Kaye J Williams

Kaye J Williams

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Kaye J Williams

Kaye J Williams

Publications by authors named "Kaye J Williams"

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Preclinical dosimetry: exploring the use of small animal phantoms.

Radiat Oncol 2019 Jul 31;14(1):134. Epub 2019 Jul 31.

Division of Cancer Sciences, University of Manchester, Manchester Cancer Research Centre, 3rd floor Proton Beam Therapy Centre, Oak Road, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1186/s13014-019-1343-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670203PMC
July 2019

Evaluating the Efficiency of Hyaluronic Acid for Tumor Targeting via CD44.

Mol Pharm 2019 Jun 1;16(6):2481-2493. Epub 2019 May 1.

Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health , University of Manchester and Manchester Academic Health Science Centre , Stopford Building , Manchester M13 9PT , U.K.

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00083DOI Listing
June 2019

Clinical Development of Novel Drug-Radiotherapy Combinations.

Clin Cancer Res 2019 Mar 29;25(5):1455-1461. Epub 2018 Nov 29.

Radiation Oncology, NIHR University College London Hospitals Biomedical Research Centre, University College London Cancer Institute, University College London, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397668PMC
March 2019

Multi-modal imaging of long-term recovery post-stroke by positron emission tomography and matrix-assisted laser desorption/ionisation mass spectrometry.

Rapid Commun Mass Spectrom 2018 May;32(9):721-729

Wolfson Molecular Imaging Centre, Division of Informatics, Imaging and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1002/rcm.8090DOI Listing
May 2018

Data-driven mapping of hypoxia-related tumor heterogeneity using DCE-MRI and OE-MRI.

Magn Reson Med 2018 04 30;79(4):2236-2245. Epub 2017 Aug 30.

Division of Informatics, Imaging & Data Sciences, The University of Manchester, Manchester, UK.

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http://doi.wiley.com/10.1002/mrm.26860
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http://dx.doi.org/10.1002/mrm.26860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836865PMC
April 2018

Novel carbonic anhydrase IX-targeted therapy enhances the anti-tumour effects of cisplatin in small cell lung cancer.

Int J Cancer 2018 01 3;142(1):191-201. Epub 2017 Oct 3.

Division of Diabetes, Endocrinology & Gastroenterology, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1002/ijc.31042DOI Listing
January 2018

Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer.

BMC Clin Pathol 2017 28;17:27. Epub 2017 Dec 28.

Gynaecological Oncology Research Group, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Level 5 - Research, St Mary's Hospital, Oxford Road, Manchester, M13 9WL UK.

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http://dx.doi.org/10.1186/s12907-017-0067-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745908PMC
December 2017

High-Affinity "Click" RGD Peptidomimetics as Radiolabeled Probes for Imaging α β Integrin.

ChemMedChem 2017 07 3;12(14):1142-1151. Epub 2017 Jul 3.

Institute of Medical Sciences and Kosterlitz Centre for Therapeutics, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK.

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http://dx.doi.org/10.1002/cmdc.201700328DOI Listing
July 2017

Imaging biomarker roadmap for cancer studies.

Nat Rev Clin Oncol 2017 03 11;14(3):169-186. Epub 2016 Oct 11.

CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/nrclinonc.2016.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378302PMC
March 2017

Tubulin-binding dibenz[c,e]oxepines: Part 2. Structural variation and biological evaluation as tumour vasculature disrupting agents.

Bioorg Med Chem 2017 03 19;25(5):1630-1642. Epub 2017 Jan 19.

Manchester Pharmacy School, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1016/j.bmc.2017.01.027DOI Listing
March 2017

-Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer.

Medchemcomm 2017 Mar 17;8(3):551-558. Epub 2017 Feb 17.

Division of Pharmacy and Optometry , School of Health Sciences , Manchester Academic Health Sciences Centre , University of Manchester , Manchester , M13 9PL , UK . Email:

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http://dx.doi.org/10.1039/c6md00691dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072501PMC
March 2017

Radiation enhances the therapeutic effect of Banoxantrone in hypoxic tumour cells with elevated levels of nitric oxide synthase.

Oncol Rep 2016 Apr 13;35(4):1925-32. Epub 2016 Jan 13.

Experimental Oncology Group, Manchester Pharmacy School, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.3892/or.2016.4555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774668PMC
April 2016

Dissemination via the lymphatic or angiogenic route impacts the pathology, microenvironment and hypoxia-related drug response of lung metastases.

