Publications by authors named "Kee Suck Suh"

53 Publications

Dermoscopic findings of genital keratotic lesions: Bowenoid papulosis, seborrheic keratosis, and condyloma acuminatum.

Photodiagnosis Photodyn Ther 2021 Jul 19;36:102448. Epub 2021 Jul 19.

Department of Dermatology, Kosin University College of Medicine, Busan, South Korea. Electronic address:

Dermatologists often encounter keratotic or warty lesions in the genital area. Establishing a clear diagnosis may seem challenging, particularly when the differential diagnosis includes bowenoid papulosis, seborrheic keratosis, and condyloma acuminatum. This study aimed to compare the dermoscopic features of bowenoid papulosis (BP), seborrheic keratosis, and condyloma acuminatum in the genital area. All lesions histopathologically confirmed underwent clinical assessment and dermoscopic observation. Dermoscopically, glomerular vessels were predominant in bowenoid papulosis, whereas seborrheic keratosis was the least vascular-patterned disease. Most cases of bowenoid papulosis presented mucosal pigmentation and classified as "flat". Seborrheic keratosis had a pigmented, cerebriform appearance. Condyloma acuminatum was characterised by a finger-like appearance, highly vascular-patterned features surrounded by whitish halos. Dermoscopic findings can be useful for differentiating the entity of genital keratotic lesions ahead of an invasive method. When dermoscopic features favor BP, different from genital warts, it should be removed completely but conservatively.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pdpdt.2021.102448DOI Listing
July 2021

Clinical characteristics and long-term outcome of 223 patients with mycosis fungoides at a single tertiary center in Korea: A 29-year review.

J Am Acad Dermatol 2021 Jun 29. Epub 2021 Jun 29.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea. Electronic address:

Background: Data regarding Asian patients with mycosis fungoides (MF) are limited.

Objective: We aimed to investigate the clinical profile and long-term outcomes of patients with MF in Korea.

Methods: A retrospective review of 223 patients with MF who were followed up for more than 6 months or died of MF within 6 months of diagnosis was performed.

Results: Approximately 96.4% and 3.6% of the patients had an early stage and advanced stage, respectively. The mean age at diagnosis was 44.8 years. The mean duration of symptoms before diagnosis was 47.0 months. Various subtypes were noted, including mycosis fungoides palmaris et plantaris (21.5%), folliculotropic (8.5%), pityriasis lichenoides-like (6.7%), ichthyosiform (4.0%), lichenoid purpura-like (2.7%), and hypopigmented (2.2%) MF. Juvenile patients accounted for 16.6%. The higher the skin T stage, the poorer the response to treatment. The 10-year overall survival was 96.8% in early-stage patients and 25.0% in advanced-stage patients. General prognosis was favorable, while recurrence and subtype switching were seen in 29.4% and 2.7% of patients, respectively.

Limitations: Our patients may not represent all Korean patients with MF.

Conclusion: MF in Korea has a high proportion of variants, a younger age at onset, and favorable prognosis. A high index of suspicion and skin biopsy are needed for early diagnosis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2021.06.860DOI Listing
June 2021

Comments on "Unusual Presentation of Subcutaneous Phaeohyphomycosis by " by Lee et al.

Ann Dermatol 2020 Dec 11;32(6):536-537. Epub 2020 Nov 11.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5021/ad.2020.32.6.536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875233PMC
December 2020

A Case Report on the Dermoscopic Features of Spark's Nevus.

Ann Dermatol 2020 Jun 24;32(3):233-236. Epub 2020 Apr 24.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

