Publications Authored by Kay Chapman

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.

Authors:

Evangelos Evangelou Hanneke J Kerkhof Unnur Styrkarsdottir Evangelia E Ntzani Steffan D Bos Tonu Esko Daniel S Evans Sarah Metrustry Kalliope Panoutsopoulou Yolande F M Ramos Gudmar Thorleifsson Konstantinos K Tsilidis Nigel Arden Nadim Aslam Nicholas Bellamy Fraser Birrell Francisco J Blanco Andrew Carr Kay Chapman Aaron G Day-Williams Panos Deloukas Michael Doherty Gunnar Engström Hafdis T Helgadottir Albert Hofman Thorvaldur Ingvarsson Helgi Jonsson Aime Keis J Christiaan Keurentjes Margreet Kloppenburg Penelope A Lind Andrew McCaskie Nicholas G Martin Lili Milani Grant W Montgomery Rob G H H Nelissen Michael C Nevitt Peter M Nilsson William Er Ollier Neeta Parimi Ashok Rai Stuart H Ralston Mike R Reed Jose A Riancho Fernando Rivadeneira Cristina Rodriguez-Fontenla Lorraine Southam Unnur Thorsteinsdottir Aspasia Tsezou Gillian A Wallis J Mark Wilkinson Antonio Gonzalez Nancy E Lane L Stefan Lohmander John Loughlin Andres Metspalu Andre G Uitterlinden Ingileif Jonsdottir Kari Stefansson P Eline Slagboom Eleftheria Zeggini Ingrid Meulenbelt John Pa Ioannidis Tim D Spector Joyce B J van Meurs Ana M Valdes

Ann Rheum Dis 2014 Dec 29;73(12):2130-6. Epub 2013 Aug 29.

Department of Twin Research & Genetic Epidemiology, King's College London, London, UK Department of Academic Rheumatology, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1136/annrheumdis-2012-203114	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251181	PMC

December 2014

Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies.

Authors:

Cristina Rodriguez-Fontenla Manuel Calaza Evangelos Evangelou Ana M Valdes Nigel Arden Francisco J Blanco Andrew Carr Kay Chapman Panos Deloukas Michael Doherty Tõnu Esko Carlos M Garcés Aletá Juan J Gomez-Reino Carnota Hafdis Helgadottir Albert Hofman Ingileif Jonsdottir Hanneke J M Kerkhof Margreet Kloppenburg Andrew McCaskie Evangelia E Ntzani William E R Ollier Natividad Oreiro Kalliope Panoutsopoulou Stuart H Ralston Yolande F Ramos Jose A Riancho Fernando Rivadeneira P Eline Slagboom Unnur Styrkarsdottir Unnur Thorsteinsdottir Gudmar Thorleifsson Aspasia Tsezou André G Uitterlinden Gillian A Wallis J Mark Wilkinson Guangju Zhai Yanyan Zhu David T Felson John P A Ioannidis John Loughlin Andres Metspalu Ingrid Meulenbelt Kari Stefansson Joyce B van Meurs Eleftheria Zeggini Timothy D Spector Antonio Gonzalez

Arthritis Rheumatol 2014 Apr;66(4):940-9

Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain.

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http://dx.doi.org/10.1002/art.38300	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660891	PMC

April 2014

Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data.

Ann Rheum Dis 2013 Jun 6;72(6):935-41. Epub 2012 Sep 6.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/annrheumdis-2012-202081	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664369	PMC

June 2013

No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls.

Ann Rheum Dis 2013 Jan 14;72(1):136-9. Epub 2012 Sep 14.

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/annrheumdis-2012-201932	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551219	PMC

January 2013

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.

Authors:

Eleftheria Zeggini Kalliope Panoutsopoulou Lorraine Southam Nigel W Rayner Aaron G Day-Williams Margarida C Lopes Vesna Boraska Tonu Esko Evangelos Evangelou Albert Hoffman Jeanine J Houwing-Duistermaat Thorvaldur Ingvarsson Ingileif Jonsdottir Helgi Jonnson Hanneke J Kerkhof Margreet Kloppenburg Steffan D Bos Massimo Mangino Sarah Metrustry P Eline Slagboom Gudmar Thorleifsson Emma V A Raine Madhushika Ratnayake Michelle Ricketts Claude Beazley Hannah Blackburn Suzannah Bumpstead Katherine S Elliott Sarah E Hunt Simon C Potter So-Youn Shin Vijay K Yadav Guangju Zhai Kate Sherburn Kate Dixon Elizabeth Arden Nadim Aslam Phillippa-kate Battley Ian Carluke Sally Doherty Andrew Gordon John Joseph Richard Keen Nicola C Koller Sheryl Mitchell Fiona O'Neill Ellen Paling Mike R Reed Fernando Rivadeneira Diane Swift Kirsten Walker Bridget Watkins Maggie Wheeler Fraser Birrell John P A Ioannidis Ingrid Meulenbelt Andres Metspalu Ashok Rai Donald Salter Kari Stefansson Unnur Stykarsdottir André G Uitterlinden Joyce B J van Meurs Kay Chapman Panos Deloukas William E R Ollier Gillian A Wallis Nigel Arden Andrew Carr Michael Doherty Andrew McCaskie J Mark Willkinson Stuart H Ralston Ana M Valdes Tim D Spector John Loughlin

