Publications by authors named "Kazuo Umezawa"

100Publications

Dual Agonist of Farnesoid X Receptor and G Protein-coupled Receptor TGR5 Inhibits Hepatitis B Virus Infection in Vitro and in Vivo.

Authors:
Kiyoaki Ito Akinori Okumura Junko S Takeuchi Koichi Watashi Rieko Inoue Taeko Yamauchi Kazumasa Sakamoto Yukiko Yamashita Yusuke Iguchi Mizuho Une Takaji Wakita Kazuo Umezawa Masashi Yoneda

Hepatology 2021 Jan 12. Epub 2021 Jan 12.

Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.

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January 2021

Isolation and Characterization of New Anti-Inflammatory and Antioxidant Components from Deep Marine-Derived Fungus SP. Bzo-l062.

Authors:
Xiaojie Lu Junjie He Yanhua Wu Na Du Xiaofan Li Jianhua Ju Zhangli Hu Kazuo Umezawa Liyan Wang

Mar Drugs 2020 Nov 26;18(12). Epub 2020 Nov 26.

Shenzhen Key Laboratory of Marine Bioresource and Eco-environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.

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November 2020

NF-κB and STAT3 co-operation enhances high glucose induced aggressiveness of cholangiocarcinoma cells.

Authors:
Charupong Saengboonmee Chatchai Phoomak Suangson Supabphol Kyle R Covington Oliver Hampton Chaisiri Wongkham Richard A Gibbs Kazuo Umezawa Wunchana Seubwai Marie-Claude Gingras Sopit Wongkham

Life Sci 2020 Dec 7;262:118548. Epub 2020 Oct 7.

Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.

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December 2020

Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, prevents the development of cyclosporine A nephrotoxicity in a rat model.

Authors:
Shinya Morita Kazunobu Shinoda Tadashi Yoshida Masayuki Shimoda Yoshihiko Kanno Ryuichi Mizuno Hidaka Kono Hiroshi Asanuma Ken Nakagawa Kazuo Umezawa Mototsugu Oya

BMC Pharmacol Toxicol 2020 08 12;21(1):60. Epub 2020 Aug 12.

Department of Urology, Keio University School of Medicine, Tokyo, Japan.

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August 2020

Anticancer Activity of Novel NF-kappa B Inhibitor DHMEQ by Intraperitoneal Administration.

Authors:
Kazuo Umezawa Andrzej Breborowicz Shamil Gantsev

Oncol Res 2020 12 23;28(5):541-550. Epub 2020 Jun 23.

Scientific Research Institute of Oncology, Bashkortostan State Medical UniversityUfaRussia.

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December 2020

Anti‑inflammatory effects of the NF‑κB inhibitor dehydroxymethylepoxyquinomicin on ARPE‑19 cells.

Authors:
Yoshimasa Ando Yasuhiko Sato Akihiko Kudo Takayo Watanabe Akito Hirakata Annabelle A Okada Kazuo Umezawa Hiroshi Keino

Mol Med Rep 2020 Jul 4;22(1):582-590. Epub 2020 May 4.

Department of Ophthalmology, Kyorin University School of Medicine, Tokyo 181‑8611, Japan.

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July 2020

Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin.

Authors:
Liyan Wang Mengjie Li Yinzhi Lin Shuwen Du Zhenyu Liu Jianhua Ju Hiromi Suzuki Makoto Sawada Kazuo Umezawa

J Antibiot (Tokyo) 2020 09 24;73(9):622-629. Epub 2020 Mar 24.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, 480-1195, Nagakute, Japan.

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September 2020

Inhibition of matrix metalloproteinase expression and cellular invasion by NF-κB inhibitors of microbial origin.

Authors:
Kazuo Umezawa Yinzhi Lin

Biochim Biophys Acta Proteins Proteom 2020 06 14;1868(6):140412. Epub 2020 Mar 14.

Department of Molecular Target Medicine, Aichi Medical University, Nagakute 480-1195, Japan.

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June 2020

The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation.

Authors:
Hang Fu Mohamad Alabdullah Julia Großmann Florian Spieler Reem Abdosh Veronika Lutz Katrin Kalies Kai Knöpp Max Rieckmann Susanne Koch Michel Noutsias Claudia Pilowski Jochen Dutzmann Daniel Sedding Stefan Hüttelmaier Kazuo Umezawa Karl Werdan Harald Loppnow

Cell Death Dis 2019 11 21;10(12):880. Epub 2019 Nov 21.

Universitätsklinik und Poliklinik für Innere Medizin III, Universitätsmedizin Halle (Saale), Martin-Luther-Universität Halle-Wittenberg, 06120, Halle (Saale), Germany.

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November 2019

Growth Inhibitory Effects of Dipotassium Glycyrrhizinate in Glioblastoma Cell Lines by Targeting MicroRNAs Through the NF-κB Signaling Pathway.

Authors:
Gabriel Alves Bonafé Jéssica Silva Dos Santos Jussara Vaz Ziegler Kazuo Umezawa Marcelo Lima Ribeiro Thalita Rocha Manoela Marques Ortega

Front Cell Neurosci 2019 28;13:216. Epub 2019 May 28.

Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, Post Graduate Program in Health Science, Universidade São Francisco (USF), Bragança Paulista, Brazil.

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May 2019

Anti-Inflammatory Effect of Dehydroxymethylepoxyquinomicin, a Nuclear factor-κB Inhibitor, on Endotoxin-Induced Uveitis in Rats In vivo and In vitro.

Authors:
Yoshimasa Ando Hiroshi Keino Akihiko Kudo Akito Hirakata Annabelle A Okada Kazuo Umezawa

Ocul Immunol Inflamm 2020 5;28(2):240-248. Epub 2019 Apr 5.

Department of Molecular Target Medicine, Aichi Medical University, Nagakute, Japan.

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January 2021

Comparison of anti-atopic dermatitis activities between DHMEQ and tacrolimus ointments in mouse model without stratum corneum.

Authors:
Huan He Xiaoxiao Gao Xiaomin Wang Xin Li Xiaoxue Jiang Zhehui Xie Ke Ma Jun Ma Kazuo Umezawa Yuyang Zhang

Int Immunopharmacol 2019 Jun 13;71:43-51. Epub 2019 Mar 13.

School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

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June 2019

JAK/STAT3 and NF-κB Signaling Pathways Regulate Cancer Stem-Cell Properties in Anaplastic Thyroid Cancer Cells.

