Publications

Effects of carbon monoxide on early dysfunction and microangiopathy following GalT-KO porcine pulmonary xenotransplantation in cynomolgus monkeys.
Xenotransplantation 2018 Jan 25;25(1). Epub 2017 Oct 25.
Division of Organ Replacement and Xenotransplantation Surgery, Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan.

Phase III, Randomized, Placebo-Controlled, Double-Blind Trial of Motesanib (AMG-706) in Combination With Paclitaxel and Carboplatin in East Asian Patients With Advanced Nonsquamous Non-Small-Cell Lung Cancer.
J Clin Oncol 2017 Nov 13;35(32):3662-3670. Epub 2017 Sep 13.
Kaoru Kubota, Nippon Medical School; Kaori Hara and Takayuki Asato, Takeda Pharmaceutical, Tokyo; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Fumihiro Oshita, Kanagawa Prefectural Ashigarakami Hospital, Matsuda; Toyoaki Hida, Aichi Cancer Center Hospital, Nagoya; Kiyotaka Yoh, National Cancer Center Hospital East, Chiba; Hidetoshi Hayashi, Hiroyasu Kaneda, and Kazuhiko Nakagawa, Kindai University Faculty of Medicine; Hidetoshi Hayashi, Kishiwada Municipal Hospital, Osaka; Terufumi Kato, Kanagawa Cardiovascular and Respiratory Center, Yokohama; Kazuhiko Yamada, Kurume University School of Medicine; Yukito Ichinose, National Kyushu Cancer Center, Fukuoka; Hiroshi Tanaka, Niigata Cancer Center Hospital, Niigata, Japan; Keunchil Park, Samsung Biomedical Research Institute, Seoul; Eun Kyung Cho, Gachon University; Kyung-Hee Lee, Inha University Hospital, Incheon, South Korea; Chih-Bin Lin, Buddhist Tzu-Chi General Hospital, Hualien; James Chih-Hsin Yang, National Taiwan University Hospital; National Taiwan University Cancer Center, Taipei City, Peoples Republic of China.

Hydrogen sulfide prevents renal ischemia-reperfusion injury in CLAWN miniature swine.
J Surg Res 2017 Nov 28;219:165-172. Epub 2017 Jun 28.
Division of Organ Replacement and Xenotransplantation Surgery, Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan. Electronic address:

Aplastic anemia in a lung adenocarcinoma patient receiving pemetrexed.
Invest New Drugs 2017 Oct 30;35(5):662-664. Epub 2017 Mar 30.
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.

DNA hypermethyation and silencing ofcorrelated with advanced stage and poor postoperative prognosis of esophageal squamous cell carcinoma.
Oncotarget 2017 Oct 28;8(48):84434-84448. Epub 2017 Sep 28.
Department of Gastroenterology, The Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Chiba, Japan.

Programmed cell death-ligand 1 expression and immunoscore in stage II and III non-small cell lung cancer patients receiving adjuvant chemotherapy.
Oncotarget 2017 Sep 27;8(37):61618-61625. Epub 2017 Jun 27.
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.

Fatty acids in a high-fat diet potentially induce gastric parietal-cell damage and metaplasia in mice.
J Gastroenterol 2017 Aug 21;52(8):889-903. Epub 2016 Nov 21.
Department of Gastroenterology, The Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.

Synchronous triple primary cancers of the pharynx and esophagus.
Clin J Gastroenterol 2017 Jun 17;10(3):208-213. Epub 2017 Mar 17.
Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-81-6 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Association of EGFR Exon 19 Deletion and EGFR-TKI Treatment Duration with Frequency of T790M Mutation in EGFR-Mutant Lung Cancer Patients.
Sci Rep 2016 Nov 4;6:36458. Epub 2016 Nov 4.
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan.

A multicenter phase II trial of S-1 combined with bevacizumab after platinum-based chemotherapy in patients with advanced non-squamous non-small cell lung cancer.
Cancer Chemother Pharmacol 2016 Sep 11;78(3):501-7. Epub 2016 Jul 11.
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka, 830-0011, Japan.

Telomere Visualization in Tissue Sections using Pyrrole-Imidazole Polyamide Probes.
Sci Rep 2016 Jul 6;6:29261. Epub 2016 Jul 6.
Structural Biology Center, National Institute of Genetics, and Department of Genetics, Sokendai (Graduate University for Advanced Studies), Mishima, Shizuoka 411-8540, Japan.


Predictive relevance of PD-L1 expression combined with CD8+ TIL density in stage III non-small cell lung cancer patients receiving concurrent chemoradiotherapy.
Eur J Cancer 2016 Mar 6;55:7-14. Epub 2016 Jan 6.
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan.

Salvage Esophagectomy After Definitive Chemoradiotherapy for Patients with Esophageal Squamous Cell Carcinoma: Who Really Benefits from this High-Risk Surgery?
Ann Surg Oncol 2015 Dec 11;22(13):4438-44. Epub 2015 Apr 11.
Department of Gastroenterological Surgery, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.

