Kayode K Ojo

Kayode K Ojo

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Kayode K Ojo

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Methionyl-tRNA synthetase inhibitor has potent in vivo activity in a novel Giardia lamblia luciferase murine infection model.

J Antimicrob Chemother 2020 Feb 3. Epub 2020 Feb 3.

Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1093/jac/dkz567DOI Listing
February 2020

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 04 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
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http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019

Development of 5-Aminopyrazole-4-carboxamide-based Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy.

J Med Chem 2019 03 15;62(6):3135-3146. Epub 2019 Mar 15.

Department of Medicine, Division of Allergy & Infectious Disease, Center for Emerging & Re-Emerging Infectious Disease (CERID) , University of Washington , Seattle , Washington 98109 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559944PMC
March 2019

Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum.

PLoS Negl Trop Dis 2018 08 6;12(8):e0006673. Epub 2018 Aug 6.

Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0006673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095626PMC
August 2018

Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis.

Antimicrob Agents Chemother 2018 07 26;62(7). Epub 2018 Jun 26.

Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA

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http://dx.doi.org/10.1128/AAC.00147-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021680PMC
July 2018

In vitro growth inhibition of Theileria equi by bumped kinase inhibitors.

Vet Parasitol 2018 Feb 1;251:90-94. Epub 2018 Jan 1.

Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, 99164, USA.

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http://dx.doi.org/10.1016/j.vetpar.2017.12.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959018PMC
February 2018

In vitro efficacy of bumped kinase inhibitors against Besnoitia besnoiti tachyzoites.

Int J Parasitol 2017 10 9;47(12):811-821. Epub 2017 Sep 9.

SALUVET, Animal Health Department, Faculty of Veterinary Sciences, Complutense University of Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ijpara.2017.08.005DOI Listing
October 2017

Extended-spectrum antiprotozoal bumped kinase inhibitors: A review.

Exp Parasitol 2017 Sep 5;180:71-83. Epub 2017 Jan 5.

Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exppara.2017.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498274PMC
September 2017

Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.

PLoS One 2016 8;11(8):e0160350. Epub 2016 Aug 8.

Center for Emerging and Re-emerging Infectious Diseases (CERID), Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160350PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976878PMC
August 2017

Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy.

Int J Parasitol 2016 Dec 8;46(13-14):871-880. Epub 2016 Oct 8.

Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, WA 98109, USA; Department of Global Health, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijpara.2016.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130624PMC
December 2016

Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G.

mBio 2016 12 6;7(6). Epub 2016 Dec 6.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA

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http://dx.doi.org/10.1128/mBio.02011-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142624PMC
December 2016

5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents.

Bioorg Med Chem Lett 2016 11 10;26(22):5487-5491. Epub 2016 Oct 10.

Division of Allergy & Infectious Disease, Center for Emerging & Reemerging Infectious Disease (CERID), University of Washington, Seattle, WA 98109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159281PMC
November 2016

Identification and Validation of Small-Gatekeeper Kinases as Drug Targets in Giardia lamblia.

PLoS Negl Trop Dis 2016 Nov 2;10(11):e0005107. Epub 2016 Nov 2.

Department of Biology, University of Washington, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0005107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091913PMC
November 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Bumped kinase inhibitor prohibits egression in Babesia bovis.

Vet Parasitol 2016 Jan 5;215:22-8. Epub 2015 Nov 5.

Department of Veterinary Microbiology & Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vetpar.2015.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724059PMC
January 2016

A novel CDPK1 inhibitor--a potential treatment for cryptosporidiosis in calves?

Parasitol Res 2015 Jan 15;114(1):335-6. Epub 2014 Nov 15.

Institut für Parasitologie, Universität Leipzig, An den Tierkliniken 35, 04103, Leipzig, Germany,

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http://dx.doi.org/10.1007/s00436-014-4228-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087976PMC
January 2015

Theileria equi isolates vary in susceptibility to imidocarb dipropionate but demonstrate uniform in vitro susceptibility to a bumped kinase inhibitor.

Parasit Vectors 2015 Jan 20;8:33. Epub 2015 Jan 20.

Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, 99164-7040, USA.

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http://www.parasitesandvectors.com/content/8/1/33
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http://dx.doi.org/10.1186/s13071-014-0611-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311422PMC
January 2015

The gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites.