Spark's nevus is a compound word composed of Spitz nevus and Clark's nevus. It is one of the combined melanocytic nevi which is more common in female and usually presents as a sharp circumscribed hyperpigmented macule on the lower extremities. On histopathologic findings, both cytologic features of Spitz nevus characterized as large spindle or epithelioid melanocytes containing large nuclei with abundant cytoplasm, and architecture of Clark's nevus characterized as elongation of rete ridges, bridging of the nests, concentric and lamellar fibrosis can be seen. A 24-year-old female presented with an asymptomatic, solitary, dark-brown-colored papule surrounded by brownish patch that looked similar to dysplastic nevus or malignant melanoma on the buttock. On dermoscopic examination, it showed brown-to-black globules, diffuse homogenous pigmentation with blue-white structures, and a surrounding brownish reticular pattern that faded away. On histopathologic findings, overall asymmetrical structure, epithelioid large melanocytes containing large nuclei with abundant cytoplasm, and Kamino body were seen in the central portion. Also, lentiginous hyperplasia, bridging of the nests composed of melanocytes containing foamy cytoplasm, concentric and lamellar fibrosis along with the elongation of rete ridge, and perivascular lymphocytic infiltration were seen in the peripheral portion. The diagnosis of Spark's nevus was made. Following its definition, this combined nevus is diagnosed histopathologically, but the clinicodermoscopic features have not been well described. Herein, we report a case of Spark's nevus in which dermoscopy was helpful for differentiating it from malignant melanoma.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5021/ad.2020.32.3.233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992624PMC
June 2020

Usefulness of dermoscopy in identifying amyloid purpura.

J Dermatol 2021 Jun 20;48(6):e260-e262. Epub 2021 Apr 20.

Department of Dermatology, Kosin University College of Medicine, Busan, South Korea.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.15854DOI Listing
June 2021

Mycobacterium marinum Infection Spreading in a "Birds in Flocks" Pattern: All Caseating Granuloma is Not Tuberculosis.

Acta Derm Venereol 2020 Jul 2;100(14):adv00200. Epub 2020 Jul 2.

Department of Dermatology, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-gu, Busan, 602-702, Korea.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3538DOI Listing
July 2020

The effectiveness of high-dose ultraviolet A-1 phototherapy for acute exacerbation of atopic dermatitis in Asians.

Photodermatol Photoimmunol Photomed 2020 Jul 18;36(4):263-270. Epub 2020 Mar 18.

Department of Dermatology, Kosin University College of Medicine, Busan, South Korea.

Background/purpose: Atopic dermatitis (AD) is an inflammatory skin disease characterized by a chronic course of exacerbations and remissions. High-dose ultraviolet A-1 (UVA-1) phototherapy has been effective in the treatment of acute exacerbations of AD. However, there have been no case studies in Asian patients to date. We investigated the effectiveness of high-dose UVA-1 phototherapy for treating acute exacerbation of AD in Asian patients.

Method: This study included 16 patients with acute exacerbation of AD. High-dose (100 J/cm ) regimens of UVA-1 therapy were employed. Therapeutic effectiveness was assessed based on the findings of clinical examinations and scoring of AD (SCORAD) index before treatment and after the 5th and 10th sessions of treatment. Additionally, side effects and recurrence during follow-up were retrospectively evaluated.

Results: The patients were between 7 and 50 years of age, with a mean age of 25.8 years. The SCORAD index was between 41 and 89.5, with a mean score of 64.9. Among the 16 patients, two patients discontinued treatment due to the aggravation of erythema and pruritus. Of the 14 patients who completed the 10 sessions of high-dose UVA-1 phototherapy, nine patients (64.3%) showed complete remission and five patients (35.7%) showed partial remission. The mean SCORAD index reduced from 64.9 (before treatment) to 23.3 (after the 10th session of treatment).

Conclusion: This is the first case study of high-dose UVA-1 phototherapy for acute exacerbation of AD in Asian patients, suggesting that high-dose UVA-1 phototherapy can be a well-tolerated and effective treatment for acute exacerbated AD. Future large-scale prospective studies are needed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/phpp.12546DOI Listing
July 2020

Low-dose Methotrexate Treatment for Solitary or Localized Primary Cutaneous Anaplastic Large Cell Lymphoma: A Long-term Follow-up Study.

Acta Derm Venereol 2020 02 29;100(4):adv00069. Epub 2020 Feb 29.

Department of Dermatology, Kosin University College of Medicine, 49267 Busan, Korea.

