Kay L Double

Kay L Double

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Kay L Double

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Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease.

Aging Cell 2019 Dec 20;18(6):e13031. Epub 2019 Aug 20.

Brain and Mind Centre and Discipline of Pharmacology, Faculty of Medical and Health, The University of Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1111/acel.13031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826160PMC
December 2019

Meta-analysis of copper and iron in Parkinson's disease brain and biofluids.

Mov Disord 2019 Dec 31. Epub 2019 Dec 31.

Brain and Mind Centre and Discipline of Pharmacology, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.1002/mds.27947DOI Listing
December 2019

Expression of tyrosine hydroxylase isoforms and phosphorylation at serine 40 in the human nigrostriatal system in Parkinson's disease.

Neurobiol Dis 2019 10 2;130:104524. Epub 2019 Jul 2.

School of Biomedical Sciences and Pharmacy and Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.104524DOI Listing
October 2019

Reduction in IGF1 mRNA in the Human Subependymal Zone During Aging.

Aging Dis 2019 Feb 1;10(1):197-204. Epub 2019 Feb 1.

1Schizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, Australia.

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http://dx.doi.org/10.14336/AD.2018.0317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345338PMC
February 2019

Accumulation of dysfunctional SOD1 protein in Parkinson's disease is not associated with mutations in the SOD1 gene.

Acta Neuropathol 2018 01 19;135(1):155-156. Epub 2017 Oct 19.

Discipline of Biomedical Science and Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.

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http://dx.doi.org/10.1007/s00401-017-1779-6DOI Listing
January 2018

Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers.

Aging Cell 2017 10 1;16(5):1195-1199. Epub 2017 Aug 1.

Discipline of Biomedical Science and Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.

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http://dx.doi.org/10.1111/acel.12641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595679PMC
October 2017

Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain.

Metallomics 2017 10;9(10):1447-1455

Discipline of Biomedical Science and Brain and Mind Centre, Sydney Medical School, The University of Sydney, Camperdown, NSW 2006, Australia.

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http://dx.doi.org/10.1039/c7mt00244kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647261PMC
October 2017

Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease.

Metallomics 2017 07;9(7):852-864

School of Medical Sciences (Pharmacology), and Bosch Institute, The University of Sydney, New South Wales 2006, Australia.

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http://dx.doi.org/10.1039/c7mt00039aDOI Listing
July 2017

Reducing the burden of neurological disease and mental illness.

Med J Aust 2017 05;206(8):341-342

Queensland Brain Institute, University of Queensland, Brisbane, QLD.

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http://dx.doi.org/10.5694/mja17.00141DOI Listing
May 2017

Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson's disease.

NPJ Parkinsons Dis 2017 5;3. Epub 2017 Jan 5.

Department of Medicine (Royal Melbourne Hospital) at the Doherty Institute, The University of Melbourne, Parkville, Melbourne, VIC Australia.

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http://dx.doi.org/10.1038/s41531-016-0004-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460187PMC
January 2017

Tension-referenced measures of gastrocnemius slack length and stiffness in Parkinson's disease.

Mov Disord 2016 12 11;31(12):1914-1918. Epub 2016 Mar 11.

Sydney Medical School, University of Sydney, NSW, Australia.

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http://dx.doi.org/10.1002/mds.26530DOI Listing
December 2016

Decline in Proliferation and Immature Neuron Markers in the Human Subependymal Zone during Aging: Relationship to EGF- and FGF-Related Transcripts.

Front Aging Neurosci 2016 25;8:274. Epub 2016 Nov 25.

Schizophrenia Research Laboratory, Neuroscience Research AustraliaSydney, NSW, Australia; Schizophrenia Research InstituteSydney, NSW, Australia; School of Psychiatry, Faculty of Medicine, University of New South WalesSydney, NSW, Australia.

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http://dx.doi.org/10.3389/fnagi.2016.00274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123444PMC
November 2016

Copper dyshomoeostasis in Parkinson's disease: implications for pathogenesis and indications for novel therapeutics.

