Kay-Uwe Wagner

Kay-Uwe Wagner

UNVERIFIED PROFILE

Are you Kay-Uwe Wagner?   Register this Author

Register author
Kay-Uwe Wagner

Kay-Uwe Wagner

Publications by authors named "Kay-Uwe Wagner"

Are you Kay-Uwe Wagner?   Register this Author

96Publications

1423Reads

50Profile Views

The Multifaceted Roles of the Tumor Susceptibility Gene 101 (TSG101) in Normal Development and Disease.

Cancers (Basel) 2020 Feb 14;12(2). Epub 2020 Feb 14.

Department of Oncology, Wayne State University School of Medicine and Tumor Biology Program, Barbara Ann Karmanos Cancer Institute, 4100 John R, EL01TM, Detroit, MI 48201, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers12020450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073217PMC
February 2020

Efficient tissue-type specific expression of target genes in a tetracycline-controlled manner from the ubiquitously active Eef1a1 locus.

Sci Rep 2020 Jan 14;10(1):207. Epub 2020 Jan 14.

Department of Oncology, Wayne State University School of Medicine and Tumor Biology Program, Barbara Ann Karmanos Cancer Institute, 4100 John R, EL01TM, Detroit, MI, 48201, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-57052-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959320PMC
January 2020

Regulation and New Treatment Strategies in Breast Cancer.

J Life Sci (Westlake Village) 2019 Dec;1(3):23-38

Karmanos Cancer Institute at Wayne State University School of Medicine, Detroit, MI 48202.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039658PMC
December 2019

Tsg101 positively regulates physiologic-like cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R.

FASEB J 2019 Jun 18;33(6):7451-7466. Epub 2019 Mar 18.

Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201802338RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529337PMC
June 2019

Loss of Jak2 protects cardiac allografts from chronic rejection by attenuating Th1 response along with increased regulatory T cells.

Am J Transl Res 2019 15;11(2):624-640. Epub 2019 Feb 15.

The Center for Biomedical Research, Ministry of Education and Ministry of Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413256PMC
February 2019

Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression.

Cell Rep 2018 11;25(8):2192-2207.e5

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE 68198-5950, USA; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; Tumor Biology Program, Barbara Ann Karmanos Cancer Institute, 4100 John R Street, EL01TM, Detroit, MI 48201, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.10.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431084PMC
November 2018

AKT3 drives adenoid cystic carcinoma development in salivary glands.

Cancer Med 2018 02 28;7(2):445-453. Epub 2017 Dec 28.

Department of Physiology, Center of Physiology and Pharmacology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cam4.1293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806106PMC
February 2018

Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells.

Mol Cell Endocrinol 2017 08 8;451:31-39. Epub 2017 May 8.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198-6805, USA; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198-6805, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03037207173024
Publisher Site
http://dx.doi.org/10.1016/j.mce.2017.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515553PMC
August 2017

Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers.

Cell Rep 2017 02;18(9):2243-2255

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE 68198-5950, USA; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE 68198-5950, USA; Department of Pathology and Microbiology, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE 68198-5950, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2017.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369772PMC
February 2017

Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation.

Proc Natl Acad Sci U S A 2016 12 5;113(51):E8228-E8237. Epub 2016 Dec 5.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1615677113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187741PMC
December 2016

Generation of Janus kinase 1 (JAK1) conditional knockout mice.

Genesis 2016 Nov 19;54(11):582-588. Epub 2016 Oct 19.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, Nebraska, 68198-5950, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dvg.22982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988131PMC
November 2016

Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy.

Biol Cell 2016 Nov 23;108(11):324-337. Epub 2016 Aug 23.

McLaughlin Research Institute, Great Falls, MT, 59405, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/boc.201600014DOI Listing
November 2016

Genetically engineered mucin mouse models for inflammation and cancer.

Cancer Metastasis Rev 2015 Dec;34(4):593-609

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10555-015-9549-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520780PMC
December 2015

Mouse models of breast cancer.

Methods Mol Biol 2015 ;1267:47-71

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE, 68198-5950, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-2297-0_3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492279PMC
September 2015

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets.

Nat Commun 2015 Apr 9;6:6744. Epub 2015 Apr 9.