Authors:
Ken Shiraiwa Michiko Matsuse Yuka Nakazawa Tomoo Ogi Keiji Suzuki Vladimir Saenko Shuhang Xu Kazuo Umezawa Shunichi Yamashita Kazuhiro Tsukamoto Norisato Mitsutake

Thyroid 2019 05 15;29(5):674-682. Epub 2019 Mar 15.

1 Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.

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May 2019

Dehydroxymethylepoxyquinomicin suppresses atopic dermatitis-like lesions in a stratum corneum-removed murine model through NF-κB inhibition.

Authors:
Xiaoxue Jiang Huan He Zhehui Xie Huimin Wen Xiaoran Li Xin Li Jun Ma Kazuo Umezawa Yuyang Zhang

Immunopharmacol Immunotoxicol 2019 Feb 6;41(1):32-39. Epub 2019 Feb 6.

a School of Life Science and Biopharmaceutics , Shenyang Pharmaceutical University , Shenyang , China.

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February 2019

Conophylline inhibits high fat diet-induced non-alcoholic fatty liver disease in mice.

Authors:
Tomohiko Ohashi Yukiomi Nakade Mayu Ibusuki Rena Kitano Taeko Yamauchi Satoshi Kimoto Tadahisa Inoue Yuji Kobayashi Yoshio Sumida Kiyoaki Ito Haruhisa Nakao Kazuo Umezawa Masashi Yoneda

PLoS One 2019 28;14(1):e0210068. Epub 2019 Jan 28.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Aichi Medical University, Nagakute, Aichi, Japan.

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September 2019

Isolation of ketomycin from Actinomycetes as an inhibitor of 2D and 3D cancer cell invasion.

Authors:
Yinzhi Lin Yue Chen Tamami Ukaji Shoshiro Okada Kazuo Umezawa

J Antibiot (Tokyo) 2019 03 3;72(3):148-154. Epub 2018 Dec 3.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, Nagakute, Japan.

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March 2019

The plant alkaloid conophylline inhibits matrix formation of fibroblasts.

Authors:
Takehiko Tezuka Akinobu Ota Sivasundaram Karnan Katsuhiko Matsuura Kazuhisa Yokoo Yoshitaka Hosokawa Davide Vigetti Alberto Passi Sonoko Hatano Kazuo Umezawa Hideto Watanabe

J Biol Chem 2018 12 30;293(52):20214-20226. Epub 2018 Oct 30.

Institute for Molecular Science of Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan and

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December 2018

Conophylline suppresses pancreatic cancer desmoplasia and cancer-promoting cytokines produced by cancer-associated fibroblasts.

Authors:
Norihiro Ishii Kenichiro Araki Takehiko Yokobori Kei Hagiwara Dorgormaa Gantumur Takahiro Yamanaka Tadashi Handa Mariko Tsukagoshi Takamichi Igarashi Akira Watanabe Norio Kubo Norifumi Harimoto Atsushi Masamune Kazuo Umezawa Hiroyuki Kuwano Ken Shirabe

Cancer Sci 2019 Jan 13;110(1):334-344. Epub 2018 Dec 13.

Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan.

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January 2019

NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model.

Authors:
Hitomi Fukatsu Naoki Koide Saeko Tada-Oikawa Kiyora Izuoka Akihiko Ikegami Sahoko Ichihara Tamami Ukaji Naoko Morita Yoshikazu Naiki Takayuki Komatsu Kazuo Umezawa

Mol Med Rep 2018 Dec 3;18(6):5279-5285. Epub 2018 Oct 3.

Department of Molecular Target Medicine, Aichi Medical University, Nagakute, Aichi 480‑1195, Japan.

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December 2018

Carbapenem-resistant in a Febrile Neutropenia Patient With Acute Myelogenous Leukemia After Hematopoietic Stem Cell Transplantation.

Authors:
Satomi Asai Toshio Ohshima Hideo Iwashita Yoshikazu Ishii Kotaro Aoki Yuki Minakawa Shinichiro Machida Kazuo Umezawa Kazuhiro Tateda Hayato Miyachi

Infect Dis Clin Pract (Baltim Md) 2018 Sep 21;26(5):e38-e39. Epub 2018 Apr 21.

Department of Laboratory Medicine Tokai University School of Medicine Infection Control Division Tokai University Hospital Kanagawa, Japan.

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September 2018

Development of a sensitive immunochromatographic kit using fluorescent silica nanoparticles for rapid serodiagnosis of amebiasis.

Authors:
Hiroshi Tachibana Azumi Kakino Makoto Kazama Meng Feng Satomi Asai Kazuo Umezawa Tsukasa Nozaki Takashi Makiuchi Takayuki Kamada Hideki Watanabe Noriyuki Horiki Xunjia Cheng Gohta Masuda

Parasitology 2018 12 9;145(14):1890-1895. Epub 2018 May 9.

Department of Infectious Diseases,Tokyo Metropolitan Cancer and Infectious Diseases Center,Komagome Hospital,Tokyo 113-8677,Japan.

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December 2018

Corrigendum to "poly (ADP-ribose) polymerase inhibition synergizes with the NF-κB inhibitor DHMEQ to kill hepatocellular carcinoma cells" [Biochim. Biophys. Acta 1853(12)(2015) 3224-3234].

Authors:
Nadia Lampiasi Kazuo Umezawa Giuseppe Montalto Melchiorre Cervello

Biochim Biophys Acta Mol Cell Res 2018 Jul 21;1865(7):1023. Epub 2018 Apr 21.

Institute of Biomedicine and Molecular Immunology "Alberto Monroy", National Research Council, Via Ugo La Malfa 153, 90146 Palermo, Italy.

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July 2018

DTCM-glutarimide Delays Growth and Radiosensitizes Glioblastoma.

Authors:
Gabriela Molinari Roberto Helder Henrique Paiva Lucas Eduardo Botelho de Souza Julia Alejandra Pezuk Gabriela Maciel Vieira Harley Francisco de Oliveira Kazuo Umezawa Luiz Gonzaga Tone María Sol Brassesco

Anticancer Agents Med Chem 2018 ;18(9):1323-1329

Department of Biology, Faculty of Philosophy, Sciences and Letters at Ribeirao Preto, University of Sao Paulo, Brazil.

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June 2019

Inhibition of Late and Early Phases of Cancer Metastasis by the NF-κB Inhibitor DHMEQ Derived from Microbial Bioactive Metabolite Epoxyquinomicin: A Review.

