Kazuma Murakami

Kazuma Murakami

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Kazuma Murakami

Publications by authors named "Kazuma Murakami"

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An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease.

Biochem Biophys Res Commun 2019 Jul 1;515(3):462-467. Epub 2019 Jun 1.

Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan; Department of Mechanism of Aging, National Center for Geriatrics and Gerontology, Obu, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.05.131DOI Listing
July 2019

Three Structural Features of Functional Food Components and Herbal Medicine with Amyloid β42 Anti-Aggregation Properties.

Molecules 2019 Jun 5;24(11). Epub 2019 Jun 5.

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.3390/molecules24112125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600243PMC
June 2019

Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation.

Chem Commun (Camb) 2018 Dec;55(2):182-185

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

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http://xlink.rsc.org/?DOI=C8CC08618D
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http://dx.doi.org/10.1039/c8cc08618dDOI Listing
December 2018

The Taurine Transporter Eaat2 Functions in Ensheathing Glia to Modulate Sleep and Metabolic Rate.

Curr Biol 2018 11 8;28(22):3700-3708.e4. Epub 2018 Nov 8.

Jupiter Life Science Initiative, Florida Atlantic University, Jupiter, FL 33458, USA; Department of Biological Sciences, Florida Atlantic University, Jupiter, FL 33458, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09609822183140
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http://dx.doi.org/10.1016/j.cub.2018.10.039DOI Listing
November 2018

Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers.

Chem Commun (Camb) 2018 Jun;54(49):6272-6275

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.1039/c8cc03230kDOI Listing
June 2018

Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine.

Bioorg Med Chem 2018 05 2;26(8):1538-1546. Epub 2018 Feb 2.

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2018.01.028DOI Listing
May 2018

A Toxic Conformer of Aβ42 with a Turn at 22-23 is a Novel Therapeutic Target for Alzheimer's Disease.

Sci Rep 2017 09 18;7(1):11811. Epub 2017 Sep 18.

Department of Advanced Aging Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.

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http://dx.doi.org/10.1038/s41598-017-11671-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603611PMC
September 2017

Synthesized Aβ42 Caused Intracellular Oxidative Damage, Leading to Cell Death, via Lysosome Rupture.

Cell Struct Funct 2017 May 12;42(1):71-79. Epub 2017 Apr 12.

Research Unit for Physiological Chemistry, Kyoto University.

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http://dx.doi.org/10.1247/csf.17006DOI Listing
May 2017

Synthetic Models of Quasi-Stable Amyloid β40 Oligomers with Significant Neurotoxicity.

ACS Chem Neurosci 2017 04 12;8(4):807-816. Epub 2017 Jan 12.

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University , Kyoto 606-8502, Japan.

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http://dx.doi.org/10.1021/acschemneuro.6b00390DOI Listing
April 2017

Semisynthesis and Structure-Activity Studies of Uncarinic Acid C Isolated from Uncaria rhynchophylla as a Specific Inhibitor of the Nucleation Phase in Amyloid β42 Aggregation.

J Nat Prod 2016 10 4;79(10):2521-2529. Epub 2016 Oct 4.

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University , Kyoto 606-8502, Japan.

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http://dx.doi.org/10.1021/acs.jnatprod.6b00392DOI Listing
October 2016

Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids.

Bioorg Med Chem 2016 Jan 12;24(2):304-13. Epub 2015 Dec 12.

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.12.021DOI Listing
January 2016

Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region.

Biochem Biophys Res Commun 2015 Oct 11;466(3):463-7. Epub 2015 Sep 11.

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.09.051DOI Listing
October 2015

Conformation-specific antibodies to target amyloid β oligomers and their application to immunotherapy for Alzheimer's disease.

Authors:
Kazuma Murakami

Biosci Biotechnol Biochem 2014 ;78(8):1293-305

a Division of Food Science and Biotechnology , Graduate School of Agriculture, Kyoto University , Kyoto , Japan.

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http://dx.doi.org/10.1080/09168451.2014.940275DOI Listing
April 2015

Development: better sleep on it, children.

Curr Biol 2014 Jun;24(12):R569-R571

Department of Biology, University of Nevada, Reno, NV 89557, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384164PMC
June 2014

Inhibition of amyloid β aggregation by acteoside, a phenylethanoid glycoside.

Biosci Biotechnol Biochem 2013 7;77(6):1329-32. Epub 2013 Jun 7.

Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1271/bbb.130101DOI Listing
February 2014

Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation.

Biosci Biotechnol Biochem 2013 7;77(5):1100-3. Epub 2013 May 7.

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1271/bbb.120925DOI Listing
December 2013

Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease.

Biochem Biophys Res Commun 2013 Aug 4;438(1):1-5. Epub 2013 Jun 4.

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-Ku, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2013.05.106DOI Listing
August 2013

Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues.

J Biol Chem 2013 Aug 21;288(32):23212-24. Epub 2013 Jun 21.

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M113.464222
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http://dx.doi.org/10.1074/jbc.M113.464222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743493PMC
August 2013

Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity.

Bioorg Med Chem 2013 May 25;21(10):2695-702. Epub 2013 Mar 25.

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.1016/j.bmc.2013.03.013DOI Listing
May 2013

Development of a platinum complex as an anti-amyloid agent for the therapy of Alzheimer's disease.

Angew Chem Int Ed Engl 2013 Mar 10;52(12):3374-8. Epub 2013 Feb 10.

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010, Australia.

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http://dx.doi.org/10.1002/anie.201209885DOI Listing
March 2013

Lack of the consensus sequence necessary for tryptophan prenylation in the ComX pheromone precursor.

Biosci Biotechnol Biochem 2012 7;76(8):1492-6. Epub 2012 Aug 7.

Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi 464-8601, Japan.