Intussusception causing postoperative intestinal obstruction following free jejunum transfer in adults: two case reports and review of the literature.
Surg Case Rep 2015 Dec 11;1(1):28. Epub 2015 Mar 11.
Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Ulcerative colitis in a patient with non-small-cell lung cancer receiving bevacizumab.
Invest New Drugs 2015 Oct 18;33(5):1133-5. Epub 2015 Aug 18.
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Kurume, Fukuoka, Japan.

Digital PCR analysis of plasma cell-free DNA for non-invasive detection of drug resistance mechanisms in EGFR mutant NSCLC: Correlation with paired tumor samples.
Oncotarget 2015 Oct;6(31):30850-8
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan.



Monitoring of Allogeneic Islet Grafts in Nonhuman Primates Using MRI.
Transplantation 2015 Aug;99(8):1574-81
1 Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA. 2 Division of Transplantation, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 3 Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA. 4 Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA.


Significance of programmed cell death-ligand 1 expression and its association with survival in patients with small cell lung cancer.
J Thorac Oncol 2015 Mar;10(3):426-30
*Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan; and †Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka, Japan.

Aberrant DNA hypermethylation reduces the expression of the desmosome-related molecule periplakin in esophageal squamous cell carcinoma.
Cancer Med 2015 Mar 12;4(3):415-25. Epub 2015 Jan 12.
Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.

Outcomes of lymphadenectomy for lymph node recurrence after esophagectomy or definitive chemoradiotherapy for squamous cell carcinoma of the esophagus.
Gen Thorac Cardiovasc Surg 2014 Nov 26;62(11):685-92. Epub 2014 Jun 26.
Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan,

Protective effect of neutralization of the extracellular high-mobility group box 1 on renal ischemia-reperfusion injury in miniature swine.
Transplantation 2014 Nov;98(9):937-43
1 Division of Organ Replacement and Xenotransplantation Surgery, Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan. 2 Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 3 Address correspondence to Kazuhiko Yamada, M.D., Ph.D., Center for Advanced Biomedical Science and Swine Research, Kagoshima University 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.

Lactobacillus salivarius WB21-containing tablets for the treatment of oral malodor: a double-blind, randomized, placebo-controlled crossover trial--reply to letter.
Oral Surg Oral Med Oral Pathol Oral Radiol 2014 Oct 18;118(4):506. Epub 2014 Jul 18.
Section of General Dentistry, Department of General Dentistry, Fukuoka Dental College, Fukuoka, Japan.

Rapid exchange between atmospheric CO2 and carbonate anion intercalated within magnesium rich layered double hydroxide.
ACS Appl Mater Interfaces 2014 Oct 13;6(20):18352-9. Epub 2014 Oct 13.
International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS) , 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.

Development of antidonor antibody directed toward non-major histocompatibility complex antigens in tolerant animals.
Transplantation 2014 Sep;98(5):514-9
1 Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 2 Catholic University of Louvain, Belgium. 3 Address correspondence to: David H. Sachs, M.D., Transplantation Biology Research Center, Massachusetts General Hospital, MGH-East, Bldg. 149-9019, 13th Street, Boston, MA, 02129.

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of xenocorneal transplantation.
Xenotransplantation 2014 Sep-Oct;21(5):420-30. Epub 2014 Sep 1.
Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea; Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea; Xenotransplantation Research Center, Seoul National University College Of Medicine and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.

The rejuvenating effects of leuprolide acetate on the aged baboon's thymus.
Transpl Immunol 2014 Sep 18;31(3):134-9. Epub 2014 Sep 18.
Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA 02129, United States; Harvard Medical School, Boston, MA 02129, United States.

Porcine cytomegalovirus infection is associated with early rejection of kidney grafts in a pig to baboon xenotransplantation model.
Transplantation 2014 Aug;98(4):411-8
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Cambridge, MA. 1 Address correspondence to: Kazuhiko Yamada, M.D., Ph.D., Organ Transplantation Tolerance and Xenotransplantation Laboratory, Transplantation Biology Research Center, Massachusetts General Hospital, MGH-East, Bldg. 149-9019, 13th Street, Boston, MA, 02129.

Results of life-supporting galactosyltransferase knockout kidneys in cynomolgus monkeys using two different sources of galactosyltransferase knockout Swine.
Transplantation 2014 Aug;98(4):419-26
1 Division of Organ Replacement and Xenotransplantation Surgery, Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan. 2 Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan. 3 Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 4 Research and Development Department, Nippon Institute for Biological Science, Tokyo, Japan. 5 Laboratory of Developmental Engineering, Meiji University School of Agriculture, Tokyo, Japan. 6 Address correspondence to: Kazuhiko Yamada, M.D., Ph.D., Center for Advanced Biomedical Science and Swine Research, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.

