Kay Huebner

Kay Huebner

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Kay Huebner

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Abrogation of esophageal carcinoma development in miR-31 knockout rats.

Proc Natl Acad Sci U S A 2020 Mar 2;117(11):6075-6085. Epub 2020 Mar 2.

Department of Cancer Biology and Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210;

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http://dx.doi.org/10.1073/pnas.1920333117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084137PMC
March 2020

PREFACE.

Authors:
Kay Huebner

Genes Chromosomes Cancer 2019 05 28;58(5):257-259. Epub 2019 Jan 28.

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http://dx.doi.org/10.1002/gcc.22722DOI Listing
May 2019

Loss of fragile histidine triad (Fhit) protein expression alters the translation of cancer-associated mRNAs.

BMC Res Notes 2018 Mar 14;11(1):178. Epub 2018 Mar 14.

Center for RNA Biology, The Ohio State University, 484 West 12th Ave., Columbus, OH, 43210, USA.

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http://dx.doi.org/10.1186/s13104-018-3278-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853088PMC
March 2018

Impact of FHIT loss on the translation of cancer-associated mRNAs.

Mol Cancer 2017 12 28;16(1):179. Epub 2017 Dec 28.

Center for RNA Biology, The Ohio State University, Columbus, OH, 43210, USA.

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http://dx.doi.org/10.1186/s12943-017-0749-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745650PMC
December 2017

The ubiquitous 'cancer mutational signature' 5 occurs specifically in cancers with deleted alleles.

Oncotarget 2017 Nov 6;8(60):102199-102211. Epub 2017 Nov 6.

Department of Cancer Biology & Genetics, The Ohio State University Comprehensive Cancer Center & Wexner Medical Center, Biomedical Research Tower, Columbus, OH 43210, USA.

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http://dx.doi.org/10.18632/oncotarget.22321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731946PMC
November 2017

Fhit down-regulation is an early event in pancreatic carcinogenesis.

Virchows Arch 2017 Jun 13;470(6):647-653. Epub 2017 Mar 13.

Comprehensive Cancer Center, Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1007/s00428-017-2105-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568551PMC
June 2017

Fragile Genes That Are Frequently Altered in Cancer: Players Not Passengers.

Cytogenet Genome Res 2016 16;150(3-4):208-216. Epub 2017 Feb 16.

Department of Cancer Biology and Genetics, Comprehensive Cancer Center, Ohio State University Wexner Medical Center, Columbus, OH, USA.

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http://dx.doi.org/10.1159/000455753DOI Listing
April 2017

Identification of Fhit as a post-transcriptional effector of Thymidine Kinase 1 expression.

Biochim Biophys Acta Gene Regul Mech 2017 Mar 14;1860(3):374-382. Epub 2017 Jan 14.

Department of Cancer Biology and Genetics, The Ohio State University, 460 West 12 Ave., Columbus, OH 43210 USA.

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http://dx.doi.org/10.1016/j.bbagrm.2017.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325794PMC
March 2017

Fhit and Wwox loss-associated genome instability: A genome caretaker one-two punch.

Adv Biol Regul 2017 Jan 26;63:167-176. Epub 2016 Sep 26.

Department of Cancer Biology and Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2016.09.008DOI Listing
January 2017

Fhit loss-associated initiation and progression of neoplasia in vitro.

Cancer Sci 2016 Nov 3;107(11):1590-1598. Epub 2016 Oct 3.

Department of Cancer Biology and Genetics, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

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http://dx.doi.org/10.1111/cas.13032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132276PMC
November 2016

Reduction in squamous cell carcinomas in mouse skin by dietary zinc supplementation.

Cancer Med 2016 08 17;5(8):2032-42. Epub 2016 May 17.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.

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http://dx.doi.org/10.1002/cam4.768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873604PMC
August 2016

TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation.

Cancer Res 2015 May 25;75(9):1908-21. Epub 2015 Feb 25.

Program in Molecular Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado. Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado. Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417413PMC
May 2015

WWOX: a fragile tumor suppressor.

Exp Biol Med (Maywood) 2015 Mar 22;240(3):296-304. Epub 2014 Dec 22.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University Wexner Medical Center, Columbus, Ohio 43210, USA

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http://dx.doi.org/10.1177/1535370214561590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471953PMC
March 2015

Fhit deficiency-induced global genome instability promotes mutation and clonal expansion.

