Kazuyuki Sugahara

Kazuyuki Sugahara

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Kazuyuki Sugahara

Publications by authors named "Kazuyuki Sugahara"

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Insight into the role of chondroitin sulfate E in angiogenesis.

FEBS J 2019 Aug 10;286(15):2921-2936. Epub 2019 Apr 10.

Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, Greece.

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http://dx.doi.org/10.1111/febs.14830DOI Listing
August 2019

[A trial of simple and rapid carbapenemase big five gene analysis using LAMP method].

Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi 2018 Dec;28(2):77-83

Department of Medical Technology and Science, Faculty of Fukuoka Health Care, International University of Health and Welfare. Department of Medical Laboratory Science, International University of Health and Welfare Graduate School. Department of Clinical Laboratory, Medical Kouhoukai Takagi Hospital.

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December 2018

Sequencing of chondroitin sulfate oligosaccharides using a novel exolyase from a marine bacterium that degrades hyaluronan and chondroitin sulfate/dermatan sulfate.

Biochem J 2017 11 9;474(22):3831-3848. Epub 2017 Nov 9.

National Glycoengineering Research Center, School of Life Science and Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, 27 South Shanda Rd, Jinan 250100, PR China

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http://dx.doi.org/10.1042/BCJ20170591DOI Listing
November 2017

Defect in dermatan sulfate in urine of patients with Ehlers-Danlos syndrome caused by a CHST14/D4ST1 deficiency.

Clin Biochem 2017 Aug 24;50(12):670-677. Epub 2017 Feb 24.

Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan; Laboratory of Proteoglycan Signaling and Therapeutics, Graduate School of Life Science Hokkaido University, Sapporo 001-0021, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2017.02.018DOI Listing
August 2017

[Utility of the Rapid Staining with the Use of Microwave for Detection of Genus ].

Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi 2017 Mar;27(1):33-41

Microbiology Discipline, Pathology Course, Saga University Medical School.

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March 2017

Pathophysiological Significance of Dermatan Sulfate Proteoglycans Revealed by Human Genetic Disorders.

Pharmaceuticals (Basel) 2017 Mar 27;10(2). Epub 2017 Mar 27.

Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan.

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http://dx.doi.org/10.3390/ph10020034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490391PMC
March 2017

Chondroitin sulfate/dermatan sulfate sulfatases from mammals and bacteria.

Glycoconj J 2016 12 15;33(6):841-851. Epub 2016 Aug 15.

National Glycoengineering Research Center, Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, and Shenzhen Research Institute, Shandong University, Jinan, 250100, Peoples, Republic of China.

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http://dx.doi.org/10.1007/s10719-016-9720-0DOI Listing
December 2016

Fundamental biomaterial properties of tough glycosaminoglycan-containing double network hydrogels newly developed using the molecular stent method.

Acta Biomater 2016 10 15;43:38-49. Epub 2016 Jul 15.

Department of Sports Medicine, Graduate School of Medicine, Hokkaido University, Kita-15 Nishi-7, Sapporo 060-8638, Japan.

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http://dx.doi.org/10.1016/j.actbio.2016.07.023DOI Listing
October 2016

Mutations in Biosynthetic Enzymes for the Protein Linker Region of Chondroitin/Dermatan/Heparan Sulfate Cause Skeletal and Skin Dysplasias.

Biomed Res Int 2015 25;2015:861752. Epub 2015 Oct 25.

Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan ; Laboratory of Proteoglycan Signaling and Therapeutics, Graduate School of Life Science, Hokkaido University, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.1155/2015/861752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637088PMC
August 2016

Molecular interactions between chondroitin-dermatan sulfate and growth factors/receptors/matrix proteins.

Curr Opin Struct Biol 2015 Oct 9;34:35-42. Epub 2015 Jul 9.

Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan; Laboratory of Proteoglycan Signaling and Therapeutics, Graduate School of Life Science, Hokkaido University, Sapporo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2015.06.004DOI Listing
October 2015

Human genetic disorders and knockout mice deficient in glycosaminoglycan.

Biomed Res Int 2014 13;2014:495764. Epub 2014 Jul 13.

Laboratory of Proteoglycan Signaling and Therapeutics, Frontier Research Center for Post-Genomic Science and Technology, Graduate School of Life Science, Hokkaido University, West-11, North-21, Kita-ku, Sapporo, Hokkaido 001-0021, Japan.

