Publications by authors named "Kaylene J Simpson"

70Publications

Loss of HPV type 16 E7 restores cGAS-STING responses in human papilloma virus-positive oropharyngeal squamous cell carcinomas cells.

J Microbiol Immunol Infect 2020 Jul 30. Epub 2020 Jul 30.

Menzies Health Institute Queensland, School of Medical Science, Griffith University, Southport, Queensland, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jmii.2020.07.010DOI Listing
July 2020

GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma.

J Pathol 2020 Nov 15;252(3):317-329. Epub 2020 Sep 15.

Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/path.5528DOI Listing
November 2020

Lysosomal degradation products induce virulence.

Proc Natl Acad Sci U S A 2020 03 9;117(12):6801-6810. Epub 2020 Mar 9.

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia;

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http://dx.doi.org/10.1073/pnas.1921344117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104363PMC
March 2020

FGFR3 signaling and function in triple negative breast cancer.

Cell Commun Signal 2020 Jan 27;18(1):13. Epub 2020 Jan 27.

Cancer Program, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.

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http://dx.doi.org/10.1186/s12964-019-0486-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986078PMC
January 2020

Society of Biomolecular Imaging and Informatics Special Issue.

Assay Drug Dev Technol 2019 01;17(1):1-2

2 Peter MacCallum Cancer Centre, Melbourne, Australia.

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http://dx.doi.org/10.1089/adt.2018.29086.sbi2DOI Listing
January 2019

Society of Biomolecular Imaging and Informatics Special Issue.

Assay Drug Dev Technol 2018 Aug/Sep;16(6):289-290

2 Peter MacCallum Cancer Centre , Melbourne, Australia .

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http://dx.doi.org/10.1089/adt.2018.29080.ediDOI Listing
October 2019

A Comprehensive Protocol Resource for Performing Pooled shRNA and CRISPR Screens.

Methods Mol Biol 2018 ;1725:201-227

Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-4939-7568-6_17DOI Listing
January 2019

Discovering cancer vulnerabilities using high-throughput micro-RNA screening.

Nucleic Acids Res 2017 Dec;45(22):12657-12670

The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.

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http://dx.doi.org/10.1093/nar/gkx1072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728403PMC
December 2017

A Functional Kinase Short Interfering Ribonucleic Acid Screen Using Protease-Activated Receptor 2-Dependent Opening of Transient Receptor Potential Vanilloid-4.

Assay Drug Dev Technol 2018 01 17;16(1):15-26. Epub 2017 Nov 17.

1 School of Health and Biomedical Sciences, RMIT University , Bundoora, Australia .

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http://dx.doi.org/10.1089/adt.2017.799DOI Listing
January 2018

Society of Biomolecular Imaging and Informatics Special Issue.

Assay Drug Dev Technol 2017 Aug/Sep;15(6):237-238

2 Peter MacCallum Cancer Centre , Melbourne, Australia .

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http://dx.doi.org/10.1089/adt.2017.29063.ediDOI Listing
July 2019

Signalome-wide assessment of host cell response to hepatitis C virus.

Nat Commun 2017 05 8;8:15158. Epub 2017 May 8.

Infection &Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton Victoria 3800, Australia.

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http://dx.doi.org/10.1038/ncomms15158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424167PMC
May 2017

Systematic high-content genome-wide RNAi screens of endothelial cell migration and morphology.

Sci Data 2017 03 1;4:170009. Epub 2017 Mar 1.

Tumour Angiogenesis Program, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Victoria 3000, Australia.

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http://dx.doi.org/10.1038/sdata.2017.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332011PMC
March 2017

Knocking down the obstacles to functional genomics data sharing.

Sci Data 2017 03 1;4:170019. Epub 2017 Mar 1.

ICCB-Longwood Screening Facility, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/sdata.2017.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332007PMC
March 2017

Metabolic profiling and in vitro assessment of anthelmintic fractions of Picria fel-terrae Lour.

Int J Parasitol Drugs Drug Resist 2016 12 26;6(3):171-178. Epub 2016 Aug 26.

Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, 3800, Australia; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, 3010, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ijpddr.2016.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030326PMC
December 2016

A Phenotypic High-Content Screening Assay to Identify Regulators of Membrane Protein Localization.