PLoS One 2013 14;8(11):e80730. Epub 2013 Nov 14.

Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080730PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828255PMC
February 2015

FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis.

Oncotarget 2015 Feb;6(5):3409-19

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413662PMC
http://dx.doi.org/10.18632/oncotarget.2636DOI Listing
February 2015

The FHIT gene product: tumor suppressor and genome "caretaker".

Cell Mol Life Sci 2014 Dec 5;71(23):4577-87. Epub 2014 Oct 5.

Biomedical Sciences Graduate Program, Ohio State University Wexner Medical Center, Columbus, OH, USA.

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http://dx.doi.org/10.1007/s00018-014-1722-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233150PMC
December 2014

Pluripotent stem cell miRNAs and metastasis in invasive breast cancer.

J Natl Cancer Inst 2014 Dec 11;106(12). Epub 2014 Oct 11.

Department of Molecular Virology, Immunology and Molecular Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH (SV, GN, AD, SC, MiG, RAe, RG, GDL, PG, PD, TW, SEW, FP, NZ, HA, KFH, CMC); Biosystems Analysis, LTTA, Deptartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy, (SV, MES, JM, MaG, MM, CZ, FC, MP, JP, MN); Fate Therapeutics, San Diego, CA (RAb); Department of Chemistry, The Scripps Research Institute, La Jolla, CA (CD); Department of Urology, Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA (RB); Comprehensive Cancer Center, The Ohio State University, Columbus, OH (KM); Deptartment of Internal Medicine, James Cancer Hospital and Ohio State University Comprehensive Cancer Center, The Ohio State University (CLS); Division of Pathology, II University of Rome "La Sapienza," Ospedale Santo Andrea, Rome, Italy (AV); Department of Surgery, Thomas Jefferson University Medical College, Philadelphia, PA (ALR).

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http://dx.doi.org/10.1093/jnci/dju324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334797PMC
December 2014

FHIT suppresses epithelial-mesenchymal transition (EMT) and metastasis in lung cancer through modulation of microRNAs.

PLoS Genet 2014 Oct 23;10(10):e1004652. Epub 2014 Oct 23.

Department of Molecular Virology, Immunology and Medical Genetics, and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207614PMC
October 2014

Androgen receptor status is a prognostic marker in non-basal triple negative breast cancers and determines novel therapeutic options.

PLoS One 2014 5;9(2):e88525. Epub 2014 Feb 5.

Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088525PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914993PMC
September 2014

Replicative Stress and the FHIT Gene: Roles in Tumor Suppression, Genome Stability and Prevention of Carcinogenesis.

Cancers (Basel) 2014 Jun 4;6(2):1208-19. Epub 2014 Jun 4.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

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http://dx.doi.org/10.3390/cancers6021208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074825PMC
June 2014

Histone H1 phosphorylation in breast cancer.

J Proteome Res 2014 May 7;13(5):2453-67. Epub 2014 Apr 7.

Department of Molecular Virology, Immunology and Medical Genetics, ‡Comprehensive Cancer Center, §Department of Chemistry & Biochemistry, ⊥Veterinary Biosciences, College of Veterinary Medicine, and ∥Department of Internal Medicine, Division of Hematology, The Ohio State University , Columbus, Ohio 43210, United States.

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http://dx.doi.org/10.1021/pr401248fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012839PMC
May 2014

Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation.

Proc Natl Acad Sci U S A 2014 Mar 10;111(12):4536-41. Epub 2014 Mar 10.

Department of Molecular Virology, Immunology and Medical Genetics, Wexner Medical Center and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.

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http://dx.doi.org/10.1073/pnas.1402604111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970505PMC
March 2014

Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss-induced global genome instability.

Genes Chromosomes Cancer 2013 Nov 9;52(11):1017-29. Epub 2013 Aug 9.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, OH.

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http://dx.doi.org/10.1002/gcc.22097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293015PMC
November 2013

Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer.

PLoS One 2013 6;8(2):e55910. Epub 2013 Feb 6.

Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055910PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566108PMC
August 2013

Initiation of genome instability and preneoplastic processes through loss of Fhit expression.

PLoS Genet 2012 29;8(11):e1003077. Epub 2012 Nov 29.

Biomedical Sciences Graduate Program, Ohio State University, Columbus, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510054PMC
May 2013

Characterization of the role of Fhit in suppression of DNA damage.

