Kazuko Sakai

Kazuko Sakai

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Kazuko Sakai

Kazuko Sakai

Publications by authors named "Kazuko Sakai"

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A Case of Metastatic Malignant Breast Adenomyoepithelioma With a Codon-61 Mutation of HRAS.

Clin Breast Cancer 2019 Oct 20;19(5):e589-e592. Epub 2019 Jun 20.

Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1016/j.clbc.2019.05.001DOI Listing
October 2019

Clinical and immune profiling for cancer of unknown primary site.

J Immunother Cancer 2019 Sep 13;7(1):251. Epub 2019 Sep 13.

Department of Medical Oncology, Kindai University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

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http://dx.doi.org/10.1186/s40425-019-0720-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743146PMC
September 2019

[Current Status and Future Direction of Cancer Genomic Medicine].

Gan To Kagaku Ryoho 2019 Sep;46(9):1357-1360

Dept. of Genome Biology, Kindai University Faculty of Medicine.

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September 2019

Liquid biopsy-based comprehensive gene mutation profiling for gynecological cancer using CAncer Personalized Profiling by deep Sequencing.

Sci Rep 2019 Jul 18;9(1):10426. Epub 2019 Jul 18.

Department of Obstetrics and Gynecology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama, 641-0012, Japan.

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http://dx.doi.org/10.1038/s41598-019-47030-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639322PMC
July 2019

Successful long-term treatment of non-small cell lung cancer positive for rearrangement with pemetrexed.

Onco Targets Ther 2019 8;12:5355-5358. Epub 2019 Jul 8.

Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, Japan.

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http://dx.doi.org/10.2147/OTT.S211582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625745PMC
July 2019

Patients with SMARCA4-deficient thoracic sarcoma and severe skeletal-related events.

Lung Cancer 2019 Jun 8;132:59-64. Epub 2019 Apr 8.

Department of Thoracic Oncology, Osaka International Cancer Institute, 3-1-69 Otemae Chuoku, Osaka City, Japan.

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http://dx.doi.org/10.1016/j.lungcan.2019.03.029DOI Listing
June 2019

New Era for Next-Generation Sequencing in Japan.

Cancers (Basel) 2019 May 28;11(6). Epub 2019 May 28.

Department of Genome Biology, Kindai University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511, Japan.

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http://dx.doi.org/10.3390/cancers11060742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627271PMC
May 2019

Serpina3n, Dominantly Expressed in Female Osteoblasts, Suppresses the Phenotypes of Differentiated Osteoblasts in Mice.

Endocrinology 2018 11;159(11):3775-3790

Department of Physiology and Regenerative Medicine, Kindai University Faculty of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1210/en.2018-00639DOI Listing
November 2018

Genital mucosal melanoma with somatic SF3B1 R625C mutation.

Eur J Dermatol 2018 Jun;28(3):414-415

Dermatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.

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http://dx.doi.org/10.1684/ejd.2018.3281DOI Listing
June 2018

Clinical characteristics of non-small cell lung cancer harboring mutations in exon 20 of or .

Oncotarget 2018 Apr 20;9(30):21132-21140. Epub 2018 Apr 20.

Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, Japan.

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http://dx.doi.org/10.18632/oncotarget.24958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940408PMC
April 2018

Lymph node metastatic melanoma from ungual melanoma: Identification of somatic mutations in KIT and LZTR1.

J Dermatol 2018 Jan 25;45(1):e5-e6. Epub 2017 Sep 25.

Department of Dermatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.

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http://dx.doi.org/10.1111/1346-8138.14071DOI Listing
January 2018

Elevated plasma levels of procoagulant microparticles are a novel risk factor for thrombosis in patients with myeloproliferative neoplasms.

Int J Hematol 2017 Nov 5;106(5):691-703. Epub 2017 Aug 5.

Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, 377-2, Ohno-higashi, Osakasayama, Osaka, Japan.

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http://dx.doi.org/10.1007/s12185-017-2302-5DOI Listing
November 2017

DS-8201a, a new HER2-targeting antibody-drug conjugate incorporating a novel DNA topoisomerase I inhibitor, overcomes HER2-positive gastric cancer T-DM1 resistance.

Int J Cancer 2017 10 12;141(8):1682-1689. Epub 2017 Jul 12.

Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka-Sayamashi, Osaka, Japan.

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http://dx.doi.org/10.1002/ijc.30870DOI Listing
October 2017

Clonal composition of human ovarian cancer based on copy number analysis reveals a reciprocal relation with oncogenic mutation status.