1] Simmons Cancer Center, UT Southwestern Medical Center, Dallas, Texas 75390, USA [2] Department of Pathology, UT Southwestern Medical Center, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms7744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403382PMC
April 2015

Generation of conditional knockout mice.

Methods Mol Biol 2014 ;1194:21-35

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, DRCII, Rm. 5031, 985950 Nebraska Medical Center, Omaha, NE, 68198-5950, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-1215-5_2DOI Listing
March 2015

Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells.

Stem Cells 2014 Jul;32(7):1878-89

Department of Pharmacology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/stem.1711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063883PMC
July 2014

Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis.

Mol Cell Biol 2014 Apr 27;34(7):1363-77. Epub 2014 Jan 27.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.

View Article

Download full-text PDF

Source
http://mcb.asm.org/cgi/doi/10.1128/MCB.01220-13
Publisher Site
http://dx.doi.org/10.1128/MCB.01220-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993568PMC
April 2014

Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies.

Cancer Res 2014 Apr 26;74(8):2138-43. Epub 2014 Mar 26.

Authors' Affiliations: Eppley Institute for Research in Cancer and Allied Diseases; and Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-13-3437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992817PMC
April 2014

Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cells.

BMC Cancer 2014 Mar 15;14:195. Epub 2014 Mar 15.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE 68198-5950, U,S,A.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2407-14-195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068023PMC
March 2014

D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells.

Mol Cell Endocrinol 2014 Jan 4;382(1):583-592. Epub 2013 Apr 4.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE 68198-5950, USA; Department of Pathology and Microbiology, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE 68198-5950, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mce.2013.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740091PMC
January 2014

Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.

PLoS One 2013 2;8(4):e60902. Epub 2013 Apr 2.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060902PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614894PMC
September 2013

Loss of Jak2 impairs endothelial function by attenuating Raf-1/MEK1/Sp-1 signaling along with altered eNOS activities.

Am J Pathol 2013 Aug 6;183(2):617-25. Epub 2013 Jun 6.

Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2013.04.007DOI Listing
August 2013

Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.

Mol Endocrinol 2013 Aug 19;27(8):1333-42. Epub 2013 Jun 19.

Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2013-1110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188962PMC
August 2013

G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.

J Biol Chem 2013 May 2;288(19):13842-9. Epub 2013 Apr 2.

Departments of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M113.450049
Publisher Site
http://dx.doi.org/10.1074/jbc.M113.450049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650420PMC
May 2013

Generation of a novel MMTV-tTA transgenic mouse strain for the targeted expression of genes in the embryonic and postnatal mammary gland.

PLoS One 2012 31;7(8):e43778. Epub 2012 Aug 31.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043778PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432039PMC
February 2013

A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death.

PLoS One 2012 30;7(3):e34308. Epub 2012 Mar 30.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034308PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316634PMC
November 2012

The two faces of Janus kinases and their respective STATs in mammary gland development and cancer.

J Carcinog 2011 8;10:32. Epub 2011 Dec 8.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, DRC2, Rm. 5033, Omaha, NE, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/1477-3163.90677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262999PMC
August 2012

Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells.

Cell Signal 2012 Jun;24(6):1276-86

Dpto. Biología del Cáncer, Instituto de Investigaciones Biomédicas A. Sols (CSIC/UAM), Arturo Duperier 4, 28029 Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2012.02.011DOI Listing
June 2012

BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia.

Nat Chem Biol 2012 Jan 29;8(3):285-93. Epub 2012 Jan 29.

CeMM-Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nchembio.775
Publisher Site
http://dx.doi.org/10.1038/nchembio.775DOI Listing
January 2012

IRF4 is a suppressor of c-Myc induced B cell leukemia.

PLoS One 2011 27;6(7):e22628. Epub 2011 Jul 27.

Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022628PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144921PMC
December 2011

Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression.

Cancer Res 2011 Dec 28;71(24):7513-24. Epub 2011 Oct 28.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-11-1783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242818PMC
December 2011

Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species.

Cardiovasc Res 2011 Jul 24;91(1):171-9. Epub 2011 Feb 24.

Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvr059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112021PMC
July 2011

Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH.

Mol Endocrinol 2011 Jul 28;25(7):1223-30. Epub 2011 Apr 28.

University of California, San Francisco (UCSF), Cardiovascular Research Institute, San Francisco, California 94158-9001, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2011-0047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125097PMC
July 2011

Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice.