Adv Biol Regul 2013 Jan 11;53(1):77-85. Epub 2012 Oct 11.

Biomedical Sciences Graduate Program, Ohio State University, Columbus, OH 43210, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22124926120009
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http://dx.doi.org/10.1016/j.jbior.2012.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578162PMC
January 2013

Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer.

Carcinogenesis 2012 Sep 10;33(9):1736-44. Epub 2012 Jun 10.

Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University Columbus, OH 43210, USA.

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http://dx.doi.org/10.1093/carcin/bgs204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514898PMC
September 2012

Stem cell-related markers in primary breast cancers and associated metastatic lesions.

Mod Pathol 2012 Jul 2;25(7):949-55. Epub 2012 Mar 2.

Department of Pathology, Yildirim Beyazit University, Ankara Ataturk Research and Training Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1038/modpathol.2012.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400504PMC
July 2012

Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA.

Proc Natl Acad Sci U S A 2012 Feb 6;109(8):3024-9. Epub 2012 Feb 6.

Data Mining for Analysis of Biosystems, Department of Morphology and Embryology, and Medical Oncology, Università degli Studi, 44100 Ferrara, Italy.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1200010109
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http://dx.doi.org/10.1073/pnas.1200010109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286983PMC
February 2012

Response of subtype-specific human breast cancer-derived cells to poly(ADP-ribose) polymerase and checkpoint kinase 1 inhibition.

Cancer Sci 2011 Oct 21;102(10):1882-8. Epub 2011 Jul 21.

Molecular Virology, Immunology and Medical Genetics, and Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio, USA.

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http://dx.doi.org/10.1111/j.1349-7006.2011.02016.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193851PMC
October 2011

Hits, Fhits and Nits: beyond enzymatic function.

Adv Enzyme Regul 2011 28;51(1):208-17. Epub 2010 Oct 28.

Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University Medical Center, Columbus, OH 43210, United States.

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http://dx.doi.org/10.1016/j.advenzreg.2010.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041834PMC
August 2011

Common fragile site tumor suppressor genes and corresponding mouse models of cancer.

J Biomed Biotechnol 2011 29;2011:984505. Epub 2010 Dec 29.

Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1155/2011/984505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035048PMC
June 2011

Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis.

Carcinogenesis 2011 Apr 18;32(4):554-60. Epub 2011 Jan 18.

Department of Pharmacology and Experimental Therapeutics, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1093/carcin/bgr004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066417PMC
April 2011

Effect of zinc supplementation on N-nitrosomethylbenzylamine-induced forestomach tumor development and progression in tumor suppressor-deficient mouse strains.

Carcinogenesis 2011 Mar 19;32(3):351-8. Epub 2010 Nov 19.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1093/carcin/bgq251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047237PMC
March 2011

Molecular biology: DNA fragility put into context.

Authors:
Kay Huebner

Nature 2011 Feb;470(7332):46-7

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http://dx.doi.org/10.1038/470046aDOI Listing
February 2011

Pathology and biology associated with the fragile FHIT gene and gene product.

J Cell Biochem 2010 Apr;109(5):858-65

Integrated Biomedical Science Graduate Program, Ohio State University Medical Center, Columbus, Ohio, USA.

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http://dx.doi.org/10.1002/jcb.22481DOI Listing
April 2010

Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland.

Oral Oncol 2010 Mar 8;46(3):195-9. Epub 2010 Jan 8.

Hacettepe University, Faculty of Medicine, Department of Pathology, Ankara, Turkey.

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http://dx.doi.org/10.1016/j.oraloncology.2009.12.003DOI Listing
March 2010

WWOX gene and gene product: tumor suppression through specific protein interactions.

Future Oncol 2010 Feb;6(2):249-59

The Lautenberg Center for Immunology, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Pharmacy Building, Jerusalem 91120, Israel.

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http://dx.doi.org/10.2217/fon.09.152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832309PMC
February 2010

Nit1 and Fhit tumor suppressor activities are additive.

J Cell Biochem 2009 Aug;107(6):1097-106

Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1002/jcb.22207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762784PMC
August 2009

Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis.

Proc Natl Acad Sci U S A 2009 Aug 21;106(31):12753-8. Epub 2009 Jul 21.

