graduate school of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Treatment of diabetic mice with the SGLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality.
NPJ Aging Mech Dis 2017 8;3:12. Epub 2017 Sep 8.
Department of Molecular Genetics, Graduate School of Medical Sciences, Institute of Resource Development and Analysis, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556 Japan.

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