Publications by authors named "Keerthilatha M Pai"

93 Publications

Bilateral Bell's palsy in a young female: a rare case report.

Med Pharm Rep 2021 Jan 29;94(1):118-120. Epub 2021 Jan 29.

Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Bell's palsy is described as a type of facial paralysis, which is unilateral in 70% of the cases. Bell's palsy accounts for about 23% of bilateral facial paralysis. Here, we present a rare case of bilateral Bell's palsy in a 15-year-old female who developed sudden facial weakness with no associated symptoms. The patient was subjected to thorough clinical, laboratory, and necessary radiological investigations. As there was no conclusive evidence from any of the investigations, this could be a case of idiopathic bilateral Bell's palsy. This is the first ever case of bilateral Bell's palsy in a young female which has been reported in the Indian population.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.15386/mpr-1389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880067PMC
January 2021

A review on human body fluids for the diagnosis of viral infections: scope for rapid detection of COVID-19.

Expert Rev Mol Diagn 2021 01 1;21(1):31-42. Epub 2021 Feb 1.

Centre of Excellence for Biophotonics, Department of Atomic and Molecular Physics, Manipal Academic of Higher Education, Manipal, India.

: The unprecedented outbreaks of corona virus disease of 2019 (COVID-19) have highlighted the necessity of readily available, reliable, precise, and faster techniques for its detection. Nasopharyngeal swab has been the gold standard for the diagnosis of COVID-19. However, it is not an ideal screening procedure for massive screening as it implicates the patient's stay in the hospital or at home until diagnosis, thus causing crowding of the specimen at the diagnostic centers. Present study deal with the exploration of potential application of different body fluids using certain highly objective techniques (Optical and e-Nose) for faster detection of molecular markers thereby diagnosing viral infections.: This report presents an evaluation of different body fluids, and their advantages for the rapid detection of COVID-19, coupled with highly sensitive optical techniques for the detection of molecular biomarkers.: Tears, saliva, and breath samples can provide valuable information about viral infections. Our brief review strongly recommends the application of saliva/tears and exhaled breath as clinical samples using technics such as high-performance liquid chromatography-laser-induced fluorescence, photoacoustic spectroscopy, and e-Nose, respectively, for the fast diagnosis of viral infections.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737159.2021.1874355DOI Listing
January 2021

Occupation-related musculoskeletal disorders among dental professionals.

Med Pharm Rep 2020 Oct 25;93(4):405-409. Epub 2020 Oct 25.

Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Background And Aim: Dentists are exposed to a wide range of work-related factors that may result in various occupational diseases of which musculoskeletal disorders (MSDs) are common. The purpose of this study was to determine the prevalence and distribution of MSDs among dental professionals of our institution and to compare the prevalence of MSDs among the various dental specialists.

Methods: A self-administered questionnaire, which included basic demographic details, work experience in dentistry, and work profile related questions along with the Standard Nordic Questionnaire, was administered to the study participants. Statistical analysis for the data obtained was performed using SPSS Version 16.0 (Chicago, SPSS Inc.). The chi-square test was applied to test the association between MSD and variables such as gender, designation, type of dentistry and usage of computers. The Mann Whitney U test was used to assess the relationship between MSD and age, experience, sick leave, number of patients attended per day. A p-value < 0.05 was considered significant.

Results: 151 subjects participated in the study, and the prevalence of MSD in the last 12 months among dental professionals was 58.3% (88 out of 151 subjects). The most common site affected by MSD was the neck (66.7%). Also, it was noted that among various dental specialists, the Endodontists suffered the maximum (88.02%) musculoskeletal pain. Fifty individuals (33.11%) suffered from pain in multiple sites.

Conclusion: Work-related musculoskeletal disorders and pain can be reduced through proper operator-patient positioning, taking adequate breaks between patients, maintaining good physical health through regular exercises.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.15386/mpr-1581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664727PMC
October 2020

Oral manifestations in chronic kidney disease patients undergoing hemodialysis: a hospital-based study.