Assay Drug Dev Technol 2016 10 23;14(8):478-488. Epub 2016 Sep 23.

1 Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre , Victoria, Australia .

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http://dx.doi.org/10.1089/adt.2016.733DOI Listing
October 2016

Society of Biomolecular Imaging and Informatics Special Issue, October 2016.

Assay Drug Dev Technol 2016 10 23;14(8):437-438. Epub 2016 Sep 23.

2 Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre , Melbourne, Australia .

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http://dx.doi.org/10.1089/adt.2016.29046.ediDOI Listing
October 2016

Society of Biomolecular Imaging and Informatics Special Issue.

Assay Drug Dev Technol 2016 09;14(7):365-6

2 Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre , Parkville, Australia .

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http://dx.doi.org/10.1089/adt.2016.29045.ediDOI Listing
September 2016

An interactive web-based application for Comprehensive Analysis of RNAi-screen Data.

Nat Commun 2016 Feb 23;7:10578. Epub 2016 Feb 23.

Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncomms10578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477503PMC
February 2016

Phosphorylation of NS5A Serine-235 is essential to hepatitis C virus RNA replication and normal replication compartment formation.

Virology 2016 Apr 10;491:27-44. Epub 2016 Feb 10.

School of Biological Sciences and Research Centre for Infectious Diseases, University of Adelaide, Adelaide, Australia; Centre for Cancer Biology, SA Pathology, Adelaide, Australia.

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http://dx.doi.org/10.1016/j.virol.2016.01.018DOI Listing
April 2016

Colloquium: SBI(2) HCS/HCA Informatics and Data Analysis--Best Practices and Unmet Needs September 15, 2015.

Assay Drug Dev Technol 2015 Nov;13(9):509-14

3 Peter MacCallum Cancer Centre , East Melbourne, Australia .

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http://dx.doi.org/10.1089/adt.2015.29027.colDOI Listing
November 2015

Society of Biomolecular Imaging and Informatics Special Issue, November 2015.

Assay Drug Dev Technol 2015 Nov;13(9):507-8

Guest Editor.

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http://dx.doi.org/10.1089/adt.2015.29028.mfeDOI Listing
November 2015

Society of Biomolecular Imaging and Informatics special issue.

Assay Drug Dev Technol 2015 Sep 14;13(7):339-40. Epub 2015 Aug 14.

Guest Editor.

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http://dx.doi.org/10.1089/adt.2015.29019.mfeDOI Listing
September 2015

High-content assay for measuring intracellular growth of Leishmania in human macrophages.

Assay Drug Dev Technol 2015 Sep 6;13(7):389-401. Epub 2015 Aug 6.

1 Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne , Parkville, Australia .

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http://dx.doi.org/10.1089/adt.2015.652DOI Listing
September 2015

Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma.

Clin Cancer Res 2015 Jul 10;21(14):3216-29. Epub 2015 Apr 10.

St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia. Department of Medicine, St. Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, Australia. ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-3026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506243PMC
July 2015

Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition.

Mol Cancer Ther 2015 Jun 7;14(6):1495-503. Epub 2015 Apr 7.

Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0039DOI Listing
June 2015

Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin-Deficient Cells.

Mol Cancer Ther 2015 May 16;14(5):1213-23. Epub 2015 Mar 16.

Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-1092DOI Listing
May 2015

Whole-genome multiparametric screening to identify modulators of epithelial-to-mesenchymal transition.

Assay Drug Dev Technol 2014 Sep;12(7):385-94

1 University of Malaya , Kuala Lumpur, Malaysia .

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http://dx.doi.org/10.1089/adt.2014.593DOI Listing
September 2014

High-throughput approaches to measuring cell death.

Cold Spring Harb Protoc 2014 Jun 2;2014(6):591-601. Epub 2014 Jun 2.

Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1101/pdb.top072561DOI Listing
June 2014

A high-throughput, multiplex cell death assay using an RNAi screening approach.

Cold Spring Harb Protoc 2014 Jun 2;2014(6):663-76. Epub 2014 Jun 2.

Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1101/pdb.prot080267DOI Listing
June 2014

Functional genomics down under: RNAi screening in the Victorian Centre for Functional Genomics.

Comb Chem High Throughput Screen 2014 May;17(4):343-55

Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.2174/1386207317666140323134315DOI Listing
May 2014

Genome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat.