Although low-dose methotrexate (MTX) has been used widely in treatment of a variety of dermatological diseases, including multifocal primary cutaneous anaplastic large cell lymphoma (PCALCL), it has not been established for use in the treatment guidelines for solitary or localized PCALCL. Furthermore, there has been no report of long-term follow-up data in Asian patients with PCALCL treated with low-dose MTX. To investigate the effectiveness and clinical outcome of treatment with low-dose MTX, clinical and long-term follow-up data of 7 patients with solitary or localized PCALCL were analysed retrospectively. Of the 7 patients, 6 (85.7%) showed a complete response and 1 (14.3%) showed partial remission. During follow-up, mean duration of 92.1 months, 5 patients developed one or more cutaneous relapses. At the last follow-up, all of the patients with PCALCL were alive without disease. These results indicate that low-dose MTX is a highly effective and safe treatment for solitary or localized PCALCL as well as multiple relapsed lesions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3413DOI Listing
February 2020

Dysplastic nevus : Clinical features and usefulness of dermoscopy.

J Dermatol 2019 Feb 6;46(2):e76-e77. Epub 2018 Aug 6.

Department of Dermatology, Kosin University College of Medicine, Busan, South Korea.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.14583DOI Listing
February 2019

Erratum: Folliculotropic Mycosis Fungoides in 20 Korean Cases: Clinical and Histopathologic Features and Response to Ultraviolet A-1 and/or Photodynamic Therapy.

Ann Dermatol 2018 Aug 28;30(4):510. Epub 2018 Jun 28.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

[This corrects the article on p. 192 in vol. 30, PMID: 29606817.].
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5021/ad.2018.30.4.510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029964PMC
August 2018

Folliculotropic Mycosis Fungoides in 20 Korean Cases: Clinical and Histopathologic Features and Response to Ultraviolet A-1 and/or Photodynamic Therapy.

Ann Dermatol 2018 Apr 21;30(2):192-201. Epub 2018 Feb 21.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

Background: Folliculotropic mycosis fungoides (FMF) is a variant of mycosis fungoides (MF) that is characterized clinically by variable types of skin eruptions, including plaques, acneiform lesions, and alopecic patches. Histopathologically, FMF is characterized by folliculotropic infiltrates.

Objective: This study was conducted to scrutinize the clinical and histopathologic features of FMF in Koreans and the responses to phototherapy.

Methods: Twenty Koreans diagnosed with MF who had histopathologic evidence of folliculotropism were enrolled.

Results: Eighteen patients had head-and-neck-region infiltration, while five had solitary lesion. In all patients, the atypical lymphocytic infiltrate had a perifollicular distribution. Twelve patients were treated with ultraviolet A (UVA)-1. Eleven of these 12 patients with early-stage FMF experienced >80% improvement (8: complete remission; 3: partial remission). Four patients, including 2 who relapsed after UVA-1, were treated with photodynamic therapy (PDT), reaching complete remission after PDT.

Conclusion: As FMF has variable clinical presentations, skin biopsy is required to confirm the diagnosis. And both UVA-1 and methyl aminolevulinate-PDT are clinically effective in treatment of early-stage FMF.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5021/ad.2018.30.2.192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839891PMC
April 2018

Histopathologic Finding of Perieschar Lesions in Tsutsugamushi Disease Shows Lymphocytic Vasculitis Mimicking Angiocentric Lymphoma.

Ann Dermatol 2018 Feb 26;30(1):29-35. Epub 2017 Dec 26.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

Background: Tsutsugamushi disease is an acute, febrile, infectious disease caused by . Several studies investigating the histopathologic findings of eschars in tsutsugamushi disease reported leukocytoclastic vasculitis and neutrophil infiltration as the major findings. However, these findings may result from secondary changes following tissue necrosis. The histopathologic findings of perieschar lesions may be important to understand the primary changes associated with tsutsugamushi disease.

Objective: To investigate characteristic histopathologic features of perieschar lesions and suppose the mechanism of vascular pathophysiological changes associated with tsutsugamushi disease.

Methods: We analyzed histopathological slides of perieschar lesions in 12 patients diagnosed with tsutsugamushi disease.