Minerva Stomatol 2020 Oct 14;69(5):302-308. Epub 2020 May 14.

Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Background: Chronic kidney disease (CKD-HD) patients undergoing routine hemodialysis have been reported to have oral signs and symptoms due to disease process or various comorbidities like diabetes mellitus (DM). Both CKD and DM can cause oral changes. Hence this study aimed to evaluate the prevalence of oral symptoms and signs in CKD-HD patients and to rule out DM as possible confounding factor for the oral findings.

Methods: Oral manifestations were assessed in 102 CKD-HD patients, and compared with 100 DM patients and 101 non-diabetic patients with no renal impairment.

Results: Most common symptom reported by patients with CKD-HD were xerostomia, altered taste. The most prevalent objective findings were oral dryness. There was statistically significant difference in symptoms and signs between CKD-HD and non-CKD patients. However, no significant difference between CKD-HD with and without DM.

Conclusions: This study showed increased prevalence of oral findings in CKD patients. It also revealed that Diabetes mellitus cannot be a contributing factor for increased prevalence of oral manifestations in CKD patients.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.23736/S0026-4970.20.04300-9DOI Listing
October 2020

Comparison of Conventional Techniques and Higher Imaging Modalities in the Evaluation of Relation between the Third Molar and Inferior Alveolar Nerve Canal: A Pilot Study.

Contemp Clin Dent 2019 Jan-Mar;10(1):93-98

Department of Medical Imaging, School of Allied Health Sciences, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Context: Mandibular third molars are the most commonly impacted teeth, and their surgical removal can be associated with inferior alveolar nerve (IAN) injury. To avoid the deleterious complication of nerve injury on patients, a thorough visualization of IAN and its localization are essential.

Aims And Objectives: The aims and objectives of this study were to evaluate the efficacy of two conventional localization techniques in determining the relationship of mandibular third molars to IAN and to assess its reliability in comparison with computed tomography (CT).

Settings And Design: Panoramic radiograph (PR) was taken using Kodak 8000C Digital Panoramic and Cephalometric system. Intraoral periapical radiographs (IOPAs) were taken using Kodak 2200 Intraoral X-ray machine. CT scan images were taken using multidetector CT scans.

Materials And Methods: Two IOPAs (0° and -20° vertical angulation) and PR and CT scan images of thirty mandibular third molars were taken. Two combinations were used (i) a combination of two IOPAs and (ii) a combination of PR and IOPA (-20°). Tube-shift localization technique was applied to both these combinations to derive the relation between third molar and IAN canal as "in contact," "separate," "buccal," "lingual," and "in line with the apex" and the results were compared with CT images.

Statistical Analysis: Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated using SPSS software version 15.0.

Results: The combination of PR and IOPA radiographs showed 14 teeth to be in contact with IAN. This gave a sensitivity of 100%, specificity of 94.1%, PPV of 92.9%, and a NPV of 100% in determining the relation as "in contact" or "separate." 78.3%, 85.7%, 94.7%, and 54.5% were the sensitivity, specificity, PPV, and NPV in localizing it as "buccal," "lingual," or "in line with apex." These results were better than that of the combination of the two IOPAs.

Conclusions: Localization using PR and IOPA could better deduce the relation between IAN and mandibular third molar.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/ccd.ccd_430_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975005PMC
February 2020

Solitary Large Intraoral Neurilemmoma of the Maxillary Vestibule: A Rare Case with Brief Literature Review.

J Contemp Dent Pract 2019 Jul 1;20(7):847-850. Epub 2019 Jul 1.

Manipal College of Dental Sciences, Manipal University, Karnataka, India.

Aim: This current report aimed at presenting a rare case of a large solitary intraoral neurilemmoma of the buccal vestibule followed by a brief review of literature of neurilemmoma published between 1997 and 2017.

