Kazuma Ohyashiki

Kazuma Ohyashiki

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Kazuma Ohyashiki

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Author Correction: Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm.

Nat Commun 2019 Aug 28;10(1):3943. Epub 2019 Aug 28.

Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo Ward, Kumamoto, 860-0811, Japan.

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http://dx.doi.org/10.1038/s41467-019-11919-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713738PMC
August 2019

A unique breast involvement detected by MRI-DWIBS in T cell acute lymphoblastic leukemia.

Breast J 2019 Jul 12. Epub 2019 Jul 12.

Department of Hematology, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1111/tbj.13457DOI Listing
July 2019

Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm.

Nat Commun 2019 04 10;10(1):1653. Epub 2019 Apr 10.

Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo Ward, Kumamoto, 860-0811, Japan.

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http://dx.doi.org/10.1038/s41467-019-09710-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458132PMC
April 2019

Copanlisib, a novel phosphoinositide 3-kinase inhibitor, combined with carfilzomib inhibits multiple myeloma cell proliferation.

Ann Hematol 2019 Mar 15;98(3):723-733. Epub 2018 Nov 15.

Department of Hematology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

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http://link.springer.com/10.1007/s00277-018-3547-7
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http://dx.doi.org/10.1007/s00277-018-3547-7DOI Listing
March 2019

Therapeutic targeting of Aurora A kinase in Philadelphia chromosome-positive ABL tyrosine kinase inhibitor-resistant cells.

Oncotarget 2018 Aug 21;9(65):32496-32506. Epub 2018 Aug 21.

Department of Hematology, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.18632/oncotarget.25985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126699PMC
August 2018

Extracellular vesicle-mediated cell-cell communication in haematological neoplasms.

Philos Trans R Soc Lond B Biol Sci 2018 Jan;373(1737)

Department of Hematology, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1098/rstb.2016.0484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717438PMC
January 2018

Targeting peroxisome proliferator-activated receptors: a novel strategy for Philadelphia chromosome-positive leukemia cells.

Leuk Lymphoma 2017 11 15;58(11):2762-2764. Epub 2017 May 15.

a Department of Hematology , Tokyo Medical University , Tokyo , Japan.

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http://dx.doi.org/10.1080/10428194.2017.1312373DOI Listing
November 2017

Amyloid Angiopathy-related Severe Hemorrhage with Multiple Myeloma.

Intern Med 2017 11 25;56(21):2957-2958. Epub 2017 Sep 25.

Department of Hematology, Tokyo Medical University, Japan.

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http://dx.doi.org/10.2169/internalmedicine.8609-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709649PMC
November 2017

Genetic variations of bone marrow mesenchymal stromal cells derived from acute leukemia and myelodysplastic syndrome by targeted deep sequencing.

Leuk Res 2017 11 21;62:23-28. Epub 2017 Sep 21.

Department of Molecular Oncology, Institute of Medical Science, Tokyo Medical University, 160-0023, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2017.09.008DOI Listing
November 2017

Unique radiological features of two cases of primary pulmonary diffuse large B-cell lymphoma.

Thorax 2017 09 14;72(9):859-860. Epub 2017 Jul 14.

Department of Hematology, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1136/thoraxjnl-2017-210248DOI Listing
September 2017

Teriflunomide restores 5-azacytidine sensitivity via activation of pyrimidine salvage in 5-azacytidine-resistant leukemia cells.

Oncotarget 2017 Sep 22;8(41):69906-69915. Epub 2017 Jul 22.

Department of Molecular Oncology, Institute for Medical Science, Tokyo Medical University, Nishi-Shinjuku, Shinjuku, Tokyo, Japan.

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http://dx.doi.org/10.18632/oncotarget.19436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642525PMC
September 2017

Replenishing exosomes from older bone marrow stromal cells with miR-340 inhibits myeloma-related angiogenesis.

Blood Adv 2017 May 16;1(13):812-823. Epub 2017 May 16.

Department of Molecular Oncology, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1182/bloodadvances.2016003251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727805PMC
May 2017

Low body weight and body mass index may be associated with musculoskeletal pain following imatinib discontinuation in chronic myeloid leukemia.

Leuk Res Rep 2017 12;7:33-35. Epub 2017 Apr 12.

Department of Hematology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

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http://dx.doi.org/10.1016/j.lrr.2017.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402624PMC
April 2017

Assessing the safety and efficacy of ruxolitinib in a multicenter, open-label study in Japanese patients with myelofibrosis.

Int J Hematol 2017 Mar 10;105(3):309-317. Epub 2016 Nov 10.

Department of Medicine and Biosystemic Science, Kyushu University, Fukuoka, 812-8582, Japan.

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http://dx.doi.org/10.1007/s12185-016-2130-zDOI Listing
March 2017

Poly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells.

Cancer Lett 2017 02 25;386:131-140. Epub 2016 Nov 25.

Department of Pediatrics and Developmental Biology, Graduate School of Medicine, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8519, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.11.021DOI Listing
February 2017

Exosomes promote bone marrow angiogenesis in hematologic neoplasia: the role of hypoxia.