Results: In the epidermis, exocytosis of mononuclear cells (75.0%) and basal vacuolar changes (66.7%) were frequent. In the dermis, perivascular, interstitial, and perineural mononuclear cell infiltration (100.0%, 83.3%, and 83.3%, respectively), as well as thrombosis (83.3%), atypical lymphocyte infiltration (91.7%), and mitotic figures (83.3%) were commonly seen. Lymphocytic vasculitis and mononuclear cell infiltration around eccrine glands were found in all cases, but eosinophil infiltration was only found in one patient (8.3%). However, the characteristic findings of eschar lesions, such as leukocytoclastic vasculitis and neutrophil infiltration, were not found in perieschar lesions.

Conclusion: The major histopathologic findings in the perieschar lesions of tsutsugamushi disease were lymphocytic vasculitis and atypical lymphocytic infiltration, mimicking lymphoma. Therefore, we suggest that this lesion should be added to the list of pseudolymphomas. To observe these characteristic histopathologic features, we also recommend that skin biopsies should be performed on perieschar lesions, not eschar lesions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5021/ad.2018.30.1.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762473PMC
February 2018

Superficial mycosis of the foot caused by Cladophialophora boppii.

J Dermatol 2018 Jun 10;45(6):e144-e145. Epub 2018 Jan 10.

Department of Dermatology, Kosin University College of Medicine, Busan, South Korea.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.14195DOI Listing
June 2018

Kerion celsi caused by Trichophyton erinacei from a hedgehog treated with terbinafine.

J Dermatol 2017 Sep 5;44(9):1070-1071. Epub 2016 Nov 5.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.13647DOI Listing
September 2017

Degos-Like Lesions Associated with Systemic Lupus Erythematosus.

Ann Dermatol 2017 Apr 24;29(2):215-218. Epub 2017 Mar 24.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

Degos disease, also referred to as malignant atrophic papulosis, was first described in 1941 by Köhlmeier and was independently described by Degos in 1942. Degos disease is characterized by diffuse, papular skin eruptions with porcelain-white centers and slightly raised erythematous telangiectatic rims associated with bowel infarction. Although the etiology of Degos disease is unknown, autoimmune diseases, coagulation disorders, and vasculitis have all been considered as underlying pathogenic mechanisms. Approximately 15% of Degos disease have a benign course limited to the skin and no history of gastrointestinal or central nervous system (CNS) involvement. A 29-year-old female with history of systemic lupus erythematosus (SLE) presented with a 2-year history of asymptomatic lesions on the dorsum of all fingers and both knees. The patient had only skin lesions and no gastrointestinal or CNS vasculitis symptoms. Her skin lesions were umbilicated, atrophic porcelain-white lesions with a rim of erythema. On the basis of clinical, histologic, and laboratory findings, a diagnosis of Degos-like lesions associated with SLE was made. The patient had been treated for SLE for 7 years. Her treatment regimen was maintained over a 2 month follow-up period, and the skin lesions improved slightly with no development of new lesions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5021/ad.2017.29.2.215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383749PMC
April 2017

Usefulness of Dermoscopy in the Differential Diagnosis of Ruptured and Unruptured Epidermal Cysts.

Ann Dermatol 2017 Feb 3;29(1):33-38. Epub 2017 Feb 3.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

Background: An epidermal cyst is a common keratin-filled epithelial-lined cyst. The treatment of choice for epidermal cysts is surgical excision. If the cyst becomes ruptured, incision and drainage with oral antibiotic therapy or intralesional steroid injection are required.

Objective: To analyze the dermoscopic features that can differentiate between ruptured and unruptured epidermal cysts.

Methods: The clinical and dermoscopic features of the pathologically confirmed epidermal cysts of two subgroups of 38 patients, 20 with unruptured cysts and 18 with ruptured cysts, were reviewed.

Results: With regard to the dermoscopic features, an ivory- white background color and punctum were commonly found in both groups (>0.05). The unruptured-cyst group showed higher frequencies of pore sign (<0.05), blue-white veil (>0.05), no vascular structure, and arborizing telangiectasia (<0.05), but the ruptured-cyst group usually had red lacunae (>0.05) and peripheral linear branched vessels (with an erythematous rim) (<0.05).