Cancer Lett 2017 10 19;405:22-28. Epub 2017 Jul 19.

Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

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http://dx.doi.org/10.1016/j.canlet.2017.07.013DOI Listing
October 2017

[Clinical Application of NGS-Based Clinical Sequencing].

Gan To Kagaku Ryoho 2017 Oct;44(10):813-816

Dept. of Genome Biology, Kindai University Faculty of Medicine.

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October 2017

Ciliated muconodular papillary tumors of the lung with KRAS/BRAF/AKT1 mutation.

Diagn Pathol 2017 Aug 22;12(1):62. Epub 2017 Aug 22.

Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.

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http://dx.doi.org/10.1186/s13000-017-0651-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568349PMC
August 2017

Clinical significance of Akt2 in advanced pancreatic cancer treated with erlotinib.

Int J Oncol 2017 Jun 18;50(6):2049-2058. Epub 2017 Apr 18.

Department of Genome Biology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, Japan.

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http://dx.doi.org/10.3892/ijo.2017.3961DOI Listing
June 2017

Phylloid hypomelanosis associated with a mosaic trisomy 13 in the 13q31.3-qter region: atypical phylloid distribution and typical hypomelanosis.

Pigment Cell Melanoma Res 2017 03 7;30(2):269-272. Epub 2017 Mar 7.

Department of Dermatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.

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http://dx.doi.org/10.1111/pcmr.12566DOI Listing
March 2017

Clinical Response to Everolimus of EGFR-Mutation-Positive NSCLC With Primary Resistance to EGFR TKIs.

Clin Lung Cancer 2017 01 4;18(1):e85-e87. Epub 2016 Oct 4.

Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1016/j.cllc.2016.08.004DOI Listing
January 2017

MEK inhibitors against MET-amplified non-small cell lung cancer.

Int J Oncol 2016 Dec 17;49(6):2236-2244. Epub 2016 Oct 17.

Department of Genome Biology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, Japan.

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http://dx.doi.org/10.3892/ijo.2016.3736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118002PMC
December 2016

Case report: Durable response to afatinib in a patient with lung cancer harboring two uncommon mutations of EGFR and a KRAS mutation.

Lung Cancer 2016 11 4;101:11-15. Epub 2016 Sep 4.

Department of Medical Oncology, Kindai University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

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http://dx.doi.org/10.1016/j.lungcan.2016.09.001DOI Listing
November 2016

Association of EGFR Exon 19 Deletion and EGFR-TKI Treatment Duration with Frequency of T790M Mutation in EGFR-Mutant Lung Cancer Patients.

Sci Rep 2016 11 4;6:36458. Epub 2016 Nov 4.

Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan.

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http://dx.doi.org/10.1038/srep36458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095551PMC
November 2016

Successful human epidermal growth receptor 2-targeted therapy beyond disease progression for extramammary Paget's disease.

Invest New Drugs 2016 06 9;34(3):394-6. Epub 2016 Feb 9.

Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

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http://dx.doi.org/10.1007/s10637-016-0329-8DOI Listing
June 2016

Heterogeneity in resistance mechanisms causes shorter duration of epidermal growth factor receptor kinase inhibitor treatment in lung cancer.

Lung Cancer 2016 Jan 25;91:36-40. Epub 2015 Nov 25.

Division of Thoracic Surgery, Department of Surgery, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Japan.

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http://dx.doi.org/10.1016/j.lungcan.2015.11.016DOI Listing
January 2016

EGFR and HER2 signals play a salvage role in MEK1-mutated gastric cancer after MEK inhibition.

Int J Oncol 2015 Aug 16;47(2):499-505. Epub 2015 Jun 16.

Department of Genome Biology, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan.

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http://dx.doi.org/10.3892/ijo.2015.3050DOI Listing
August 2015

[PI3K and mTOR pathway and molecular targeted agents].

Nihon Rinsho 2015 Aug;73(8):1315-22

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August 2015

Development of on-chip multi-imaging flow cytometry for identification of imaging biomarkers of clustered circulating tumor cells.

PLoS One 2014 20;9(8):e104372. Epub 2014 Aug 20.

Kanagawa Academy of Science and Technology, Takatsu, Kawasaki, Japan; Department of Biomedical Information, Division of Biosystems, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104372PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139271PMC
May 2015

Chronic nicotine exposure mediates resistance to EGFR-TKI in EGFR-mutated lung cancer via an EGFR signal.

Lung Cancer 2015 Apr 7;88(1):16-23. Epub 2015 Feb 7.

