Kazuhiro Higuchi

Division of Hepatobiliary-Pancreatic, Gastrointestinal, Endocrine and Pediatric Surgery, Department of Surgery, University of Miyazaki Faculty of Medicine, Miyazaki, Japan.

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March 2019

Dirhodium(ii)-catalyzed ortho C-H amination of sterically congested N,N-dialkylanilines.

Authors:

Motoki Ito Tomoya Nakagawa Kazuhiro Higuchi Shigeo Sugiyama

Org Biomol Chem 2018 10;16(38):6876-6881

Meiji Pharmaceutical University, 2-522-1 Noshio Kiyose, Tokyo 204-8588, Japan.

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October 2018

Total Synthesis of (+)-Gliocladin C Based on One-Pot Construction of a 3a-(3-Indolyl)pyrroloindoline Skeleton by Sulfonium-Mediated Cross-Coupling of Tryptophan and Indole.

Authors:

Masanori Tayu Yi Hui Shiori Takeda Kazuhiro Higuchi Nozomi Saito Tomomi Kawasaki

Org Lett 2017 12 5;19(24):6582-6585. Epub 2017 Dec 5.

Meiji Pharmaceutical University , Kiyose, Tokyo 204-8588, Japan.

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December 2017

Direct C2-Functionalization of Indoles Triggered by the Generation of Iminium Species from Indole and Sulfonium Salt.

Authors:

Masanori Tayu Kazuya Nomura Koki Kawachi Kazuhiro Higuchi Nozomi Saito Tomomi Kawasaki

Chemistry 2017 Aug 20;23(45):10925-10930. Epub 2017 Jul 20.

Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo, 204-8588, Japan.

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August 2017

Design and Synthesis of Non-peptide RGD Mimics for Evaluation of Their Utility as Anti-platelet Agents.

Authors:

Kazuhiro Higuchi Hideki Hikita Asumi Murayama Daichi Yuri Natsu Kobayakawa Takashi Takahashi Shigeru Kojima Hiroko Ueno Tomomi Hatakeyama Airi Kato Masanori Tayu Etsuko Oyama Shigeo Sugiyama Kazuyuki Ishii Hidenobu Takahashi Tomomi Kawasaki

Chem Pharm Bull (Tokyo) 2016 ;64(12):1726-1738

Meiji Pharmaceutical University.

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January 2017

Port-site implantation of Type A Masaoka Stage I thymoma after video-assisted thoracic surgery: a case report.

Authors:

Naohiro Nose Kazuhiro Higuchi Eiichi Chosa Takanori Ayabe Masaki Tomita Kunihide Nakamura

J Surg Case Rep 2016 Sep 25;2016(9). Epub 2016 Sep 25.

Division of Thoracic and Breast Surgery, Department of Surgery Faculty of Medicine, University Of Miyazaki, 5200 Kiyotake, Miyazaki 889-1692, Japan.

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September 2016

Synthesis and ABCG2 inhibitory evaluation of 5-N-acetylardeemin derivatives.

Authors:

Daigo Hayashi Naoki Tsukioka Yutaka Inoue Yoshiki Matsubayashi Toshimasa Iizuka Kazuhiro Higuchi Yoji Ikegami Tomomi Kawasaki

Bioorg Med Chem 2015 May 12;23(9):2010-23. Epub 2015 Mar 12.

Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan. Electronic address:

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May 2015

DMSO/Tf2O-mediated cross-coupling of tryptamine with substituted aniline to access C3a-N1'-linked pyrroloindoline alkaloids.

Authors:

Masanori Tayu Takako Ishizaki Kazuhiro Higuchi Tomomi Kawasaki

Org Biomol Chem 2015 Apr;13(13):3863-5

Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.

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April 2015

Asymmetric total synthesis of (-)-leuconoxine via chiral phosphoric acid catalyzed desymmetrization of a prochiral diester.

Authors:

Kazuhiro Higuchi Shin Suzuki Reeko Ueda Norifumi Oshima Emiko Kobayashi Masanori Tayu Tomomi Kawasaki

Org Lett 2015 Jan 19;17(1):154-7. Epub 2014 Dec 19.

Meiji Pharmaceutical University , 2-522-1 Noshio Kiyose, Tokyo 204-8588, Japan.

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January 2015

Thionium-based one-pot construction of homo-/heterodimeric pyrroloindoline from tryptamine.

Authors:

Masanori Tayu Kazuhiro Higuchi Takako Ishizaki Tomomi Kawasaki

Org Lett 2014 Jul 2;16(14):3613-5. Epub 2014 Jul 2.

Meiji Pharmaceutical University , 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.

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July 2014

Sulfoxide-TFAA and nucleophile combination as new reagent for aliphatic C-H functionalization at indole 2α-position.

Authors:

Masanori Tayu Kazuhiro Higuchi Masato Inaba Tomomi Kawasaki

Org Biomol Chem 2013 Jan 30;11(3):496-502. Epub 2012 Nov 30.

Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.

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January 2013

Synthesis of phenserine analogues and evaluation of their cholinesterase inhibitory activities.

Authors:

Masashi Shinada Fuminori Narumi Yuji Osada Koji Matsumoto Takayasu Yoshida Kazuhiro Higuchi Tomomi Kawasaki Hiroyuki Tanaka Mitsutoshi Satoh

Bioorg Med Chem 2012 Aug 6;20(16):4901-14. Epub 2012 Jul 6.

Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.

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August 2012

Osteosarcoma in Sprague-Dawley rats after long-term treatment with teriparatide (human parathyroid hormone (1-34)).

Authors:

Atsushi Watanabe Shigeki Yoneyama Mikio Nakajima Norihiro Sato Ryoko Takao-Kawabata Yukihiro Isogai Aki Sakurai-Tanikawa Kazuhiro Higuchi Akihito Shimoi Hideyuki Yamatoya Kenji Yoshida Terutomo Kohira

J Toxicol Sci 2012 ;37(3):617-29

Pharmaceuticals Research Center, Asahi Kasei Pharma Corporation, Shizuoka, Japan.

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October 2012

Active thionium species mediated functionalization at the 2α-position of indole derivatives.

Authors:

Kazuhiro Higuchi Masanori Tayu Tomomi Kawasaki

Chem Commun (Camb) 2011 Jun 10;47(23):6728-30. Epub 2011 May 10.

Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.

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June 2011

Total syntheses of (-)-fructigenine A and (-)-5-N-acetylardeemin.

Authors:

Satoshi Takiguchi Toshimasa Iizuka Yuh-suke Kumakura Kohta Murasaki Naoko Ban Kazuhiro Higuchi Tomomi Kawasaki

J Org Chem 2010 Feb;75(4):1126-31

Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.

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February 2010

First total synthesis of hinckdentine A.

Authors:

Kazuhiro Higuchi Yukihiro Sato Mei Tsuchimochi Kenta Sugiura Masatoshi Hatori Tomomi Kawasaki

Org Lett 2009 Jan;11(1):197-9

Meiji Pharmaceutical University, 2-522-1 Noshio Kiyose, Tokyo 204-8588, Japan.

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January 2009

Synthesis of the benzo-fused indolizidine alkaloid mimics.

Authors:

Daniel L Comins Kazuhiro Higuchi

Beilstein J Org Chem 2007 Nov 30;3:42. Epub 2007 Nov 30.

Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA.

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November 2007

Simple indole alkaloids and those with a nonrearranged monoterpenoid unit.

Authors:

Kazuhiro Higuchi Tomomi Kawasaki

Nat Prod Rep 2007 Aug 23;24(4):843-68. Epub 2007 Mar 23.

Meiji Pharmaceutical University, 2-522-1 Kiyose, Tokyo 204-8588, Japan.

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August 2007

Simple indole alkaloids and those with a nonrearranged monoterpenoid unit.

Authors:

Tomomi Kawasaki Kazuhiro Higuchi

Nat Prod Rep 2005 Dec 11;22(6):761-93. Epub 2005 Nov 11.

Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.

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December 2005

Asymmetric total synthesis of fredericamycin A: an intramolecular cycloaddition pathway.

Authors:

Shuji Akai Toshiaki Tsujino Nobuhisa Fukuda Kiyosei Iio Yoshifumi Takeda Ken-ichi Kawaguchi Tadaatsu Naka Kazuhiro Higuchi Emi Akiyama Hiromichi Fujioka Yasuyuki Kita

Chemistry 2005 Oct;11(21):6286-97

Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.

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October 2005

Gene expression of cardiac mast cell chymase and tryptase in a murine model of heart failure caused by viral myocarditis.

Authors:

Katsura Kitaura-Inenaga Masatake Hara Kazuhiro Higuchi Kanjo Yamamoto Akira Yamaki Koh Ono Atsushi Nakano Makoto Kinoshita Shigetake Sasayama Akira Matsumori

Circ J 2003 Oct;67(10):881-4

Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan.

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October 2003

A convenient synthesis of the beraprost intermediate: a useful method for introducing a C3 unit at the benzyl position.

Authors:

Kazuhiro Higuchi Kazuyuki Sawada Hisanori Nambu Takeshi Shogaki Yasuyuki Kita

Org Lett 2003 Oct;5(20):3703-4

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6, Yamada-oka, Suita, Osaka 565-0871, Japan.

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October 2003

Asymmetric Total Synthesis of Fredericamycin A.

Authors:

Yasuyuki Kita Kazuhiro Higuchi Yutaka Yoshida Kiyosei Iio Shinji Kitagaki Shuji Akai Hiromichi Fujioka

Angew Chem Int Ed Engl 1999 Mar;38(5):683-686

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6, Yamada-oka, Suita, Osaka 565-0871 (Japan), Fax: (+81) 6-6879-8229.

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March 1999

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