Conclusion: Dermoscopy is helpful in differentiating between ruptured and unruptured epidermal cysts.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5021/ad.2017.29.1.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318524PMC
February 2017

Diagnostic usefulness of dermoscopy in differentiating lichen aureus from nummular eczema.

J Dermatol 2017 May 3;44(5):533-537. Epub 2016 Dec 3.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

Lichen aureus (LA) is a variant of pigmented purpuric dermatosis that is characterized clinically by rust macules, papules or plaques, mainly on the legs. In some cases, LA can be difficult to be distinguished from nummular eczema (NE) with the naked eye. Dermoscopy can be applied to skin lesions, revealing additional features that can be highly valuable for correct diagnosis. This study was conducted to investigate characteristic dermoscopic findings of LA and to identify distinctive features that can differentiate it from NE. Fourteen LA patients and 14 NE patients diagnosed by skin biopsy were enrolled. Skin lesions were evaluated via polarized dermoscopy. On dermoscopy, "coppery orange diffuse coloration of background", "round to oval red globules", "gray dots", and "networks of brownish to gray interconnected lines" were more commonly seen in LA (100%, 92.9%, 42.9% and 64.3%, respectively) compared with NE. "Scales", "shiny yellow clods" and "irregularly distributed brownish-red globules" were more commonly seen in NE (100%, 85.7% and 57.1%, respectively) compared with LA. Dermoscopy provides valuable information for diagnosis of LA and aids in differentiating it from NE.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.13701DOI Listing
May 2017

Pityriasis Lichenoides-like Mycosis Fungoides: Clinical and Histologic Features and Response to Phototherapy.

Ann Dermatol 2016 Oct 30;28(5):540-547. Epub 2016 Sep 30.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

Background: Pityriasis lichenoides (PL)-like skin lesions rarely appear as a specific manifestation of mycosis fungoides (MF).

Objective: We investigated the clinicopathological features, immunophenotypes, and treatments of PL-like MF.

Methods: This study included 15 patients with PL-like lesions selected from a population of 316 patients diagnosed with MF at one institution.

Results: The patients were between 4 and 59 years of age. Four patients were older than 20 years of age. All of the patients had early-stage MF. In all patients, the atypical lymphocytic infiltrate had a perivascular distribution with epidermotropism. The CD4/CD8 ratio was <1 in 12 patients. Thirteen patients were treated with either narrowband ultraviolet B (NBUVB) or psoralen+ultraviolet A (PUVA), and all of them had complete responses.

Conclusion: PL-like MF appears to have a favorable prognosis and occurrence of this variant in adults is uncommon. MF should be suspected in the case of a PL-like skin eruption. Therefore, biopsy is required to confirm the diagnosis of PL-like MF, and NBUVB is a clinically effective treatment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5021/ad.2016.28.5.540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064181PMC
October 2016

Cutaneous Lymphoma in Korea: A Nationwide Retrospective Study.

Acta Derm Venereol 2016 May;96(4):535-9

Department of Dermatology, Ajou University School of Medicine, 164, World Cup-ro, Yeongtong-gu, Suwon, 443-380, Korea.

The epidemiological and clinicopathological features of cutaneous lymphoma may vary by geographical area. However, only a few large-scale epidemiological studies of cutaneous lymphoma have been performed, mainly in the USA and Europe. This aim of this study was to determine the recent characteristics of cutaneous lymphoma in Korea according to the WHO/EORTC classification. A total of 422 patients with newly diagnosed cutaneous lymphoma from January 2009 to December 2013 comprising 293 cases of mature T-cell and natural killer (NK)-cell lymphoma and 39 cases of mature B-cell lymphoma were retrospectively reviewed. The incidence of mature B-cell lymphoma was lower in Korea than in Europe and the USA. Diffuse large B-cell lymphoma was more prevalent in Korea than in Western countries. The incidence of extranodal NK/T-cell lymphoma, nasal-type was higher in Korea than in Western countries and Japan.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-2283DOI Listing
May 2016

Epidemiology of deep cutaneous fungal infections in Korea (2006-2010).

J Dermatol 2015 Oct 24;42(10):962-6. Epub 2015 Jun 24.

Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.

