Keiryn L Bennett

Keiryn L Bennett

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Keiryn L Bennett

Publications by authors named "Keiryn L Bennett"

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Proteogenomic Analysis to Identify Missing Proteins from Haploid Cell Lines.

Proteomics 2018 04;18(8):e1700386

Department of Applied Chemistry College of Applied Science, Kyung Hee University, Yongin-si, Republic of Korea.

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http://dx.doi.org/10.1002/pmic.201700386DOI Listing
April 2018

Effects of Alanyl-Glutamine Treatment on the Peritoneal Dialysis Effluent Proteome Reveal Pathomechanism-Associated Molecular Signatures.

Mol Cell Proteomics 2018 03 4;17(3):516-532. Epub 2017 Dec 4.

From the ‡Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria;

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http://dx.doi.org/10.1074/mcp.RA117.000186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836375PMC
March 2018

Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders.

ACS Chem Biol 2018 03 29;13(3):553-560. Epub 2018 Jan 29.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Science , Lazarettgasse 14, AKH Bt. 25.3 , 1090 Vienna , Austria.

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http://pubs.acs.org/doi/10.1021/acschembio.7b00969
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http://dx.doi.org/10.1021/acschembio.7b00969DOI Listing
March 2018

A Comprehensive Analytical Strategy To Identify Malondialdehyde-Modified Proteins and Peptides.

Anal Chem 2017 04 15;89(7):3847-3852. Epub 2017 Mar 15.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences , 1090, Vienna, Austria.

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http://dx.doi.org/10.1021/acs.analchem.6b05065DOI Listing
April 2017

Expanding the Interactome of the Noncanonical NF-κB Signaling Pathway.

J Proteome Res 2016 09 1;15(9):2900-2909. Epub 2016 Aug 1.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

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http://dx.doi.org/10.1021/acs.jproteome.5b01004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295629PMC
September 2016

FASIL-MS: An Integrated Proteomic and Bioinformatic Workflow To Universally Quantitate In Vivo-Acetylated Positional Isomers.

J Proteome Res 2016 08 5;15(8):2579-94. Epub 2016 Jul 5.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences , A-1090 Vienna, Austria.

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http://dx.doi.org/10.1021/acs.jproteome.6b00130DOI Listing
August 2016

A Surface Biotinylation Strategy for Reproducible Plasma Membrane Protein Purification and Tracking of Genetic and Drug-Induced Alterations.

J Proteome Res 2016 Feb 12;15(2):647-58. Epub 2016 Jan 12.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences , 1090 Vienna, Austria.

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http://dx.doi.org/10.1021/acs.jproteome.5b01066DOI Listing
February 2016

Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling.

Nat Methods 2015 Nov 21;12(11):1055-7. Epub 2015 Sep 21.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1038/nmeth.3590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629415PMC
November 2015

Gene essentiality and synthetic lethality in haploid human cells.

Science 2015 Nov 15;350(6264):1092-6. Epub 2015 Oct 15.

Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria. Cancer Genomics Center (CGC.nl), Plesmanlaan 121, 1066CX, Amsterdam, Netherlands.

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http://www.sciencemag.org/cgi/doi/10.1126/science.aac7557
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http://dx.doi.org/10.1126/science.aac7557DOI Listing
November 2015

Identification of new phosphorylation sites of AMPA receptors in the rat hippocampus--A resource for neuroscience research.

Proteomics Clin Appl 2015 Oct 15;9(9-10):808-16. Epub 2015 May 15.

Department of Pediatrics, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/prca.201400057DOI Listing
October 2015

Frontal cortex and hippocampus neurotransmitter receptor complex level parallels spatial memory performance in the radial arm maze.

Behav Brain Res 2015 Aug 28;289:157-68. Epub 2015 Apr 28.

Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 18, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2015.04.043DOI Listing
August 2015

Dietary magnesium restriction reduces amygdala-hypothalamic GluN1 receptor complex levels in mice.

Brain Struct Funct 2015 Jul 8;220(4):2209-21. Epub 2014 May 8.

Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 18, 1090, Vienna, Austria.

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http://dx.doi.org/10.1007/s00429-014-0779-8DOI Listing
July 2015

Erratum to: Dietary magnesium restriction reduces amygdala-hypothalamic GluN1 receptor complex levels in mice.

Brain Struct Funct 2015 Jul;220(4):2223

Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 18, 1090, Vienna, Austria.

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http://dx.doi.org/10.1007/s00429-014-0820-yDOI Listing
July 2015

A Modular Synthesis of Modified Phosphoanhydrides.