Background: The diagnosis of slow-growing intraoral lesions requires a thorough patient history and clinical examination. Despite the best efforts of even the most experienced oral medicine expert, a definitive diagnosis may sometimes only be reached through excisional biopsy and histopathological evaluation.

Case Description: To the best of our knowledge, there have been only two cases of neurilemmoma of the buccal vestibule reported in the literature till date and, looking at the size of the lesion, our case is the largest among the ones reported.

Conclusion: In the present case, a rare presentation of solitary buccal vestibular neurilemmoma establishes the need for the consideration of a wide range of pathologies in the differential diagnosis.

Clinical Significance: Clinicians should include neurilemmoma in their differential diagnosis for asymptomatic, slow-growing intraoral growths and ensure complete excision to prevent tumor recurrence. The reader should be able to recognize the clinical features of neurilemmoma and describe the histopathological features and management of the condition.
View Article and Find Full Text PDF

Download full-text PDF

Source
July 2019

Diffuse gingival enlargement: an unusual diagnostic clue for pulmonary tuberculosis.

Lancet Infect Dis 2018 11 24;18(11):1288. Epub 2018 Oct 24.

Department of Pathology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1473-3099(18)30229-9DOI Listing
November 2018

Oral hygiene and dentition status in children and adults with hemophilia: A case-control study.

Spec Care Dentist 2018 Nov 26;38(6):391-394. Epub 2018 Sep 26.

Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.

Background & Objectives: People with hemophilia constitute a significant proportion of the population and an oral health care professional faces a considerable challenge while treating them. This study aimed to assess the oral health and dentition status as well as fear of dental treatment in patients with hemophilia and compare it with age-matched healthy subjects.

Patients & Methods: This single-center, case-control cross-sectional study was performed on 100 subjects with hemophilia and 100 age-matched healthy controls. Oral health and dentition status was recorded for all the subjects and scored using the simplified oral hygiene index (OHI-S), plaque index, and the dmft/DMFT index.

Results: There were a total of 41 children and 59 adults in the hemophilia group and 36 children and 64 adults in the healthy group. When compared to healthy subjects it was observed that individuals with hemophilia had higher debris and calculus scores which was indicative of poor orodental status. There was no significant difference observed in the DMFT scores among the study groups.

Interpretation & Conclusions: The oral hygiene of the hemophilics was poorer when compared to the healthy controls. The findings highlight the need for establishing interdisciplinary care for such individuals.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/scd.12324DOI Listing
November 2018

Orofacial Manifestations of Leukemic Children on Treatment: A Descriptive Study.

Int J Clin Pediatr Dent 2018 May-Jun;11(3):193-198. Epub 2018 Jun 1.

Professor and Dean, Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal, Karnataka, India.

Aim: To study the prevalence of orofacial manifestations in leukemic children undergoing treatment and to correlate these manifestations with various stages of chemotherapy.

Materials And Methods: A prospective noninvasive study comprising 43 acute lymphocytic leukemic pediatric patients at various stages of therapy. They were examined on day of their each blood examination, and lesions were recorded on a self-designed pro forma. A total of 133 observations were recorded by a single observer. The treatment was divided into the phase of induction, consolidation, maintenance, and relapse.

Results: The data were analyzed using Statistical Package for the Social Sciences (SPSS) version 10.1. There were 24 males and 19 females in this study, aged between 3 and 13 years. The common oral lesions seen were dental caries, lymphadenopathy (86.04%), pallor (65.11%), ulcers (13.95%), mucositis (16.27%), gingival enlargement, hemorrhages (20.93%), candidiasis, herpes simplex virus (HSV) infection, xerostomia (44.18%), paresthesia, and tooth mobility. Herpes simplex virus infection was seen only during induction and consolidation phases. Ulcers were seen during all phases of therapy.