Department of Experimental and Diagnostic Medicine, Interdisciplinary Center for the Study of Inflammation, Emilia Romagna Laboratory BioPharmaNet Laboratory, University of Ferrara, 44100 Ferrara, Italy.

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http://dx.doi.org/10.1073/pnas.0906484106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722368PMC
August 2009

Fragile gene product, Fhit, in oxidative and replicative stress responses.

Cancer Sci 2009 Jul 23;100(7):1145-50. Epub 2009 Mar 23.

Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

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http://doi.wiley.com/10.1111/j.1349-7006.2009.01168.x
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http://dx.doi.org/10.1111/j.1349-7006.2009.01168.xDOI Listing
July 2009

Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells.

Int Immunol 2009 Jun 24;21(6):691-703. Epub 2009 Apr 24.

Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1093/intimm/dxp038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686614PMC
June 2009

Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions.

J Biol Chem 2009 Jan 12;284(2):1040-9. Epub 2008 Nov 12.

Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University and Comprehensive Cancer Center, Columbus, Ohio 43210, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M806638200
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http://dx.doi.org/10.1074/jbc.M806638200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613607PMC
January 2009

Fhit tumor suppressor: guardian of the preneoplastic genome.

Future Oncol 2008 Dec;4(6):815-24

Ohio State University Comprehensive Cancer Center, Department of Molecular Virology, Molecular Virology and Medical Genetics. 460 W 12th Avenue, 43210 Columbus, OH, USA.

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http://dx.doi.org/10.2217/14796694.4.6.815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400506PMC
December 2008

Molecular parameters of genome instability: roles of fragile genes at common fragile sites.

J Cell Biochem 2008 Aug;104(5):1525-33

Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1002/jcb.21560DOI Listing
August 2008

Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells.

Cancer Sci 2008 Jul 2;99(7):1370-6. Epub 2008 May 2.

Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2008.00841.xDOI Listing
July 2008

Wwox and Ap2gamma expression levels predict tamoxifen response.

Clin Cancer Res 2007 Oct;13(20):6115-21

Department of Pathology, Hacettepe University, Ankara, Turkey.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-1282DOI Listing
October 2007

Wwox suppresses prostate cancer cell growth through modulation of ErbB2-mediated androgen receptor signaling.

Mol Cancer Res 2007 Sep 17;5(9):957-65. Epub 2007 Aug 17.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-0211DOI Listing
September 2007

A Fhit-ing role in the DNA damage checkpoint response.

Cell Cycle 2007 May 29;6(9):1044-8. Epub 2007 May 29.

Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan.

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http://dx.doi.org/10.4161/cc.6.9.4213DOI Listing
May 2007

Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression.

Clin Cancer Res 2007 Jan;13(1):268-74

Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-2038DOI Listing
January 2007

Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor.

J Biol Chem 2006 Sep 24;281(38):28244-53. Epub 2006 Jul 24.

Comprehensive Cancer Center and Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, 43210, USA.

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http://dx.doi.org/10.1074/jbc.M603590200DOI Listing
September 2006

Protein expression profiling identifies cyclophilin A as a molecular target in Fhit-mediated tumor suppression.

Mol Cancer Res 2006 Aug;4(8):529-38

Comprehensive Cancer Center and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Room 455C, Wiseman Hall, 410 West 12th Avenue, Columbus, 43210, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-06-0060DOI Listing
August 2006

A role for the WWOX gene in prostate cancer.

Cancer Res 2006 Jul;66(13):6477-81

Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0956DOI Listing
July 2006

Roles of FHIT and WWOX fragile genes in cancer.

Cancer Lett 2006 Jan 12;232(1):27-36. Epub 2005 Oct 12.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.canlet.2005.06.048DOI Listing
January 2006

Fhit and CHK1 have opposing effects on homologous recombination repair.

Cancer Res 2005 Oct;65(19):8613-6

Beijing Institute of Biotechnology, Beijing, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1966DOI Listing
October 2005

WWOX gene restoration prevents lung cancer growth in vitro and in vivo.

Proc Natl Acad Sci U S A 2005 10 13;102(43):15611-6. Epub 2005 Oct 13.

Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, Ohio State University, 410 West 12th Avenue, Columbus, OH 43201, USA.

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http://dx.doi.org/10.1073/pnas.0505485102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266103PMC
October 2005

Modulation of gene expression in precancerous rat esophagus by dietary zinc deficit and replenishment.