Authors:
Yinzhi Lin Tamami Ukaji Naoki Koide Kazuo Umezawa

Int J Mol Sci 2018 Mar 3;19(3). Epub 2018 Mar 3.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, 1-1 Yazako-Karimata, Nagakute 480-1195, Japan.

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March 2018

Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegenerative disease models.

Authors:
Kazuo Umezawa Itaru Kojima Siro Simizu Yinzhi Lin Hitomi Fukatsu Naoki Koide Yukiomi Nakade Masashi Yoneda

Hum Cell 2018 Apr 16;31(2):95-101. Epub 2017 Dec 16.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, 480-1195, Japan.

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April 2018

The Implementation of a Hospital-wide Practice for the Selective Use of Carbapenems Based on the Monitoring of Susceptibility of Pseudomonas aeruginosa Isolates.

Authors:
Toshio Ohshima Satomi Asai Miki Miyazawa Yukari Yamamoto Akifumi Hisada Chie Kumazawa Masayoshi Hashimoto Katsuji Fukawa Hideo Iwashita Kazuo Umezawa Sanetoshi Yamada Yoshiro Yamamoto Hayato Miyachi

Tokai J Exp Clin Med 2017 Dec 20;42(4):176-181. Epub 2017 Dec 20.

Department of Laboratory Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

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December 2017

Antineoplastic Effects of NF-κB Inhibition by DHMEQ (Dehydroxymethylepoxyquinomicin) Alone and in Co-treatment with Radio-and Chemotherapy in Medulloblastoma Cell Lines.

Authors:
Priscila M M Ramos Julia A Pezuk Angel M Castro-Gamero Harley F Oliveira Carlos A Scrideli Kazuo Umezawa Luiz G Tone

Anticancer Agents Med Chem 2018 ;18(4):541-549

Department of Genetics, Ribeirao Preto Medical School, University of Sao Paulo, Brazil.

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July 2019

Microenvironmental stromal cells abrogate NF-κB inhibitor-induced apoptosis in chronic lymphocytic leukemia.

Authors:
Carl Philipp Simon-Gabriel Katharina Foerster Shifa Saleem Dorothee Bleckmann Marco Benkisser-Petersen Nicolas Thornton Kazuo Umezawa Sarah Decker Meike Burger Hendrik Veelken Rainer Claus Christine Dierks Justus Duyster Katja Zirlik

Haematologica 2018 01 9;103(1):136-147. Epub 2017 Nov 9.

Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center, Faculty of Medicine, University of Freiburg, Germany

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January 2018

The unfolded protein response mediated by PERK is casually related to the pathogenesis of intervertebral disc degeneration.

Authors:
Takeshi Fujii Nobuyuki Fujita Satoshi Suzuki Takashi Tsuji Takashi Takaki Kazuo Umezawa Kota Watanabe Takeshi Miyamoto Keisuke Horiuchi Morio Matsumoto Masaya Nakamura

J Orthop Res 2018 05 28;36(5):1334-1345. Epub 2017 Nov 28.

Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo, 160-8582, Japan.

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May 2018

Novel p-terphenyl glycoside with a rare 2,6-dideoxyhexopyranose moiety from Actinomycete strain SF2911 that inhibits cancer cell migration.

Authors:
Liyan Wang Menjie Li Jianqiang Tang Yinzhi Lin Kulrawee Sidthipong Naomi Sumida Nobuaki Kushida Kazuo Umezawa

J Antibiot (Tokyo) 2017 Oct 19;70(10):987-990. Epub 2017 Jul 19.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, Nagakute, Japan.

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October 2017

A novel inhibitor of farnesyltransferase with a zinc site recognition moiety and a farnesyl group.

Authors:
Ayumi Tanaka Mohamed O Radwan Akiyuki Hamasaki Asumi Ejima Emiko Obata Ryoko Koga Hiroshi Tateishi Yoshinari Okamoto Mikako Fujita Mitsuyoshi Nakao Kazuo Umezawa Fuyuhiko Tamanoi Masami Otsuka

Bioorg Med Chem Lett 2017 08 20;27(16):3862-3866. Epub 2017 Jun 20.

Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address:

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August 2017

Conophylline inhibits non-alcoholic steatohepatitis in mice.

Authors:
Yukiomi Nakade Kazumasa Sakamoto Taeko Yamauchi Tadahisa Inoue Yuji Kobayashi Takaya Yamamoto Norimitsu Ishii Tomohiko Ohashi Yoshio Sumida Kiyoaki Ito Haruhisa Nakao Yoshitaka Fukuzawa Kazuo Umezawa Masashi Yoneda

PLoS One 2017 8;12(6):e0178436. Epub 2017 Jun 8.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Aichi Medical University, Nagakute, Aichi, Japan.

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September 2017

Clinical Serum Therapy: Benefits, Cautions, and Potential Applications.

Authors:
Toru Hifumi Akihiko Yamamoto Manabu Ato Kyoko Sawabe Kazunori Morokuma Nobuya Morine Yutaka Kondo Eiichiro Noda Atsushi Sakai Jin Takahashi Kazuo Umezawa

Keio J Med 2017 Dec 28;66(4):57-64. Epub 2017 Apr 28.

Department of Emergency and Critical Care Medicine, Tokai University School of Medicine, Kanagawa, Japan.

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December 2017

External application of NF-κB inhibitor DHMEQ suppresses development of atopic dermatitis-like lesions induced with DNCB/OX in BALB/c mice.

Authors:
Xiaoxue Jiang Yi Lan Bing Wei Cailing Dai Yaru Gu Jun Ma Xiaoyan Liu Kazuo Umezawa Yuyang Zhang

Immunopharmacol Immunotoxicol 2017 Jun;39(3):157-164

a Department of Pharmacology, School of Life Science and Biopharmaceutics , Shenyang Pharmaceutical University , Shenyang , China.

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June 2017

Simultaneous and multi-point measurement of ammonia emanating from human skin surface for the estimation of whole body dermal emission rate.

Authors:
Shota Furukawa Yoshika Sekine Keita Kimura Kazuo Umezawa Satomi Asai Hayato Miyachi

J Chromatogr B Analyt Technol Biomed Life Sci 2017 May 2;1053:60-64. Epub 2017 Apr 2.

Department of Laboratory Medicine, School of Medicine, Tokai University, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

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May 2017

Abnormal differentiation of stem cells into enteroendocrine cells in rats with DSS-induced colitis.

