Publications by authors named "Kazumasa Aoyama"

36Publications

PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome.

Leukemia 2020 Aug 21. Epub 2020 Aug 21.

Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.

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http://dx.doi.org/10.1038/s41375-020-01023-1DOI Listing
August 2020

Bmi1 counteracts hematopoietic stem cell aging by repressing target genes and enforcing the stem cell gene signature.

Biochem Biophys Res Commun 2020 01 1;521(3):612-619. Epub 2019 Nov 1.

Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.10.153DOI Listing
January 2020

Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche.

Exp Hematol 2019 08 11;76:24-37. Epub 2019 Aug 11.

Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan; Division of Stem Cell and Molecular Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2019.07.006DOI Listing
August 2019

Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling.

Biochem Biophys Res Commun 2019 04 2;511(4):765-771. Epub 2019 Mar 2.

Laboratory of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.02.130DOI Listing
April 2019

Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome.

iScience 2018 Nov 15;9:161-174. Epub 2018 Oct 15.

Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670 Japan; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223231PMC
November 2018

Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048.

Oncogene 2019 01 3;38(5):637-655. Epub 2018 Sep 3.

Laboratory of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.

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http://www.nature.com/articles/s41388-018-0481-z
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http://dx.doi.org/10.1038/s41388-018-0481-zDOI Listing
January 2019

Enhancement of TGF-β-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP).

Biochem Biophys Res Commun 2017 08 28;490(3):1045-1051. Epub 2017 Jun 28.

Laboratory of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.06.163DOI Listing
August 2017

Protective role for lipid modifications of Src-family kinases against chromosome missegregation.

Sci Rep 2016 12 12;6:38751. Epub 2016 Dec 12.

Laboratory of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.

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http://dx.doi.org/10.1038/srep38751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150256PMC
December 2016

The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.

J Exp Med 2016 07 11;213(8):1459-77. Epub 2016 Jul 11.

Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan

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http://dx.doi.org/10.1084/jem.20151121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986523PMC
July 2016

Design, Synthesis, and Biological Evaluation of Beauveriolide Analogues Bearing Photoreactive Amino Acids.

Chem Pharm Bull (Tokyo) 2016 Jul 26;64(7):754-65. Epub 2016 Mar 26.

Graduate School of Pharmaceutical Sciences, Tohoku University.

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http://dx.doi.org/10.1248/cpb.c16-00095DOI Listing
July 2016

Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner.

Blood 2015 Sep 28;126(10):1172-83. Epub 2015 Jul 28.

Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan;

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http://dx.doi.org/10.1182/blood-2015-03-634428DOI Listing
September 2015

c-Abl-mediated tyrosine phosphorylation of JunB is required for Adriamycin-induced expression of p21.

Biochem J 2015 Oct 27;471(1):67-77. Epub 2015 Jul 27.

Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan

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http://www.biochemj.org/content/ppbiochemj/471/1/67.full.pdf
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http://biochemj.org/cgi/doi/10.1042/BJ20150372
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http://dx.doi.org/10.1042/BJ20150372DOI Listing
October 2015

c-Abl induces stabilization of histone deacetylase 1 (HDAC1) in a kinase activity-dependent manner.

Cell Biol Int 2015 Apr 5;39(4):446-56. Epub 2015 Jan 5.

Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.

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http://dx.doi.org/10.1002/cbin.10413DOI Listing
April 2015

Overexpression of zinc-finger protein 777 (ZNF777) inhibits proliferation at low cell density through down-regulation of FAM129A.

J Cell Biochem 2015 Jun;116(6):954-68

Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.

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http://dx.doi.org/10.1002/jcb.25046DOI Listing
June 2015

Formation of long and winding nuclear F-actin bundles by nuclear c-Abl tyrosine kinase.

Exp Cell Res 2013 Dec 13;319(20):3251-68. Epub 2013 Sep 13.

Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8675, Japan.

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http://dx.doi.org/10.1016/j.yexcr.2013.09.003DOI Listing
December 2013

Nuclear ErbB4 signaling through H3K9me3 is antagonized by EGFR-activated c-Src.

J Cell Sci 2013 Jan 10;126(Pt 2):625-37. Epub 2012 Dec 10.

Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.

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http://dx.doi.org/10.1242/jcs.116277DOI Listing
January 2013

Nuclear c-Abl-mediated tyrosine phosphorylation induces chromatin structural changes through histone modifications that include H4K16 hypoacetylation.

Exp Cell Res 2011 Dec 2;317(20):2874-903. Epub 2011 Oct 2.

Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.

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http://dx.doi.org/10.1016/j.yexcr.2011.09.013DOI Listing
December 2011

Cost-effective gene transfection by DNA compaction at pH 4.0 using acidified, long shelf-life polyethylenimine.

Cytotechnology 2010 Jan 23;62(1):73-82. Epub 2010 Mar 23.

Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba, 260-8675, Japan.

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http://link.springer.com/10.1007/s10616-010-9259-z
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http://dx.doi.org/10.1007/s10616-010-9259-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303003PMC
January 2010