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http://www.hindawi.com/journals/bmri/2014/495764/
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http://dx.doi.org/10.1155/2014/495764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122003PMC
May 2015

Novel chondroitin sulfate oligosaccharide motifs as biomarkers: insights into their involvement in brain development.

Adv Exp Med Biol 2015 ;842:165-83

Faculty of Advanced Life Science Frontier Research Center for Post-Genomic Science and Technology 5F, North-21 West-11 Kita-ku, Sapporo, 001-0021, Japan,

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http://dx.doi.org/10.1007/978-3-319-11280-0_11DOI Listing
May 2015

Cloning and characterization of a novel chondroitin sulfate/dermatan sulfate 4-O-endosulfatase from a marine bacterium.

J Biol Chem 2015 Mar 3;290(12):7823-32. Epub 2015 Feb 3.

From the National Glycoengineering Research Center and State Key Laboratory of Microbial Technology, Shandong University, 27 South Shanda Road, Jinan 250100, China and

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http://dx.doi.org/10.1074/jbc.M114.629154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367281PMC
March 2015

Glycosaminoglycans and glycomimetics in the central nervous system.

Molecules 2015 Feb 19;20(3):3527-48. Epub 2015 Feb 19.

John van Geest Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 0PY, UK.

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http://dx.doi.org/10.3390/molecules20033527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272379PMC
February 2015

Sulfation patterns of exogenous chondroitin sulfate affect chondrogenic differentiation of ATDC5 cells.

J Orthop Sci 2014 Nov 11;19(6):1028-35. Epub 2014 Sep 11.

Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.

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http://dx.doi.org/10.1007/s00776-014-0643-yDOI Listing
November 2014

A novel eliminase from a marine bacterium that degrades hyaluronan and chondroitin sulfate.

J Biol Chem 2014 Oct 13;289(40):27886-98. Epub 2014 Aug 13.

From the National Glycoengineering Research Center, and State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, China and

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http://dx.doi.org/10.1074/jbc.M114.590752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183822PMC
October 2014

Roles of glycosaminoglycans and glycanmimetics in tumor progression and metastasis.

Glycoconj J 2014 Oct;31(6-7):461-7

Laboratory of Chemical Biology, Department of Chemistry, Bangalore University, Palace Road, Bangalore, 560001, India,

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http://dx.doi.org/10.1007/s10719-014-9551-9DOI Listing
October 2014

Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans.

J Biol Chem 2014 Sep 8;289(38):26584-96. Epub 2014 Aug 8.

From the Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan,

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http://dx.doi.org/10.1074/jbc.M114.555987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176229PMC
September 2014

Effects of sesamin on the biosynthesis of chondroitin sulfate proteoglycans in human articular chondrocytes in primary culture.

Glycoconj J 2014 Apr 12;31(3):221-30. Epub 2013 Dec 12.

Thailand Excellence Center for Tissue Engineering and Stem Cells, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Intavaroros Road, Sripoom, Muang, Chiang Mai, 50200, Thailand.

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http://link.springer.com/10.1007/s10719-013-9514-6
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http://dx.doi.org/10.1007/s10719-013-9514-6DOI Listing
April 2014

Proteoglycans and glycosaminoglycans improve toughness of biocompatible double network hydrogels.

Adv Mater 2014 Jan 22;26(3):436-42. Epub 2013 Oct 22.

Laboratory of Soft & Wet Matter, Graduate School of Life Science, Hokkaido University, Kita-10-Nishi-8, Kita-ku, Sapporo, 060-0810, Japan.

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http://dx.doi.org/10.1002/adma.201303387DOI Listing
January 2014

Expression of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase involved in chondroitin sulfate synthesis is responsible for pulmonary metastasis.

Biomed Res Int 2013 20;2013:656319. Epub 2013 Feb 20.

Laboratory of Proteoglycan Signaling and Therapeutics, Frontier Research Center for Post-Genomic Science and Technology, Graduate School of Life Science Hokkaido University, West-11, North-21, Kita-ku, Sapporo, Hokkaido 001-0021, Japan.

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http://dx.doi.org/10.1155/2013/656319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595098PMC
September 2013

Loss of dermatan sulfate epimerase (DSE) function results in musculocontractural Ehlers-Danlos syndrome.

Hum Mol Genet 2013 Sep 23;22(18):3761-72. Epub 2013 May 23.

Department of Pediatrics I, Division of Human Genetics, Innsbruck Medical University, Anichstrasse 35, Innsbruck, Austria.

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http://dx.doi.org/10.1093/hmg/ddt227DOI Listing
September 2013

Interaction of chondroitin sulfate and dermatan sulfate from various biological sources with heparin-binding growth factors and cytokines.