Authors:
Magdy El-Salhy Kazuo Umezawa Jan Gunnar Hatlebakk Odd Helge Gilja

Mol Med Rep 2017 Apr 1;15(4):2106-2112. Epub 2017 Mar 1.

Division of Gastroenterology, Department of Clinical Medicine, University of Bergen, 5007 Bergen, Norway.

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April 2017

Inhibition of MMP-2-mediated cellular invasion by NF-κB inhibitor DHMEQ in 3D culture of breast carcinoma MDA-MB-231 cells: A model for early phase of metastasis.

Authors:
Tamami Ukaji Yinzhi Lin Shoshiro Okada Kazuo Umezawa

Biochem Biophys Res Commun 2017 03 8;485(1):76-81. Epub 2017 Feb 8.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, 1-1 Yazako-Karimata, Nagakute 480-1195, Japan. Electronic address:

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March 2017

Inhibition of NF-kappaB with Dehydroxymethylepoxyquinomicin modifies the function of human peritoneal mesothelial cells.

Authors:
Patrycja Sosińska Ewa Baum Beata Maćkowiak Ryszard Staniszewski Tomasz Jasinski Kazuo Umezawa Andrzej Bręborowicz

Am J Transl Res 2016 15;8(12):5756-5765. Epub 2016 Dec 15.

Department of Pathophysiology, Poznań University of Medical Sciences Poznań, Poland.

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December 2016

Rational design, synthesis and in vitro evaluation of novel exo-methylene butyrolactone salicyloylamide as NF-κB inhibitor.

Authors:
Kulrawee Sidthipong Jun Ma Wei Lin Yu Yan Feng Wang Susumu Kobayashi Satoshi Kishino Naoki Koide Takashi Yokochi Kuniki Kato Shoshiro Okada Kazuo Umezawa

Bioorg Med Chem Lett 2017 02 8;27(3):562-566. Epub 2016 Dec 8.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, 1-1 Yazako-Karimata, Nagakute 480-1195, Japan. Electronic address:

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February 2017

Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response.

Authors:
Joshua T Burgess Emma Bolderson Mark N Adams Anne-Marie Baird Shu-Dong Zhang Kathy A Gately Kazuo Umezawa Kenneth J O'Byrne Derek J Richard

Cell Death Dis 2016 11 10;7(11):e2469. Epub 2016 Nov 10.

Cancer and Ageing Program, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology (QUT) and Princess Alexandra Hospital, Level 6, Translational Research Institute, Brisbane, QLD, Australia.

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November 2016

Enteroendocrine cells, stem cells and differentiation progenitors in rats with TNBS-induced colitis.

Authors:
Magdy El-Salhy Tarek Mazzawi Kazuo Umezawa Odd Helge Gilja

Int J Mol Med 2016 Dec 24;38(6):1743-1751. Epub 2016 Oct 24.

Division of Gastroenterology, Institute of Clinical Medicine, University of Bergen, 5020 Bergen, Norway.

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December 2016

Inhibition of nuclear factor-κB signaling suppresses Spint1-deletion-induced tumor susceptibility in the ApcMin/+ model.

Authors:
Makiko Kawaguchi Koji Yamamoto Ai Kanemaru Hiroyuki Tanaka Kazuo Umezawa Tsuyoshi Fukushima Hiroaki Kataoka

Oncotarget 2016 Oct;7(42):68614-68622

Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

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October 2016

Effects of AP‑1 and NF‑κB inhibitors on colonic endocrine cells in rats with TNBS‑induced colitis.

Authors:
Magdy El-Salhy Kazuo Umezawa

Mol Med Rep 2016 Aug 27;14(2):1515-22. Epub 2016 Jun 27.

Department of Molecular Target Medicine, School of Aichi Medical University, School of Medicine, Nagakute, Aichi 480‑1195, Japan.

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August 2016

Identification of poly(rC) binding protein 2 (PCBP2) as a target protein of immunosuppressive agent 15-deoxyspergualin.

Authors:
Masataka Murahashi Siro Simizu Masahiko Morioka Kazuo Umezawa

Biochem Biophys Res Commun 2016 08 31;476(4):445-449. Epub 2016 May 31.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, 1-1 Yazako-Karimata, Nagakute 480-1195, Japan. Electronic address:

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August 2016

A national survey examining recognition, demand for antivenom, and overall level of preparedness for redback spider bites in Japan.

Authors:
Toru Hifumi Tomoya Okazaki Arisa Manabe Hideyuki Hamaya Satoshi Egawa Satoshi Fujimi Akihiko Yamamoto Yuichi Koido Yuko Abe Kenya Kawakita Kazuo Umezawa Yasuhiro Kuroda

Acute Med Surg 2016 10 18;3(4):310-314. Epub 2016 Apr 18.

Emergency Medical Center Kagawa University Hospital Kagawa Japan.

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October 2016

Anti-inflammatory effects of novel AP-1 and NF-κB inhibitors in dextran-sulfate-sodium-induced colitis in rats.

Authors:
Magdy El-Salhy Kazuo Umezawa

Int J Mol Med 2016 Jun 12;37(6):1457-64. Epub 2016 Apr 12.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan.

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June 2016

Design and synthesis of 15-deoxyspergualin-biotin conjugates as novel binding probes for target protein screening.

Authors:
Masahiko Morioka Kuniki Kato Kazuo Umezawa

J Antibiot (Tokyo) 2016 07 23;69(7):574-8. Epub 2016 Mar 23.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, Aichi, Japan.

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July 2016

Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters.

Authors:
Shun Katsuyama Kumi Sugino Yukiko Sasazawa Yoshihiko Nakano Harumi Aono Keisuke Morishita Makoto Kawatani Kazuo Umezawa Hiroyuki Osada Siro Simizu

FEBS Lett 2016 04 3;590(8):1152-62. Epub 2016 Apr 3.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.

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April 2016

Treatment with novel AP-1 and NF-κB inhibitors restores the colonic endocrine cells to normal levels in rats with DSS-induced colitis.

Authors:
Magdy El-Salhy Kazuo Umezawa

Int J Mol Med 2016 Mar 5;37(3):556-64. Epub 2016 Feb 5.

Department of Molecular Target Medicine, School of Aichi Medical University, School of Medicine, Nagakute, Aichi, Japan.

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March 2016

Angiopoietin-like Protein 2 Is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration.