Clin Exp Metastasis 2015 Aug 26;32(6):567-77. Epub 2015 Jun 26.

Hypoxia & Therapeutics Group, Manchester Pharmacy School, University of Manchester, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1007/s10585-015-9728-zDOI Listing
August 2015

Binary behaviour of an oxidation-responsive MRI nano contrast agent.

Chem Commun (Camb) 2015 Jan;51(6):1074-6

Manchester Pharmacy School, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1039/c4cc08024fDOI Listing
January 2015

Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport.

Mol Cancer Ther 2014 Dec 3;13(12):2805-16. Epub 2014 Oct 3.

Manchester Pharmacy School, Manchester Cancer Research Centre, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-1091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258406PMC
December 2014

Transmission FT-IR chemical imaging on glass substrates: applications in infrared spectral histopathology.

Anal Chem 2014 Feb 17;86(3):1648-53. Epub 2014 Jan 17.

Manchester Institute of Biotechnology, University of Manchester , 131 Princess Street, Manchester M1 7DN, U.K.

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http://dx.doi.org/10.1021/ac403412nDOI Listing
February 2014

Detection of apoptosis by PET/CT with the diethyl ester of [¹⁸F]ML-10 and fluorescence imaging with a dansyl analogue.

Bioorg Med Chem 2014 Jan 20;22(1):341-9. Epub 2013 Nov 20.

Wolfson Molecular Imaging Centre, University of Manchester, M20 3LJ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2013.11.019DOI Listing
January 2014

A novel untargeted metabolomics correlation-based network analysis incorporating human metabolic reconstructions.

BMC Syst Biol 2013 Oct 23;7:107. Epub 2013 Oct 23.

School of Chemistry, Manchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, UK.

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http://dx.doi.org/10.1186/1752-0509-7-107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874763PMC
October 2013

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Breast Cancer Res 2013 Oct 1;15(5):R92. Epub 2013 Oct 1.

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http://dx.doi.org/10.1186/bcr3493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907091PMC
October 2013

Inhibiting the phosphatidylinositide 3-kinase pathway blocks radiation-induced metastasis associated with Rho-GTPase and Hypoxia-inducible factor-1 activity.

Radiother Oncol 2013 Sep 25;108(3):548-53. Epub 2013 Jul 25.

Hypoxia and Therapeutics Group, Manchester Pharmacy School, University of Manchester, UK.

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http://dx.doi.org/10.1016/j.radonc.2013.06.027DOI Listing
September 2013

Inhibition of carbonic anhydrase activity modifies the toxicity of doxorubicin and melphalan in tumour cells in vitro.

J Enzyme Inhib Med Chem 2013 Apr 19;28(2):360-9. Epub 2012 Nov 19.

Hypoxia and Therapeutics Group, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.3109/14756366.2012.736979DOI Listing
April 2013

Carbonic anhydrase IX as a target for metastatic disease.

Bioorg Med Chem 2013 Mar 11;21(6):1470-6. Epub 2012 Oct 11.

Hypoxia and Therapeutics Group, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Stopford Building, Oxford Road, Rm. 3.125, M13 9PL Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.bmc.2012.09.062DOI Listing
March 2013

Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.

J Med Chem 2012 Jun 5;55(11):5591-600. Epub 2012 Jun 5.

Hypoxia and Therapeutics Group, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom.

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http://pubs.acs.org/doi/10.1021/jm300529u
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http://dx.doi.org/10.1021/jm300529uDOI Listing
June 2012

GDC-0941 inhibits metastatic characteristics of thyroid carcinomas by targeting both the phosphoinositide-3 kinase (PI3K) and hypoxia-inducible factor-1α (HIF-1α) pathways.

J Clin Endocrinol Metab 2011 Dec 12;96(12):E1934-43. Epub 2011 Oct 12.

Hypoxia and Therapeutics Group, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom.

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http://dx.doi.org/10.1210/jc.2011-1426DOI Listing
December 2011

Hypoxia-inducible factor in thyroid carcinoma.

J Thyroid Res 2011 16;2011:762905. Epub 2011 Jun 16.

Hypoxia and Therapeutics Group, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.4061/2011/762905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134378PMC
November 2011

In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts.

Mol Cancer Ther 2009 Dec;8(12):3266-75

Experimental Oncology Group, School of Pharmacology & Pharmaceutical Sciences, University of Manchester and Manchester Cancer Research Center, Stopford Building, Oxford Road, Manchester M13 9PT, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-0396DOI Listing
December 2009

Antiangiogenics and radiotherapy.