Department of Genome Biology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2015.01.027DOI Listing
April 2015

Oral L-carnitine supplementation increases trimethylamine-N-oxide but reduces markers of vascular injury in hemodialysis patients.

J Cardiovasc Pharmacol 2015 Mar;65(3):289-95

*Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan; †Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan; ‡Division of Nephrology, Wada Cardiovascular Clinic, Tosu, Japan; §Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Kanazawa, Japan; and ¶Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan.

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http://pdfs.journals.lww.com/cardiovascularpharm/2015/03000/
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http://dx.doi.org/10.1097/FJC.0000000000000197DOI Listing
March 2015

Inter- and intra-tumor profiling of multi-regional colon cancer and metastasis.

Biochem Biophys Res Commun 2015 Feb 24;458(1):52-6. Epub 2015 Jan 24.

Department of Genome Biology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.01.064DOI Listing
February 2015

Inhibition of β-Catenin enhances the anticancer effect of irreversible EGFR-TKI in EGFR-mutated non-small-cell lung cancer with a T790M mutation.

J Thorac Oncol 2015 Jan;10(1):93-101

Departments of *Genome Biology and †Medical Oncology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan; and ‡Department of Medical Oncology, Kishiwada Municipal Hospital, Kishiwada, Japan.

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http://dx.doi.org/10.1097/JTO.0000000000000353DOI Listing
January 2015

Multiple regulatory mechanisms of hepatocyte growth factor expression in malignant cells with a short poly(dA) sequence in the HGF gene promoter.

Oncol Lett 2015 Jan 11;9(1):405-410. Epub 2014 Nov 11.

Department of Genome Biology, Faculty of Medicine, Kinki University, Osaka-Sayama, Osaka 589-8511, Japan.

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http://dx.doi.org/10.3892/ol.2014.2702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246610PMC
January 2015

Effects of switching from oral administration to intravenous injection of l-carnitine on lipid metabolism in hemodialysis patients.

Clin Kidney J 2014 Oct 29;7(5):470-4. Epub 2014 Jul 29.

Division of Nephrology, Department of Medicine , Kurume University School of Medicine , Kurume , Japan.

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http://dx.doi.org/10.1093/ckj/sfu082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379340PMC
October 2014

Potential inhibitory effects of L-carnitine supplementation on tissue advanced glycation end products in patients with hemodialysis.

Rejuvenation Res 2013 Dec;16(6):460-6

1 Division of Nephrology, Department of Medicine, Kurume University School of Medicine , Kurume, Japan .

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http://dx.doi.org/10.1089/rej.2013.1459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869449PMC
December 2013

Human papillomavirus DNA and p16 expression in Japanese patients with oropharyngeal squamous cell carcinoma.

Cancer Med 2013 Dec 27;2(6):933-41. Epub 2013 Oct 27.

Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

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http://dx.doi.org/10.1002/cam4.151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892398PMC
December 2013

Evidence for a positive association between serum carnitine and free testosterone levels in uremic men with hemodialysis.

Rejuvenation Res 2013 Jun;16(3):200-5

Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.

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http://dx.doi.org/10.1089/rej.2012.1399DOI Listing
June 2013

Effects of switching from calcium carbonate to lanthanum carbonate on bone mineral metabolism in hemodialysis patients.

Ther Apher Dial 2013 Apr;17 Suppl 1:35-40

Division of Nephrology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume city, Fukuoka, Japan.

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http://dx.doi.org/10.1111/1744-9987.12037DOI Listing
April 2013

Decreased serum carnitine is independently correlated with increased tissue accumulation levels of advanced glycation end products in haemodialysis patients.

Nephrology (Carlton) 2012 Nov;17(8):689-94

Division of Nephrology, Department of Medicine Department of Pathophysiology and Therapeutics of Diabetic Complications Department of Community Medicine, Kurume University School of Medicine, Kurume Sugi Cardiovascular Hospital, Omuta, Japan.

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http://dx.doi.org/10.1111/j.1440-1797.2012.01642.xDOI Listing
November 2012

Clinical outcomes of thoracic radiotherapy for locally advanced NSCLC with EGFR mutations or EML4-ALK rearrangement.

Anticancer Res 2012 Oct;32(10):4533-7

Department of Medical Oncology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.

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October 2012

Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification.

Mol Cancer Ther 2012 Jul 22;11(7):1557-64. Epub 2012 Jun 22.

Department of Medical Oncology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0934DOI Listing
July 2012