Parasitology 2014 Sep 13;141(11):1499-1509. Epub 2014 Jun 13.

Center for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Seattle, USA.

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http://dx.doi.org/10.1017/S0031182014000857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390295PMC
September 2014

Bumped kinase inhibitor 1294 treats established Toxoplasma gondii infection.

Antimicrob Agents Chemother 2014 Jun 31;58(6):3547-9. Epub 2014 Mar 31.

Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA

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http://dx.doi.org/10.1128/AAC.01823-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068437PMC
June 2014

From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules.

ChemMedChem 2013 Jul 14;8(7):1127-37. Epub 2013 Jun 14.

Drug Discovery Unit (DDU), Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.201300072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728731PMC
July 2013

Nigeria's dracunculiasis eradication triumph and the need for caution.

J Infect Dev Ctries 2011 Dec 13;5(12):901-2. Epub 2011 Dec 13.

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http://dx.doi.org/10.3855/jidc.2315DOI Listing
December 2011

Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy.

Antimicrob Agents Chemother 2008 Oct 21;52(10):3710-7. Epub 2008 Jul 21.

Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195-7185, USA.

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http://dx.doi.org/10.1128/AAC.00364-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565902PMC
October 2008

Antimicrobial resistance gene distribution: a socioeconomic and sociocultural perspective.

GMS Krankenhhyg Interdiszip 2008 Sep 3;3(3):Doc26. Epub 2008 Sep 3.

Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831251PMC
September 2008

Growing problem of multidrug-resistant enteric pathogens in Africa.

Emerg Infect Dis 2007 Nov;13(11):1640-6

Department of Biology, Haverford College, Haverford, Pennsylvania 19041, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375797PMC
http://dx.doi.org/10.3201/eid1311.070674DOI Listing
November 2007

The presence of a conjugative Gram-positive Tn2009 in Gram-negative commensal bacteria.

J Antimicrob Chemother 2006 Jun 21;57(6):1065-9. Epub 2006 Mar 21.

Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1093/jac/dkl094DOI Listing
June 2006

CTX-M-15 extended-spectrum (beta)-lactamase from Nigerian Klebsiella pneumoniae.

J Antimicrob Chemother 2006 Jan 30;57(1):24-30. Epub 2005 Nov 30.

Department of Pharmaceutical Microbiology, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1093/jac/dki429DOI Listing
January 2006

Characterization of pRAS1-like plasmids from atypical North American psychrophilic Aeromonas salmonicida.

FEMS Microbiol Lett 2005 Jan;242(1):59-63

Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Box 357238, Seattle, WA 98195-7238, USA.

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http://dx.doi.org/10.1016/j.femsle.2004.10.039DOI Listing
January 2005

Distribution and molecular analysis of mef(A)-containing elements in tetracycline-susceptible and -resistant Streptococcus pyogenes clinical isolates with efflux-mediated erythromycin resistance.

J Antimicrob Chemother 2004 Dec 24;54(6):991-8. Epub 2004 Nov 24.

Institute of Microbiology and Biomedical Sciences, Marche Polytechnic University, 60131 Ancona, Italy.

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http://dx.doi.org/10.1093/jac/dkh481DOI Listing
December 2004

Nucleotide sequence and organization of the multiresistance plasmid pSCFS1 from Staphylococcus sciuri.

J Antimicrob Chemother 2004 Nov 7;54(5):936-9. Epub 2004 Oct 7.

Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft (FAL), Höltystrasse 10, 31535 Neustadt-Mariensee, Germany.

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http://academic.oup.com/jac/article/54/5/936/812075/Nucleoti
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http://dx.doi.org/10.1093/jac/dkh457DOI Listing
November 2004

Gram-positive merA gene in gram-negative oral and urine bacteria.

FEMS Microbiol Lett 2004 Sep;238(2):411-6

University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.femsle.2004.08.004DOI Listing
September 2004

Staphylococcus sciuri gene erm(33), encoding inducible resistance to macrolides, lincosamides, and streptogramin B antibiotics, is a product of recombination between erm(C) and erm(A).

Antimicrob Agents Chemother 2002 Nov;46(11):3621-3

Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft (FAL), 31535 Neustadt-Mariensee, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC128728PMC
http://dx.doi.org/10.1128/aac.46.11.3621-3623.2002DOI Listing
November 2002