Publications by authors named "Kazuo Umezawa"

100Publications

Isolation and Characterization of New Anti-Inflammatory and Antioxidant Components from Deep Marine-Derived Fungus SP. Bzo-l062.

Mar Drugs 2020 Nov 26;18(12). Epub 2020 Nov 26.

Shenzhen Key Laboratory of Marine Bioresource and Eco-environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.

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November 2020

NF-κB and STAT3 co-operation enhances high glucose induced aggressiveness of cholangiocarcinoma cells.

Life Sci 2020 Dec 7;262:118548. Epub 2020 Oct 7.

Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.

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December 2020

Anticancer Activity of Novel NF-kappa B Inhibitor DHMEQ by Intraperitoneal Administration.

Oncol Res 2020 12 23;28(5):541-550. Epub 2020 Jun 23.

Scientific Research Institute of Oncology, Bashkortostan State Medical UniversityUfaRussia.

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December 2020

Anti‑inflammatory effects of the NF‑κB inhibitor dehydroxymethylepoxyquinomicin on ARPE‑19 cells.

Mol Med Rep 2020 Jul 4;22(1):582-590. Epub 2020 May 4.

Department of Ophthalmology, Kyorin University School of Medicine, Tokyo 181‑8611, Japan.

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July 2020

Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin.

J Antibiot (Tokyo) 2020 09 24;73(9):622-629. Epub 2020 Mar 24.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, 480-1195, Nagakute, Japan.

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September 2020

Inhibition of matrix metalloproteinase expression and cellular invasion by NF-κB inhibitors of microbial origin.

Biochim Biophys Acta Proteins Proteom 2020 06 14;1868(6):140412. Epub 2020 Mar 14.

Department of Molecular Target Medicine, Aichi Medical University, Nagakute 480-1195, Japan.

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June 2020

Growth Inhibitory Effects of Dipotassium Glycyrrhizinate in Glioblastoma Cell Lines by Targeting MicroRNAs Through the NF-κB Signaling Pathway.

Front Cell Neurosci 2019 28;13:216. Epub 2019 May 28.

Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, Post Graduate Program in Health Science, Universidade São Francisco (USF), Bragança Paulista, Brazil.

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May 2019

Comparison of anti-atopic dermatitis activities between DHMEQ and tacrolimus ointments in mouse model without stratum corneum.

Int Immunopharmacol 2019 Jun 13;71:43-51. Epub 2019 Mar 13.

School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

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June 2019

Dehydroxymethylepoxyquinomicin suppresses atopic dermatitis-like lesions in a stratum corneum-removed murine model through NF-κB inhibition.

Immunopharmacol Immunotoxicol 2019 Feb 6;41(1):32-39. Epub 2019 Feb 6.

a School of Life Science and Biopharmaceutics , Shenyang Pharmaceutical University , Shenyang , China.

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February 2019

Conophylline inhibits high fat diet-induced non-alcoholic fatty liver disease in mice.

PLoS One 2019 28;14(1):e0210068. Epub 2019 Jan 28.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Aichi Medical University, Nagakute, Aichi, Japan.

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September 2019

Isolation of ketomycin from Actinomycetes as an inhibitor of 2D and 3D cancer cell invasion.

J Antibiot (Tokyo) 2019 03 3;72(3):148-154. Epub 2018 Dec 3.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, Nagakute, Japan.

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March 2019

The plant alkaloid conophylline inhibits matrix formation of fibroblasts.

J Biol Chem 2018 12 30;293(52):20214-20226. Epub 2018 Oct 30.

Institute for Molecular Science of Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan and

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December 2018

Carbapenem-resistant in a Febrile Neutropenia Patient With Acute Myelogenous Leukemia After Hematopoietic Stem Cell Transplantation.

Infect Dis Clin Pract (Baltim Md) 2018 Sep 21;26(5):e38-e39. Epub 2018 Apr 21.

Department of Laboratory Medicine Tokai University School of Medicine Infection Control Division Tokai University Hospital Kanagawa, Japan.

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September 2018

Development of a sensitive immunochromatographic kit using fluorescent silica nanoparticles for rapid serodiagnosis of amebiasis.

Parasitology 2018 12 9;145(14):1890-1895. Epub 2018 May 9.

Department of Infectious Diseases,Tokyo Metropolitan Cancer and Infectious Diseases Center,Komagome Hospital,Tokyo 113-8677,Japan.

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December 2018

Corrigendum to "poly (ADP-ribose) polymerase inhibition synergizes with the NF-κB inhibitor DHMEQ to kill hepatocellular carcinoma cells" [Biochim. Biophys. Acta 1853(12)(2015) 3224-3234].