Clinical Significance: Orofacial manifestations may be seen as the first sign of leukemia and a dentist may play a significant role in the diagnosis of the disease This study highlights not only about commonly occurring lesions but also their variation during various phases of therapy. To the best of our knowledge, no study has such an extensive reporting of orofacial manifestations of acute lymphocytic leukemia (ALL) patients under treatment. Aggarwal A, Pai KM. Orofacial Manifestations of Leukemic Children on Treatment: A Descriptive Study. Int J Clin Pediatr Dent 2018;11(3):193-198.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5005/jp-journals-10005-1510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102430PMC
June 2018

Evaluation of the Effect of Age, Gender, and Skeletal Class on the Dimensions of Sella Turcica Using Lateral Cephalogram.

Contemp Clin Dent 2018 Apr-Jun;9(2):195-199

Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India.

Context: Sella turcica or pituitary fossa is a saddle-shaped concavity housing the pituitary gland and seen clearly on lateral cephalogram. This makes it a good source of additional diagnostic information related to pathology of the pituitary gland or to various syndromes that affect the craniofacial region.

Aims: The aim of this retrospective study was to determine the average dimensions and morphological variations of the sella turcica in different age groups and to evaluate any difference in size between males and females in the study population.

Settings And Design: All the lateral cephalograms were taken by trained radiographic technicians using Planmeca Promax Ceph X-ray Machine, Finland, Inc., in a standardized manner using the same cephalostat.

Materials And Methods: Four hundred and eighty lateral cephalograms were obtained under standardized conditions. With age range between 7 and 43 years, all the radiographs were distributed according to skeletal class and gender. Size and morphology of sella turcica were recorded and compared with age, gender, and skeletal class.

Statistical Analysis Used: A Student's -test, one-way ANOVA test, and Pearson's correlation coefficient were used.

Results: The mean age of the study population was found to be 16.8 years comprising 48.6% males and 51.3% females. There was a gradual increase in linear dimensions of sella turcica with the advancement of age. The normal sella was observed in 20.6%, whereas 79.35% showed variation in morphology. Oblique anterior wall was a most common abnormal variant, whereas pyramidal shaped dorsum was rarest.

Conclusions: There was no statistically significant difference in linear dimensions or morphological variations with age, gender, or type of malocclusion.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/ccd.ccd_805_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968682PMC
June 2018

Rebamipide gargle in preventive management of chemo-radiotherapy induced oral mucositis.

Oral Oncol 2017 09 28;72:179-182. Epub 2017 Jul 28.

Department of Oral Medicine & Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka 576104, India.

Background & Objectives: Oral mucositis is inflammation of mucosa of oral cavity which is an inevitable and acute side effect in patients undergoing chemoradiotherapy for head & neck cancer. Though many agents have been tried in prevention & treatment of oral mucositis, until date no single agent exists that is universally established to be effective.

Methods: 60 Patients diagnosed with Head & Neck cancer recruited for concurrent chemo-radiotherapy were assigned in a double blind fashion into 2 groups using computer based 1:1 ratio randomization. Subjects in Group 1 were given Rebamipide gargle while subjects in Group 2 were given Placebo gargle in similar colour coded bottles to gargle 6 times/day. Subjective assessment of oral mucositis was done by Numeric Rating Scale (NRS) and objective scoring according to RTOG system.

Results: All subjects in the Group 1 reported good treatment compliance but 4 subjects in Group 2 developed burning sensation to gargle and were excluded. Onset of oral mucositis was 3.5days earlier in Group 2 (mean=11.17) as compared to Group 1 (mean=14.63). At the end of chemo-radiotherapy, severity of oral mucositis was significantly lower in Group 1 (mean=1.97) than in Group 2 (mean=2.81).

Interpretation & Conclusion: Findings of this study revealed that Rebamipide gargle may be an effective means to prolong the onset of oral mucositis and may reduce the severity of oral mucositis in undergoing chemo-radiotherapy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2017.07.024DOI Listing
September 2017

A randomized control trial measuring the effectiveness of a mouth-exercising device for mucosal burning in oral submucous fibrosis: a commentary.