J Pharm Pharmacol 2008 Aug;60(8):1029-36

University of Manchester, Department of Pharmacy, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1211/jpp.60.8.0009DOI Listing
August 2008

Overexpression of cytochrome P450 NADPH reductase sensitises MDA 231 breast carcinoma cells to 5-fluorouracil: possible mechanisms involved.

Toxicol In Vitro 2008 Apr 7;22(3):582-8. Epub 2007 Dec 7.

National Institute for Cellular Biotechnology (NICB), Dublin City University, Glasnevin, Dublin 9, Ireland.

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http://dx.doi.org/10.1016/j.tiv.2007.11.017DOI Listing
April 2008

Hypoxia-targeted over-expression of carboxylesterase as a means of increasing tumour sensitivity to irinotecan (CPT-11).

J Gene Med 2007 Apr;9(4):244-52

Paterson Institute for Cancer Research, Christie Hospital NHS Trust, and School of Pharmacy and Pharmaceutical Sciences, University of Manchester, UK.

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http://dx.doi.org/10.1002/jgm.1016DOI Listing
April 2007

Combining radiotherapy with AZD2171, a potent inhibitor of vascular endothelial growth factor signaling: pathophysiologic effects and therapeutic benefit.

Mol Cancer Ther 2007 Feb;6(2):599-606

Department of Pharmacy, University of Manchester, Coupland Street, Manchester M13 9PL, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-06-0508DOI Listing
February 2007

Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1.

Mol Pharmacol 2006 Feb 27;69(2):411-8. Epub 2005 Oct 27.

Experimental Oncology, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, UK.

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http://dx.doi.org/10.1124/mol.105.015743DOI Listing
February 2006

Cancer chemotherapy and drug metabolism.

Drug Metab Dispos 2005 Aug;33(8):1083-96

Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1124/dmd.105.004374DOI Listing
August 2005

Tirapazamine administered as a neoadjuvant to radiotherapy reduces metastatic dissemination.

Clin Cancer Res 2005 Jun;11(11):4212-6

School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-2162DOI Listing
June 2005

Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumor cells.

Int J Radiat Oncol Biol Phys 2005 May;62(1):213-22

School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.ijrobp.2005.01.031DOI Listing
May 2005

Hypoxia in tumors: molecular targets for anti-cancer therapeutics.

Adv Enzyme Regul 2004 ;44:93-108

School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Manchester M13 9PL, UK.

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http://dx.doi.org/10.1016/j.advenzreg.2003.11.019DOI Listing
March 2005

Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy.

J Clin Invest 2004 Dec;114(12):1800-11

Tumour Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1172/JCI22046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535067PMC
December 2004

Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: reversing tumor radioresistance and effecting cure.

Cancer Res 2004 Feb;64(4):1396-402

School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Coupland III Building, Oxford Road, Manchester M13 9PL, UK.

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February 2004

Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors.

Radiother Oncol 2004 Jan;70(1):91-7

Division of Experimental Therapy, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.radonc.2003.09.012DOI Listing
January 2004

3-substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro.

Biochem Pharmacol 2003 Oct;66(7):1199-206

School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.

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http://dx.doi.org/10.1016/s0006-2952(03)00452-0DOI Listing
October 2003

Combining bioreductive drugs and radiation for the treatment of solid tumors.

Semin Radiat Oncol 2003 Jan;13(1):42-52

School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1053/srao.2003.50008DOI Listing
January 2003

Antiangiogenic, bioreductive and gene therapy approaches to the treatment of hypoxic tumours.

Curr Pharm Des 2002 ;8(15):1319-33

School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

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http://dx.doi.org/10.2174/1381612023394548DOI Listing
November 2002

Rescue of hypoxia-inducible factor-1alpha-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor.

Cancer Res 2002 May;62(10):2962-70

Institute of Physiology, Section of Diagnostic Imaging, School of Veterinary Medicine, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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May 2002

Synthesis and enzymatic evaluation of pyridinium-substituted uracil derivatives as novel inhibitors of thymidine phosphorylase.

Bioorg Med Chem 2002 Mar;10(3):525-30

School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.

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http://dx.doi.org/10.1016/s0968-0896(01)00309-1DOI Listing
March 2002

Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): evidence of an anabolic role for the HIF-1 pathway.

Cancer Res 2002 Feb;62(3):688-95

CRC Biomedical Magnetic Resonance Research Group, Department of Biochemistry and Immunology, St. George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK.

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February 2002