J Mol Cell Cardiol 2011 Jun 17;50(6):1026-34. Epub 2011 Mar 17.

Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2011.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092026PMC
June 2011

Jak2 is necessary for neuroendocrine control of female reproduction.

J Neurosci 2011 Jan;31(1):184-92

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.2974-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079260PMC
January 2011

ESCRT proteins: Double-edged regulators of cellular signaling.

Bioarchitecture 2011 Jan;1(1):45-48

Eppley Institute for Research in Cancer and Allied Diseases and UNMC-Eppley Cancer Center; Omaha, NE USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/bioa.1.1.15173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158637PMC
January 2011

Erythropoietin protects against diabetes through direct effects on pancreatic beta cells.

J Exp Med 2010 Dec 13;207(13):2831-42. Epub 2010 Dec 13.

Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A1, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20100665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005231PMC
December 2010

Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.

Proc Natl Acad Sci U S A 2010 Nov 25;107(45):19455-60. Epub 2010 Oct 25.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1008271107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984176PMC
November 2010

Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions.

Proc Natl Acad Sci U S A 2010 Sep 30;107(37):16107-12. Epub 2010 Aug 30.

Eppley Institute for Research in Cancer and Allied Diseases and University of Nebraska Medical Center-Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1009471107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941294PMC
September 2010

Temporally and spatially controlled expression of transgenes in embryonic and adult tissues.

Transgenic Res 2010 Jun 8;19(3):499-509. Epub 2009 Oct 8.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, DRCII, Rm. 5033, Omaha, NE 68198-5950, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11248-009-9329-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866092PMC
June 2010

Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.

Mol Cell Biol 2010 Jun 12;30(12):2957-70. Epub 2010 Apr 12.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE 68198-5950, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.00851-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876679PMC
June 2010

Targeting janus kinase 2 in Her2/neu-expressing mammary cancer: Implications for cancer prevention and therapy.

Cancer Res 2009 Aug 28;69(16):6642-50. Epub 2009 Jul 28.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, 68198-5950, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-09-0746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758773PMC
August 2009

Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging.

Genesis 2009 Apr;47(4):234-45

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198-6805, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dvg.20480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775060PMC
April 2009

A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis.

Neoplasia 2008 Dec;10(12):1325-34

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586683PMC
http://dx.doi.org/10.1593/neo.08524DOI Listing
December 2008

Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression.

J Mammary Gland Biol Neoplasia 2008 Mar 29;13(1):93-103. Epub 2008 Jan 29.

Eppley Institute for Research in Cancer and Allied Diseases, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10911-008-9062-zDOI Listing
March 2008

Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice.

Proc Natl Acad Sci U S A 2007 Sep 4;104(37):14718-23. Epub 2007 Sep 4.

Department of Cell and Cancer Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0706933104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976199PMC
September 2007

The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells.

Mol Endocrinol 2007 Aug 22;21(8):1877-92. Epub 2007 May 22.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198-6805, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2006-0316DOI Listing
August 2007

Parity-induced mammary epithelial cells are multipotent and express cell surface markers associated with stem cells.

Dev Biol 2007 Mar 13;303(1):29-44. Epub 2006 Dec 13.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Rm. 8009, Omaha, NE 68198-6805, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ydbio.2006.12.017DOI Listing
March 2007

Epithelial-specific and stage-specific functions of insulin-like growth factor-I during postnatal mammary development.

Endocrinology 2006 Nov 10;147(11):5412-23. Epub 2006 Aug 10.

Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2006-0427DOI Listing
November 2006

Expression of the whey acidic protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells.

Genesis 2005 Sep;43(1):1-11

Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gene.20149DOI Listing
September 2005

Loss of the LIM domain protein Lmo4 in the mammary gland during pregnancy impedes lobuloalveolar development.

Oncogene 2005 Jul;24(30):4820-8

The Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, 1G Royal Parade, Parkville, VIC 3050, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.onc.1208638DOI Listing
July 2005

Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expression.

Oncogene 2005 Jan;24(4):552-60

Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.onc.1208185DOI Listing
January 2005

Pregnancy and stem cell behavior.

J Mammary Gland Biol Neoplasia 2005 Jan;10(1):25-36

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10911-005-2538-1DOI Listing
January 2005

Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS.