Authors:
Manabu Hirasawa Keiyo Takubo Hideto Osada Seiji Miyake Eriko Toda Motoyoshi Endo Kazuo Umezawa Kazuo Tsubota Yuichi Oike Yoko Ozawa

J Biol Chem 2016 Apr 2;291(14):7373-85. Epub 2016 Feb 2.

From the Laboratory of Retinal Cell Biology and the Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan,

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April 2016

Inhibition of NF-κB Activity Enhances Sensitivity to Anticancer Drugs in Cholangiocarcinoma Cells.

Authors:
Wunchana Seubwai Kulthida Vaeteewoottacharn Ratthaphol Kraiklang Kazuo Umezawa Seiji Okada Sopit Wongkham

Oncol Res 2016 ;23(1-2):21-8

Department of Forensic Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

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October 2016

Inhibition of NF-κB Activity Enhances Sensitivity to Anticancer Drugs in Cholangiocarcinoma Cells.

Authors:
Wunchana Seubwai Kulthida Vaeteewoottacharn Ratthaphol Kraiklang Kazuo Umezawa Seiji Okada Sopit Wongkham

Oncol Res 2016 Jan;23(1):21-28

Department of Forensic Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

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January 2016

The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-κB Axis during Retinal Inflammation.

Authors:
Tomohiro Okamoto Yoko Ozawa Mamoru Kamoshita Hideto Osada Eriko Toda Toshihide Kurihara Norihiro Nagai Kazuo Umezawa Kazuo Tsubota

PLoS One 2016 15;11(1):e0146517. Epub 2016 Jan 15.

Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

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July 2016

Novel anti-inflammatory agent 3-[(dodecylthiocarbonyl)-methyl]-glutarimide ameliorates murine models of inflammatory bowel disease.

Authors:
Nobuki Ichikawa Kenichiro Yamashita Tohru Funakoshi Shin Ichihara Moto Fukai Masaomi Ogura Nozomi Kobayashi Masaaki Zaitsu Tadashi Yoshida Susumu Shibasaki Yasuyuki Koshizuka Yusuke Tsunetoshi Masanori Sato Takahiro Einama Michitaka Ozaki Kazuo Umezawa Tomomi Suzuki Satoru Todo

Inflamm Res 2016 Mar 18;65(3):245-60. Epub 2015 Dec 18.

Department of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.

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March 2016

Outbreak of drug-resistant Acinetobacter baumannii ST219 caused by oral care using tap water from contaminated hand hygiene sinks as a reservoir.

Authors:
Kazuo Umezawa Satomi Asai Toshio Ohshima Hideo Iwashita Maya Ohashi Mika Sasaki Akihiro Kaneko Sadaki Inokuchi Hayato Miyachi

Am J Infect Control 2015 Nov 19;43(11):1249-51. Epub 2015 Sep 19.

Department of Laboratory Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.

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November 2015

Inhibition of IGF-1-Mediated Cellular Migration and Invasion by Migracin A in Ovarian Clear Cell Carcinoma Cells.

Authors:
Tamami Ukaji Yinzhi Lin Kouji Banno Shoshiro Okada Kazuo Umezawa

PLoS One 2015 11;10(9):e0137663. Epub 2015 Sep 11.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, 1-1 Yazako-Karimata, Nagakute, 480-1195, Japan.

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May 2016

Novel metal chelating molecules with anticancer activity. Striking effect of the imidazole substitution of the histidine-pyridine-histidine system.

Authors:
Taha F S Ali Kana Iwamaru Halil Ibrahim Ciftci Ryoko Koga Masahiro Matsumoto Yasunori Oba Hiromasa Kurosaki Mikako Fujita Yoshinari Okamoto Kazuo Umezawa Mitsuyoshi Nakao Takuichiro Hide Keishi Makino Jun-ichi Kuratsu Mohamed Abdel-Aziz Gamal El-Din A A Abuo-Rahma Eman A M Beshr Masami Otsuka

Bioorg Med Chem 2015 Sep 29;23(17):5476-82. Epub 2015 Jul 29.

Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address:

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September 2015

Brefeldin A exerts differential effects on anaplastic lymphoma kinase positive anaplastic large cell lymphoma and classical Hodgkin lymphoma cell lines.

Authors:
Takashi Toda Mariko Watanabe Junji Kawato Marshall E Kadin Masaaki Higashihara Takao Kunisada Kazuo Umezawa Ryouichi Horie

Br J Haematol 2015 Sep 24;170(6):837-46. Epub 2015 Jun 24.

Department of Haematology, School of Medicine, Kitasato University, Kanagawa, Japan.

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September 2015

A nuclear factor-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates GVHD in allogeneic bone marrow transplantation.

Authors:
Sohsaku Yamanouchi Yasushi Adachi Tomohiko Shimo Kazuo Umezawa Mitsuhiko Okigaki Shoji Tsuji Ming Li Junji Takaya Tomohiro Kuge Susumu Ikehara Kazunari Kaneko

Immunobiology 2015 Sep 11;220(9):1059-66. Epub 2015 May 11.

Department of Pediatrics, Kansai Medical University, Hirakata City, Osaka 573-1010, Japan.

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September 2015

Down-regulation of NF kappa B activation is an effective therapeutic modality in acquired platinum-resistant bladder cancer.

Authors:
Yujiro Ito Eiji Kikuchi Nobuyuki Tanaka Takeo Kosaka Eriko Suzuki Ryuichi Mizuno Toshiaki Shinojima Akira Miyajima Kazuo Umezawa Mototsugu Oya

BMC Cancer 2015 Apr 29;15:324. Epub 2015 Apr 29.

Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

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April 2015

Sonographic evaluation of the treatment response in patients with immunoglobulin G4-related disease of the submandibular glands.

Authors:
Satomi Asai Shinji Sato Kenji Okami Noboru Takanashi Kazuo Umezawa Anar Damdinsuren Hiromichi Matsushita Naoya Nakamura Yasuo Suzuki Hayato Miyachi

J Ultrasound Med 2015 May;34(5):783-8

Departments of Laboratory Medicine (S.A., A.D., H.Ma., H.Mi.), Rheumatology (S.S., Y.S.), Otolaryngology (K.O.), Critical Care and Emergency Medicine (K.U.), and Pathology (N.N.), Tokai University School of Medicine, Isehara, Japan; and Clinical Laboratory Center, Tokai University Hospital, Isehara, Japan (N.T.).

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May 2015

Venomous snake bites: clinical diagnosis and treatment.