Glycoconj J 2013 Aug 29;30(6):619-32. Epub 2012 Dec 29.

Laboratory of Proteoglycan Signaling and Therapeutics, Frontier Research Center for Post-Genomic Science and Technology, Hokkaido University Graduate School of Life Science, West-11, North-21, Kita-ku, Sapporo, Hokkaido, 001-0021, Japan.

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http://dx.doi.org/10.1007/s10719-012-9463-5DOI Listing
August 2013

Glycosaminoglycans are functional ligands for receptor for advanced glycation end-products in tumors.

FEBS J 2013 May 24;280(10):2462-70. Epub 2013 Feb 24.

Laboratory of Proteoglycan Signaling and Therapeutics, Hokkaido University Graduate School of Life Science, Sapporo, Japan.

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http://dx.doi.org/10.1111/febs.12156DOI Listing
May 2013

Mass preparation of oligosaccharides by the hydrolysis of chondroitin sulfate polysaccharides with a subcritical water microreaction system.

Carbohydr Res 2013 Apr 8;371:16-21. Epub 2013 Feb 8.

Laboratory of Proteoglycan Signaling and Therapeutics, Hokkaido University Graduate School of Life Science, Frontier Research Center for Post-Genomic Science and Technology, Nishi-11, Kita-21, Sapporo, Hokkaido 001-0021, Japan.

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http://dx.doi.org/10.1016/j.carres.2013.01.024DOI Listing
April 2013

Human genetic disorders caused by mutations in genes encoding biosynthetic enzymes for sulfated glycosaminoglycans.

J Biol Chem 2013 Apr 1;288(16):10953-61. Epub 2013 Mar 1.

Laboratory of Proteoglycan Signaling and Therapeutics, Graduate School of Life Science, Hokkaido University, Sapporo 001-0021 Japan.

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http://dx.doi.org/10.1074/jbc.R112.437038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630846PMC
April 2013

EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner.

J Biol Chem 2013 Mar 10;288(13):9321-33. Epub 2013 Feb 10.

Department of Biochemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.

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http://dx.doi.org/10.1074/jbc.M112.416909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611003PMC
March 2013

Highly sulfated hexasaccharide sequences isolated from chondroitin sulfate of shark fin cartilage: insights into the sugar sequences with bioactivities.

Glycobiology 2013 Feb 26;23(2):155-68. Epub 2012 Sep 26.

Faculty of Advanced Life Science, Graduate School of Life Science, Hokkaido University, Sapporo, Hokkaido, Japan.

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http://dx.doi.org/10.1093/glycob/cws137DOI Listing
February 2013

Hyaluronidases Have Strong Hydrolytic Activity toward Chondroitin 4-Sulfate Comparable to that for Hyaluronan.

Biomolecules 2012 Nov 12;2(4):549-63. Epub 2012 Nov 12.

Laboratory of Proteoglycan Signaling and Therapeutics, Hokkaido University Graduate School of Life Science, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.3390/biom2040549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030862PMC
November 2012

ISCSM2011 chondroitin sulfate E-type structure at tumor cell surface is involved in experimental metastasis.

Adv Exp Med Biol 2012 ;749:33-45

Hokkaido University Graduate School of Life Science, Sapporo, Hokkaido, Japan.

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http://link.springer.com/10.1007/978-1-4614-3381-1_3
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http://dx.doi.org/10.1007/978-1-4614-3381-1_3DOI Listing
August 2012

[Evolution of infectious disease diagnostic testing and the possible use of genetic testing].

Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi 2011 ;22(1-2):1-9

Sugahara Biotech Education & Research Institute, Inc.

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June 2012

Receptor for advanced glycation end products (RAGE) functions as receptor for specific sulfated glycosaminoglycans, and anti-RAGE antibody or sulfated glycosaminoglycans delivered in vivo inhibit pulmonary metastasis of tumor cells.

J Biol Chem 2012 Jun 9;287(23):18985-94. Epub 2012 Apr 9.

Laboratory of Proteoglycan Signaling and Therapeutics, Graduate School of Life Science, Hokkaido University, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.1074/jbc.M111.313437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365932PMC
June 2012

Glycosaminoglycan chain analysis and characterization (glycosylation/epimerization).

