Publications by authors named "Keiko Akagi"

50Publications

Human papillomavirus insertions identify the PIM family of serine/threonine kinases as targetable driver genes in head and neck squamous cell carcinoma.

Cancer Lett 2020 04 17;476:23-33. Epub 2020 Jan 17.

Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States. Electronic address:

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April 2020

Identification of Rare Variants Predisposing to Thyroid Cancer.

Thyroid 2019 07 13;29(7):946-955. Epub 2019 May 13.

1Human Cancer Genetics Program and Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.

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July 2019

Metaplastic breast cancer in a patient with neurofibromatosis type 1 and somatic loss of heterozygosity.

Cold Spring Harb Mol Case Stud 2018 04 2;4(2). Epub 2018 Apr 2.

The Arthur G. James Comprehensive Cancer Center and Richard J. Solove Research Institute, The Ohio State University, Columbus, Ohio 43210, USA.

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April 2018

HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression.

PLoS Genet 2018 01 24;14(1):e1007179. Epub 2018 Jan 24.

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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January 2018

In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice.

Circ Res 2017 Sep 8;121(8):923-929. Epub 2017 Aug 8.

From the Department of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program (M.E.R., L.X., Y.G., T.M.A.A., J.M., R.H.) and Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute (B.D.C., P.J.M., P.M.L.J.), The Ohio State University Wexner Medical Center, Columbus; Genomics Shared Resource, The Ohio State University Comprehensive Cancer Center, Columbus (S.C.W., D.E.S.); and Department of Cancer Biology and Genetics (K.A., D.E.S.) and Human Cancer Genetics Program, and Department of Biomedical Informatics (adjunct) (D.E.S.), The Ohio State University, Columbus.

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September 2017

Chromatin states shape insertion profiles of the piggyBac, Tol2 and Sleeping Beauty transposons and murine leukemia virus.

Sci Rep 2017 03 2;7:43613. Epub 2017 Mar 2.

Department of Physiology II, Nara Medical University, Kashihara, Nara 634-8521, Japan.

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March 2017

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.

Cell 2017 02 16;168(5):817-829.e15. Epub 2017 Feb 16.

Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address:

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February 2017

A germline mutation in SRRM2, a splicing factor gene, is implicated in papillary thyroid carcinoma predisposition.

Sci Rep 2015 Jul 2;5:10566. Epub 2015 Jul 2.

Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America.

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July 2015

Sleeping Beauty mouse models identify candidate genes involved in gliomagenesis.

PLoS One 2014 25;9(11):e113489. Epub 2014 Nov 25.

School of Pharmacy and University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Madison, WI, United States of America.

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August 2015

Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.

Nature 2014 Sep 20;513(7519):512-6. Epub 2014 Jul 20.

Department of Pediatrics and Benniof Children's Hospital, University of California, San Francisco, California 94143, USA.

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September 2014

An antisense promoter in mouse L1 retrotransposon open reading frame-1 initiates expression of diverse fusion transcripts and limits retrotransposition.

Nucleic Acids Res 2014 Apr 3;42(7):4546-62. Epub 2014 Feb 3.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA, Laboratory of Molecular Technology, Advanced Technology Program, SAIC-Frederick, Inc., Frederick, MD 21702, USA, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA, Human Cancer Genetics Program, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA, Internal Medicine, The Ohio State University, Columbus, OH 43210, USA and Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA.

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April 2014

How do mammalian transposons induce genetic variation? A conceptual framework: the age, structure, allele frequency, and genome context of transposable elements may define their wide-ranging biological impacts.

Bioessays 2013 Apr 14;35(4):397-407. Epub 2013 Jan 14.

Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.

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April 2013

Mouse endogenous retroviruses can trigger premature transcriptional termination at a distance.

Genome Res 2012 May 23;22(5):870-84. Epub 2012 Feb 23.

Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.

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May 2012

A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening.

Nat Methods 2011 Oct 23;8(12):1071-7. Epub 2011 Oct 23.

Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

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October 2011

Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155.

Nat Med 2011 Sep 25;17(10):1275-82. Epub 2011 Sep 25.

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA.

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September 2011

Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.

Proc Natl Acad Sci U S A 2010 Mar 1;107(11):5106-11. Epub 2010 Mar 1.

Departments of Pediatrics, Medicine, Laboratory Medicine, and Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, USA.

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March 2010

MouseIndelDB: a database integrating genomic indel polymorphisms that distinguish mouse strains.

Nucleic Acids Res 2010 Jan 20;38(Database issue):D600-6. Epub 2009 Nov 20.

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

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January 2010

Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene.

Biochem Biophys Res Commun 2009 Nov 2;389(2):366-71. Epub 2009 Sep 2.

Division of Functional Genomics, Molecular & Cellular Targeting Translational Oncology Center, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan.

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November 2009

Gene targeting in mouse embryonic stem cells.

Methods Mol Biol 2009 ;530:141-64

Mouse Cancer Genetics Program, NCI-Frederick, Frederick, MD, USA.

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May 2009

Extensive variation between inbred mouse strains due to endogenous L1 retrotransposition.

Genome Res 2008 Jun 1;18(6):869-80. Epub 2008 Apr 1.

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA.

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June 2008

Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice.

EMBO J 2006 Jul 6;25(14):3422-31. Epub 2006 Jul 6.

Cancer Genetic Unit, Horizontal Medical Research Organization, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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July 2006

Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.

Nature 2005 Jul;436(7048):221-6

National Cancer Institute, Center for Cancer Research, Frederick, Maryland 21702, USA.

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July 2005

RTCGD: retroviral tagged cancer gene database.

Nucleic Acids Res 2004 Jan;32(Database issue):D523-7

Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD 21701, USA.

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January 2004

Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein.

Blood 2003 Mar 17;101(5):1934-40. Epub 2002 Oct 17.

Mouse Cancer Genetics Program and the Basic Research Laboratory, National Cancer Institute, Frederick, MD 21702, USA.

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March 2003

New genes involved in cancer identified by retroviral tagging.

Nat Genet 2002 Sep 19;32(1):166-74. Epub 2002 Aug 19.

Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland 21702, USA.

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September 2002

Docking protein SNT1 is a critical mediator of fibroblast growth factor signaling during Xenopus embryonic development.

Dev Dyn 2002 Mar;223(2):216-28

Regulation of Cell Growth Laboratory, National Cancer Institute-Frederick, Frederick, MD 21702, USA.

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March 2002