Publications by authors named "Kazuyoshi Yanagihara"

100Publications

Expression of Asporin reprograms cancer cells to acquire resistance to oxidative stress.

Cancer Sci 2021 Jan 4. Epub 2021 Jan 4.

Department of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.

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January 2021

Sixteen Different Types of Lipid-Conjugated siRNAs Containing Saturated and Unsaturated Fatty Acids and Exhibiting Enhanced RNAi Potency.

ACS Chem Biol 2021 01 21;16(1):150-164. Epub 2020 Dec 21.

Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Chiba 277-8577, Japan.

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January 2021

Long Noncoding RNA HOTAIR Promotes Epithelial-Mesenchymal Transition and Is a Suitable Target to Inhibit Peritoneal Dissemination in Human Scirrhous Gastric Cancers.

Pathobiology 2020 16;87(5):277-290. Epub 2020 Sep 16.

Division of Translational Research, Exploratory Oncology and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan.

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September 2020

Cancer cells with high-metastatic potential promote a glycolytic shift in activated fibroblasts.

PLoS One 2020 17;15(6):e0234613. Epub 2020 Jun 17.

Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.

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August 2020

Efficacy of a Third-Generation Oncolytic Herpes Virus G47Δ in Advanced Stage Models of Human Gastric Cancer.

Mol Ther Oncolytics 2020 Jun 8;17:205-215. Epub 2020 Apr 8.

Division of Innovative Cancer Therapy, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

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June 2020

Annexin A10 is involved in the induction of pancreatic duodenal homeobox‑1 in gastric cancer tissue, cells and organoids.

Oncol Rep 2020 Feb 2;43(2):581-590. Epub 2019 Dec 2.

Department of Molecular Pathology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734‑8551, Japan.

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February 2020

HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway.

Cancers (Basel) 2019 Nov 7;11(11). Epub 2019 Nov 7.

Laboratory STREINTH (Stress Response and Innovative Therapies), Inserm IRFAC UMR_S1113, Université de Strasbourg, 3 av. Molière, 67200 Strasbourg, France.

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November 2019

A novel strategy for treatment of cancer cachexia targeting xanthine oxidase in the brain.

J Pharmacol Sci 2019 May 4;140(1):109-112. Epub 2019 May 4.

Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, 104-0045, Japan; Division of Supportive Care Research, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Tokyo, 104-0045, Japan; Innovation Center for Supportive, Palliative and Psychosocial Care, National Cancer Center Hospital, Tokyo, 104-0045, Japan. Electronic address:

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May 2019

Antitumor effect of palmitic acid-conjugated DsiRNA for colon cancer in a mouse subcutaneous tumor model.

Chem Biol Drug Des 2019 04 11;93(4):570-581. Epub 2019 Jan 11.

Department of Life Science, Faculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan.

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April 2019

Establishment of a novel cell line from a rare human duodenal poorly differentiated neuroendocrine carcinoma.

Oncotarget 2018 Nov 23;9(92):36503-36514. Epub 2018 Nov 23.

Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.

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November 2018

Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment.

Oncogene 2019 03 20;38(12):2162-2176. Epub 2018 Nov 20.

Department of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.

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March 2019

MicroRNAs Associated with Epithelial-Mesenchymal Transition Can Be Targeted to Inhibit Peritoneal Dissemination of Human Scirrhous Gastric Cancers.

Pathobiology 2018 30;85(4):232-246. Epub 2018 May 30.

Division of Translational Research, Exploratory Oncology and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.

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November 2018

Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma.

Cancer Genomics Proteomics 2018 May-Jun;15(3):165-174

Department of Translational Oncology, National Cancer Center Research Institute, Tokyo, Japan.

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October 2018

PLOD2 as a potential regulator of peritoneal dissemination in gastric cancer.

Int J Cancer 2018 09 20;143(5):1202-1211. Epub 2018 Apr 20.

Department of Gastroenterological Surgery, Kumamoto University, Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.

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September 2018

Aberrant alternative splicing of RHOA is associated with loss of its expression and activity in diffuse-type gastric carcinoma cells.

Biochem Biophys Res Commun 2018 01 13;495(2):1942-1947. Epub 2017 Dec 13.

Department of Cancer Cell Research, Sasaki Institute, Sasaki Foundation, 2-2 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan. Electronic address:

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January 2018

Effects of 5-fluorouracil, adriamycin and irinotecan on HSC-39, a human scirrhous gastric cancer cell line.

Oncol Rep 2017 Apr 20;37(4):2366-2374. Epub 2017 Feb 20.

Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan.

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April 2017

All-trans retinoic acid enhances cytotoxic effect of T cells with an anti-CD38 chimeric antigen receptor in acute myeloid leukemia.