Clin Sci (Lond) 2016 Apr;130(8):565-74

Brain and Mind Centre and Discipline of Biomedical Sciences, School of Medical Sciences, Sydney Medical School, The University of Sydney, Sydney, NSW 2050, Australia

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http://www.clinsci.org/content/ppclinsci/130/8/565.full.pdf
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http://dx.doi.org/10.1042/CS20150153DOI Listing
April 2016

Iron and dopamine: a toxic couple.

Brain 2016 Apr;139(Pt 4):1026-35

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http://dx.doi.org/10.1093/brain/aww022DOI Listing
April 2016

Using Sepia melanin as a PD model to describe the binding characteristics of neuromelanin - A critical review.

J Chem Neuroanat 2015 Mar-Apr;64-65:20-32. Epub 2015 Feb 11.

School of Pharmacy and Medical Sciences, University of South Australia, North Terrace, Adelaide, SA 5000, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jchemneu.2015.02.001DOI Listing
February 2016

Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway.

PLoS One 2014 11;9(3):e91151. Epub 2014 Mar 11.

Schizophrenia Research Institute, Sydney, New South Wales, Australia; Schizophrenia Research Laboratory, Neuroscience Research Australia, Sydney, New South Wales, Australia; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091151PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949980PMC
May 2015

Upper limb function is normal in patients with restless legs syndrome (Willis-Ekbom Disease).

Clin Neurophysiol 2015 Apr 18;126(4):736-42. Epub 2014 Jul 18.

Discipline of Biomedical Sciences, School of Medical Sciences, Sydney Medical School, University of Sydney, Darlington, NSW 2008, Australia; Neuroscience Research Australia, Randwick, NSW 2031, Australia.

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http://dx.doi.org/10.1016/j.clinph.2014.07.010DOI Listing
April 2015

Testosterone attenuates and the selective estrogen receptor modulator, raloxifene, potentiates amphetamine-induced locomotion in male rats.

Horm Behav 2015 Apr 5;70:73-84. Epub 2015 Mar 5.

Schizophrenia Research Institute, Sydney, Australia; Schizophrenia Research Laboratory, Neuroscience Research Australia, Barker Street, Sydney, Australia; School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S0018506X150003
Publisher Site
http://dx.doi.org/10.1016/j.yhbeh.2015.02.005DOI Listing
April 2015

Hand function is impaired in healthy older adults at risk of Parkinson's disease.

J Neural Transm (Vienna) 2014 Nov 3;121(11):1377-86. Epub 2014 May 3.

School of Pharmacy and Medical Sciences and Sansom Institute, University of South Australia, GPO Box 2471, Adelaide, SA, 5001, Australia,

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http://dx.doi.org/10.1007/s00702-014-1218-yDOI Listing
November 2014

Copper pathology in vulnerable brain regions in Parkinson's disease.

Neurobiol Aging 2014 Apr 2;35(4):858-66. Epub 2013 Oct 2.

Neuroscience Research Australia, Sydney, Australia; School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia; Discipline of Biomedical Science, School of Medical Sciences, Sydney Medical School, The University of Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.09.034DOI Listing
April 2014

Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra.

Mov Disord 2013 Sep 14;28(10):1351-9. Epub 2013 May 14.

Neuroscience Research Australia and the School of Medical Sciences, University of New South Wales, Randwick, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1002/mds.25493DOI Listing
September 2013

Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease.

Neurobiol Aging 2013 Mar 24;34(3):873-86. Epub 2012 Aug 24.

Neuroscience Research Australia and the School of Medical Sciences, The University of New South Wales, Randwick, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.07.019DOI Listing
March 2013

Localization of copper and copper transporters in the human brain.

Metallomics 2013 Jan;5(1):43-51

Neuroscience Research Australia and The University of New South Wales, Randwick, NSW 2031, Australia.

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http://dx.doi.org/10.1039/c2mt20151hDOI Listing
January 2013

L-DOPA is incorporated into brain proteins of patients treated for Parkinson's disease, inducing toxicity in human neuroblastoma cells in vitro.