Cancer Res 2005 Sep;65(17):7790-9

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1345DOI Listing
September 2005

Concordant loss of fragile gene expression early in breast cancer development.

Pathol Int 2005 Aug;55(8):471-8

Department of Pathology, Haceteppe University, Ankara, Turkey.

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http://dx.doi.org/10.1111/j.1440-1827.2005.01855.xDOI Listing
August 2005

Hypermethylation patterns in the Fhit regulatory region are tissue specific.

Mol Carcinog 2005 Jul;43(3):175-81

Department of Microbiology-Immunology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/mc.20100DOI Listing
July 2005

4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacin.

Carcinogenesis 2005 Mar 9;26(3):571-8. Epub 2004 Dec 9.

Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA.

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http://dx.doi.org/10.1093/carcin/bgh352DOI Listing
March 2005

Involvement of the Fhit gene in the ionizing radiation-activated ATR/CHK1 pathway.

J Cell Physiol 2005 Feb;202(2):518-23

Department of Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1002/jcp.20139DOI Listing
February 2005

Differentially expressed genes execute zinc-induced apoptosis in precancerous esophageal epithelium of zinc-deficient rats.

Oncogene 2004 Oct;23(49):8040-8

Kimmel Cancer Center, Jefferson Medical College, 1020 Locust Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1038/sj.onc.1207974DOI Listing
October 2004

CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors.

Oncogene 2004 May;23(22):3990-8

Kimmel Cancer Center, Thomas Jefferson University, 1008 BLSB, 233S. 10th Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1038/sj.onc.1207526DOI Listing
May 2004

Loss of WWOX expression in gastric carcinoma.

Clin Cancer Res 2004 May;10(9):3053-8

Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1158/1078-0432.ccr-03-0594DOI Listing
May 2004

The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma.

Cancer 2004 Apr;100(8):1605-14

Department of Pathology, Hacettepe University, Ankara, Turkey.

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http://dx.doi.org/10.1002/cncr.20137DOI Listing
April 2004

Fhit is a physiological target of the protein kinase Src.

Proc Natl Acad Sci U S A 2004 Mar 8;101(11):3775-9. Epub 2004 Mar 8.

Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1073/pnas.0400481101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC374320PMC
March 2004

Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses.

Curr Gene Ther 2004 Mar;4(1):53-63

Center for Molecular Medicine, Jichi Medical School, Tochigi 329-0498, Japan.

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http://dx.doi.org/10.2174/1566523044578031DOI Listing
March 2004

Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic.

Proc Natl Acad Sci U S A 2003 Dec 20;100(25):14988-93. Epub 2003 Nov 20.

Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1073/pnas.2336256100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC299872PMC
December 2003

Regression of upper gastric cancer in mice by FHIT gene delivery.

FASEB J 2003 Sep 3;17(12):1768-70. Epub 2003 Jul 3.

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1096/fj.03-0241fjeDOI Listing
September 2003

Combined cyclin D1 overexpression and zinc deficiency disrupts cell cycle and accelerates mouse forestomach carcinogenesis.

Cancer Res 2003 Jul;63(14):4244-52

Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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July 2003

The histidine triad protein Hint is not required for murine development or Cdk7 function.

Mol Cell Biol 2003 Jun;23(11):3929-35

Haartman Institute and Helsinki University Central Hospital, Biomedicum Helsinki, 00014 University of Helsinki, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC155213PMC
http://dx.doi.org/10.1128/mcb.23.11.3929-3935.2003DOI Listing
June 2003

WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer.

Cancer Res 2003 Feb;63(4):878-81

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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February 2003

Candidate tumor suppressor genes at FRA7G are coamplified with MET and do not suppress malignancy in a gastric cancer.

Genomics 2003 Feb;81(2):105-7

Kimmel Cancer Center, Thomas Jefferson University, 233 S. 10th Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/s0888-7543(02)00029-0DOI Listing
February 2003

p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice.

Cancer Res 2003 Jan;63(1):186-95

Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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January 2003

FHIT: from gene discovery to cancer treatment and prevention.

Lancet Oncol 2002 Dec;3(12):748-54

Kimmel Cancer Center, Thomas Jefferson University, PA 19107, USA.

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http://dx.doi.org/10.1016/s1470-2045(02)00931-2DOI Listing
December 2002