Authors:
Toru Hifumi Atsushi Sakai Yutaka Kondo Akihiko Yamamoto Nobuya Morine Manabu Ato Keigo Shibayama Kazuo Umezawa Nobuaki Kiriu Hiroshi Kato Yuichi Koido Junichi Inoue Kenya Kawakita Yasuhiro Kuroda

J Intensive Care 2015 1;3(1):16. Epub 2015 Apr 1.

Emergency Medical Center, Kagawa University Hospital, 1750-1 Ikenobe, Miki, Kita, Kagawa, 761-0793 Japan.

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April 2015

Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-κB Inhibitor DHMEQ in Mast Cells.

Authors:
Naruto Noma Masataka Asagiri Masatoshi Takeiri Saori Ohmae Kenji Takemoto Keiko Iwaisako Nagahiro Minato Mari Maeda-Yamamoto Siro Simizu Kazuo Umezawa

Int Arch Allergy Immunol 2015 13;166(2):84-90. Epub 2015 Mar 13.

Innovation Center for Immunoregulation and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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July 2015

Induction of indoleamine 2, 3-dioxygenase in human dendritic cells by a cholera toxin B subunit-proinsulin vaccine.

Authors:
Jacques C Mbongue Dequina A Nicholas Kangling Zhang Nan-Sun Kim Brittany N Hamilton Marco Larios Guangyu Zhang Kazuo Umezawa Anthony F Firek William H R Langridge

PLoS One 2015 25;10(2):e0118562. Epub 2015 Feb 25.

Center for Health Disparities and Molecular Medicine, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States of America; Mass Spectrometer Core Facility, Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda University School of Medicine, Department of Basic Sciences, Loma Linda, CA, United States of America.

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January 2016

Inhibition of canonical NF-κB nuclear localization by (-)-DHMEQ via impairment of DNA binding.

Authors:
Kana Horie Jun Ma Kazuo Umezawa

Oncol Res 2015 ;22(2):105-15

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.

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February 2017

3-[(dodecylthiocarbonyl)methyl]-glutarimide attenuates graft arterial disease by suppressing alloimmune responses and vascular smooth muscle cell proliferation.

Authors:
Masaaki Zaitsu Kenichiro Yamashita Susumu Shibasaki Yusuke Tsunetoshi Moto Fukai Masaomi Ogura Tadashi Yoshida Rumi Igarashi Nozomi Kobayashi Kazuo Umezawa Satoru Todo

Transplantation 2015 May;99(5):948-56

1 Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 2 Department of Transplant Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 3 Department of Molecular Target Medicine Screening, Aichi Medical University School of Medicine, Nagakude, Japan.

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May 2015

Inhibition of RANKL- and LPS-induced osteoclast differentiations by novel NF-κB inhibitor DTCM-glutarimide.

Authors:
Naoki Koide Ayumi Kaneda Takashi Yokochi Kazuo Umezawa

Int Immunopharmacol 2015 Mar 21;25(1):162-8. Epub 2015 Jan 21.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan. Electronic address:

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March 2015

Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mammalian target of rapamycin (mTOR)-independent autophagy.

Authors:
Yukiko Sasazawa Natsumi Sato Kazuo Umezawa Siro Simizu

J Biol Chem 2015 Mar 16;290(10):6168-78. Epub 2015 Jan 16.

From the Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama 223-8522, Japan and

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March 2015

Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, reduces chemokines and adhesion molecule expression induced by IL-1β in human corneal fibroblasts.

Authors:
Sosuke Inokawa Takayo Watanabe Hiroshi Keino Yasuhiko Sato Akito Hirakata Annabelle A Okada Ken Fukuda Atsuki Fukushima Kazuo Umezawa

Graefes Arch Clin Exp Ophthalmol 2015 Apr 18;253(4):557-63. Epub 2014 Dec 18.

Department of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.

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April 2015

Activation of apoptosis by caspase-3-dependent specific RelB cleavage in anticancer agent-treated cancer cells: involvement of positive feedback mechanism.

Authors:
Mizuki Kuboki Ayumi Ito Siro Simizu Kazuo Umezawa

Biochem Biophys Res Commun 2015 Jan 13;456(3):810-4. Epub 2014 Dec 13.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, 1-1 Yazako-Karimata, Nagakute 480-1195, Japan. Electronic address:

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January 2015

Galectin-3 up-regulation in hypoxic and nutrient deprived microenvironments promotes cell survival.

Authors:
Rafael Yamashita Ikemori Camila Maria Longo Machado Karina Mie Furuzawa Suely Nonogaki Eduardo Osinaga Kazuo Umezawa Marcelo Alex de Carvalho Liana Verinaud Roger Chammas

PLoS One 2014 4;9(11):e111592. Epub 2014 Nov 4.

Faculdade de Medicina da Universidade de São Paulo, Instituto do Câncer do Estado de São Paulo, São Paulo, SP, Brazil.

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June 2015

Aberrant expression of NF-κB in liver fluke associated cholangiocarcinoma: implications for targeted therapy.

Authors:
Wunchana Seubwai Chaisiri Wongkham Anucha Puapairoj Narong Khuntikeo Ake Pugkhem Chariya Hahnvajanawong Jariya Chaiyagool Kazuo Umezawa Seiji Okada Sopit Wongkham

PLoS One 2014 29;9(8):e106056. Epub 2014 Aug 29.

Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

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June 2015

An outbreak of blaOXA-51-like- and blaOXA-66-positive Acinetobacter baumannii ST208 in the emergency intensive care unit.

Authors:
Satomi Asai Kazuo Umezawa Hideo Iwashita Toshio Ohshima Maya Ohashi Mika Sasaki Hideki Hayashi Mari Matsui Keigo Shibayama Sadaki Inokuchi Hayato Miyachi

J Med Microbiol 2014 Nov 20;63(Pt 11):1517-1523. Epub 2014 Aug 20.

Infection Control Division, Tokai University Hospital, 143 Shimokasuya, Isehara 259-1193, Japan.

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November 2014

Novel approaches to target NF-κB and other signaling pathways in cancer stem cells.

Authors:
Tamami Ukaji Kazuo Umezawa

Adv Biol Regul 2014 Sep 1;56:108-15. Epub 2014 Jul 1.

Department of Molecular Target Medicine Screening, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan. Electronic address:

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September 2014

Poly (ADP-ribose) polymerase inhibition synergizes with the NF-κB inhibitor DHMEQ to kill hepatocellular carcinoma cells.