Exp Neurol 2012 Nov 1;238(1):29-37. Epub 2011 Oct 1.

The Cell Biology Group, The Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW 2042, Australia.

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http://dx.doi.org/10.1016/j.expneurol.2011.09.029DOI Listing
November 2012

Neuronal vulnerability in Parkinson's disease.

Authors:
Kay L Double

Parkinsonism Relat Disord 2012 Jan;18 Suppl 1:S52-4

Neurosdence Research Australia and University of New South Wales, Sydney, NSW, 2031, Australia.

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http://dx.doi.org/10.1016/S1353-8020(11)70018-9DOI Listing
January 2012

Low serum progranulin predicts the presence of mutations: a prospective study.

J Alzheimers Dis 2010 ;22(3):981-4

Neuroscience Research Australia and the University of New South Wales, Randwick, Australia.

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http://dx.doi.org/10.3233/JAD-2010-101032DOI Listing
June 2011

Pathophysiology of transcranial sonography signal changes in the human substantia nigra.

Int Rev Neurobiol 2010 ;90:107-20

Neuroscience Research Australia and the University of New South Wales, Sydney, NSW, Australia.

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http://dx.doi.org/10.1016/S0074-7742(10)90008-1DOI Listing
March 2011

Effect of age on proliferation-regulating factors in human adult neurogenic regions.

J Neurochem 2010 Nov 28;115(4):956-64. Epub 2010 Sep 28.

Brain Sciences University of New South Wales, Randwick, NSW, Australia.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06992.xDOI Listing
November 2010

Neuromelanin-bound ferric iron as an experimental model of dopaminergic neurodegeneration in Parkinson's disease.

Parkinsonism Relat Disord 2008 27;14 Suppl 2:S185-8. Epub 2008 Jun 27.

University of Würzburg, Department of Child and Adolescent Psychiatry and Psychotherapy, Laboratory for Clinical Neurobiology, Würzburg, Germany.

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http://dx.doi.org/10.1016/j.parkreldis.2008.04.028DOI Listing
December 2008

Haplotype analysis of the IGF2-INS-TH gene cluster in Parkinson's disease.

Am J Med Genet B Neuropsychiatr Genet 2008 Jun;147B(4):495-9

School of Biomolecular and Biomedical Sciences, Eskitis Institute, Griffith University, Brisbane, Australia.

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http://dx.doi.org/10.1002/ajmg.b.30633DOI Listing
June 2008

Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.

Brain 2005 Nov 6;128(Pt 11):2654-64. Epub 2005 Jul 6.

Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1093/brain/awh584DOI Listing
November 2005

Differential effects of human neuromelanin and synthetic dopamine melanin on neuronal and glial cells.

J Neurochem 2005 Oct 31;95(2):599-608. Epub 2005 Aug 31.

Clinical Neurochemistry and National Parkinson Foundation Center of Excellence Laboratories, Clinic and Policlinic for Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2005.03404.xDOI Listing
October 2005

Dolichol is the major lipid component of human substantia nigra neuromelanin.

J Neurochem 2005 Feb;92(4):990-5

Centre for Vascular Research, University of New South Wales, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02975.xDOI Listing
February 2005

Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease.

Neurotox Res 2003 ;5(1-2):35-44

Clinical Neurochemistry, Department of Child and Youth Psychiatry and Psychotherapy, University of Würzburg, Füchsleinstrasse 15, D-97080 Würzburg, Germany.

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http://dx.doi.org/10.1007/bf03033371DOI Listing
November 2003

Iron-binding characteristics of neuromelanin of the human substantia nigra.

Biochem Pharmacol 2003 Aug;66(3):489-94

Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia.

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http://dx.doi.org/10.1016/s0006-2952(03)00293-4DOI Listing
August 2003

Identifying the pattern of olfactory deficits in Parkinson disease using the brief smell identification test.

Arch Neurol 2003 Apr;60(4):545-9

Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1001/archneur.60.4.545DOI Listing
April 2003