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http://dx.doi.org/10.1271/bbb.120206DOI Listing
February 2013

Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease.

Curr Alzheimer Res 2013 Jan;10(1):11-20

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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January 2013

[A causal analysis of the determinants of trust of the Forest Administration in the prefecture where the forest environmental tax was introduced].

Authors:
Kazuma Murakami

Shinrigaku Kenkyu 2012 Dec;83(5):461-9

Asia Pacific Institute of Research, Nakanoshima, Kita-ku, Osaka 530-6691, Japan.

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http://dx.doi.org/10.4992/jjpsy.83.461DOI Listing
December 2012

Stimulation of the amyloidogenic pathway by cytoplasmic superoxide radicals in an Alzheimer's disease mouse model.

Biosci Biotechnol Biochem 2012 7;76(6):1098-103. Epub 2012 Jun 7.

Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

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http://dx.doi.org/10.1271/bbb.110934DOI Listing
November 2012

Identification and biological activities of bryostatins from Japanese bryozoan.

Biosci Biotechnol Biochem 2012 7;76(5):1041-3. Epub 2012 May 7.

Department of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Japan.

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http://dx.doi.org/10.1271/bbb.120026DOI Listing
October 2012

Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein.

Bioorg Med Chem 2012 Oct 12;20(19):5844-9. Epub 2012 Aug 12.

Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572, Japan.

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http://dx.doi.org/10.1016/j.bmc.2012.08.001DOI Listing
October 2012

Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42.

ACS Chem Neurosci 2012 Sep 6;3(9):674-81. Epub 2012 Jun 6.

Department of Pharmacology, Graduate School of Pharmaceutical Science, Kyoto University, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.1021/cn300033kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447395PMC
September 2012

Formation of the 42-mer Amyloid β Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer's Disease.

J Amino Acids 2011 16;2011:654207. Epub 2011 Jan 16.

Laboratory of Organic Chemistry in Life Science, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.4061/2011/654207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276080PMC
August 2012

Preparation of stable amyloid β-protein oligomers of defined assembly order.

Methods Mol Biol 2012 ;849:23-31

Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/978-1-61779-551-0_3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767166PMC
August 2012

Vitamin C restores behavioral deficits and amyloid-β oligomerization without affecting plaque formation in a mouse model of Alzheimer's disease.

J Alzheimers Dis 2011 ;26(1):7-18

Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan.

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http://dx.doi.org/10.3233/JAD-2011-101971DOI Listing
January 2012

Geranyl modification on the tryptophan residue of ComXRO-E-2 pheromone by a cell-free system.

FEBS Lett 2012 Jan 17;586(2):174-9. Epub 2011 Dec 17.

Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya, Aichi 464-8601, Japan.

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http://dx.doi.org/10.1016/j.febslet.2011.12.012DOI Listing
January 2012

Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice.

Biochem Biophys Res Commun 2011 May 28;409(1):34-9. Epub 2011 Apr 28.

Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2011.04.101DOI Listing
May 2011

Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model.

Biosci Biotechnol Biochem 2010 7;74(11):2299-306. Epub 2010 Nov 7.

Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

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http://dx.doi.org/10.1271/bbb.100524DOI Listing
March 2011

E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity.

Int J Alzheimers Dis 2010 Dec 19;2011:431320. Epub 2010 Dec 19.

Laboratory of Organic Chemistry in Life Science, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.4061/2011/431320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017891PMC
December 2010

Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23.

ACS Chem Neurosci 2010 Nov 28;1(11):747-56. Epub 2010 Sep 28.

Department of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan; Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173-0015, Japan.

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http://dx.doi.org/10.1021/cn100072eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368655PMC
November 2010

RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity.

PLoS One 2009 Nov 10;4(11):e7694. Epub 2009 Nov 10.

Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007694PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770325PMC
November 2009

Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative.

Biochem Biophys Res Commun 2009 May 14;382(2):457-61. Epub 2009 Mar 14.

Research Team for Molecular Biomarkers, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0900518
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http://dx.doi.org/10.1016/j.bbrc.2009.03.053DOI Listing
May 2009

Isomerization and/or racemization at Asp23 of Abeta42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro.

Biochem Biophys Res Commun 2008 Feb 17;366(3):745-51. Epub 2007 Dec 17.

Laboratory of Organic Chemistry in Life Science, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2007.12.009DOI Listing
February 2008

Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40.

Chembiochem 2007 Dec;8(18):2308-14

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.1002/cbic.200700240DOI Listing
December 2007

Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR.

Bioorg Med Chem 2005 Dec 22;13(24):6803-9. Epub 2005 Sep 22.

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.1016/j.bmc.2005.07.071DOI Listing
December 2005

Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease.

J Am Chem Soc 2005 Nov;127(43):15168-74

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.1021/ja054041cDOI Listing
November 2005

Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease.

J Biosci Bioeng 2005 May;99(5):437-47

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.1263/jbb.99.437DOI Listing
May 2005

Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement.

J Biol Chem 2004 Dec 30;279(50):52781-8. Epub 2004 Sep 30.

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M406262200
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http://dx.doi.org/10.1074/jbc.M406262200DOI Listing
December 2004

Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease.

J Biol Chem 2003 Nov 27;278(46):46179-87. Epub 2003 Aug 27.

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.1074/jbc.M301874200DOI Listing
November 2003

Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23.

Biochem Biophys Res Commun 2002 Jul;295(2):306-11

Laboratory of Organic Chemistry in Life Science, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.1016/s0006-291x(02)00670-8DOI Listing
July 2002

Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23.

Biochem Biophys Res Commun 2002 May;294(1):5-10

Laboratory of Organic Chemistry in Life Science, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.1016/S0006-291X(02)00430-8DOI Listing
May 2002