Methods Mol Biol 2012 ;836:99-115

Laboratory of Proteoglycan Signaling and Therapeutics, Frontier Research Center for Post-Genomic Science and Technology, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.1007/978-1-61779-498-8_7DOI Listing
May 2012

Specific interaction of the envelope glycoproteins E1 and E2 with liver heparan sulfate involved in the tissue tropismatic infection by hepatitis C virus.

Glycoconj J 2012 May 3;29(4):211-20. Epub 2012 Jun 3.

Laboratory of Proteoglycan Signaling and Therapeutics, Hokkaido University Graduate School of Life Science, West-11, North-21, Kita-ku, Sapporo, 001-0021, Japan.

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http://dx.doi.org/10.1007/s10719-012-9388-zDOI Listing
May 2012

Chondroitin sulfate "wobble motifs" modulate maintenance and differentiation of neural stem cells and their progeny.

J Biol Chem 2012 Jan 17;287(5):2935-42. Epub 2011 Nov 17.

Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.R111.298430
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http://dx.doi.org/10.1074/jbc.R111.298430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270950PMC
January 2012

Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype.

J Biol Chem 2011 Sep 11;286(35):30377-83. Epub 2011 Jul 11.

Department of Pathology, Center for Metabolic Bone Disease, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

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http://dx.doi.org/10.1074/jbc.M111.254789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162396PMC
September 2011

Involvement of human natural killer-1 (HNK-1) sulfotransferase in the biosynthesis of the GlcUA(3-O-sulfate)-Gal-Gal-Xyl tetrasaccharide found in α-thrombomodulin from human urine.

J Biol Chem 2011 Sep 2;286(38):33003-11. Epub 2011 Aug 2.

Laboratory of Proteoglycan Signaling and Therapeutics, Frontier Research Center for Post-genomic Science and Technology, Graduate School of Life Science, Hokkaido University, West-11, North-21, Kita-ku, Sapporo, Hokkaido 001-0021, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.279174
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http://dx.doi.org/10.1074/jbc.M111.279174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190911PMC
September 2011

Paradoxical effects of chondroitin sulfate-E on Japanese encephalitis viral infection.

Biochem Biophys Res Commun 2011 Jun 20;409(4):717-22. Epub 2011 May 20.

Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Sapporo 001-0020, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2011.05.072DOI Listing
June 2011

Dermatan sulfate epimerase 2 is the predominant isozyme in the formation of the chondroitin sulfate/dermatan sulfate hybrid structure in postnatal developing mouse brain.

Glycobiology 2011 May 21;21(5):565-74. Epub 2010 Dec 21.

Laboratory of Proteoglycan Signaling and Therapeutics, Hokkaido University Graduate School of Life Science, Sapporo, Japan.

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http://dx.doi.org/10.1093/glycob/cwq208DOI Listing
May 2011

Dermatan sulfate in tunicate phylogeny: order-specific sulfation pattern and the effect of [→4IdoA(2-sulfate)β-1→3GalNAc(4-sulfate)β-1→] motifs in dermatan sulfate on heparin cofactor II activity.

BMC Biochem 2011 May 29;12:29. Epub 2011 May 29.

Laboratório de Bioquímica e Biologia Celular de Glicoconjugados, Hospital Universitário Clementino Fraga Filho and Programa de Glicobiologia, Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

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http://dx.doi.org/10.1186/1471-2091-12-29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127831PMC
May 2011

Demonstration of the hepatocyte growth factor signaling pathway in the in vitro neuritogenic activity of chondroitin sulfate from ray fish cartilage.

Biochim Biophys Acta 2011 Apr 9;1810(4):406-13. Epub 2011 Jan 9.

Laboratory of Proteoglycan Signaling and Therapeutics, Hokkaido University Graduate School of Life Science, Frontier Research Center for Post-genomic Science and Technology, Nishi-11, Kita-21, Kita-ku, Sapporo, Hokkaido 001-0021, Japan.

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http://dx.doi.org/10.1016/j.bbagen.2011.01.001DOI Listing
April 2011

Evolution of glycosaminoglycans: Comparative biochemical study.

Commun Integr Biol 2011 Mar;4(2):150-8

Laboratory of Proteoglycan Signaling and Therapeutics; Faculty of Advanced Life Science; Graduate School of Life Science; Hokkaido University; Sapporo, Japan.

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http://dx.doi.org/10.4161/cib.4.2.14547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104567PMC
March 2011

A small oxazine compound as an anti-tumor agent: a novel pyranoside mimetic that binds to VEGF, HB-EGF, and TNF-α.

Cancer Lett 2010 Nov 17;297(2):231-43. Epub 2010 Jun 17.