Curr Opin Hematol 2016 May;23(3):268-73

aDepartment of Molecular Oncology, Institute of Medical Science bDepartments of Molecular Science cHematology, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1097/MOH.0000000000000235DOI Listing
May 2016

Fatal Cyberlindnera fabianii fungemia in a patient with mixed phenotype acute leukemia after umbilical cord blood transplantation.

Int J Hematol 2016 May 15;103(5):592-5. Epub 2016 Feb 15.

Laboratory of Space and Environmental Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan.

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http://dx.doi.org/10.1007/s12185-016-1953-yDOI Listing
May 2016

Downregulation of Plasma miR-215 in Chronic Myeloid Leukemia Patients with Successful Discontinuation of Imatinib.

Int J Mol Sci 2016 Apr 15;17(4):570. Epub 2016 Apr 15.

Department of Molecular Oncology, Institute of Medical Science, Tokyo Medical University, Tokyo 160-0023, Japan.

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http://dx.doi.org/10.3390/ijms17040570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849026PMC
April 2016

Effect of combined deferasirox and 5-azacytidine treatment on human leukemia cells in vitro.

Ann Hematol 2015 Sep 6;94(9):1601-2. Epub 2015 Jun 6.

Institute of Medical Science, Tokyo Medical University, 6-7-1 Nishishinjuku, Tokyo, 160-0023, Japan,

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http://dx.doi.org/10.1007/s00277-015-2417-9DOI Listing
September 2015

Anti-leukemic activity of axitinib against cells harboring the BCR-ABL T315I point mutation.

J Hematol Oncol 2015 Aug 4;8:97. Epub 2015 Aug 4.

Department of Hematology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

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https://jhoonline.biomedcentral.com/articles/10.1186/s13045-
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http://dx.doi.org/10.1186/s13045-015-0190-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523922PMC
August 2015

Downregulated microRNA-148b in circulating PBMCs in chronic myeloid leukemia patients with undetectable minimal residual disease: a possible biomarker to discontinue imatinib safely.

Drug Des Devel Ther 2014 25;8:1151-9. Epub 2014 Aug 25.

Department of Hematology, Tokyo Medical University, Tokyo, Japan ; Department of Molecular Science, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.2147/DDDT.S66812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149385PMC
May 2015

Diffuse large B-cell lymphoma resembling a metastatic liver tumour.

Br J Haematol 2015 Jan 14;168(1). Epub 2014 Oct 14.

Department of Haematology, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1111/bjh.13163DOI Listing
January 2015

Constitutive activation of the ATM/BRCA1 pathway prevents DNA damage-induced apoptosis in 5-azacytidine-resistant cell lines.

Biochem Pharmacol 2014 Jun 26;89(3):361-9. Epub 2014 Mar 26.

Institute for Medical Science, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku, Tokyo 160-0023, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S00062952140018
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http://dx.doi.org/10.1016/j.bcp.2014.03.008DOI Listing
June 2014

Combination of the ABL kinase inhibitor imatinib with the Janus kinase 2 inhibitor TG101348 for targeting residual BCR-ABL-positive cells.

J Hematol Oncol 2014 Apr 28;7:37. Epub 2014 Apr 28.

First Department of Internal Medicine, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023, Japan.

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http://dx.doi.org/10.1186/1756-8722-7-37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012544PMC
April 2014

Genetic variants in C5 and poor response to eculizumab.

N Engl J Med 2014 Feb;370(7):632-9

From Osaka University Graduate School of Medicine (J.N., M.Y., H.S., Y.K.) and World Premier International Immunology Frontier Research Center and Research Institute for Microbial Diseases, Osaka University, Suita (T.K.), Medical Research Institute and Hard Tissue Genome Research Center, Tokyo Medical and Dental University (S.H., J.I.), Tokyo Medical University (K.O.), and Alexion Pharma (M.H.), Tokyo, Tokai University School of Medicine, Isehara (K.A.), Fukushima Medical University, Fukushima (H.N., T.S.), Ichinomiya Municipal Hospital, Ichinomiya (K.K.), Hamanomachi Hospital, Fukuoka (T.E.), Yamaguchi Grand Medical Center, Hofu (T.T.), Niigata University Medical and Dental Hospital, Niigata (M.M.), Japanese Red Cross Takayama Hospital, Takayama (T.M.), and Iwate Prefectual Central Hospital, Morioka (Y.W.) - all in Japan; University of Buenos Aires, Buenos Aires (A.L.B., A.L.); and Alexion Pharmaceuticals, Cheshire, CT (L.L., K.J., P.T.).

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http://dx.doi.org/10.1056/NEJMoa1311084DOI Listing
February 2014

Transfusion-transmitted hepatitis E in a patient with myelodysplastic syndromes.

Blood Transfus 2014 Jan 2;12(1):103-6. Epub 2013 Oct 2.

First Department of Internal Medicine, Division of Haematology, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.