Clin Transl Immunology 2016 Dec 9;5(12):e116. Epub 2016 Dec 9.

Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University , Hiroshima, Japan.

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December 2016

Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion.

Cancer Res 2017 02 28;77(3):684-695. Epub 2016 Nov 28.

Department of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, Akita, Japan.

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February 2017

High mannose-binding Pseudomonas fluorescens lectin (PFL) downregulates cell surface integrin/EGFR and induces autophagy in gastric cancer cells.

BMC Cancer 2016 Feb 6;16:63. Epub 2016 Feb 6.

Department of Life Sciences, Faculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan.

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February 2016

In Vivo RNAi Efficacy of Palmitic Acid-Conjugated Dicer-Substrate siRNA in a Subcutaneous Tumor Mouse Model.

Chem Biol Drug Des 2016 06 15;87(6):811-23. Epub 2016 Feb 15.

Laboratory of Molecular Cell Biology, Department of Life Sciences, Faculty of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima, 731-0153, Japan.

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June 2016

Aminopeptidase N (APN/CD13) as a target molecule for scirrhous gastric cancer.

Clin Res Hepatol Gastroenterol 2016 Sep 13;40(4):494-503. Epub 2016 Jan 13.

Department of Esophageal and Gastroenterological Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

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September 2016

Site-specific fibroblasts regulate site-specific inflammatory niche formation in gastric cancer.

Gastric Cancer 2017 Jan 22;20(1):92-103. Epub 2015 Dec 22.

Laboratory of Cancer Biology, Department of Integrated Bioscience, Graduate School of Frontier Science, University of Tokyo, Kashiwa, Chiba, Japan.

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January 2017

Fukutin, identified by the Escherichia coli ampicillin secretion trap (CAST) method, participates in tumor progression in gastric cancer.

Gastric Cancer 2016 Apr 30;19(2):443-452. Epub 2015 Jul 30.

Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

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April 2016

A GSDMB enhancer-driven HSV thymidine kinase-expressing vector for controlling occult peritoneal dissemination of gastric cancer cells.

BMC Cancer 2015 May 29;15:439. Epub 2015 May 29.

Department of Translational Oncology, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo, 104-0045, Japan.

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May 2015

rs2294008T, a risk allele for gastric and gallbladder cancers, suppresses the PSCA promoter by recruiting the transcription factor YY1.

Genes Cells 2015 May 27;20(5):382-91. Epub 2015 Feb 27.

Division of Genetics, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo, 104-0045, Japan.

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May 2015

Agr2 mediates paracrine effects on stromal fibroblasts that promote invasion by gastric signet-ring carcinoma cells.

Cancer Res 2015 Jan 8;75(2):356-66. Epub 2014 Dec 8.

Department of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, Akita, Japan.

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January 2015

MicroRNA-145 is a potential prognostic factor of scirrhous type gastric cancer.

Oncol Rep 2014 Oct 16;32(4):1720-6. Epub 2014 Jul 16.

Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Minami‑ku, Hiroshima 734-8551, Japan.

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October 2014

Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer.

Oncol Rep 2014 Jul 6;32(1):403-10. Epub 2014 May 6.

Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima 734-8551, Japan.

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July 2014

Marked antitumor effect of NK012, a SN-38-incorporating micelle formulation, in a newly developed mouse model of liver metastasis resulting from gastric cancer.

Ther Deliv 2014 Feb;5(2):129-38

Division of Translational Research, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan.

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February 2014

Stromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cells.

PLoS One 2014 10;9(1):e85485. Epub 2014 Jan 10.

Division of Metastasis and Invasion Signaling, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.

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October 2014

MicroRNA-148a is downregulated in gastric cancer, targets MMP7, and indicates tumor invasiveness and poor prognosis.

Cancer Sci 2014 02 6;105(2):236-43. Epub 2014 Jan 6.

Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.

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February 2014

MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer.

Cancer Sci 2014 Feb 8;105(2):228-35. Epub 2014 Jan 8.

Department of Molecular Pathology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

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February 2014

Gene-silencing potency of symmetric and asymmetric lipid-conjugated siRNAs and its correlation with dicer recognition.

Bioconjug Chem 2013 Dec 9;24(12):2045-57. Epub 2013 Dec 9.

Faculty of Pharmacy, Yasuda Women's University , 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima 731-0153, Japan.

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December 2013

Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer.

PLoS One 2012 2;7(11):e47545. Epub 2012 Nov 2.

Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.

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May 2013

Prostate stem cell antigen gene is expressed in islets of pancreas.

Anat Cell Biol 2012 Sep 30;45(3):149-54. Epub 2012 Sep 30.

Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan.

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September 2012

Enhancement of gene silencing effect and membrane permeability by Peptide-conjugated 27-nucleotide small interfering RNA.