Biochim Biophys Acta Mol Cell Res 2018 Jul 21;1865(7):1023. Epub 2018 Apr 21.

Institute of Biomedicine and Molecular Immunology "Alberto Monroy", National Research Council, Via Ugo La Malfa 153, 90146 Palermo, Italy.

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July 2018

Inhibition of Late and Early Phases of Cancer Metastasis by the NF-κB Inhibitor DHMEQ Derived from Microbial Bioactive Metabolite Epoxyquinomicin: A Review.

Int J Mol Sci 2018 Mar 3;19(3). Epub 2018 Mar 3.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, 1-1 Yazako-Karimata, Nagakute 480-1195, Japan.

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March 2018

Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegenerative disease models.

Hum Cell 2018 Apr 16;31(2):95-101. Epub 2017 Dec 16.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, 480-1195, Japan.

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April 2018

The unfolded protein response mediated by PERK is casually related to the pathogenesis of intervertebral disc degeneration.

J Orthop Res 2018 05 28;36(5):1334-1345. Epub 2017 Nov 28.

Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo, 160-8582, Japan.

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May 2018

Novel p-terphenyl glycoside with a rare 2,6-dideoxyhexopyranose moiety from Actinomycete strain SF2911 that inhibits cancer cell migration.

J Antibiot (Tokyo) 2017 Oct 19;70(10):987-990. Epub 2017 Jul 19.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, Nagakute, Japan.

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October 2017

A novel inhibitor of farnesyltransferase with a zinc site recognition moiety and a farnesyl group.

Bioorg Med Chem Lett 2017 08 20;27(16):3862-3866. Epub 2017 Jun 20.

Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address:

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August 2017

Conophylline inhibits non-alcoholic steatohepatitis in mice.

PLoS One 2017 8;12(6):e0178436. Epub 2017 Jun 8.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Aichi Medical University, Nagakute, Aichi, Japan.

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September 2017

Clinical Serum Therapy: Benefits, Cautions, and Potential Applications.

Keio J Med 2017 Dec 28;66(4):57-64. Epub 2017 Apr 28.

Department of Emergency and Critical Care Medicine, Tokai University School of Medicine, Kanagawa, Japan.

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December 2017

External application of NF-κB inhibitor DHMEQ suppresses development of atopic dermatitis-like lesions induced with DNCB/OX in BALB/c mice.

Immunopharmacol Immunotoxicol 2017 Jun;39(3):157-164

a Department of Pharmacology, School of Life Science and Biopharmaceutics , Shenyang Pharmaceutical University , Shenyang , China.

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June 2017

Simultaneous and multi-point measurement of ammonia emanating from human skin surface for the estimation of whole body dermal emission rate.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 May 2;1053:60-64. Epub 2017 Apr 2.

Department of Laboratory Medicine, School of Medicine, Tokai University, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

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May 2017

Abnormal differentiation of stem cells into enteroendocrine cells in rats with DSS-induced colitis.

Mol Med Rep 2017 Apr 1;15(4):2106-2112. Epub 2017 Mar 1.

Division of Gastroenterology, Department of Clinical Medicine, University of Bergen, 5007 Bergen, Norway.

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April 2017

Inhibition of MMP-2-mediated cellular invasion by NF-κB inhibitor DHMEQ in 3D culture of breast carcinoma MDA-MB-231 cells: A model for early phase of metastasis.

Biochem Biophys Res Commun 2017 03 8;485(1):76-81. Epub 2017 Feb 8.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, 1-1 Yazako-Karimata, Nagakute 480-1195, Japan. Electronic address:

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March 2017

Inhibition of NF-kappaB with Dehydroxymethylepoxyquinomicin modifies the function of human peritoneal mesothelial cells.

Am J Transl Res 2016 15;8(12):5756-5765. Epub 2016 Dec 15.

Department of Pathophysiology, Poznań University of Medical Sciences Poznań, Poland.

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December 2016

Rational design, synthesis and in vitro evaluation of novel exo-methylene butyrolactone salicyloylamide as NF-κB inhibitor.

Bioorg Med Chem Lett 2017 02 8;27(3):562-566. Epub 2016 Dec 8.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, 1-1 Yazako-Karimata, Nagakute 480-1195, Japan. Electronic address:

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February 2017

Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response.

Cell Death Dis 2016 11 10;7(11):e2469. Epub 2016 Nov 10.

Cancer and Ageing Program, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology (QUT) and Princess Alexandra Hospital, Level 6, Translational Research Institute, Brisbane, QLD, Australia.