Authors:
Nadia Lampiasi Kazuo Umezawa Giuseppe Montalto Melchiorre Cervello

Biochim Biophys Acta 2014 Nov 26;1843(11):2662-73. Epub 2014 Jul 26.

Institute of Biomedicine and Molecular Immunology "Alberto Monroy", National Research Council, Via Ugo La Malfa 153, 90146 Palermo, Italy.

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November 2014

AMPK-NF-κB axis in the photoreceptor disorder during retinal inflammation.

Authors:
Mamoru Kamoshita Yoko Ozawa Shunsuke Kubota Seiji Miyake Chiduru Tsuda Norihiro Nagai Kenya Yuki Shigeto Shimmura Kazuo Umezawa Kazuo Tsubota

PLoS One 2014 21;9(7):e103013. Epub 2014 Jul 21.

Department of Ophthalmology, Keio University School of Medicine, Shinjuku, Tokyo, Japan.

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November 2015

Strategic targeting of the PI3K-NFκB axis in cisplatin-resistant NSCLC.

Authors:
Susan Heavey Peter Godwin Anne-Marie Baird Martin P Barr Kazuo Umezawa Sinéad Cuffe Stephen P Finn Kenneth J O'Byrne Kathy Gately

Cancer Biol Ther 2014 Oct 15;15(10):1367-77. Epub 2014 Jul 15.

Thoracic Oncology Research Group; Institute of Molecular Medicine; Trinity Centre for Health Sciences; St. James's Hospital; Dublin, Ireland.

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October 2014

p62/SQSTM1 plays a protective role in oxidative injury of steatotic liver in a mouse hepatectomy model.

Authors:
Sanae Haga Takeaki Ozawa Yuma Yamada Naoki Morita Izuru Nagashima Hiroshi Inoue Yuka Inaba Natsumi Noda Riichiro Abe Kazuo Umezawa Michitaka Ozaki

Antioxid Redox Signal 2014 Dec 30;21(18):2515-30. Epub 2014 Jul 30.

1 Laboratory of Molecular and Functional Bio-imaging, Faculty of Health Sciences, Hokkaido University , Sapporo, Japan .

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December 2014

Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production.

Authors:
Chino Matsui Yoko Ikeda Hironobu Iinuma Nobuaki Kushida Takao Kunisada Siro Simizu Kazuo Umezawa

J Antibiot (Tokyo) 2014 Nov 4;67(11):787-90. Epub 2014 Jun 4.

Department of Molecular Target Medicine Screening, Aichi Medical University School of Medicine, Nagakute, Japan.

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November 2014

C-mannosylation of human hyaluronidase 1: possible roles for secretion and enzymatic activity.

Authors:
Yuki Goto Yuki Niwa Takehiro Suzuki Naoshi Dohmae Kazuo Umezawa Siro Simizu

Int J Oncol 2014 Jul 12;45(1):344-50. Epub 2014 May 12.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.

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July 2014

Inhibition of receptor activator of nuclear factor-κB ligand- or lipopolysaccharide-induced osteoclast formation by conophylline through downregulation of CREB.

Authors:
Naoki Koide Yuichiro Kondo Erdenezaya Odkhuu Jambalganiin Ulziisaikhan Tamami Ukaji Takashi Yokochi Kazuo Umezawa

Immunol Lett 2014 Sep 2;161(1):31-7. Epub 2014 May 2.

Department of Molecular Target Medicine Screening, Aichi Medical University School of Medicine, Nagakute, Japan.

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September 2014

Combined inhibition of NF-κB and Bcl-2 triggers synergistic reduction of viability and induces apoptosis in melanoma cells.

Authors:
Mariko Watanabe Kazuo Umezawa Masaaki Higashihara Ryouichi Horie

Oncol Res 2013 ;21(4):173-80

Department of Hematology, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan.

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December 2014

DSE-FRET: A new anticancer drug screening assay for DNA binding proteins.

Authors:
Toru Miyagi Bunsyo Shiotani Ryuya Miyoshi Takuya Yamamoto Takanori Oka Kazuo Umezawa Takahiro Ochiya Mikihisa Takano Hidetoshi Tahara

Cancer Sci 2014 Jul 14;105(7):870-4. Epub 2014 May 14.

Department of Cellular and Molecular Biology, Graduate School of Biomedical & Health Science, Hiroshima University, Hiroshima, Japan; Japanese Red Cross Kanto-koshinetsu Block Blood Center, Tokyo, Japan.

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July 2014

The NF-κB inhibitor DHMEQ decreases survival factors, overcomes the protective activity of microenvironment and synergizes with chemotherapy agents in classical Hodgkin lymphoma.

Authors:
Marta Celegato Cinzia Borghese Kazuo Umezawa Naike Casagrande Alfonso Colombatti Antonino Carbone Donatella Aldinucci

Cancer Lett 2014 Jul 2;349(1):26-34. Epub 2014 Apr 2.

Department of Experimental Oncology 2, CRO Aviano National Cancer Institute, Aviano, PN, Italy. Electronic address:

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July 2014

Amelioration of severe TNBS induced colitis by novel AP-1 and NF- κ B inhibitors in rats.

Authors:
Magdy El-Salhy Kazuo Umezawa Odd Helge Gilja Jan G Hatlebakk Doris Gundersen Trygve Hausken

ScientificWorldJournal 2014 30;2014:813804. Epub 2014 Jan 30.

Division of Gastroenterology, Department of Clinical Medicine, University of Bergen, P.O Box 7800, 5020 Bergen, Norway.

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January 2015

Involvement of conserved tryptophan residues for secretion of TIMP-2.

Authors:
Tamami Ukaji Yukiko Sasazawa Kazuo Umezawa Siro Simizu

Oncol Lett 2014 Mar 23;7(3):631-634. Epub 2013 Dec 23.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Kanagawa 223-8522, Japan.

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March 2014

The NF-κB specific inhibitor DHMEQ prevents thrombus formation in a mouse model of antiphospholipid syndrome.

Authors:
Misato Nishimura Tokiko Nii Gulzhan Trimova Shuhei Miura Kazuo Umezawa Akira Ushiyama Tetsuo Kubota

J Nephropathol 2013 Apr 1;2(2):114-21. Epub 2013 Apr 1.

Tokyo Medical and Dental University Graduate School of Health Care Sciences, Tokyo, Japan.

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April 2013

Activation of Akt involves resistance to NF-κB inhibition and abrogation of both triggers synergistic apoptosis in lung adenocarcinoma cells.