Molecules 2012 Sep 14;17(9):11089-102. Epub 2012 Sep 14.

Faculty of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima 731-0153, Japan.

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September 2012

SiRNAs conjugated with aromatic compounds induce RISC-mediated antisense strand selection and strong gene-silencing activity.

Biochem Biophys Res Commun 2012 Oct 7;426(4):571-7. Epub 2012 Sep 7.

Faculty of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima 731-0153, Japan.

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October 2012

Lipid-conjugated 27-nucleotide double-stranded RNAs with dicer-substrate potency enhance RNAi-mediated gene silencing.

Mol Pharm 2012 May 24;9(5):1374-83. Epub 2012 Apr 24.

Department of Life Science, Faculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan.

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May 2012

Changes in the melanocortin receptors in the hypothalamus of a rat model of cancer cachexia.

Synapse 2012 Aug 17;66(8):747-51. Epub 2012 Apr 17.

Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

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August 2012

Coordinated expression of REG4 and aldehyde dehydrogenase 1 regulating tumourigenic capacity of diffuse-type gastric carcinoma-initiating cells is inhibited by TGF-β.

J Pathol 2012 Nov 8;228(3):391-404. Epub 2012 May 8.

Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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November 2012

Amino-modified and lipid-conjugated dicer-substrate siRNA enhances RNAi efficacy.

Bioconjug Chem 2012 Feb 26;23(2):164-73. Epub 2012 Jan 26.

Laboratory of Molecular Cell Biology, Department of Life Science, Yasuda Women's University Faculty of Pharmacy, Hiroshima, Japan.

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February 2012

Bone morphogenetic protein-2 and -4 play tumor suppressive roles in human diffuse-type gastric carcinoma.

Am J Pathol 2011 Dec 11;179(6):2920-30. Epub 2011 Oct 11.

Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

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December 2011

Palmitic acid-conjugated 21-nucleotide siRNA enhances gene-silencing activity.

Mol Pharm 2011 Dec 24;8(6):2193-203. Epub 2011 Oct 24.

Laboratory of Molecular Cell Biology, Department of Life Science, Faculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan.

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December 2011

Tumor environment changed by combretastatin derivative (Cderiv) pretreatment that leads to effective tumor targeting, MRI studies, and antitumor activity of polymeric micelle carrier systems.

Pharm Res 2012 Jan 26;29(1):178-86. Epub 2011 Jul 26.

Medical Engineering Laboratory, Research Center for Medical Science, The Jikei University School of Medicine, Nishi-shinbashi 3-25-8, Minato-ku, Tokyo 105-8461, Japan.

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January 2012

Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma.

Oncol Rep 2011 Apr 18;25(4):989-95. Epub 2011 Jan 18.

Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikatacho, Kita-ku, Okayama 700-8558, Japan.

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April 2011

The metastasis-associated microRNA miR-516a-3p is a novel therapeutic target for inhibiting peritoneal dissemination of human scirrhous gastric cancer.

Cancer Res 2011 Feb 17;71(4):1442-53. Epub 2010 Dec 17.

Department of Biochemistry and Division of Disease Models, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.

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February 2011

Loss of WW domain-containing oxidoreductase expression in the progression and development of gastric carcinoma: clinical and histopathologic correlations.

Virchows Arch 2010 Oct 25;457(4):423-32. Epub 2010 Aug 25.

Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Chuo-ku, Kobe 650-0017, Japan.

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October 2010

Synergistic and persistent effect of T-cell immunotherapy with anti-CD19 or anti-CD38 chimeric receptor in conjunction with rituximab on B-cell non-Hodgkin lymphoma.

Br J Haematol 2010 Oct 30;151(1):37-46. Epub 2010 Jul 30.

Department of Haematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.

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October 2010

The antitumor effect of a thermosensitive polymeric hydrogel containing paclitaxel in a peritoneal carcinomatosis model.

Invest New Drugs 2012 Feb 29;30(1):1-7. Epub 2010 Jul 29.

Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

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February 2012

Efficacy of RAD001 (everolimus) against advanced gastric cancer with peritoneal dissemination.

Invest New Drugs 2011 Dec 8;29(6):1198-205. Epub 2010 Jun 8.

Shien-Lab and Support Facility of Project Ward, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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December 2011

Constitutive suppression of PRL-3 inhibits invasion and proliferation of gastric cancer cell in vitro and in vivo.

Pathobiology 2010 28;77(3):155-62. Epub 2010 May 28.

Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.

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August 2010

Negative regulation of the tight junction protein tricellulin by snail-induced epithelial-mesenchymal transition in gastric carcinoma cells.

Pathobiology 2010 22;77(2):106-13. Epub 2010 Mar 22.

Department of Pathology, Division of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.

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June 2010