Cell Cycle 2004 Nov 8;3(11):1451-6. Epub 2004 Nov 8.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.3.11.1211DOI Listing
November 2004

Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice.

Oncogene 2004 Sep;23(41):6980-5

Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198-6805, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.onc.1207827DOI Listing
September 2004

Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice.

Genesis 2004 Sep;40(1):52-7

Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gene.20063DOI Listing
September 2004

Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells.

J Biol Chem 2004 Aug 21;279(34):35984-94. Epub 2004 Jun 21.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198-6805, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M400408200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201394PMC
August 2004

Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice.

Mol Cell Biol 2004 Jun;24(12):5510-20

Eppley Institute for Research in Cancer and Allied Diseases and Department of Pathology, University of Nebraska Medical Center, Omaha, 68198-6805, USA.

View Article

Download full-text PDF

Source
http://mcb.asm.org/cgi/doi/10.1128/MCB.24.12.5510-5520.2004
Publisher Site
http://dx.doi.org/10.1128/MCB.24.12.5510-5520.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419899PMC
June 2004

Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.

Cancer Res 2004 Mar;64(6):1959-65

Advanced Medical Discovery Institute, University Health Network, 620 University Avenue, Suite 706, Toronto, Ontario M5G 2C1, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.can-03-2270DOI Listing
March 2004

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten.

Proc Natl Acad Sci U S A 2004 Feb 27;101(6):1725-30. Epub 2004 Jan 27.

Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute and University Health Network, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0308217100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC341836PMC
February 2004

Models of breast cancer: quo vadis, animal modeling?

Authors:
Kay-Uwe Wagner

Breast Cancer Res 2004 31;6(1):31-8. Epub 2003 Oct 31.

University of Nebraska Medical Center, Omaha, Nebraska, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/bcr723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC314446PMC
January 2004

Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5.

Development 2003 Nov 3;130(21):5257-68. Epub 2003 Sep 3.

Department of Structural and Cellular Biology, Tulane Cancer Center, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, Louisiana 70112-2699, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.00715DOI Listing
November 2003

Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation.

Oncogene 2003 Jun;22(25):3875-87

Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.onc.1206426DOI Listing
June 2003

HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland.

Development 2003 Apr;130(8):1713-24

Division of Biological Sciences, Molecular Biology Section, University of California San Diego, La Jolla, CA 92093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.00403DOI Listing
April 2003

Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues.

Mol Cell Biol 2003 Jan;23(1):150-62

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68198-6805, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC140677PMC
http://dx.doi.org/10.1128/mcb.23.1.150-162.2003DOI Listing
January 2003

Targeted deletion of the Tsg101 gene results in cell cycle arrest at G1/S and p53-independent cell death.

J Biol Chem 2002 Nov 29;277(45):43216-23. Epub 2002 Aug 29.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198-6805, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M207662200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201509PMC
November 2002

Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.

Development 2002 Sep;129(17):4159-70

Department of Molecular and Medical Pharmacology, UCLA School of Medicine, 650 Circle Drive South, 90095-1735, USA.

View Article

Download full-text PDF

Source
http://dev.biologists.org/content/develop/129/17/4159.full.p
Web Search
September 2002

Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility.

J Biol Chem 2002 May 7;277(20):17830-5. Epub 2002 Mar 7.

Laboratory of Genetics and Physiology, NIDDK, the Laboratory of Immunoregulation, Immune Activation Section, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M200186200
Publisher Site
http://dx.doi.org/10.1074/jbc.M200186200DOI Listing
May 2002

Basal activation of transcription factor signal transducer and activator of transcription (Stat5) in nonpregnant mouse and human breast epithelium.

Mol Endocrinol 2002 May;16(5):1108-24

United States Military Cancer Institute and Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20852, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/mend/article-lookup/doi/10.1210/men
Publisher Site
http://dx.doi.org/10.1210/mend.16.5.0839DOI Listing
May 2002

An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal.

Development 2002 Mar;129(6):1377-86

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Rm. 8009, Omaha, NE 68198-6805, USA.

View Article

Download full-text PDF

Source
March 2002

Bcl-x is not required for maintenance of follicles and corpus luteum in the postnatal mouse ovary.

Biol Reprod 2002 Feb;66(2):438-44

Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1095/biolreprod66.2.438DOI Listing
February 2002