Authors:
Tomiteru Togano Mariko Watanabe Kinji Itoh Kazuo Umezawa Noriyuki Masuda Masaaki Higashihara Ryouichi Horie

Lung Cancer 2014 Feb 13;83(2):139-45. Epub 2013 Nov 13.

Department of Hematology, School of Medicine, Kitasato University, 1-15-1 Minami-ku, Kitasato, Sagamihara, Kanagawa 252-0374, Japan. Electronic address:

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February 2014

Inhibition of the NF-κB pathway as a candidate therapeutic strategy for cryopyrin-associated periodic syndrome.

Authors:
Satoka Shimogaki Sayaka Ito Sachiyo Komatsu Ryuji Koike Nobuyuki Miyasaka Kazuo Umezawa Tetsuo Kubota

Mod Rheumatol 2014 May 4;24(3):517-24. Epub 2013 Nov 4.

Department of Microbiology and Immunology, Tokyo Medical and Dental University Graduate School of Health Care Sciences , Tokyo , Japan.

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May 2014

Synergistic effect of 5-azacytidine and NF-κB inhibitor DHMEQ on apoptosis induction in myeloid leukemia cells.

Authors:
Tomiteru Togano Makoto Nakashima Mariko Watanabe Kazuo Umezawa Toshiki Watanabe Masaaki Higashihara Ryouichi Horie

Oncol Res 2012 ;20(12):571-7

Department of Hematology, School of Medicine, Kitasato University, Minami-ku, Sagamihara, Kanagawa, Japan.

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July 2014

Conophylline suppresses hepatic stellate cells and attenuates thioacetamide-induced liver fibrosis in rats.

Authors:
Norio Kubo Rie Saito Kunihisa Hamano Masahiro Nagasawa Fumiaki Aoki Izumi Takei Kazuo Umezawa Hiroyuki Kuwano Itaru Kojima

Liver Int 2014 Aug 2;34(7):1057-67. Epub 2013 Oct 2.

Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan; Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Maebashi, Japan.

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August 2014

Determination of topological structure of ARL6ip1 in cells: identification of the essential binding region of ARL6ip1 for conophylline.

Authors:
Masahiro Kuroda Shintaro Funasaki Tsuyoshi Saitoh Yukiko Sasazawa Shigeru Nishiyama Kazuo Umezawa Siro Simizu

FEBS Lett 2013 Nov 25;587(22):3656-60. Epub 2013 Sep 25.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.

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November 2013

Earthworm-derived pore-forming toxin lysenin and screening of its inhibitors.

Authors:
Neelanun Sukumwang Kazuo Umezawa

Toxins (Basel) 2013 Aug 8;5(8):1392-401. Epub 2013 Aug 8.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Kanagawa 223-8522, Japan.

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August 2013

Effect of a novel nuclear factor-κB activation inhibitor on renal ischemia-reperfusion injury.

Authors:
Hidaka Kono Ken Nakagawa Shinya Morita Kazunobu Shinoda Ryuichi Mizuno Eiji Kikuchi Akira Miyajima Kazuo Umezawa Mototsugu Oya

Transplantation 2013 Nov;96(10):863-70

1 Department of Urology, Keio University School of Medicine, Tokyo, Japan. 2 Department of Molecular Target Medicine Screening, Aichi Medical University, Nagakute, Japan. 3 Address correspondence to: Ken Nakagawa, M.D., Department of Urology, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo 160-8582, Japan.

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November 2013

Efficacy of DHMEQ, a NF-κB inhibitor, in islet transplantation: I. HMGB1 suppression by DHMEQ prevents early islet graft damage.

Authors:
Daisuke Kuraya Masaaki Watanabe Yasuyuki Koshizuka Masaomi Ogura Tadashi Yoshida Yoh Asahi Hirofumi Kamachi Takashi Nakamura Hideyoshi Harashima Michitaka Ozaki Kazuo Umezawa Michiaki Matsushita Kenichiro Yamashita Satoru Todo

Transplantation 2013 Sep;96(5):445-53

First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan.

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September 2013

Efficacy of DHMEQ, a NF-κB inhibitor, in islet transplantation: II. Induction DHMEQ treatment ameliorates subsequent alloimmune responses and permits long-term islet allograft acceptance.

Authors:
Masaaki Watanabe Kenichiro Yamashita Hirofumi Kamachi Daisuke Kuraya Yasuyuki Koshizuka Susumu Shibasaki Yoh Asahi Hitoshi Ono Shin Emoto Masaomi Ogura Tadashi Yoshida Michitaka Ozaki Kazuo Umezawa Michiaki Matsushita Satoru Todo

Transplantation 2013 Sep;96(5):454-62

First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan.

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September 2013

Pleiotropic potential of dehydroxymethylepoxyquinomicin for NF-κB suppression via reactive oxygen species and unfolded protein response.

Authors:
Shotaro Nakajima Hironori Kato Liubao Gu Shuhei Takahashi Hisashi Johno Kazuo Umezawa Masanori Kitamura

J Immunol 2013 Jun 20;190(12):6559-69. Epub 2013 May 20.

Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.

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June 2013

p53 dysfunction precedes the activation of nuclear factor-κB during disease progression in mice expressing Tax, a human T-cell leukemia virus type 1 oncoprotein.

Authors:
Takeo Ohsugi Takaomi Ishida Tatsuya Shimasaki Seiji Okada Kazuo Umezawa

Carcinogenesis 2013 Sep 30;34(9):2129-36. Epub 2013 Apr 30.

Division of Microbiology and Genetics, Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

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September 2013

A novel nuclear factor κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates puromycin aminonucleoside-induced nephrosis in mice.

Authors:
Tomohiko Shimo Yasushi Adachi Sohsaku Yamanouchi Shoji Tsuji Takahisa Kimata Kazuo Umezawa Mitsuhiko Okigaki Junji Takaya Susumu Ikehara Kazunari Kaneko

Am J Nephrol 2013 19;37(4):302-9. Epub 2013 Mar 19.

Department of Pediatrics, Kansai Medical University, Osaka, Japan.

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August 2013

Screening of new bioactive metabolites for diabetes therapy.

Authors:
Kulrawee Sidthipong Satoru Todo Izumi Takei Itaru Kojima Kazuo Umezawa

Intern Emerg Med 2013 Apr;8 Suppl 1:S57-9

Aichi Medical University School of Medicine, Nagakute, 480-1195, Japan.

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April 2013