Lancet 2012 Sep 3;380(9844):815-23. Epub 2012 Jul 3.

Wellcome Trust Sanger Institute, Morgan Building, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(	Web Search
http://linkinghub.elsevier.com/retrieve/pii/S014067361260681	Publisher Site
http://dx.doi.org/10.1016/S0140-6736(12)60681-3	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443899	PMC

September 2012

Genetic factors in OA pathogenesis.

Authors:

Kay Chapman Ana M Valdes

Bone 2012 Aug 8;51(2):258-64. Epub 2011 Dec 8.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/j.bone.2011.11.026	DOI Listing

August 2012

Defining the power limits of genome-wide association scan meta-analyses.

Authors:

Kay Chapman Teresa Ferreira Andrew Morris Jennifer Asimit Eleftheria Zeggini

Genet Epidemiol 2011 Dec 15;35(8):781-9. Epub 2011 Sep 15.

Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1002/gepi.20627	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428938	PMC

December 2011

A variant in MCF2L is associated with osteoarthritis.

Am J Hum Genet 2011 Sep 25;89(3):446-50. Epub 2011 Aug 25.

Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1016/j.ajhg.2011.08.001	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169824	PMC

September 2011

The effect of genome-wide association scan quality control on imputation outcome for common variants.

Eur J Hum Genet 2011 May 26;19(5):610-4. Epub 2011 Jan 26.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ejhg.2010.242	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083623	PMC

May 2011

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.

Authors:

Evangelos Evangelou Ana M Valdes Hanneke J M Kerkhof Unnur Styrkarsdottir Yanyan Zhu Ingrid Meulenbelt Rik J Lories Fotini B Karassa Przemko Tylzanowski Steffan D Bos Toru Akune Nigel K Arden Andrew Carr Kay Chapman L Adrienne Cupples Jin Dai Panos Deloukas Michael Doherty Sally Doherty Gunnar Engstrom Antonio Gonzalez Bjarni V Halldorsson Christina L Hammond Deborah J Hart Hafdis Helgadottir Albert Hofman Shiro Ikegawa Thorvaldur Ingvarsson Qing Jiang Helgi Jonsson Jaakko Kaprio Hiroshi Kawaguchi Kalle Kisand Margreet Kloppenburg Urho M Kujala L Stefan Lohmander John Loughlin Frank P Luyten Akihiko Mabuchi Andrew McCaskie Masahiro Nakajima Peter M Nilsson Nao Nishida William E R Ollier Kalliope Panoutsopoulou Tom van de Putte Stuart H Ralston Fernado Rivadeneira Janna Saarela Stefan Schulte-Merker Dongquan Shi P Eline Slagboom Akihiro Sudo Agu Tamm Ann Tamm Gudmar Thorleifsson Unnur Thorsteinsdottir Aspasia Tsezou Gillian A Wallis J Mark Wilkinson Noriko Yoshimura Eleftheria Zeggini Guangju Zhai Feng Zhang Ingileif Jonsdottir Andre G Uitterlinden David T Felson Joyce B van Meurs Kari Stefansson John P A Ioannidis Timothy D Spector

Ann Rheum Dis 2011 Feb 10;70(2):349-55. Epub 2010 Nov 10.

Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.

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http://dx.doi.org/10.1136/ard.2010.132787	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615180	PMC

February 2011

Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility.

Authors:

Ingrid Meulenbelt Steffan D Bos Kay Chapman Ruud van der Breggen Jeanine J Houwing-Duistermaat Dennis Kremer Margreet Kloppenburg Andrew Carr Aspasia Tsezou Antonio González John Loughlin P Eline Slagboom

Ann Rheum Dis 2011 Jan 19;70(1):164-7. Epub 2010 Aug 19.

Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1136/ard.2010.133660	DOI Listing

January 2011

Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis.

Authors:

James M Wilkins Lorraine Southam Zehra Mustafa Kay Chapman John Loughlin

BMC Med Genet 2009 Dec 19;10:141. Epub 2009 Dec 19.

University of Oxford, Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, OX3 7LD, UK.

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http://dx.doi.org/10.1186/1471-2350-10-141	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807860	PMC

December 2009

Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism.

Authors:

Rainer J Egli Lorraine Southam James M Wilkins Inken Lorenzen Manuel Pombo-Suarez Antonio Gonzalez Andrew Carr Kay Chapman John Loughlin

Arthritis Rheum 2009 Jul;60(7):2055-64

RMS Foundation, Bettlach, Switzerland.

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http://dx.doi.org/10.1002/art.24616	DOI Listing

July 2009

Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand.

Arthritis Rheum 2009 Jun;60(6):1710-21

Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.

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http://dx.doi.org/10.1002/art.24524	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412885	PMC

June 2009

Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations.

Authors:

Ingrid Meulenbelt Kay Chapman Rebeca Dieguez-Gonzalez Dongquan Shi Aspasia Tsezou Jin Dai Konstantinos N Malizos Margreet Kloppenburg Andrew Carr Masahiro Nakajima Ruud van der Breggen Nico Lakenberg Juan J Gomez-Reino Qing Jiang Shiro Ikegawa Antonio Gonzalez John Loughlin Eline P Slagboom

Hum Mol Genet 2009 Apr 30;18(8):1518-23. Epub 2009 Jan 30.

Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/hmg/ddp053	DOI Listing

April 2009

Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns.

Authors:

Jennifer J Pointon Kay Chapman David Harvey Anne-Marie Sims Linda Bradbury Kari Laiho Markku Kauppi Kalevi Kaarela Jaakko Tuomilehto Matthew A Brown B Paul Wordsworth

J Rheumatol 2008 Aug 15;35(8):1609-12. Epub 2008 Jul 15.

NIHR OxfordMusculoskeletal Biomedical Research Unit and BotnarResearch Centre, Oxford, UK.

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August 2008

A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility.

Hum Mol Genet 2008 May 24;17(10):1497-504. Epub 2008 Feb 24.

Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/hmg/ddn038	DOI Listing

May 2008

An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage.

Authors:

Lorraine Southam Julio Rodriguez-Lopez James M Wilkins Manuel Pombo-Suarez Sarah Snelling Juan J Gomez-Reino Kay Chapman Antonio Gonzalez John Loughlin

Hum Mol Genet 2007 Sep 6;16(18):2226-32. Epub 2007 Jul 6.

Botnar Research Centre, University of Oxford, UK.

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http://dx.doi.org/10.1093/hmg/ddm174	DOI Listing

September 2007

A novel LEMD3 mutation common to patients with osteopoikilosis with and without melorheostosis.

Authors:

Ana R Couto Jacome Bruges-Armas Chris A Peach Kay Chapman Matthew A Brown B Paul Wordsworth Yun Zhang

Calcif Tissue Int 2007 Aug 11;81(2):81-4. Epub 2007 Jul 11.

Serviço Especializado de Epidemiologia e Biologia Molecular, Hospital de Santo Espírito and Instituto de Biologia Molecular e Celular da Universidade do Porto, Angra do Heroísmo, Açores, GARG/IBMC, 9700-856, Porto, Portugal.

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http://link.springer.com/content/pdf/10.1007/s00223-007-9043	Web Search
http://link.springer.com/10.1007/s00223-007-9043-z	Publisher Site
http://dx.doi.org/10.1007/s00223-007-9043-z	DOI Listing

August 2007

Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee.

Authors:

Ana M Valdes John Loughlin Mark Van Oene Kay Chapman Gabriela L Surdulescu Michael Doherty Tim D Spector

Arthritis Rheum 2007 Jan;56(1):137-46

St. Thomas' Hospital, and King's College London, London, UK.

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http://doi.wiley.com/10.1002/art.22301	Publisher Site
http://dx.doi.org/10.1002/art.22301	DOI Listing

January 2007

Association of the interleukin-1 gene cluster with osteoarthritis of the hip: comment on the article by Meulenbelt et al and the letter by Smith et al.

Authors:

Kay Chapman John Loughlin

Arthritis Rheum 2006 Nov;54(11):3722-3

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http://dx.doi.org/10.1002/art.22182	DOI Listing

November 2006

Presence of a primary hip osteoarthritis susceptibility locus on chromosome 6: comment on the article by Meenagh et al.