Laboratory of Proteoglycan Signaling and Therapeutics, Faculty of Advanced Life Science, Hokkaido University Graduate School of Life Science, Sapporo, Japan.

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http://dx.doi.org/10.1016/j.canlet.2010.05.016DOI Listing
November 2010

Synthesis of the glycosaminoglycan-protein linkage tetraosyl peptide moieties of betaglycan, which serve as a hexosamine acceptor for enzymatic glycosyl transfer.

Carbohydr Res 2010 Oct 31;345(15):2115-23. Epub 2010 Aug 31.

Department of Regional Environment, Faculty of Regional Sciences, Tottori University, Tottori 680-8551, Japan.

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http://dx.doi.org/10.1016/j.carres.2010.06.019DOI Listing
October 2010

Structure of pleiotrophin- and hepatocyte growth factor-binding sulfated hexasaccharide determined by biochemical and computational approaches.

J Biol Chem 2010 Sep 28;285(36):27673-85. Epub 2010 Jun 28.

Faculty of Advanced Life Science, Hokkaido University Graduate School of Life Science, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.1074/jbc.M110.118703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2934635PMC
September 2010

A non-sulfated chondroitin stabilizes membrane tubulation in cnidarian organelles.

J Biol Chem 2010 Aug 9;285(33):25613-23. Epub 2010 Jun 9.

Department of Molecular Evolution and Genomics, Institute of Zoology, Heidelberg University, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.107904
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http://dx.doi.org/10.1074/jbc.M110.107904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919125PMC
August 2010

Development of a mouse monoclonal antibody against the chondroitin sulfate-protein linkage region derived from shark cartilage.

Glycoconj J 2010 May 25;27(4):387-99. Epub 2010 Mar 25.

Laboratory of Proteoglycan Signaling and Therapeutics, Graduate School of Life Science, Hokkaido University, Frontier Research Center for Post-Genomic Science and Technology, Nishi 11-choume, Kita 21-jo, Kita-ku, Sapporo, Hokkaido, 001-0021, Japan.

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http://dx.doi.org/10.1007/s10719-010-9286-1DOI Listing
May 2010

Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence.

Glycobiology 2010 Mar 4;20(3):300-9. Epub 2009 Nov 4.

Laboratory of Proteoglycan Signaling and Therapeutics, Hokkaido University Graduate School of Life Science, Sapporo, Japan.

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http://dx.doi.org/10.1093/glycob/cwp174DOI Listing
March 2010

Genetic diagnosis of community-acquired MRSA: a multiplex real-time PCR method for Staphylococcal cassette chromosome mec typing and detecting toxin genes.

Tohoku J Exp Med 2010 Feb;220(2):165-70

Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University Hospital, Nagasaki, Japan.

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http://dx.doi.org/10.1620/tjem.220.165DOI Listing
February 2010

Analysis of the structure and neuritogenic activity of chondroitin sulfate/dermatan sulfate hybrid chains from porcine fetal membranes.

Glycoconj J 2010 Jan 29;27(1):49-60. Epub 2009 Aug 29.

Laboratory of Proteoglycan Signaling and Therapeutics, Graduate School of Life Science, Hokkaido University, Frontier Research Center for Post-Genomic Science and Technology, Nishi 11-choume, Kita 21-jo, Kita-ku, Sapporo, Hokkaido, 001-0021, Japan.

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http://dx.doi.org/10.1007/s10719-009-9253-xDOI Listing
January 2010

Isolation and characterization of a novel chondroitin sulfate from squid liver integument rich in N-acetylgalactosamine(4,6-disulfate) and glucuronate(3-sulfate) residues.

Carbohydr Res 2009 Aug 5;344(12):1526-32. Epub 2009 Mar 5.

Laboratory of Proteoglycan Signaling and Therapeutics, Hokkaido University, Graduate School of Life Science, Kita-ku, Sapporo 001-0021, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S000862150900082
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http://dx.doi.org/10.1016/j.carres.2009.02.029DOI Listing
August 2009

In vitro activity of garenoxacin against Streptococcus pneumoniae mutants with characterized resistance mechanisms.

Antimicrob Agents Chemother 2009 Aug 18;53(8):3572-5. Epub 2009 May 18.

Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City 852-8501, Japan.

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http://dx.doi.org/10.1128/AAC.00176-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715604PMC
August 2009

Involvement of chondroitin sulfate E in the liver tumor focal formation of murine osteosarcoma cells.

Glycobiology 2009 Jul 17;19(7):735-42. Epub 2009 Mar 17.