Deep cutaneous fungal infections (DCFI) occur worldwide and their prevalence is influenced by personal factors of the affected patients and the geographic and cultural features. Surveillance studies of DCFI with respect to the various clinical backgrounds of affected patients can ultimately help to improve their outcome. Expanding on our previous study, we performed a retrospective analysis of patients with DCFI who were treated in a group of university teaching hospitals in Korea to determine the trends within a 5-year period. A retrospective medical record review of patients with DCFI treated between 2006 and 2010 at 16 university teaching hospitals located throughout Korea was performed. Among the 51 cases of DCFI (median patient age, 47.0 years), opportunistic infections in immunocompromised hosts accounted for half. Patients in this group included 11 who were transplant recipients and 12 with malignancies. Overall, Candida (13/51) was the most common causative organism, followed by Sporothrix (12) and Aspergillus (6). Papuloplaques and nodular lesions were the typical presentation, with maculopatches and ulcers also occurring in considerable numbers. Ten patients had systemic involvement. Eight immunocompromised patients did not recover from the disease despite systemic antifungal treatment. Our results highlight the equal involvement of opportunistic and primary pathogens in DCFI, as determined in cases from a 5-year period. Especially in immunocompromised hosts with non-specific skin findings, clinical suspicion is important because failure to diagnose a DCFI causes significant morbidity and possibly even death.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.12968DOI Listing
October 2015

Clinicopathological Manifestations of Ichthyosiform Mycosis Fungoides.

Acta Derm Venereol 2016 Jan;96(1):100-1

Department of Dermatology, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-gu, Busan, 602-702, Korea.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-2159DOI Listing
January 2016

Mites and burrows are frequently found in nodular scabies by dermoscopy and histopathology.

J Am Acad Dermatol 2014 Nov 15;71(5):1022-3. Epub 2014 Oct 15.

Department of Dermatology, Kosin University College of Medicine, Busan, South Korea. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2014.06.028DOI Listing
November 2014

Treatment of acne vulgaris with fractional radiofrequency microneedling.

J Dermatol 2014 Jul 8;41(7):586-91. Epub 2014 May 8.

Department of Dermatology, Kosin University College of Medicine, Busan, South Korea.

Fractional radiofrequency microneedling is a novel radiofrequency technique that uses insulated microneedles to deliver energy to the deep dermis at the point of penetration without destruction of the epidermis. It has been used for the treatment of various dermatological conditions including wrinkles, atrophic scars and hypertrophic scars. There have been few studies evaluating the efficacy of fractional radiofrequency microneedling in the treatment of acne, and none measuring objective parameters like the number of inflammatory and non-inflammatory acne lesions or sebum excretion levels. The safety and efficacy of fractional radiofrequency microneedling in the treatment of acne vulgaris was investigated. In a prospective clinical trial, 25 patients with moderate to severe acne were treated with fractional radiofrequency microneedling. The procedure was carried out three times at 1-month intervals. Acne lesion count, subjective satisfaction score, sebum excretion level and adverse effects were assessed at baseline and at 4, 8 and 12 weeks after the first treatment as well as 4, 8 and 12 weeks after the last treatment. Number of acne lesions (inflammatory and non-inflammatory) decreased. Sebum excretion and subjective satisfaction were more favorable at every time point compared with the baseline values (P < 0.05). Inflammatory lesions responded better than non-inflammatory lesions (P < 0.05). Adverse effects such as pinpoint bleeding, pain and erythema were noted, but were transient and not severe enough to stop treatment. Fractional radiofrequency microneedling is a safe and effective treatment for acne vulgaris.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.12471DOI Listing
July 2014

Tick bite on glans penis: the role of dermoscopy.

Ann Dermatol 2013 Nov 30;25(4):528-30. Epub 2013 Nov 30.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5021/ad.2013.25.4.528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870237PMC
November 2013

Clinicopathological features of mycosis fungoides in patients exposed to Agent Orange during the Vietnam War.

J Dermatol 2013 Aug 3;40(8):606-12. Epub 2013 Jun 3.

Department of Dermatology, Kosin University College of Medicine, Busan, South Korea.