Oral Surg Oral Med Oral Pathol Oral Radiol 2017 06 21;123(6):735. Epub 2017 Feb 21.

Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oooo.2017.01.016DOI Listing
June 2017

Comment on "Establishing a targeted plan for prophylactic dental extractions in patients with laryngeal cancer receiving adjuvant radiotherapy".

Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jan 28;123(1):137-138. Epub 2016 Sep 28.

Associate Professor, Department of Public Health Dentistry, Manipal College of Dental Sciences, Manipal, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oooo.2016.07.041DOI Listing
January 2017

Mandibular changes on panoramic imaging after head and neck radiotherapy: a commentary.

Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Dec 17;122(6):783-784. Epub 2016 Aug 17.

Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oooo.2016.07.027DOI Listing
December 2016

Enhanced salivary secretion by interferential current stimulation in patients with dry mouth: a pilot study-a commentary.

Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Oct 19;122(4):519-20. Epub 2016 Jul 19.

Professor and Head, Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oooo.2016.05.025DOI Listing
October 2016

Maxillary pseudotumor as initial manifestation of von Willebrand disease, type 2: report of a rare case and literature review-a commentary.

Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Aug 24;122(2):259-60. Epub 2016 May 24.

Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oooo.2016.05.011DOI Listing
August 2016

Comments on "Cone beam computed tomography (CBCT) sialography-an adjunct to salivary gland ultrasonography in the evaluation of recurrent salivary gland swelling".

Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Jul 1;122(1):111-2. Epub 2016 Apr 1.

Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oooo.2016.02.019DOI Listing
July 2016

Hybrid ameloblastoma: An amalgam of rare and conventional ameloblastoma.

Contemp Clin Dent 2016 Jan-Mar;7(1):90-4

Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India.

Ameloblastoma is a common benign odontogenic tumor with multiple histologic types. This case report describes an unusual type of ameloblastoma called "Hybrid Ameloblastoma" with features of both follicular and desmoplastic ameloblastoma in a 50-year-old female. This is a very rare form of ameloblastoma as <30 cases have been reported so far in literature. Though this rare form of ameloblastoma is only a histologic variant, it poses a great challenge to diagnosticians and thus to surgeons as there will be mismatch of biopsy reports at different sites in the same tumor thereby changing the treatment plan. This case report is one such example of diverse presentation of this ameloblastoma with conflicting histopathological diagnosis at initial biopsy and on surgical excision.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/0976-237X.177089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792065PMC
April 2016

Salivary Glucose as a Diagnostic Marker for Diabetes Mellitus.

J Diabetes Sci Technol 2016 07;10(4):991-992

3 Department of Public Health Dentistry, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/1932296816637619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928231PMC
July 2016

Accuracy of diagnosis of salivary gland tumors with the use of ultrasonography, computed tomography, and magnetic resonance imaging: a meta-analysis--a commentary.

Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Mar 24;121(3):341. Epub 2015 Nov 24.

Postgraduate Student, Manipal College of Dental Sciences, Manipal University, Manipal, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oooo.2015.10.036DOI Listing
March 2016

Re: "Five-year alveolar bone level changes in women of varying skeletal bone mineral density and bone trabeculation--a commentary".

Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Mar 14;121(3):340. Epub 2015 Nov 14.

Associate Professor, Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal, India. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oooo.2015.10.026DOI Listing
March 2016

Postradiation trismus and its impact on quality of life in patients with head and neck cancer: a commentary.

Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Feb 10;121(2):196-7. Epub 2015 Dec 10.

Professor and Head, Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oooo.2015.06.042DOI Listing
February 2016

Benign fibrous histiocytoma: A rare case involving jaw bone.

Contemp Clin Dent 2015 Sep;6(Suppl 1):S266-8

Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India.