Sci Data 2014 8;1:140017. Epub 2014 Jul 8.

Victorian Centre for Functional Genomics, The Peter MacCallum Cancer Centre , St Andrews Place, East Melbourne, Victoria 3002, Australia ; Sir Peter MacCallum Department of Oncology, The University of Melbourne , Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1038/sdata.2014.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322586PMC
November 2015

A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation.

J Cell Sci 2013 Dec 17;126(Pt 23):5377-90. Epub 2013 Sep 17.

School of Biomedical Sciences, The University of Queensland, St. Lucia, Queensland, 4072, Australia.

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http://dx.doi.org/10.1242/jcs.128280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843137PMC
December 2013

Strategies and challenges for systematically mapping biologically significant molecular pathways regulating carcinoma epithelial-mesenchymal transition.

Cells Tissues Organs 2013 14;197(6):424-34. Epub 2013 Jun 14.

University of Malaya, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1159/000351717DOI Listing
January 2014

Functional analysis of genes in regions commonly amplified in high-grade serous and endometrioid ovarian cancer.

Clin Cancer Res 2013 Mar 29;19(6):1411-21. Epub 2013 Jan 29.

Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3433DOI Listing
March 2013

Comparative high-throughput RNAi screening methodologies in C. elegans and mammalian cells.

N Biotechnol 2012 May 28;29(4):459-70. Epub 2012 Jan 28.

Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Australia.

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http://dx.doi.org/10.1016/j.nbt.2012.01.003DOI Listing
May 2012

Psidin, a conserved protein that regulates protrusion dynamics and cell migration.

Genes Dev 2011 Apr 15;25(7):730-41. Epub 2011 Mar 15.

Department of Biological Chemistry, Center for Cell Dynamics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1101/gad.2028611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070935PMC
April 2011

FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.

Mol Cell Biol 2009 Sep 29;29(18):4906-17. Epub 2009 Jun 29.

Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Griffin Building, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.1128/MCB.00077-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738298PMC
September 2009

Identification of genes that regulate epithelial cell migration using an siRNA screening approach.

Nat Cell Biol 2008 Sep;10(9):1027-38

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncb1762DOI Listing
September 2008

Posttranscriptional regulation of the breast cancer susceptibility gene BRCA1 by the RNA binding protein HuR.

Cancer Res 2008 Nov;68(22):9469-78

School of Molecular and Microbial Sciences, The University of Queensland and The Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1159DOI Listing
November 2008

Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1.

Curr Biol 2008 Apr;18(7):532-7

Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1016/j.cub.2008.03.024DOI Listing
April 2008

Generation of a functional mammary gland from a single stem cell.

Nature 2006 Jan;439(7072):84-8

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1038/nature04372DOI Listing
January 2006

The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo.

Cancer Res 2005 Dec;65(23):10970-6

Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2327DOI Listing
December 2005

Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma.

Cancer Res 2004 Dec;64(23):8694-701

Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston Massachusetts 02215, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-04-2247DOI Listing
December 2004

MMTV-trBrca1 mice display strain-dependent abnormalities in vaginal development.

Int J Dev Biol 2004 Sep;48(7):675-8

Department of Biochemistry and Molecular Biology, University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1387/ijdb.041849ksDOI Listing
September 2004

Brca1 inactivation induces p27(Kip1)-dependent cell cycle arrest and delayed development in the mouse mammary gland.

Oncogene 2004 Aug;23(36):6136-45

Molecular Oncology Laboratory, Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne 3002, Australia.

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http://www.nature.com/articles/1207805
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http://dx.doi.org/10.1038/sj.onc.1207805DOI Listing
August 2004

The comparative biology of whey proteins.

J Mammary Gland Biol Neoplasia 2002 Jul;7(3):313-26

Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1023/a:1022856801175DOI Listing
July 2002

Maternal regulation of milk composition, milk production, and pouch young development during lactation in the tammar wallaby (Macropus eugenii ).

Biol Reprod 2003 Mar;68(3):929-36

Division of Molecular Biology and Genetics, Victorian Institute of Animal Science, Attwood, Victoria 3049, Australia.

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http://dx.doi.org/10.1095/biolreprod.102.005934DOI Listing
March 2003