There are no reports on the clinicopathological features of mycosis fungoides (MF) among veterans exposed to Agent Orange, one of the herbicides used during the Vietnam War. To evaluate the clinical, histopathological and genotypic findings of Vietnam War veterans with MF and a positive history of exposure to Agent Orange, we performed a comparative clinicopathological study between MF patients with a history of Agent Orange exposure and those without a history of Agent Orange exposure. Twelve Vietnam War veterans with MF were identified. The mean interval from Agent Orange exposure to diagnosis was 24.5 years (range, 9-35). Skin lesions were significantly present on exposed and unexposed areas. Most patients (75%) experienced pruritus (mean visual analog scale score of 6.7). MF was manifested by plaques in 10 patients and by lichenification in five. Histopathological features of most cases were consistent with MF. Biopsy specimens also demonstrated irregular acanthosis (66.7%). In the comparative study, MF patients with a history of Agent Orange exposure differed significantly from those without exposure to Agent Orange in demographic and clinical characteristics. In addition, patients with exposure had an increased tendency for lesions in the exposed area. Notably, our patients showed a higher frequency (33.3%) of mycosis fungoides palmaris et plantaris than in previous studies. Histologically, irregular acanthosis was more frequently observed than ordinary MF. Our results indicate that dermatologists should pay close attention to these clinicopathological differences. Careful assessment of history of exposure to defoliants is warranted in some cases suspicious for MF.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.12202DOI Listing
August 2013

Ultraviolet A1 phototherapy of mycosis fungoides.

Ann Dermatol 2013 Feb 14;25(1):104-7. Epub 2013 Feb 14.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5021/ad.2013.25.1.104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582907PMC
February 2013

Tinea incognito in Korea and its risk factors: nine-year multicenter survey.

J Korean Med Sci 2013 Jan 8;28(1):145-51. Epub 2013 Jan 8.

Department of Dermatology, Pusan National University School of Medicine, Busan, Korea. ; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

Tinea incognito (TI) is a dermatophytic infection which has lost its typical clinical appearance because of improper use of steroids or calcineurin inhibitors. The incidence of TI is increasing nowadays. We conducted retrospective review on 283 patients with TI from 25 dermatology training hospitals in Korea from 2002-2010 to investigate the demographical, clinical, and mycological characteristics of TI, and to determine the associated risk factors. More than half (59.3%) patients were previously treated by non-dermatologists or self-treated. The mean duration of TI was 15.0 ± 25.3 months. The most common clinical manifestations were eczema-like lesion, psoriasis-like, and lupus erythematosus-like lesion. The trunk and face were frequently involved, and 91 patients (32.2%) also had coexisting fungal infections. Among 67 isolated strains, Trichophyton rubrum was the most frequently detected (73.1%). This is the largest study of TI reported to date and the first investigational report concerning TI in Korea. We suggest that doctors should consider TI when a patient has intractable eczema-like lesions accompanied by tinea pedis/unguium. Furthermore, there should be a policy change, which would make over-the-counter high-potency topical steroids less accessible in some countries, including Korea.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3346/jkms.2013.28.1.145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546093PMC
January 2013

CD25+ folliculotropic Sézary syndrome with CD30+ large cell transformation.

Australas J Dermatol 2014 Feb 29;55(1):e4-8. Epub 2012 Nov 29.

Department of Dermatology, Kosin University College of Medicine, Busan, South Korea.

Folliculotropic Sézary syndrome is a rare and unique variant of cutaneous T-cell lymphoma (CTCL) characterised by both follicular and leukaemic involvement of mycosis fungoides (MF). It is associated with a more aggressive clinical course and fatal outcomes. Large cell transformation (LCT) of mycosis fungoides/Sézary syndrome is also associated with an aggressive disease course and shortened survival, requiring an intensive therapeutic approach. This report describes a case of folliculotropic Sézary syndrome with CD30+ LCT. Most of the larger lymphocytes in the lesions were positive for CD25, the expression of which is associated with advanced CTCL. In addition, we review the literature on this unusual CTCL and provide evidence that this entity represents a distinct clinicopathological entity occasionally associated with extracutaneous involvement and LCT.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajd.12000DOI Listing
February 2014
-->