Graduate School of Life Science, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.1093/glycob/cwp041DOI Listing
July 2009

Dermatan sulfate domains defined by the novel antibody GD3A12, in normal tissues and ovarian adenocarcinomas.

Histochem Cell Biol 2009 Jul 10;132(1):117-27. Epub 2009 Apr 10.

Department of Biochemistry 280, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, PO. Box 9101, 6500HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00418-009-0592-2DOI Listing
July 2009

Anti-tumor and anti-angiogenic activity of novel hydantoin derivatives: Inhibition of VEGF secretion in liver metastatic osteosarcoma cells.

Bioorg Med Chem 2009 Jul 9;17(14):4928-34. Epub 2009 Jun 9.

Graduate School of Life Science, Hokkaido University, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.1016/j.bmc.2009.06.004DOI Listing
July 2009

Structural and functional changes of sulfated glycosaminoglycans in Xenopus laevis during embryogenesis.

Glycobiology 2009 May 3;19(5):488-98. Epub 2009 Feb 3.

Laboratory of Proteoglycan Signaling and Therapeutics, Hokkaido University Graduate School of Life Science, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.1093/glycob/cwp005DOI Listing
May 2009

Important role of heparan sulfate in postnatal islet growth and insulin secretion.

Biochem Biophys Res Commun 2009 May 29;383(1):113-8. Epub 2009 Mar 29.

Department of Advanced Biological Sciences for Regeneration, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2009.03.140DOI Listing
May 2009

Chondroitin 4-O-sulfotransferase-1 is required for somitic muscle development and motor axon guidance in zebrafish.

Biochem J 2009 Apr;419(2):387-99

Department of Biochemistry, Kobe Pharmaceutical University, Higashinada-ku, Kobe 658-8558, Japan.

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http://dx.doi.org/10.1042/BJ20081639DOI Listing
April 2009

Potential therapeutic application of chondroitin sulfate/dermatan sulfate.

Curr Drug Discov Technol 2008 Dec;5(4):289-301

Laboratory of Proteoglycan Signaling and Therapeutics, Frontier Research Center for Post-Genomic Science and Technology, Hokkaido University Graduate School of Life Science, Nishi 11-choume, Kita 21-jo, Kita-ku, Sapporo, Hokkaido 001-0021, Japan.

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December 2008

Determination of iduronic acid and glucuronic acid in sulfated chondroitin/dermatan hybrid chains by (1)H-nuclear magnetic resonance spectroscopy.

Glycoconj J 2008 Oct 27;25(7):603-10. Epub 2008 Mar 27.

Laboratory of Proteoglycan Signaling and Therapeutics, Graduate School of Life Science, Hokkaido University, Frontier Research Center for Post-Genomic Science and Technology, Sapporo, Hokkaido, Japan.

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http://dx.doi.org/10.1007/s10719-008-9124-xDOI Listing
October 2008

Sulfation of the galactose residues in the glycosaminoglycan-protein linkage region by recombinant human chondroitin 6-O-sulfotransferase-1.

J Biol Chem 2008 Oct 11;283(41):27438-43. Epub 2008 Aug 11.

Department of Biochemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M803279200
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http://dx.doi.org/10.1074/jbc.M803279200DOI Listing
October 2008

Recent advances in the structural study of functional chondroitin sulfate and dermatan sulfate in health and disease.

Connect Tissue Res 2008 ;49(3):133-9

Laboratory of Proteoglycan Signaling and Therapeutics, Hokkaido University Graduate School of Life Science, Sapporo, Japan.

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http://dx.doi.org/10.1080/03008200802148546DOI Listing
September 2008

Spondyloepiphyseal dysplasia, Omani type: further definition of the phenotype.

Am J Med Genet A 2008 Sep;146A(18):2376-84

Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ajmg.a.32482DOI Listing
September 2008

[Fine regulatory mechanism of glycosaminoglycan biosynthesis].

Tanpakushitsu Kakusan Koso 2008 Sep;53(12 Suppl):1448-55

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September 2008

Identification of a novel chondroitin hydrolase in Caenorhabditis elegans.

J Biol Chem 2008 May 4;283(22):14971-9. Epub 2008 Apr 4.

Laboratory of Proteoglycan Signaling and Therapeutics, Hokkaido University Graduate School of Life Science, Nishi-11-choume, Kita 21-jo, Kita-ku, Sapporo, Japan.

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http://dx.doi.org/10.1074/jbc.M709236200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258886PMC
May 2008