Kay M Tye

Kay M Tye

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Kay M Tye

Publications by authors named "Kay M Tye"

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Neural mechanisms of social homeostasis.

Ann N Y Acad Sci 2019 12 15;1457(1):5-25. Epub 2019 Mar 15.

Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/nyas.14016
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http://dx.doi.org/10.1111/nyas.14016DOI Listing
December 2019

Hippocampal-Prefrontal Theta Transmission Regulates Avoidance Behavior.

Neuron 2019 11 11;104(3):601-610.e4. Epub 2019 Sep 11.

Integrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA; National Institute of Mental Health, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842114PMC
November 2019

A cortical-brainstem circuit predicts and governs compulsive alcohol drinking.

Science 2019 11;366(6468):1008-1012

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.aay1186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989100PMC
November 2019

Viewpoints: Approaches to defining and investigating fear.

Nat Neurosci 2019 08;22(8):1205-1216

Salk Institute for Biological Studies, La Jolla, California, USA.

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http://dx.doi.org/10.1038/s41593-019-0456-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943931PMC
August 2019

Dopamine tunes prefrontal outputs to orchestrate aversive processing.

Brain Res 2019 Jun 1;1713:16-31. Epub 2018 Dec 1.

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2018.11.044DOI Listing
June 2019

Leveraging calcium imaging to illuminate circuit dysfunction in addiction.

Alcohol 2019 02 6;74:47-63. Epub 2018 Jun 6.

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; The Salk Institute for Biological Sciences, 10010 N Torrey Pines Road, La Jolla, CA 92037, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07418329183008
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http://dx.doi.org/10.1016/j.alcohol.2018.05.013DOI Listing
February 2019

Double threat in striatal dopamine signaling.

Nat Neurosci 2018 10;21(10):1296-1297

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41593-018-0243-9DOI Listing
October 2018

Neural Circuit Motifs in Valence Processing.

Authors:
Kay M Tye

Neuron 2018 10;100(2):436-452

Picower Institute for Learning and Memory, Dept of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA; Salk Institute for Biological Sciences, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590698PMC
October 2018

Estimating a Separably Markov Random Field from Binary Observations.

Neural Comput 2018 04 30;30(4):1046-1079. Epub 2018 Jan 30.

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, U.S.A.

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http://dx.doi.org/10.1162/neco_a_01059DOI Listing
April 2018

Editorial overview: Neurobiology of behavior.

Curr Opin Neurobiol 2018 04 8;49:iv-ix. Epub 2018 Mar 8.

Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2018.02.019DOI Listing
April 2018

Organization of Valence-Encoding and Projection-Defined Neurons in the Basolateral Amygdala.

Cell Rep 2018 01 28;22(4):905-918. Epub 2018 Jan 28.

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.12.097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891824PMC
January 2018

A light- and calcium-gated transcription factor for imaging and manipulating activated neurons.

Nat Biotechnol 2017 Sep 26;35(9):864-871. Epub 2017 Jun 26.

Departments of Genetics, Biology, and Chemistry, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1038/nbt.3909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595644PMC
September 2017

A New Handle for a Hot Topic: Genetic Markers for Warm-Sensing.

Cell 2016 Sep;167(1):43-44

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.09.016DOI Listing
September 2016

Architectural Representation of Valence in the Limbic System.

Neuropsychopharmacology 2016 06 9;41(7):1697-715. Epub 2015 Dec 9.

Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/npp.2015.358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869057PMC
June 2016

Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation.

Neuron 2016 06 26;90(6):1286-1298. Epub 2016 May 26.

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961212PMC
June 2016

Divergent Routing of Positive and Negative Information from the Amygdala during Memory Retrieval.

Neuron 2016 04 31;90(2):348-361. Epub 2016 Mar 31.

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.

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http://dx.doi.org/10.1016/j.neuron.2016.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854303PMC
April 2016

Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation.

Cell 2016 Feb;164(4):617-31

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.12.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752823PMC
February 2016

Resolving the neural circuits of anxiety.

Nat Neurosci 2015 Oct 25;18(10):1394-404. Epub 2015 Sep 25.

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nn.4101DOI Listing
October 2015

A circuit mechanism for differentiating positive and negative associations.

Nature 2015 Apr;520(7549):675-8

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nature14366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418228PMC
April 2015

From circuits to behaviour in the amygdala.

Nature 2015 Jan;517(7534):284-92

Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://tyelab.org/wp-content/uploads/2015/01/From-circuits-t
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http://www.nature.com/doifinder/10.1038/nature14188
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http://dx.doi.org/10.1038/nature14188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565157PMC
January 2015

Decoding neural circuits that control compulsive sucrose seeking.

Cell 2015 Jan;160(3):528-41

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312417PMC
January 2015

In vivo optogenetic stimulation of the rodent central nervous system.

J Vis Exp 2015 Jan 15(95):51483. Epub 2015 Jan 15.