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November 2016

Enteroendocrine cells, stem cells and differentiation progenitors in rats with TNBS-induced colitis.

Int J Mol Med 2016 Dec 24;38(6):1743-1751. Epub 2016 Oct 24.

Division of Gastroenterology, Institute of Clinical Medicine, University of Bergen, 5020 Bergen, Norway.

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December 2016

Inhibition of nuclear factor-κB signaling suppresses Spint1-deletion-induced tumor susceptibility in the ApcMin/+ model.

Oncotarget 2016 Oct;7(42):68614-68622

Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

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October 2016

Effects of AP‑1 and NF‑κB inhibitors on colonic endocrine cells in rats with TNBS‑induced colitis.

Mol Med Rep 2016 Aug 27;14(2):1515-22. Epub 2016 Jun 27.

Department of Molecular Target Medicine, School of Aichi Medical University, School of Medicine, Nagakute, Aichi 480‑1195, Japan.

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August 2016

Identification of poly(rC) binding protein 2 (PCBP2) as a target protein of immunosuppressive agent 15-deoxyspergualin.

Biochem Biophys Res Commun 2016 08 31;476(4):445-449. Epub 2016 May 31.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, 1-1 Yazako-Karimata, Nagakute 480-1195, Japan. Electronic address:

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August 2016

Anti-inflammatory effects of novel AP-1 and NF-κB inhibitors in dextran-sulfate-sodium-induced colitis in rats.

Int J Mol Med 2016 Jun 12;37(6):1457-64. Epub 2016 Apr 12.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan.

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June 2016

Design and synthesis of 15-deoxyspergualin-biotin conjugates as novel binding probes for target protein screening.

J Antibiot (Tokyo) 2016 07 23;69(7):574-8. Epub 2016 Mar 23.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, Aichi, Japan.

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July 2016

Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters.

FEBS Lett 2016 04 3;590(8):1152-62. Epub 2016 Apr 3.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.

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April 2016

Treatment with novel AP-1 and NF-κB inhibitors restores the colonic endocrine cells to normal levels in rats with DSS-induced colitis.

Int J Mol Med 2016 Mar 5;37(3):556-64. Epub 2016 Feb 5.

Department of Molecular Target Medicine, School of Aichi Medical University, School of Medicine, Nagakute, Aichi, Japan.

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March 2016

Angiopoietin-like Protein 2 Is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration.

J Biol Chem 2016 Apr 2;291(14):7373-85. Epub 2016 Feb 2.

From the Laboratory of Retinal Cell Biology and the Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan,

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April 2016

Inhibition of NF-κB Activity Enhances Sensitivity to Anticancer Drugs in Cholangiocarcinoma Cells.

Oncol Res 2016 Jan;23(1):21-28

Department of Forensic Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

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January 2016

The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-κB Axis during Retinal Inflammation.

PLoS One 2016 15;11(1):e0146517. Epub 2016 Jan 15.

Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

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July 2016

Inhibition of IGF-1-Mediated Cellular Migration and Invasion by Migracin A in Ovarian Clear Cell Carcinoma Cells.

PLoS One 2015 11;10(9):e0137663. Epub 2015 Sep 11.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, 1-1 Yazako-Karimata, Nagakute, 480-1195, Japan.

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May 2016

Sonographic evaluation of the treatment response in patients with immunoglobulin G4-related disease of the submandibular glands.

J Ultrasound Med 2015 May;34(5):783-8

Departments of Laboratory Medicine (S.A., A.D., H.Ma., H.Mi.), Rheumatology (S.S., Y.S.), Otolaryngology (K.O.), Critical Care and Emergency Medicine (K.U.), and Pathology (N.N.), Tokai University School of Medicine, Isehara, Japan; and Clinical Laboratory Center, Tokai University Hospital, Isehara, Japan (N.T.).

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May 2015

Venomous snake bites: clinical diagnosis and treatment.

J Intensive Care 2015 1;3(1):16. Epub 2015 Apr 1.

Emergency Medical Center, Kagawa University Hospital, 1750-1 Ikenobe, Miki, Kita, Kagawa, 761-0793 Japan.

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April 2015

Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-κB Inhibitor DHMEQ in Mast Cells.

Int Arch Allergy Immunol 2015 13;166(2):84-90. Epub 2015 Mar 13.

Innovation Center for Immunoregulation and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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July 2015

Induction of indoleamine 2, 3-dioxygenase in human dendritic cells by a cholera toxin B subunit-proinsulin vaccine.