Chemistry 2015 Jul 1;21(28):10116-22. Epub 2015 Jun 1.

Department of Chemistry, University of Zürich, Winterthurerstrasse 190, 8057 Zürich (Switzerland).

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http://dx.doi.org/10.1002/chem.201500838DOI Listing
July 2015

Internalization of Pseudomonas aeruginosa Strain PAO1 into Epithelial Cells Is Promoted by Interaction of a T6SS Effector with the Microtubule Network.

MBio 2015 Jun 2;6(3):e00712. Epub 2015 Jun 2.

CNRS & Aix-Marseille Université, Laboratoire d'Ingénierie des Systèmes Macromoléculaires (UMR7255), Institut de Microbiologie de la Méditerranée, Marseille, France

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http://dx.doi.org/10.1128/mBio.00712-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453011PMC
June 2015

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity.

Cell Rep 2015 Jun 18;11(12):1919-28. Epub 2015 Jun 18.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508342PMC
June 2015

Hippocampal receptor complexes paralleling LTP reinforcement in the spatial memory holeboard test in the rat.

Behav Brain Res 2015 Apr 30;283:162-74. Epub 2015 Jan 30.

Department of Paediatrics, Medizinische Universität Wien, Währinger Gürtel 18A, 1090 Wien. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2015.01.036DOI Listing
April 2015

A longitudinal proteomic assessment of peptide degradation and loss under acidic storage conditions.

Anal Biochem 2015 Mar 3;473:11-3. Epub 2014 Dec 3.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00032697140054
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http://dx.doi.org/10.1016/j.ab.2014.11.020DOI Listing
March 2015

Identification of kinase inhibitor targets in the lung cancer microenvironment by chemical and phosphoproteomics.

Mol Cancer Ther 2014 Nov 4;13(11):2751-62. Epub 2014 Sep 4.

Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Vienna, Austria. Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-14
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http://dx.doi.org/10.1158/1535-7163.MCT-14-0152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221415PMC
November 2014

The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production.

Virology 2014 Aug 14;462-463:34-41. Epub 2014 Jun 14.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2014.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139193PMC
August 2014

Evaluating the promiscuous nature of tyrosine kinase inhibitors assessed in A431 epidermoid carcinoma cells by both chemical- and phosphoproteomics.

ACS Chem Biol 2014 Jul 14;9(7):1490-8. Epub 2014 May 14.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University , Padualaan 8, 3584 CH Utrecht, The Netherlands.

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http://dx.doi.org/10.1021/cb500116cDOI Listing
July 2014

Comprehensive comparative and semiquantitative proteome of a very low number of native and matched epstein-barr-virus-transformed B lymphocytes infiltrating human melanoma.

J Proteome Res 2014 Jun 6;13(6):2830-45. Epub 2014 May 6.

Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna , Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1021/pr401270yDOI Listing
June 2014

abFASP-MS: affinity-based filter-aided sample preparation mass spectrometry for quantitative analysis of chemically labeled protein complexes.

J Proteome Res 2014 Feb 17;13(2):1147-55. Epub 2014 Jan 17.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences , Lazarettgasse 14, 1090 Vienna, Austria.

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http://dx.doi.org/10.1021/pr4009892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923452PMC
February 2014

Interactome of two diverse RNA granules links mRNA localization to translational repression in neurons.

Cell Rep 2013 Dec 19;5(6):1749-62. Epub 2013 Dec 19.

Department of Neuronal Cell Biology, Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria; Max-Planck-Institute for Developmental Biology, 72076 Tübingen, Germany; Department for Anatomy & Cell Biology, Ludwig-Maximilians-University, 80336 Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247130069
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http://dx.doi.org/10.1016/j.celrep.2013.11.023DOI Listing
December 2013

A miniaturized chemical proteomic approach for target profiling of clinical kinase inhibitors in tumor biopsies.

J Proteome Res 2013 Sep 20;12(9):4005-17. Epub 2013 Aug 20.

Department of Protein Biochemistry and Proteomics, Technological Centre of the Palacký University, Centre of the Region Haná for Biotechnological and Agricultural Research, Olomouc, Czech Republic.

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http://dx.doi.org/10.1021/pr400309pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127982PMC
September 2013

Affinity purification strategies for proteomic analysis of transcription factor complexes.

J Proteome Res 2013 Sep 22;12(9):4018-27. Epub 2013 Aug 22.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090 Vienna, Austria.

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http://dx.doi.org/10.1021/pr4003323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768224PMC
September 2013

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

Nat Methods 2013 Apr 3;10(4):307-14. Epub 2013 Mar 3.

Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1038/nmeth.2400DOI Listing
April 2013

Combining filter-aided sample preparation and pseudoshotgun technology to profile the proteome of a low number of early passage human melanoma cells.

J Proteome Res 2013 Feb 24;12(2):1040-8. Epub 2012 Dec 24.

Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1021/pr301009uDOI Listing
February 2013

Mass spectrometric characterization of recombinant rat 5-hydroxytryptamine receptor 1A (5-HT(1A) R) expressed in tsA201 human embryonic kidney cells.

Proteomics 2012 Nov 19;12(22):3338-42. Epub 2012 Oct 19.

Department of Pediatrics, Medical University of Vienna, Vienna, Austria.

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http://doi.wiley.com/10.1002/pmic.201200183
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http://dx.doi.org/10.1002/pmic.201200183DOI Listing
November 2012

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations.

Hum Mutat 2012 Jul 16;33(7):1116-22. Epub 2012 Apr 16.

CeMM - Research Center for Molecular Medicine, Austrian Academy of Sciences, Lazarettgasse 14, Vienna, Austria.

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http://dx.doi.org/10.1002/humu.22087DOI Listing
July 2012

Optimisation of Downscaled Tandem Affinity Purifications to Identify Core Protein Complexes.

J Integr OMICS 2012 May;2(1):55-68

Department of Thoracic Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

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http://dx.doi.org/10.5584/jiomics.v2i1.81DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785125PMC
May 2012

Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression.

Mol Cell 2012 Feb;45(4):553-66

Unité de Signalisation Moléculaire et Activation Cellulaire, Institut Pasteur, CNRS URA 2582, 75724 Paris Cedex 15, France.

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http://dx.doi.org/10.1016/j.molcel.2011.12.030DOI Listing
February 2012

Systems biology analysis of protein-drug interactions.

Proteomics Clin Appl 2012 Jan 27;6(1-2):102-16. Epub 2011 Dec 27.

Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Jacques Colinge, Vienna, Austria.

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http://doi.wiley.com/10.1002/prca.201100077
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http://dx.doi.org/10.1002/prca.201100077DOI Listing
January 2012

An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B.

Mol Cancer Ther 2011 Oct 18;10(10):1846-56. Epub 2011 Jul 18.

Ce-M-M-Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090 Vienna, Austria.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0100DOI Listing
October 2011

General statistical modeling of data from protein relative expression isobaric tags.

J Proteome Res 2011 Jun 11;10(6):2758-66. Epub 2011 May 11.

CeMM , Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1021/pr1012784DOI Listing
June 2011

Initial characterization of the human central proteome.

BMC Syst Biol 2011 Jan 26;5:17. Epub 2011 Jan 26.

CeMM - Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 19/3, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1186/1752-0509-5-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039570PMC
January 2011

A chemical and phosphoproteomic characterization of dasatinib action in lung cancer.

Nat Chem Biol 2010 Apr 28;6(4):291-9. Epub 2010 Feb 28.

Department of Thoracic Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

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http://dx.doi.org/10.1038/nchembio.332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842457PMC
April 2010

A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain.

Nat Struct Mol Biol 2010 Apr 28;17(4):519-27. Epub 2010 Mar 28.

Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA.

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http://www.nature.com/articles/nsmb.1793
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http://dx.doi.org/10.1038/nsmb.1793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926940PMC
April 2010

Acid elution and one-dimensional shotgun analysis on an Orbitrap mass spectrometer: an application to drug affinity chromatography.

J Proteome Res 2009 Oct;8(10):4753-65

Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Lazarettgasse 19, 1090 Vienna, Austria.

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http://pubs.acs.org/doi/abs/10.1021/pr900455x
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http://dx.doi.org/10.1021/pr900455xDOI Listing
October 2009

Charting the molecular network of the drug target Bcr-Abl.

Proc Natl Acad Sci U S A 2009 May 20;106(18):7414-9. Epub 2009 Apr 20.

Research Center for Molecular Medicine, Austrian Academy of Sciences, Lazarettgasse 19, 1090 Vienna, Austria.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0900653106
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http://dx.doi.org/10.1073/pnas.0900653106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670881PMC
May 2009

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.

Nat Immunol 2009 Mar 21;10(3):266-72. Epub 2009 Jan 21.

Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

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http://dx.doi.org/10.1038/ni.1702DOI Listing
March 2009

RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme.

Cell 2008 Oct;135(3):462-74

Center for Anatomy & Cell Biology, Medical University of Vienna, 1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.cell.2008.09.013DOI Listing
October 2008