Department of Psychiatry, University of Pittsburgh Medical Center.

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http://dx.doi.org/10.3791/51483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354526PMC
January 2015

Neural circuit reprogramming: a new paradigm for treating neuropsychiatric disease?

Authors:
Kay M Tye

Neuron 2014 Sep;83(6):1259-61

Picower Institute for Learning and Memory, Brain & Cognitive Sciences Department, MIT, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565154PMC
September 2014

Noninvasive optical inhibition with a red-shifted microbial rhodopsin.

Nat Neurosci 2014 Aug 6;17(8):1123-9. Epub 2014 Jul 6.

1] Media Lab, Department of Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [3] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nn.3752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184214PMC
August 2014

Deciphering memory function with optogenetics.

Prog Mol Biol Transl Sci 2014 ;122:341-90

Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1016/B978-0-12-420170-5.00012-XDOI Listing
July 2014

Optogenetic insights on the relationship between anxiety-related behaviors and social deficits.

Front Behav Neurosci 2014 16;8:241. Epub 2014 Jul 16.

Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology Cambridge, MA, USA.

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http://dx.doi.org/10.3389/fnbeh.2014.00241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099964PMC
July 2014

Natural neural projection dynamics underlying social behavior.

Cell 2014 Jun;157(7):1535-51

Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123133PMC
June 2014

PTEN knockdown alters dendritic spine/protrusion morphology, not density.

J Comp Neurol 2014 Apr;522(5):1171-90

Department of Neurology & Neurotherapeutics, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390-8813; Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390-8813.

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http://dx.doi.org/10.1002/cne.23488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945606PMC
April 2014

Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior.

J Neurosci 2014 Jan;34(2):586-95

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.4257-13.2
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http://dx.doi.org/10.1523/JNEUROSCI.4257-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870937PMC
January 2014

BLA to vHPC inputs modulate anxiety-related behaviors.

Neuron 2013 Aug;79(4):658-64

The Picower Institute for Learning and Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.neuron.2013.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205569PMC
August 2013

Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors.

Brain Res 2013 May 8;1511:73-92. Epub 2012 Nov 8.

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000689931201776
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http://dx.doi.org/10.1016/j.brainres.2012.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099056PMC
May 2013

Input-specific control of reward and aversion in the ventral tegmental area.

Nature 2012 Nov 14;491(7423):212-7. Epub 2012 Oct 14.

Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nature11527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493743PMC
November 2012

Glutamate inputs to the nucleus accumbens: does source matter?

Authors:
Kay M Tye

Neuron 2012 Nov;76(4):671-3

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.neuron.2012.11.008DOI Listing
November 2012

Optogenetic investigation of neural circuits underlying brain disease in animal models.

Nat Rev Neurosci 2012 Mar 20;13(4):251-66. Epub 2012 Mar 20.

Department of Bioengineering, Stanford University, 318 Campus Drive, Clark Center, Stanford, California 94305-5444, USA.

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http://dx.doi.org/10.1038/nrn3171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682316PMC
March 2012

GABA neurons of the VTA drive conditioned place aversion.

Neuron 2012 Mar 21;73(6):1173-83. Epub 2012 Mar 21.

Department of Basic Neurosciences, University of Geneva, 1211 Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.neuron.2012.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690362PMC
March 2012

Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking.

Nature 2011 Jun 29;475(7356):377-80. Epub 2011 Jun 29.

Department of Psychiatry, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1038/nature10194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775282PMC
June 2011

High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels.

Proc Natl Acad Sci U S A 2011 May 19;108(18):7595-600. Epub 2011 Apr 19.

Experimental Biophysics, Humboldt-Universität zu Berlin, D-10115 Berlin, Germany.

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http://dx.doi.org/10.1073/pnas.1017210108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088623PMC
May 2011

Neuroplastic alterations in the limbic system following cocaine or alcohol exposure.

Curr Top Behav Neurosci 2010 ;3:3-27

Department of Neurology, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1007/7854_2009_23DOI Listing
January 2011

Methylphenidate facilitates learning-induced amygdala plasticity.

Nat Neurosci 2010 Apr 7;13(4):475-81. Epub 2010 Mar 7.

Ernest Gallo Clinic & Research Center, University of California, San Francisco, Emeryville, California, USA.

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http://dx.doi.org/10.1038/nn.2506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988577PMC
April 2010

Amygdala neural encoding of the absence of reward during extinction.

J Neurosci 2010 Jan;30(1):116-25

Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California 94608, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4240-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632518PMC
January 2010

Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning.

Nature 2008 Jun 11;453(7199):1253-7. Epub 2008 May 11.

Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA.

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http://dx.doi.org/10.1038/nature06963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759353PMC
June 2008

Amygdala neurons differentially encode motivation and reinforcement.

J Neurosci 2007 Apr;27(15):3937-45

Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5281-06.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672525PMC
April 2007