PLoS One 2015 25;10(2):e0118562. Epub 2015 Feb 25.

Center for Health Disparities and Molecular Medicine, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States of America; Mass Spectrometer Core Facility, Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda University School of Medicine, Department of Basic Sciences, Loma Linda, CA, United States of America.

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January 2016

Inhibition of canonical NF-κB nuclear localization by (-)-DHMEQ via impairment of DNA binding.

Oncol Res 2015 ;22(2):105-15

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.

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February 2017

3-[(dodecylthiocarbonyl)methyl]-glutarimide attenuates graft arterial disease by suppressing alloimmune responses and vascular smooth muscle cell proliferation.

Transplantation 2015 May;99(5):948-56

1 Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 2 Department of Transplant Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 3 Department of Molecular Target Medicine Screening, Aichi Medical University School of Medicine, Nagakude, Japan.

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May 2015

Inhibition of RANKL- and LPS-induced osteoclast differentiations by novel NF-κB inhibitor DTCM-glutarimide.

Int Immunopharmacol 2015 Mar 21;25(1):162-8. Epub 2015 Jan 21.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan. Electronic address:

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March 2015

Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mammalian target of rapamycin (mTOR)-independent autophagy.

J Biol Chem 2015 Mar 16;290(10):6168-78. Epub 2015 Jan 16.

From the Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama 223-8522, Japan and

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March 2015

Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, reduces chemokines and adhesion molecule expression induced by IL-1β in human corneal fibroblasts.

Graefes Arch Clin Exp Ophthalmol 2015 Apr 18;253(4):557-63. Epub 2014 Dec 18.

Department of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.

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April 2015

Activation of apoptosis by caspase-3-dependent specific RelB cleavage in anticancer agent-treated cancer cells: involvement of positive feedback mechanism.

Biochem Biophys Res Commun 2015 Jan 13;456(3):810-4. Epub 2014 Dec 13.

Department of Molecular Target Medicine, Aichi Medical University School of Medicine, 1-1 Yazako-Karimata, Nagakute 480-1195, Japan. Electronic address:

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January 2015

Galectin-3 up-regulation in hypoxic and nutrient deprived microenvironments promotes cell survival.

PLoS One 2014 4;9(11):e111592. Epub 2014 Nov 4.

Faculdade de Medicina da Universidade de São Paulo, Instituto do Câncer do Estado de São Paulo, São Paulo, SP, Brazil.

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June 2015

Aberrant expression of NF-κB in liver fluke associated cholangiocarcinoma: implications for targeted therapy.

PLoS One 2014 29;9(8):e106056. Epub 2014 Aug 29.

Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

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June 2015

Novel approaches to target NF-κB and other signaling pathways in cancer stem cells.

Adv Biol Regul 2014 Sep 1;56:108-15. Epub 2014 Jul 1.

Department of Molecular Target Medicine Screening, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan. Electronic address:

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September 2014

Poly (ADP-ribose) polymerase inhibition synergizes with the NF-κB inhibitor DHMEQ to kill hepatocellular carcinoma cells.

Biochim Biophys Acta 2014 Nov 26;1843(11):2662-73. Epub 2014 Jul 26.

Institute of Biomedicine and Molecular Immunology "Alberto Monroy", National Research Council, Via Ugo La Malfa 153, 90146 Palermo, Italy.

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November 2014

AMPK-NF-κB axis in the photoreceptor disorder during retinal inflammation.

PLoS One 2014 21;9(7):e103013. Epub 2014 Jul 21.

Department of Ophthalmology, Keio University School of Medicine, Shinjuku, Tokyo, Japan.

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November 2015

Strategic targeting of the PI3K-NFκB axis in cisplatin-resistant NSCLC.

Cancer Biol Ther 2014 Oct 15;15(10):1367-77. Epub 2014 Jul 15.

Thoracic Oncology Research Group; Institute of Molecular Medicine; Trinity Centre for Health Sciences; St. James's Hospital; Dublin, Ireland.

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October 2014

p62/SQSTM1 plays a protective role in oxidative injury of steatotic liver in a mouse hepatectomy model.

Antioxid Redox Signal 2014 Dec 30;21(18):2515-30. Epub 2014 Jul 30.

1 Laboratory of Molecular and Functional Bio-imaging, Faculty of Health Sciences, Hokkaido University , Sapporo, Japan .

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December 2014

Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production.

J Antibiot (Tokyo) 2014 Nov 4;67(11):787-90. Epub 2014 Jun 4.

Department of Molecular Target Medicine Screening, Aichi Medical University School of Medicine, Nagakute, Japan.