Authors:

Kay Chapman Andrew Carr John Loughlin Janet S Sinsheimer

Arthritis Rheum 2006 Mar;54(3):1026-7

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http://doi.wiley.com/10.1002/art.21676	Publisher Site
http://dx.doi.org/10.1002/art.21676	DOI Listing

March 2006

Investigating the aspartic acid (D) repeat of asporin as a risk factor for osteoarthritis in a UK Caucasian population.

Authors:

Zehra Mustafa Barbara Dowling Kay Chapman Janet S Sinsheimer Andrew Carr John Loughlin

Arthritis Rheum 2005 Nov;52(11):3502-6

Botnar Research Centre, Institute of Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, Oxford OX3 7LD, UK.

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http://dx.doi.org/10.1002/art.21399	DOI Listing

November 2005

The common HFE variants C282Y and H63D are not associated with primary OA of the hip or knee.

Authors:

John Loughlin Andrew Carr Kay Chapman

J Rheumatol 2005 Feb;32(2):391-2; author reply 392

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February 2005

Microsatellite association mapping of a primary osteoarthritis susceptibility locus on chromosome 6p12.3-q13.

Authors:

Lorraine Southam Barbara Dowling Athena Ferreira Lucy Marcelline Zehra Mustafa Kay Chapman Graham Bentham Andrew Carr John Loughlin

Arthritis Rheum 2004 Dec;50(12):3910-4

University of Oxford, Oxford, UK.

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http://doi.wiley.com/10.1002/art.20634	Publisher Site
http://dx.doi.org/10.1002/art.20634	DOI Listing

December 2004

Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.

Authors:

John Loughlin Barbara Dowling Kay Chapman Lucy Marcelline Zehra Mustafa Lorraine Southam Athena Ferreira Cathleen Ciesielski Dennis A Carson Maripat Corr

Proc Natl Acad Sci U S A 2004 Jun 21;101(26):9757-62. Epub 2004 Jun 21.

Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Oxford OX1 7LD, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0403456101	Publisher Site
http://dx.doi.org/10.1073/pnas.0403456101	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC470747	PMC

June 2004

Common variants within the interleukin 4 receptor alpha gene (IL4R) are associated with susceptibility to osteoarthritis.

Authors:

Tracy Forster Kay Chapman John Loughlin

Hum Genet 2004 Mar 24;114(4):391-5. Epub 2004 Jan 24.

Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, UK.

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http://dx.doi.org/10.1007/s00439-004-1083-0	DOI Listing

March 2004

Finer linkage mapping of primary osteoarthritis susceptibility loci on chromosomes 4 and 16 in families with affected women.

Authors:

Tracy Forster Kay Chapman Lucy Marcelline Zehra Mustafa Lorraine Southam John Loughlin

Arthritis Rheum 2004 Jan;50(1):98-102

University of Oxford, Oxford, UK.

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http://doi.wiley.com/10.1002/art.11427	Publisher Site
http://dx.doi.org/10.1002/art.11427	DOI Listing

January 2004

Finer linkage mapping of a primary hip osteoarthritis susceptibility locus on chromosome 6.

Authors:

John Loughlin Zehra Mustafa Barbara Dowling Lorraine Southam Lucy Marcelline S Susanna Räinä Leena Ala-Kokko Kay Chapman

Eur J Hum Genet 2002 Sep;10(9):562-8

University of Oxford, Nuffield Department of Clinical Laboratory Sciences and Institute of Molecular Medicine, Oxford, UK.

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http://dx.doi.org/10.1038/sj.ejhg.5200848	DOI Listing

September 2002

Finer linkage mapping of primary hip osteoarthritis susceptibility on chromosome 11q in a cohort of affected female sibling pairs.

Authors:

Kay Chapman Zehra Mustafa Barbara Dowling Lorraine Southam Andrew Carr John Loughlin

Arthritis Rheum 2002 Jul;46(7):1780-3

University of Oxford, Oxford, UK.

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http://doi.wiley.com/10.1002/art.10412	Publisher Site
http://dx.doi.org/10.1002/art.10412	DOI Listing

July 2002

Association of the interleukin-1 gene cluster on chromosome 2q13 with knee osteoarthritis.

Authors:

John Loughlin Barbara Dowling Zehra Mustafa Kay Chapman

Arthritis Rheum 2002 Jun;46(6):1519-27

Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1002/art.10260	DOI Listing

June 2002

Kay Chapman

Kay Chapman

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