Landiolol hydrochloride for early postoperative tachycardia after transthoracic esophagectomy.
Surg Today 2014 May 15;44(5):848-54. Epub 2013 May 15.
Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo Hospital, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan,

Phase I study of carboplatin combined with pemetrexed for elderly patients with advanced non-squamous non-small cell lung cancer.
Jpn J Clin Oncol 2014 May 30;44(5):472-8. Epub 2014 Mar 30.
*Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan.

Feasibility re-evaluation of 75 mg/m² docetaxel in Japanese patients with previously treated non-small cell lung cancer.
Jpn J Clin Oncol 2014 Apr 30;44(4):338-45. Epub 2014 Jan 30.
*Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka 830-0011, Japan.

Lactobacillus salivarius WB21--containing tablets for the treatment of oral malodor: a double-blind, randomized, placebo-controlled crossover trial.
Oral Surg Oral Med Oral Pathol Oral Radiol 2014 Apr 20;117(4):462-70. Epub 2013 Dec 20.
Section of General Dentistry, Department of General Dentistry, Fukuoka Dental College, Fukuoka, Japan.

Vascularized composite allograft transplant survival in miniature swine: is MHC tolerance sufficient for acceptance of epidermis?
Transplantation 2013 Dec;96(11):966-74
1 Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 2 Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 3 Address correspondence to: Kazuhiko Yamada, M.D., Ph.D., Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, MGH-East, Building 149-9014, 13th Street, Boston, MA 02129.

Effective long-term immunosuppression in rats by subcutaneously implanted sustained-release tacrolimus pellet: effect on spinally grafted human neural precursor survival.
Exp Neurol 2013 Oct 5;248:85-99. Epub 2013 Jun 5.
Neuroregeneration Laboratory, Department of Anesthesiology, University of California - San Diego, La Jolla, CA, USA; Institute of Biology and Ecology, Faculty of Science, P.J. Safarik University, Moyzes street 11, 040 01 Kosice, Slovakia.


Phase II trial of erlotinib for Japanese patients with previously treated non-small-cell lung cancer harboring EGFR mutations: results of Lung Oncology Group in Kyushu (LOGiK0803).
Jpn J Clin Oncol 2013 Jun 18;43(6):629-35. Epub 2013 Apr 18.
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka 830-0011, Japan.

Comparison of adverse events and efficacy between gefitinib and erlotinib in patients with non-small-cell lung cancer: a retrospective analysis.
Med Oncol 2013 Mar 22;30(1):349. Epub 2012 Dec 22.
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka 830-0011, Japan.

Clinicopathological characteristics and survival difference between gastric stump carcinoma and primary upper third gastric cancer.
J Gastrointest Surg 2013 Feb 12;17(2):313-8. Epub 2012 Dec 12.
Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-10-6 Ariake, Koto-ku, Tokyo, 135-8550, Japan.


Chemotherapy for non-small cell lung cancer complicated by idiopathic interstitial pneumonia.
Oncol Lett 2012 Sep 12;4(3):477-482. Epub 2012 Jun 12.
Department of Internal Medicine, Division of Respirology, Neurology and Rheumatology, Kurume University, Kurume, Japan.


Degradation of p21Cip1 through anaphase-promoting complex/cyclosome and its activator Cdc20 (APC/CCdc20) ubiquitin ligase complex-mediated ubiquitylation is inhibited by cyclin-dependent kinase 2 in cardiomyocytes.
J Biol Chem 2011 Dec 1;286(51):44057-66. Epub 2011 Nov 1.
Laboratory of Genome Structure and Regulation, School of Biomedical Science, Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

Clinical practice in management of hydration for lung cancer patients receiving cisplatin-based chemotherapy in Japan: a questionnaire survey.
Jpn J Clin Oncol 2011 Nov 29;41(11):1308-11. Epub 2011 Sep 29.
Division of Respirology, Neurology and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka 830-0011, Japan.


Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway.
PLoS One 2011 26;6(10):e26848. Epub 2011 Oct 26.
Laboratory of Genome Structure and Regulation, School of Biomedical Science and Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

Prognostic value of EGFR mutation and ERCC1 in patients with non-small cell lung cancer undergoing platinum-based chemotherapy.
PLoS One 2013 5;8(8):e71356. Epub 2013 Aug 5.
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan.


Accuracy of transbronchial biopsy as a rebiopsy method for patients with relapse of advanced non-small-cell lung cancer after systemic chemotherapy.
BMJ Open Respir Res 2017 10;4(1):e000163. Epub 2017 Jan 10.
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine , Kurume University School of Medicine , Kurume, Fukuoka , Japan.


Preventive effect of kampo medicine (hangeshashin-to, TJ-14) plus minocycline against afatinib-induced diarrhea and skin rash in patients with non-small cell lung cancer.
Onco Targets Ther 2017 24;10:5107-5113. Epub 2017 Oct 24.
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University, Kurume City.

OF