Benign fibrous histiocytoma (BFH) is a soft tissue neoplasm which occurs mostly on the skin of extremities. BFH rarely occurs in bone and may affect femur, tibia, and pelvic bone. Jaw bone involvement is very unusual with only 11 cases reported till date. This report describes a case of BFH occurring in a 30-year-old female patient affecting left mandibular posterior region. Computed tomography revealed a well-defined expansile lytic lesion in the posterior mandible. Gross examination of the tumor revealed an admixture of fibroblasts and histiocytes in a fascicular and storiform pattern. Immunohistochemical staining was positive for CD68.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/0976-237X.166828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632234PMC
September 2015

"Role of intraoral color Doppler sonography in predicting delayed cervical lymph node metastasis in patients with early-stage tongue cancer"--a commentary.

Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Jan 28;121(1):106-7. Epub 2015 Aug 28.

Associate Professor, Department of Public Health Dentistry, Manipal College of Dental Sciences, Manipal, India.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oooo.2015.06.041DOI Listing
January 2016

Generalised fibrotic gingival enlargement in a psoriatic patient: an association or a coincidence?

BMJ Case Rep 2015 Sep 21;2015. Epub 2015 Sep 21.

Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India.

Gingival fibromatosis is a rare, benign, slow progressive fibrous overgrowth of gingiva, with great genetic and clinical heterogeneity. It can be inherited as an isolated trait (hereditary/idiopathic gingival fibromatosis), and/or as a component of a syndrome. We report a case of a young girl suffering from psoriasis who also presented with an unusual generalised idiopathic gingival fibromatosis. Psoriasis, a chronic inflammatory skin disease, of multifactorial origin, is characterised by keratinocyte hyperproliferation, dedifferentiation, neoangiogenesis and inflammation. T cell-mediated immunity is considered to be the key element in the disease process. The existence of oral mucosal alterations in patients with psoriasis is a controversial topic, as histopathological correlations are not clearly evident, and oral and cutaneous lesions do not follow a parallel course. However, this article highlights a possible association of T-lymphocyte stimulation inducing fibroblasts to undergo epidermal hyperproliferation and increased collagen production in the gingiva, which in turn may be responsible for inducing gingival hyperplasia.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2015-211071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577645PMC
September 2015

Repeat film analysis and its implications for quality assurance in dental radiology: An institutional case study.

Contemp Clin Dent 2015 Jul-Sep;6(3):392-5

Department of Public Health Dentistry, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India.

Context: The goal of any radiologist is to produce the highest quality diagnostic radiographs, while keeping patient exposure as low as reasonably achievable (ALARA).

Aims: The aim of this study was to describe the reasons for radiograph rejections through a repeat film analysis in an Indian dental school.

Settings And Design: An observational study conducted in the Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal.

Materials And Methods: During a 6-month study period, a total of 9,495 intra-oral radiographs and 2339 extraoral radiographs taken in the Radiology Department were subjected to repeat film analysis.

Statistical Analysis Used: SPSS Version 16. Descriptive analysis used.

Results: The results showed that the repeat rates were 7.1% and 5.86% for intraoral and extraoral radiographs, respectively. Among the causes for errors reported, positioning error (38.7%) was the most common, followed by improper angulations (26.1%), and improper film placement (11.2%) for intra-oral radiographs. The study found that the maximum frequency of repeats among extraoral radiographs was for panoramic radiographs (49%) followed by lateral cephalogram (33%), and paranasal sinus view (14%). It was also observed that repeat rate of intraoral radiographs was highest for internees (44.7%), and undergraduate students (28.2%).

Conclusions: The study pointed to a need for more targeted interventions to achieve the goal of keeping patient exposure ALARA in a dental school setting.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/0976-237X.161898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549993PMC
August 2015

Lipoid proteinosis: A review with two case reports.

Contemp Clin Dent 2015 Apr-Jun;6(2):233-6

Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India.