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http://dx.doi.org/10.2450/2013.0081-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926709PMC
January 2014

Exosomes derived from hypoxic leukemia cells enhance tube formation in endothelial cells.

J Biol Chem 2013 Nov 16;288(48):34343-51. Epub 2013 Oct 16.

From the Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, Tokyo 192-0392, Japan.

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http://dx.doi.org/10.1074/jbc.M113.480822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843049PMC
November 2013

Efficacy of ponatinib against ABL tyrosine kinase inhibitor-resistant leukemia cells.

Biochem Biophys Res Commun 2013 Jun 14;435(3):506-11. Epub 2013 May 14.

First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2013.05.022DOI Listing
June 2013

Combination of ponatinib with Hedgehog antagonist vismodegib for therapy-resistant BCR-ABL1-positive leukemia.

Clin Cancer Res 2013 Mar 14;19(6):1422-32. Epub 2013 Jan 14.

First Department of Internal Medicine, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-1777DOI Listing
March 2013

Clinical relevance of plasma miR-106b levels in patients with chronic obstructive pulmonary disease.

Int J Mol Med 2013 Mar 21;31(3):533-9. Epub 2013 Jan 21.

Division of Respiratory Medicine, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.3892/ijmm.2013.1251DOI Listing
March 2013

Prospective randomized study of cefepime, panipenem, or meropenem monotherapy for patients with hematological disorders and febrile neutropenia.

J Infect Chemother 2013 Feb 5;19(1):103-11. Epub 2012 Sep 5.

Department of Hematology and Chemotherapy, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, Japan.

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http://dx.doi.org/10.1007/s10156-012-0466-8DOI Listing
February 2013

[Successful treatment with rituximab for autoimmune hemolytic anemia associated with chronic lymphocytic leukemia].

Rinsho Ketsueki 2013 Feb;54(2):229-31

First Department of Internal Medicine, Tokyo Medical University, Japan.

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February 2013

Effects of the hedgehog inhibitor GDC-0449, alone or in combination with dasatinib, on BCR-ABL-positive leukemia cells.

Stem Cells Dev 2012 Nov 16;21(16):2939-48. Epub 2012 Jul 16.

First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan.

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https://www.liebertpub.com/doi/10.1089/scd.2012.0016
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http://dx.doi.org/10.1089/scd.2012.0016DOI Listing
November 2012

Efficacy and safety of doripenem for sepsis with neutropenia in Japanese patients with hematologic diseases.

Jpn J Antibiot 2012 Aug;65(4):251-62

Department of Internal Medicine, Teikyo University School of Medicine.

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August 2012

Association between ApoE phenotypes and telomere erosion in Alzheimer's disease.

J Gerontol A Biol Sci Med Sci 2012 Apr 19;67(4):330-5. Epub 2011 Oct 19.

Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1093/gerona/glr185DOI Listing
April 2012

[Clinical management of tumor lysis syndrome].

Nihon Rinsho 2012 Apr;70 Suppl 2:269-73

Department of Clinical Oncology, Tokyo Medical University Hospital.

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April 2012

Efficacy and safety of micafungin as an empirical antifungal therapy for suspected fungal infection in neutropenic patients with hematological disorders.

Ann Hematol 2012 Mar 6;91(3):449-57. Epub 2011 Sep 6.

The Fourth Department of Internal Medicine, Teikyo University School of Medicine, Mizonokuchi Hospital, Mizonokuchi, Takatsu-ku, Kawasaki City, Kanagawa, Japan.

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http://link.springer.com/10.1007/s00277-011-1316-y
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http://dx.doi.org/10.1007/s00277-011-1316-yDOI Listing
March 2012

[Lung injury associated with bortezomib therapy in Japan].

Rinsho Ketsueki 2011 Dec;52(12):1859-69

Scientific Affairs Div. Janssen Pharmaceutical K.K.

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December 2011

[A retrospective analysis of neurotoxicity induced by vinca alkaloids combined with azole anti-fungal agents in hematological malignancies].

Gan To Kagaku Ryoho 2011 Oct;38(10):1667-72

Department of Pharmacy, Tokyo Medical University Hospital, Japan.

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October 2011

Detection method for quantifying global DNA methylation by fluorescence correlation spectroscopy.

Anal Biochem 2011 Aug 27;415(2):145-50. Epub 2011 Apr 27.

Department of Molecular Science, Tokyo Medical University, Tokyo 160-0023, Japan.

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http://dx.doi.org/10.1016/j.ab.2011.04.035DOI Listing
August 2011

5q-syndrome in Japan.

Int J Hematol 2011 Jun 13;93(6):827-829. Epub 2011 May 13.

Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan.

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http://link.springer.com/10.1007/s12185-011-0868-x
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http://dx.doi.org/10.1007/s12185-011-0868-xDOI Listing
June 2011

Non-random chromosomal deletion clustering at 20q in Waldenström macroglobulinemia.

Hematology 2011 May;16(3):139-42

First Department of Internal Medicine (Hematology Division), Tokyo Medical University, Japan.

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http://dx.doi.org/10.1179/102453311X12953015767338DOI Listing
May 2011