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November 2014

C-mannosylation of human hyaluronidase 1: possible roles for secretion and enzymatic activity.

Int J Oncol 2014 Jul 12;45(1):344-50. Epub 2014 May 12.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.

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July 2014

Combined inhibition of NF-κB and Bcl-2 triggers synergistic reduction of viability and induces apoptosis in melanoma cells.

Oncol Res 2013 ;21(4):173-80

Department of Hematology, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan.

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December 2014

DSE-FRET: A new anticancer drug screening assay for DNA binding proteins.

Cancer Sci 2014 Jul 14;105(7):870-4. Epub 2014 May 14.

Department of Cellular and Molecular Biology, Graduate School of Biomedical & Health Science, Hiroshima University, Hiroshima, Japan; Japanese Red Cross Kanto-koshinetsu Block Blood Center, Tokyo, Japan.

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July 2014

Amelioration of severe TNBS induced colitis by novel AP-1 and NF- κ B inhibitors in rats.

ScientificWorldJournal 2014 30;2014:813804. Epub 2014 Jan 30.

Division of Gastroenterology, Department of Clinical Medicine, University of Bergen, P.O Box 7800, 5020 Bergen, Norway.

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January 2015

Involvement of conserved tryptophan residues for secretion of TIMP-2.

Oncol Lett 2014 Mar 23;7(3):631-634. Epub 2013 Dec 23.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Kanagawa 223-8522, Japan.

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March 2014

The NF-κB specific inhibitor DHMEQ prevents thrombus formation in a mouse model of antiphospholipid syndrome.

J Nephropathol 2013 Apr 1;2(2):114-21. Epub 2013 Apr 1.

Tokyo Medical and Dental University Graduate School of Health Care Sciences, Tokyo, Japan.

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April 2013

Activation of Akt involves resistance to NF-κB inhibition and abrogation of both triggers synergistic apoptosis in lung adenocarcinoma cells.

Lung Cancer 2014 Feb 13;83(2):139-45. Epub 2013 Nov 13.

Department of Hematology, School of Medicine, Kitasato University, 1-15-1 Minami-ku, Kitasato, Sagamihara, Kanagawa 252-0374, Japan. Electronic address:

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February 2014

Inhibition of the NF-κB pathway as a candidate therapeutic strategy for cryopyrin-associated periodic syndrome.

Mod Rheumatol 2014 May 4;24(3):517-24. Epub 2013 Nov 4.

Department of Microbiology and Immunology, Tokyo Medical and Dental University Graduate School of Health Care Sciences , Tokyo , Japan.

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May 2014

Conophylline suppresses hepatic stellate cells and attenuates thioacetamide-induced liver fibrosis in rats.

Liver Int 2014 Aug 2;34(7):1057-67. Epub 2013 Oct 2.

Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan; Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Maebashi, Japan.

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August 2014

Determination of topological structure of ARL6ip1 in cells: identification of the essential binding region of ARL6ip1 for conophylline.

FEBS Lett 2013 Nov 25;587(22):3656-60. Epub 2013 Sep 25.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.

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November 2013

Earthworm-derived pore-forming toxin lysenin and screening of its inhibitors.

Toxins (Basel) 2013 Aug 8;5(8):1392-401. Epub 2013 Aug 8.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Kanagawa 223-8522, Japan.

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August 2013

Effect of a novel nuclear factor-κB activation inhibitor on renal ischemia-reperfusion injury.

Transplantation 2013 Nov;96(10):863-70

1 Department of Urology, Keio University School of Medicine, Tokyo, Japan. 2 Department of Molecular Target Medicine Screening, Aichi Medical University, Nagakute, Japan. 3 Address correspondence to: Ken Nakagawa, M.D., Department of Urology, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo 160-8582, Japan.

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November 2013

Pleiotropic potential of dehydroxymethylepoxyquinomicin for NF-κB suppression via reactive oxygen species and unfolded protein response.

J Immunol 2013 Jun 20;190(12):6559-69. Epub 2013 May 20.

Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.

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June 2013

p53 dysfunction precedes the activation of nuclear factor-κB during disease progression in mice expressing Tax, a human T-cell leukemia virus type 1 oncoprotein.

Carcinogenesis 2013 Sep 30;34(9):2129-36. Epub 2013 Apr 30.

Division of Microbiology and Genetics, Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

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September 2013

Screening of new bioactive metabolites for diabetes therapy.

Intern Emerg Med 2013 Apr;8 Suppl 1:S57-9

Aichi Medical University School of Medicine, Nagakute, 480-1195, Japan.

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April 2013