Lipoid proteinosis (LP) is a rare autosomal recessive genodermatoses characterized by deposition of amorphous hyaline material in different parts of the body, especially the skin, mucous membranes of the upper aerodigestive tract, and internal organs. Oral cavity is most extensively affected area by the disease. This paper reports two classic cases of LP with oral manifestations but without a history of consanguinity along with a concise review of the literature on the disease.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/0976-237X.156053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456748PMC
June 2015

Ultra-sensitive high performance liquid chromatography-laser-induced fluorescence based proteomics for clinical applications.

J Proteomics 2015 Sep 12;127(Pt A):202-10. Epub 2015 May 12.

Dept. of Atomic and Molecular Physics, Manipal University, Manipal, Karnataka, India. Electronic address:

Unlabelled: An ultra-sensitive high performance liquid chromatography-laser induced fluorescence (HPLC-LIF) based technique has been developed by our group at Manipal, for screening, early detection, and staging for various cancers, using protein profiling of clinical samples like, body fluids, cellular specimens, and biopsy-tissue. More than 300 protein profiles of different clinical samples (serum, saliva, cellular samples and tissue homogenates) from volunteers (normal, and different pre-malignant/malignant conditions) were recorded using this set-up. The protein profiles were analyzed using principal component analysis (PCA) to achieve objective detection and classification of malignant, premalignant and healthy conditions with high sensitivity and specificity. The HPLC-LIF protein profiling combined with PCA, as a routine method for screening, diagnosis, and staging of cervical cancer and oral cancer, is discussed in this paper.

Biological Significance: In recent years, proteomics techniques have advanced tremendously in life sciences and medical sciences for the detection and identification of proteins in body fluids, tissue homogenates and cellular samples to understand biochemical mechanisms leading to different diseases. Some of the methods include techniques like high performance liquid chromatography, 2D-gel electrophoresis, MALDI-TOF-MS, SELDI-TOF-MS, CE-MS and LC-MS techniques. We have developed an ultra-sensitive high performance liquid chromatography-laser induced fluorescence (HPLC-LIF) based technique, for screening, early detection, and staging for various cancers, using protein profiling of clinical samples like, body fluids, cellular specimens, and biopsy-tissue. More than 300 protein profiles of different clinical samples (serum, saliva, cellular samples and tissue homogenates) from healthy and volunteers with different malignant conditions were recorded by using this set-up. The protein profile data were analyzed using principal component analysis (PCA) for objective classification and detection of malignant, premalignant and healthy conditions. The method is extremely sensitive to detect proteins with limit of detection of the order of femto-moles. The HPLC-LIF combined with PCA as a potential proteomic method for the diagnosis of oral cancer and cervical cancer has been discussed in this paper. This article is part of a Special Issue entitled: Proteomics in India.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jprot.2015.05.006DOI Listing
September 2015

Can ultrasonography findings of tongue cancer really predict cervical lymph node metastasis?

Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Feb 26;119(2):254-5. Epub 2014 Nov 26.

Associate Professor, Manipal College of Dental Sciences, Manipal, India. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oooo.2014.07.539DOI Listing
February 2015

Hypercementosis: a rare finding in a patient with systemic lupus erythematosus.

BMJ Case Rep 2014 Nov 26;2014. Epub 2014 Nov 26.

Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal, Karnataka, India.

Hypercementosis is excessive deposition of non-neoplastic cementum over normal root cementum, which alters root morphology. This cementum may be either hypocellular or cellular in nature. The aetiopathogenesis of hypercementosis is ambiguous. Although most of the cases are idiopathic, several local and systemic factors are also linked to this condition, such as Paget's disease, acromegaly, vitamin A deficiency, etc. We report two rare cases of hypercementosis associated with systemic lupus erythematosus, not previously described in the literature, and also discuss the possible aetiopathogenesis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2013-202370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248133PMC
November 2014